Travellers' diarrhoea (TD) is the most common illness among travellers, affecting up to 50% of people visiting some high-risk destinations in developing areas. TD usually is a self-limited disorder and often resolves without specific treatment; however, it may last up to two weeks in severe cases, both ruining an important trip and causing significant morbidity. Although a number of preventive agents have been investigated over the years, the use of prophylactic medication is still not recommended for travellers by most authorities, either because of "insubstantial evidence" or "potential side effects". A big discrepancy in actual practice, however, may be existed when medical professionals were facing the risk themselves. In this presentation, Dr. Ip will share some insights regarding the use of different prophylactic agents for the problem of diarrhea in travellers, and the evidence base currently existed for recommending different practices.