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Publication Awards:

  1. Zhang DY, Zhang YH, Sun HY, Lau CP, Li GR.Epidermal growth factor receptor tyrosine kinase regulates the human inward rectifier potassium K(IR)2.3 channel, stably expressed in HEK 293 cells.Br J Pharmacol. 2011 Nov;164(5):1469-78. doi: 10.1111/j.1476-5381.2011.01424.x.
  2. Wu HJ, Wu W, Sun HY, Qin GW, Wang HB, Wang P, Yalamanchili HK, Wang J, Tse HF, Lau CP, Vanhoutte PM, Li GR.Acacetin causes a frequency- and use-dependent blockade of hKv1.5 channels by binding to the S6 domain.J Mol Cell Cardiol. 2011 Dec;51(6):966-73. Epub 2011 Aug 27.
  3. Wong KY, Yim RL, So CC, Jin DY, Liang R, Chim CS.Epigenetic inactivation of the MIR34B/C in multiple myeloma.Blood. 2011 Nov 24;118(22):5901-4. Epub 2011 Oct 5.
  4. Yau T, Yao TJ, Chan P, Wong H, Pang R, Fan ST, Poon RT.The significance of early alpha-fetoprotein level changes in predicting clinical and survival benefits in advanced hepatocellular carcinoma patients receiving sorafenib.Oncologist. 2011;16(9):1270-9. Epub 2011 Sep 1.
  5. Fung J, Cheung C, Chan SC, Yuen MF, Chok KS, Sharr W, Dai WC, Chan AC, Cheung TT, Tsang S, Lam B, Lai CL, Lo CM.Entecavir monotherapy is effective in suppressing hepatitis B virus after liver transplantation.Gastroenterology. 2011 Oct;141(4):1212-9. Epub 2011 Jul 14.
  6. Chen C, Cheung BM, Tso AW, Wang Y, Law LS, Ong KL, Wat NM, Xu A, Lam KS.High plasma level of fibroblast growth factor 21 is an Independent predictor of type 2 diabetes: a 5.4-year population-based prospective study in Chinese subjects.Diabetes Care. 2011 Sep;34(9):2113-5. Epub 2011 Jul 12.
  7. Fung J, Lai CL, Young J, Wong DK, Yuen J, Seto WK, Yuen MF.Quantitative hepatitis B surface antigen levels in patients with chronic hepatitis B after 2 years of entecavir treatment.Am J Gastroenterol. 2011 Oct;106(10):1766-73. doi: 10.1038/ajg.2011.253. Epub 2011 Aug 9.
  8. Ong KL, Tso AW, Xu A, Law LS, Li M, Wat NM, Rye KA, Lam TH, Cheung BM, Lam KS.Evaluation of the combined use of adiponectin and C-reactive protein levels as biomarkers for predicting the deterioration in glycaemia after a median of 5.4 years.Diabetologia. 2011 Oct;54(10):2552-60. Epub 2011 Jul 5.
  9. Tso AW, Lam TK, Xu A, Yiu KH, Tse HF, Li LS, Law LS, Cheung BM, Cheung RT, Lam KS.Serum adipocyte fatty acid-binding protein associated with ischemic stroke and early death.Neurology. 2011 Jun 7;76(23):1968-75. Epub 2011 May 11.
  10. He ML, Liu WJ, Sun HY, Wu W, Liu J, Tse HF, Lau CP, Li GR.Effects of ion channels on proliferation in cultured human cardiac fibroblasts.J Mol Cell Cardiol. 2011 Aug;51(2):198-206. Epub 2011 May 18.
  11. Tao R, Sun HY, Lau CP, Tse HF, Lee HC, Li GR.Cyclic ADP ribose is a novel regulator of intracellular Ca(2+) oscillations in human bone marrow mesenchymal stem cells.J Cell Mol Med. 2011 Dec;15(12):2684-96.
  12. Fung J, Seto WK, Lai CL, Yuen J, Wong DK, Yuen MF. Profiles of HBV DNA in a large population of Chinese patients with chronic hepatitis B: implications for antiviral therapy. J Hepatol. 2011 Feb;54(2):195-200.
