Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences (CAS) evolved from the Institute of Materia Medica of Peking Academy of Sciences founded in 1932. SIMM's mission is to provide a comprehensive solution in drug discovery and development. By combining basic and applied research efforts and through cross-fostering between chemistry and biology, scientists at SIMM carry out studies toward the elucidation of the structural basis of bioactive substances, discovery of new targets or mechanisms of action, comprehensive pre-clinical evaluation of drug candidates, and promotion of commercialization, thereby playing an indispensable role in building China's drug innovation capabilities. Through several generations of effort, SIMM has become one of the leading interdisciplinary research centers in China. It is recognized worldwide by its outstanding achievements in both basic and applied research fields.

HKU-Pasteur Research Centre teamed up with the SIMM and identified new small molecule inhibitors of HIV replication (post-entry events) from a Traditional Chinese Medicine-based library. The Centre is currently following their pharmacological development while developing the next screening assays for Dengue and Influenza as well as the entry step of HIV.

http://www.simm.ac.cn/