Dr Siu-yuen CHAN (³¯¤p¶ê)
(sychan@hku.hk)

BSc (H.K.)
MPhil (H.K.)
PhD (Cambridge, U.K.)

 Associate Professor

Appointments

Croucher research fellow, Wellcome/CRC Institute, Cambridge, UK, 1991; Lecturer 1992-2000; Associate Professor 2001

Specialty

Molecular basis of mammalian development and genetic diseases

Current Research

My group is interested in understanding the genetic control of mammalian development and how abnormalities in this process lead to diseases. By homologous recombination in embryonic stem cells, mutant mice with a specific mutation can be created. We are using these ¡¥knockout¡¦ mice as well as transgenic mice to elucidate gene function in vivo. Currently we are working on two mutant lines which provide novel insights into the genetic control of behaviour. We are elucidating the functions of the two genes using biochemical and molecular approaches in cell cultures; as well as histochemical, electrophysiological and behavioural studies in mice.

Chan's group is inviting enthusiastic, dedicated research postgraduate students to join the detective work on finding gene functions using mouse mutants generated in the laboratory. The area is in transcription regulation and neuron function.


   Selected Publications

  1. TSPYL2 is important for G1 checkpoint maintenance upon DNA damage, K. P. Tao., S. W. Fong, Z. Lu, Y. P. Ching , K. W. Chan, S.Y. Chan (2011) PLoS One, 6(6), e21602.
  2. Subcellular localization of SUN2 is regulated by lamin A and rab5, Y. Liang, P. H. Chiu, K.Y. Yip and S.Y.Chan (2011) PLoS One, 6(5), e20507.
  3. Differential effects of glial cell line-derived neurotrophic factor and neurturin in RET/GFR£\ expressing cells, R.H.K. Lee, W.L. Wong, C.H. Chan and S.Y. Chan (2006) Journal of Neuroscience Research, 83, 80-90.
  4. Identification of genes expressed during myocardial development by Suppression Subtractive Hybridisation, S.Y. Chan, A.K.W. Chan, B.P.K. Cheung, Y. Liang, M. P. Leung (2003) Chinese Medical Journal, 116 (9), 1329-1332.
  5. Epidermal growth factor as a biologic switch in the hair cycle, K.K.L. Mak and S.Y. Chan (2003) J. Biol. Chem., 278, 26120-26126.
  6. RET receptor tyrosine kinase isoforms in kidney function and disease, D.C.W. Lee, K.W. Chan, S.Y. Chan (2002) Oncogene, 21, 5582-5592.
  7. Isolation of differentially expressed genes in human heart tissues, G. Sun*, S.Y. Chan*, Y.Yuan, K.W.Chan, G. Qiu, K. Sun and M. P. Leung * Equal contribution (2002) Biochim Biophy. Acta, Mechanism of Disease, 1588, 241-246.
  8. Overexpression of epidermal growth factor induced hypospermatogenesis in transgenic mice, R.W.C. Wong, R.W.P. Kwan, P.H.S. Mak, K.K.L. Mak, M.H. Sham and S.Y. Chan (2000) J. Biol. Chem., 275 (24), 18297-18301.
  9. Expression of epidermal growth factor in transgenic mice causes growth retardation, S.Y. Chan and R.W.C. Wong (2000) J. Biol. Chem., 275 (49), 38693-38698.

   Present Higher Degree Students

  1. Mr. Anson K.H. Tsang (PhD candidate)
    Awards:
    • Japanese Society of Developmental Biologists (JSDB) travel award 2010
    • Best presentation award, 43rd Annual meeting for the JSDB
  2. Mr. Hang Liu (MPhil candidate)
  3. Mr. Cypress Ng (MPhil candidate)

   Graduated Higher Degree Students (click to open)






 

  
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