  13. Fung J, Lai CL, Chan SC, But D, Seto WK, Cheng C, Wong DK, Lo CM, Fan ST, Yuen MF.Correlation of liver stiffness and histological features in healthy persons and in patients with occult hepatitis B, chronic active hepatitis B, or hepatitis B cirrhosis. Am J Gastroenterol. 2010 May;105(5):1116-22.
  14. Yeung P, Wong DK, Lai CL, Fung J, Seto WK, Yuen MF.Association of hepatitis B virus pre-S deletions with the development of hepatocellular carcinoma in chronic hepatitis B. J Infect Dis. 2011 Mar;203(5):646-54.
  15. Seto WK, Lai CL, Fung J, Hung I, Yuen J, Young J, Wong DK, Yuen MF.Natural history of chronic hepatitis C: genotype 1 versus genotype 6. J Hepatol. 2010 Sep;53(3):444-8.
  16. Yuen MF, Ka-Ho Wong D, Lee CK, Tanaka Y, Allain JP, Fung J, Leung J, Lin CK, Sugiyama M, Sugauchi F, Mizokami M, Lai CL.Transmissibility of Hepatitis B Virus (HBV) Infection through Blood Transfusion from Blood Donors with Occult HBV Infection. Clin Infect Dis. 2011 Mar;52(5):624-32.
  17. Yuen MF, Lee CK, Wong DK, Fung J, Hung I, Hsu A, But DY, Cheung TK, Chan P, Yuen JC, Fung FK, Seto WK, Lin CK, Lai CL. Prevalence of occult hepatitis B infection in a highly endemic area for chronic hepatitis B: a study of a large blood donor population. Gut. 2010 Oct;59(10):1389-93.
  18. Fung J, Lai CL, Cheng C, Wu R, Wong DK, Yuen MF., Mild-to-Moderate Elevation of Alanine Aminotransferase Increases Liver Stiffness Measurement by Transient Elastography in Patients With Chronic Hepatitis B. Am J Gastroenterol. 2010 Dec 14.
  19. Zhang X, Xu A, Chung SK, Cresser JH, Sweeney G, Wong RL, Lin A, Lam KS.Selective Inactivation of c-Jun NH2-Terminal Kinase in Adipose Tissue Protects Against Diet-Induced Obesity and Improves Insulin Sensitivity in Both Liver and Skeletal Muscle in Mice. Diabetes. 2011 Feb;60(2):486-95.
  20. Zhang XH, Jin MW, Sun HY, Zhang S, Li GR.The calmodulin inhibitor N-(6-aminohexyl)-5-chloro-1-naphthalene sulphonamide directly blocks human ether à-go-go-related gene potassium channels stably expressed in human embryonic kidney 293 cells. Br J Pharmacol 2010 Oct;161(4):872-84.
  21. Hung IF, To KK, Lee CK, Lin CK, Chan JF, Tse H, Cheng VC, Chen H, Ho PL, Tse CW, Ng TK, Que TL, Chan KH, Yuen KY. Effect of clinical and virological parameters on the level of neutralizing antibody against pandemic influenza A virus H1N1 2009. Clin Infect Dis. 2010 Aug 1;51(3):274-9.
  22. Chen C, Tso AW, Law LS, Cheung BM, Ong KL, Wat NM, Janus ED, Xu A, Lam KS. Plasma Level of Pigment Epithelium-Derived Factor Is Independently Associated with the Development of the Metabolic Syndrome in Chinese Men: A 10-Year Prospective Study. J Clin Endocrinol Metab. 2010 Aug 4
  23. Pang R, Law WL, Chu AC, Poon JT, Lam CS, Chow AK, Ng L, Cheung LW, Lan XR, Lan HY, Tan VP, Yau TC, Poon RT, Wong BC.A subpopulation of CD26+ cancer stem cells with metastatic capacity in human colorectal cancer.Cell Stem Cell. 2010 Jun 4;6(6):603-15.
  24. Mok MY, Lau CS. The burden and measurement of cardiovascular disease in SSc. Nat Rev Rheumatol. 2010 Jul;6(7):430-4. Epub 2010 Jun 1.
