An estimated 2-8% of children and adolescents suffer from depression, making this disorder a major public health concern. The World Health Organization estimates that depression will be among the top 2 leading contributors to burden of disease worldwide by 2020 (World Health Organization, 2002). In youth, depressive disorders are a leading cause of morbidity and mortality, often causing significant functional impairment in relationships, school and work. In addition, adolescents with depression are at increased risk for substance abuse, attempted and completed suicide and recurrent depression in adulthood. In cross-cultural studies examining prevalence of depression and suicide, youth in Hong Kong have been shown to have more severe depression (by self-report) and more prevalent suicidal thinking than their American peers (Lau et al., 1999; Stewart et al., 1999, 2002). Yet, depression often goes undiagnosed and untreated in this age group. The evidence base of therapy and medication treatments has increased substantially in the past decade, although at times the findings are difficult to interpret. Furthermore, questions arise as to how to implement the effective treatments into community practice. Development of treatment guidelines and algorithms are a way to do that. This presentation will review: 1) the assessment and diagnosis of depression in youth; 2) evidence-based treatments; and 3) how to implement these treatments in youth with depression in community practice.