Drug Discovery and Immunogen Design

Li Liu, PhD
Research Assistant Professor, AIDS Institute
BSc, PhD (Wuhan University)

Contact          
Email: liuli71@hku.hk
Tel: (852) 2818 9521; Fax: (852) 2817 7805
Office: Room 45B, 5/F, Laboratory Block, 21 Sassoon Road, Pokfulam

Selected publications
Sherman M. Cheng, James C.B. Li, Belinda S.S. Lin, Davy C.W. Lee, Li Liu, Zhiwei Chen, and Allan S.Y. Lau. HIV-1 trans-activator protein induction of suppressor of cytokine signaling-2 contributes to dysregulation of IFN signaling. Blood. Mar 2009; doi:10.1182/blood-2008-10-183525.

Huang X, Lu B, Yu W, Fang Q, Liu L, Zhuang K, Shen T, Wang H, Tian P, Zhang L, Chen Z. A novel replication-competent vaccinia vector MVTT is superior to MVA for inducing high levels of neutralizing antibody via mucosal vaccination. PLoS ONE. 2009;4(1):e4180.

Luo M, Liu H, Zhuang K, Liu L, Su B, Yang R, Tien P, Zhang L, Gui X, Chen Z. Prevalence of drug resistant HIV-1 in rural areas of Hubei province in the People’s Republic of China. J Acquir Immune Defic Syndr. 2009; 00:1–8. (Shared first author)

Chen Y*, Liu L*, Wei Q, Zhu H, Jiang H, Tu X, Qin C, Chen Z. Rhesus angiotensin converting enzyme 2 supports entry of severe acute respiratory syndrome coronavirus in Chinese macaques. Virology. 2008 Nov 10;381(1):89-97. Epub 2008 Sep 17. 2008. Sept. (Shared first author)

Ma T, Liu L, Xue H, Li L, Han C, Wang L, Chen Z, Liu G. Chemical library and structure-activity relationships of 11-demethyl-12-oxo calanolide A analogues as anti-HIV-1 agents. J Med Chem. 2008 Mar 13;51(5):1432-46. Epub 2008 Feb 20.

Liu L, Fang Q, Deng F, Wang H, Yi C, Ba L, Yu W, Lin RD, Li T, Hu ZH, Ho DD, Zhang L, Chen Z.  Resistance of cross-neutralization between palm civet coronavirus and severe acute respiratory syndrome coronavirus. J Virol. 2007 May;81(9):4694-700.

Zhu W, Fang Q, Liu L, Wang H, Zhou J, Yu W, Tien P, Zhang L, Chen Z. The attenuation of vaccinia Tian Tan strain by the removal of viral M1L-K2L genes. Journal of Virological Methods. 2007. 2007 Apr 23; : 17459491.

Zhang Y, Lu L, Ba L, Liu L, Yang L, Jia M, Wang H, Fang Q, Shi Y, Yan W, Chang G, Zhang L, Ho DD, Chen Z. Dominance of HIV-1 subtype CRF01_AE in sexually acquired cases leads to a new epidemic in Yunnan province of China. PLoS Med. 2006 Nov;3(11):e443.

Liu L, Su B, Zhuang K, Tien P, Chen Z, Zhang L. Genetic Genetic Characterization of Full-Length HIV Type 1 Genomes From 3 Infected Paid Blood Donors in Henan, China.  J Acquir Immune Defic Syndr. 2005 Dec 1;40(4):501-503.

Fang Q, Yang L, Zhu W, Liu L, Wang HB, Yu WB, Xiao GF, Tien P, Zhang L, and Chen Z. Host range, growth property and virulence of the smallpox vaccine: vaccinia virus Tian Tan strain. Virology. 2005 335: 242-251.

Su B*, Liu L*, Wang F, Gui X, Zhao M, Tien P, Zhang L and Chen Z. Human immunodeficiency virus type 1 subtype B’ dictates the AIDS epidemic among paid blood donors in Henan and Hubei Provinces of China. AIDS. 2003 Nov 21; 17 (17): 2515-2520. (Shared first author)

Zhou R, Liu L, Guo Y, Yu H, Cheng H, Huang X, Tiersch TR, Berta P. Similar gene structure of two Sox9a genes and their expression patterns during gonadal differentiation in a teleost fish, rice field eel (Monopterus albus). Mol Reprod Dev. 2003 Nov;66(3):211-7.

Huang X, Cheng H, Guo Y, Liu L, Gui J, Zhou R. 2002. A conserved family of doublesex-related genes from fishes. J Exp Zool. 2002 Apr 15;294(1):63-7.

Yi MS, Yu QX, Huang X, Liu JD, Guo YQ, Liu L, Zhou RJ. Painting the chromosomes of fishes with human sex chromosome-specific DNA probes. Yi Chuan Xue Bao. 2001;28(1):1-6. Chinese.

Liu L, Zhou R. Isolation of Sox11a, Sox11b and Sox19 genes from Rice field eel using degenerate primers and nested PCR. Aquatic Sciences. 2001. 63(2):191

Liu L, Guo YQ, Zhou RJ. The cloning and verification of the Sox9 gene of the rice field eel. Yi Chuan Xue Bao. 2001;28(6):535-9. Chinese.

Cheng H, Shi H, Zhou R, Guo Y, Liu L, Liu J, Jiang Y, Kudo T, Sutou S. Characterization of Bovidae sex-determining gene SRY. Genet Sel Evol. 2001. Nov-Dec;33(6):687-94.

Cheng H, Zhou R, Liu L, Du B, Zhou R. Cyclic core dendrimer as a new kind of vector for gene transfer into mammalian cells. Genetica. 2000. 108:53.