  25. Ma J, Wang JD, Zhang WJ, Zou B, Chen WJ, Lam CS, Chen MH, Pang R, Tan VP, Hung IF, Lan HY, Wang QY, Wong BC. Promoter hypermethylation and histone hypoacetylation contribute to pancreatic-duodenal homeobox 1 silencing in gastric cancer. Carcinogenesis. 2010 Sep;31(9):1552-60. Epub 2010 Jul 9.
  26. Zhang W, Jiang B, Guo Z, Sardet C, Zou B, Lam CS, Li J, He M, Lan HY, Pang R, Hung IF, Tan VP, Wang J, Wong BC.Four-and-a-half LIM protein 2 promotes invasive potential and epithelial-mesenchymal transition in colon cancer.Carcinogenesis. 2010 Jul;31(7):1220-9. Epub 2010 May 11
  27. Kwok KH, Ho PW, Chu AC, Ho JW, Liu HF, Yiu DC, Chan KH, Kung MH, Ramsden DB, Ho SL.Mitochondrial UCP5 is neuroprotective by preserving mitochondrial membrane potential, ATP levels, and reducing oxidative stress in MPP+ and dopamine toxicity. Free Radic Biol Med. 2010 Sep 15;49(6):1023-35. Epub 2010 Jun 19
  28. Ho JW, Ho PW, Zhang WY, Liu HF, Kwok KH, Yiu DC, Chan KH, Kung MH, Ramsden DB, Ho SL.Transcriptional regulation of UCP4 by NF-kappaB and its role in mediating protection against MPP+ toxicity.Free Radic Biol Med. 2010 Jul 15;49(2):192-204. Epub 2010 Apr 9.
  29. Chan JK, Kwong YL.Common misdiagnoses in lymphomas and avoidance strategies.Lancet Oncol. 2010 Jun;11(6):579-88. Epub 2010 Mar 12. Review.
  30. Tang SC, Lam B, Yao TJ, Leung WS, Chu CM, Ho YW, Ip MS, Lai KN. Sleep apnea is a novel risk predictor of cardiovascular morbidity and death in patients receiving peritoneal dialysis. Kidney Int. 2010 Jun;77(11):1031-8. Epub 2010 Mar 17.
  31. Ong KL, Tso AW, Lam KS, Cherny SS, Sham PC, Cheung BM. Using glycosylated hemoglobin to define the metabolic syndrome in United States adults. Diabetes Care2010; Aug: 33(8) Epub 2010 May 26

Major external competitive grants award (Name;Year;Grant;budjet approved; Projet code; Project title)

  1. Prof. CHAN DTM; 2010-11; RGC GRF HKU; 760410M; HK$986,000.00; Characterization of renal proximal tubular epithelial cell antigens that mediate anti-dsDNA antibody binding and internalization, and their pathogenic role in lupus nephritis
  2. Prof. KUNG AWC; 2010-11; RGC GRF HKU; 768610M; HK$1,000,000.00; To determine the functional variants of candidate genes identified by Genome-wide Association Study of Osteoporosis
  3. Prof. LAI KN; 2010-11; RGC GRF HKU; 768910M; HK$1,551,166.00; Renin-angiotensin system within the podocytes in IgA nephropathy
  4. Prof. LAM KSL; 2010-11; RGC GRF HKU; 769410M; HK$1,300,000.00; Obesity, adipose tissue inflammation and atherosclerosis: role of JNK activation
  5. Prof. LI RA; 2010-11; RGC GRF HKU; 772410M; HK$1,683,900.00; Non-cell autonomous directed maturation of developmentally arrested hESC/iPSC-derived cardiomyocytes
  6. Prof. TSE HF; 2010-11; RGC GRF HKU; 780110M; HK$1,600,000.00; Autologous Induced Pluripotent Stem Cells Derived Cardiomyocytes for Cardiac Repair in Porcine Ischemic Cardiomyopathy
  7. Dr. LEUNG AYH; 2010-11; RGC GRF HKU; 771110M; HK$887,400.00; A novel role of methionine aminopeptidase 2 (MetAP-2) in the regulation of hematopoietic stem cell during definitive hematopoiesis
  8. Dr. LIAN Q; 2010-11; RGC GRF HKU; 772510M; HK$808,520.00; The Roles of Mesenchymal Stem Cell Produced Stromal Cell-derived Factor-1 and Neuregulin-1 for Cardiac Progenitor Cell-mediated Myocardial Regeneration in Response to Heart Infarction
  9. Dr. MAK JCW; 2010-11; RGC GRF HKU; 774410M; HK$832,900.00; Effects of cigarette smoke on regulation of the expression of adiponectin and its receptors in airway cells
  10. Dr. SIU DCW; 2010-11; RGC GRF HKU; 777910M; HK$1,200,000.00; Driven Maturation of Embryonic Stem Cell-Derived Cardiomyocytes via Cardiac Hypertrophic Signals
  11. Dr. TSO AWK; 2010-11; RGC GRF HKU; 780210M; HK$609,445.00; Biomarkers of Obesity-related Cardiometaolic Risks in Chinese
  12. Dr. XU A; 2010-11; RGC GRF HKU; 783010M; HK$1,200,000.00; APPL2 as a Negative Regulator of Insulin Sensitivity and Glucose Uptake in Skeletal Muscle: A Novel Pathway Leading to Insulin Resistance?
  13. Prof. CHAN DTM; 2010-11; S.K. Yee Medical Foundation Grants; ; HK$190,000.00; Provision of HBVDNA assays for immunosuppressed HBsAg-positive kidney transplant recipients and patients with kidney diseases
  14. Prof. KWONG YL; 2010-11; S.K. Yee Medical Foundation Grants; ; HK$600,000.00; Provision of clofarabine for the treatment of relapsed or refractory acute leukaemia
  15. Dr. LAM DCL; 2010-11; S.K. Yee Medical Foundation Grants; ;HK$677,700.00; Establishment of molecular tests for personalized therapy regime for lung cancer
  16. Dr. LEUNG AYH; 2010-11; S.K. Yee Medical Foundation Grants; ; HK$600,000.00; Provision of free sorafenib for patients with refractory or replaced acute myeloid leukemia to bridge them to curative bone marrow transplantation
  17. Dr. TANG SCW; 2010-11; S.K. Yee Medical Foundation Grants; ;HK$765,120.00; Provision of freemycophenolate modetil for IgA nephropathy patients with persistent proteinuria despite macimal angiotensin blockade therapy in Hong Kong
  18. Dr. WANG AYM; 2010-11; S.K. Yee Medical Foundation Grants; ;HK$1,472,142.00; Providing intravenous paricalcitol treatment to the sick and poor shronic hemodialysis patients with severe secondary hyperparathyroidism resistant to existing vitamin D analogs
  19. Prof. CHAN DTM; 2009-10; RGC GRF; 760309 M; HK$615,060.00; The role of annexin II in the pathogenesis of lupus nephritis
  20. Prof. CHEUNG RTF; 2009-10; RGC GRF; 763109 M; HK$1,100,000.00; Evaluation of key mechanisms of brain injury and of a novel hemostatic treatment in a rat model of hypertensive intracerebral hemorrhage
  21. Prof. LAM KSL; 2009-10; RGC GRF; 768209 M; HK$755,760.00; Adipocyte fatty acid binding protein as a novel mediator of obesity-related fatty liver disease
  22. Prof. TAN KCB; 2009-10; RGC GRF; 776709 M; HK$1,100,000.00; Reverse cholesterol transport and diabetic nephropathy
  23. Prof.. YUEN RMF; 2009-10; RGC GRF; 782809 M; HK$661,290.00; Genetic and epigenetic analyses of occult hepatitis B virus infection
  24. Dr. CHIM JCS; 2009-10; RGC GRF; 763409 M; HK$944,700.00; Functional study of the impact of hypermethylation of tumor suppressive micro-RNA in myeloma stem cells
  25. Dr. LEUNG AYH; 2009-10; RGC GRF; 769809 M; HK$1,100,000.00; Is aldehyde dehydrogenase a negative regulator of primitive hematopoiesis during embryonic development?
  26. Dr. PANG RWC; 2009-10; RGC GRF; 774309 M; HK$1,039,170.00; Study of a novel role of Pin1 in regulating invasiveness and metastasis of hepatocellular carcinoma via Rho signaling
  27. Dr. TANG SCW; 2009-10; RGC GRF; 777009 M; HK$1,200,000.00; Role of bone morphogenetic protein-7 in diabetic nephropathy
  28. Dr. WANG J; 2009-10; RGC GRF; 778509 M; HK$708,525.00; Characterization of the role and mechanisms of FHL2 in promoting epithelial mesenchymal transition of colon cancer
  29. Dr. XU A; 2009-10; RGC GRF; 781309 M; HK$1,500,000.00; Characterization of Novel Adaptor Proteins Involved in Regulating Insulin Sensitivity and Glucose Homeostasis: from Molecular Mechanism to Physiological Implication
  30. Dr. YUNG SSY; 2009-10; RGC GRF; 783009 M; HK$944,700.00; The role of decorin in peritoneal inflammation and fibrosis
  31. Prof. LAM KSL; 2009-10 RGC CRF; ; HK$6,200,000.00; To Establish a Metabolic Study Center in Hong Kong: Focusing on the Liver-derived Hormones
  32. Prof. TSE HF 2009-10; RGC CRF; ;HK$6,700,000.00; Pluripotent Human Stem Cell Platform for Tissue Regeneration and Drug Screening for Cardiovascular Diseases
  33. Dr. LIAN Q 2009-10; NSFC/RGC; ; HK$744,000.00; Generation of corneal epithelial stem cells from human induced pluripotent stem cells (iPSC) and application for corneal epithelial tissue engineering
  34. Dr. HUNG IFN 2009-10; RFCID-Commissioned Studies on Human Swine Influenza Research-funded Project; ;HK$2,825,754.00; Harvesting Convalescent Plasma for Hyperimmune Intravenous Globulin Production: A Multicentres, Radomised Double-Bline Controlled Trial for Treatment of Patients with Serious S-OIV H1N1 Infection
  35. Prof. KWONG YL 2009-10; S.K; Yee Medical Foundation Grants; ;HK$400,000.00; Provision of ibritumomab for the treatment of lymphoma
  36. Dr. LEUNG AYH; 2009-10; S.K. Yee Medical Foundation Grants; ;HK$631,536.00; Provision of free molecular tests for patients with acute myeloid leukemia with normal cytogenetics
  37. Prof. KUNG AWC; 2008-09; RGC GRF; 766708M ; HK$2,162,190.00 Gene Identification for Osteoporosis using a Two Stage Genome-wide Association Strategy in the Chinese Population
  38. Prof. LAI KN; 2008-09; RGC GRF; 766908M; HK$1,606,826.00; Infiltrating leukocytes in the tubulointerstitium of IgA nephropathy: Their role in pathogenesis
  39. Prof. LAM KSL; 2008-09; RGC GRF; 767208M; HK$1,016,506.00; Role of JNK in adipose tissue inflammation, adipokine production and systemic insulin resistance
  40. Prof. LAN HY; 2008-09; RGC GRF; 767508M; HK$1,721,503.00; Smad Signaling in Angiotensin II-Mediated Renal Fibrosis
  41. Prof. LIANG RHS; 2008-09; RGC GRF; 770308M; HK$1,383,247.00; Is Jak2V617F mutation a stem cell event in chronic myeloproliferative disease?
  42. Prof. TSE HF; 2008-09; RGC GRF; 776908M; HK$1,129,516.00; Transplantation of Bioengineered Human Embryonic Stem Cell-derived Cardiomyocytes with Mature Electrical Phenotype in Post-infarction Heart Failure Improves Cardiac Function Without Proarrhythmia
  43. Prof. YUEN RMF; 2008-09; RGC GRF; 781108M; HK$566,592.00; Transmissibility of hepatitis B virus infection from blood donors with occult hepatitis B infection
  44. Dr. CHUNG ACK; 2008-09; RGC GRF; 763908M; HK$1,110,847.00; Functional role of PPAR interacting protein (PRIP) in diabetic nephropathy
  45. Dr. HUANG Q; 2008-09; RFC GRF; 765808M; HK$838,999.00; Large scale association studies of osteoporosis in Chinese
  46. Dr. LAN XR; 2008-09; RFC GRF; 767608M; HK$922,165.00; Mechanisms of Peritoneal Fibrosis: Role of TGF-beta Signaling
  47. Dr. LEUNG JCK; 2008-09; RGC GRF; 769308M; HK$1,119,164.00; The role of aldosterone in the pathogenesis of IgA nephropathy
  48. Dr. LI GR; 2008-09; RGC GRF; 770108M; HK$1,396,904.00; Calcium Signals and Cell Proliferation in Human Cardiac Fibroblasts
  49. Dr. MAK JCW; 2008-09; RGC GRF; 771908M; HK$1,159,037.00; Effects of intermittent hypoxia and/or cigarette smoking on endothelial injury in vivo - relevant to obstructive sleep apnea
  50. Dr. PANG RWC; 2008-09; RGC GRF; 773108M; HK$1,292,447.00; A study of the modulatory effects of p53 on Pin1-mediated tumor growth, invasion and metastasis in hepatocellular carcinoma
  51. Dr. SIU DCW; 2008-09; RGC GRF; 774708M; HK$1,552,564.00; Long-term Efficacy and Safety of a Gene-based Bio-artificial Pacemaker tested in a large animal Sick Sinus Syndrome Model
  52. Dr. TAN KCB; 2008-09; RGC GRF; 775708M; HK$740,565.00; Soluble receptor for advanced glycation end products and diabetic complications
  53. Dr. TANG SCW; 2008-09; RGC GRF; 776008M; HK$1,292,447.00; Role of N-acetyl-seryl-aspartyl-lysyl-proline in nephropathies
  54. Dr. WANG M; 2008-09; RGC GRF; 777508M; HK$598,917.00; Atrial Mechanical Dyssynchrony and Function in Sinus Node Disease Patients With And Without Atrial Fibrillation: Impacts of Different Modes of Atrial and Ventricular Pacing
  55. Dr. XU A; 2008-09; RGC GRF; 779608M; HK$1,107,306.00; Protective roles of AMP-activated protein kinase against vascular disease in diabetes: Molecular mechanisms and therapeutic intervention
  56. Dr. YUNG SSY; 2008-09; RGC GRF; 781208M; HK$912,994.00; Role of high and low molecular weight hyaluronan in the pathogenesis of lupus nephritis
  57. Dr. XU A; 2008-09; NFSC/RGC; HK$712,000.00; Adipocyte fatty acid binding protein as a novel diagnostic marker and therapeutic target to combat vascular complications of diabetes: mechanisms and clinical implications
  58. Prof. KUNG AWC; 2008-09; HHSRF; HK$134,296.00; Cost-Effective Osteoporosis Intervention Thresholds for Hong Kong Southern Chinese Postmenopausal Women
  59. Prof. LAM TP; 2008-09; RFCID; HK$478,924.00; Attitudes, beliefs and knowledge concerning antibiotic use and resistance of the general public in Hong Kong: A combined qualitative and quantitative study
  60. Prof. YUEN RMF; 2008-09; RFCID; HK$699,110.00; Virological and clinico-pathological factors in estimating the chance of recurrence of hepatocellular carcinoma after surgical resection in patients with chronic hepatitis B
  61. Dr. WONG DKH; 2008-09; RFCID; HK$566,624.00; Application of COLD-PCR sequencing for the early detection of HBV antiviral drug resistance mutations
  62. Prof. KWONG YL; 2008-09; S.K. Yee Medical Foundation Grants; HK$993,866.00; Provision of new anti-fungal drugs free-of-charge to patients with blood cancers and after bone marrow transplantation who are suffering from invasive fungal infections
  63. Prof. TSE HF; 2008-09; S.K. Yee Medical Foundation Grants; HK$1,665,000.00; Direct endomyocardial injection of autologus bone marrow cells for treatment of patients with "end-stage" Ischaemic heart failure
  64. Dr. LEUNG AYH; 2008-09; S.K. Yee Medical Foundation Grants; HK$692,700.00; Provision of free service for serum polyoma BK virus quantification to kidney transplant recipients in Hong Kong


Below lists the links for publication and research output by Speciality Divisions and Unit, taken from the Research Outputs System (ROS) database of HKU.

 

 

 

  
 


 
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