Department of Pathology
The University of Hong Kong

presents

Croucher Advanced Study Institute 2012
Tumour Microenvironment – New Concepts and Molecular Mechanisms
9 - 13, January 2012
Free Registration
Download full programme here

Introduction

Cancer is the major cause of death in Hong Kong as in most parts of the world. Traditional studies on cancer emphasize on the roles of genetic and epigenetic changes in cancer cells. In recent years, increasing volume of literature identifies the important interaction between tumour cells and the surrounding stroma. Such tumour microenvironment comprises of complicated networking including cellular and non-cellular components and affects crucial signaling pathways factors that control tumour invasion and metastasis, chemoresistance and response to metabolic stress. Understanding of the most advanced breakthroughs and development in this field is of great importance to cancer researchers. It is expected that such knowledge is of utmost importance in developing novel prognostic marker that can better predict outcome of cancer patients as well as innovative therapeutic targets that can overcome chemoresistance and improve survival of our cancer patients. These concepts are included as main themes of the proposed ASI.

The lecturers are all well-renowned masters of the field and have contributed to high impact research. It will provide a precious opportunity for researchers from Hong Kong and the region to be enlightened directly and interactively from the masters in the field. The ASI also makes available a valuable platform of scientific networking which facilitates collaborative interactions among the local participants and the masters.

Opening Address
Lecture Theatre 4
William MW Mong Block
21 Sassoon Road, Pokfulam
Hong Kong
9:00AM, January 9, 2012

by

Professor Paul K.H. TAM
Pro-Vice-Chancellor and Vice-President (Research)

Professor S.P. Lee
Dean, Li Ka Shing Faculty of Medicine

Professor Annie N.Y. CHEUNG
Event Director

Open Lectures

by

Professor Lewis CANTLEY Department of Medicine Beth Israel Deaconess Medical Center, USA Click here for abstract
Professor Douglas GREEN Department of Immunology St. Jude Children's Research Hospital, USA
Professor Tak-Wah MAK The Campbell Family for Breast Cancer Research Institute University Health Network, Canada Click here for abstract
Professor Gerry MELINO Faculty of Medicine, University of Rome, Italy Medical Research Council, Toxicology Unit United Kingdom Click here for abstract
Professor Sven PETTERSON Division of Molecular Pathology, Karolinska Institutet, Sweden
Professor Lorenz POELLINGER Department of Cell and Molecular Biology, Karolinska Institutet, Sweden

Director

Annie Nga-Yin CHEUNG
Professor
Department of Pathology
The University of Hong Kong

Organizing Committee

For registration and enquiry, please contact Miss Jackie Luk
at Tel. 2255-4875 or jackluk@pathology.hku.hk

Croucher Foundation

The Croucher Foundation is an independent private foundation established by the late Noel Croucher in 1979 to promote the standard of the natural sciences, technology and medicine in Hong Kong

• scholarships and fellowships for promising young Hong Kong scientists and medical doctors to pursue research overseas;
• senior research fellowships to enable leading scientists in Hong Kong to spend a sabbatical year away from teaching and administrative work;
• conferences, workshops and collaborative research to facilitate the exchange of ideas between Hong Kong scientists and their counterparts overseas;
• demonstration lectures to promote a wider understanding of science among Hong Kong school students and undergraduate students; and
• support for any undergraduate student in Hong Kong experiencing sudden financial difficulty.

Croucher Advanced Study Institute

An Advanced Study Institute (ASI) is a high-level teaching activity where a carefully defined subject, systematically presented, is treated in depth by lecturers of international standing, and new advances in a subject, not taught elsewhere, are reported in tutorial form. ASIs, as short courses, contribute to the dissemination of knowledge and the formation of international scientific contacts. The teaching in ASIs is aimed at established scientists with substantial scientific background in the topic being proposed.

A seminar

The role of metabonomics in exploring disease etiology

by

Yulan Wang
Wuhan Institute of Physics and Mathematics

December 12, 2011
11:00AM-12:00PM
Seminar Room 6, Laboratory Block
Li Ka Shing Faculty of Medicine
21 Sassoon Road
Pokfulam, Hong Kong

All are welcome

A Technology Symposium

Advances in Mass Spectrometry Symposium 2011
 

Co-organized by the Department of Pathology,
Centre for Reproduction, Development and Growth, LKS Faculty of Medicine
and
Agilent Technologies

11:15 AM - 4:00 PM, 25 October 2011
Lecture Theatre 3
Cheung Kung Hai Conference Centre
LKS Faculty of Medicine
Pokfulam Road, Hong Kong

All are welcome

Jointly organized by

The Hong Kong College of Pathologists

and

Department of Pathology
The University of Hong Kong

A Seminar

Bowel Cancer Screening in the UK -
Pathology and Performance Indicators

by

Dr Kevin West
Consultant Histopathologist
University Hospitals of Leicester NHS Trust

Honorary Senior Lecturer in
Cancer Studies and Molecular Medicine
Leicester Medical School

5:00 - 6:00 PM, Monday, September 5, 2011
Lecture Theatre, University Pathology Building
Queen Mary Hospital
Pokfulam Road, Hong Kong

All are welcome

HKCPath - 1 CME point
MLT Board - 1 CPD point (code: 04111081)

A Seminar

MicroRNA in the Molecular Genetic Alterations
in Multistep Hepatocarcinogenesis

by

Professor Irene Oi Lin Ng
Loke Yew Professor in Pathology
Chair Professor
Department of Pathology
The University of Hong Kong

1:00 PM, Thursday, July 28, 2011
Lecture Theatre
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04111071

A Seminar

Direct Regulation of Cancer Stem Cell Marker CD133 by c-Myc is Modulated
by both CpG Methylation and Histone H4K16 Acetylation

by

Dr Kan Junsuo
Post-doctoral Fellow
Department of Pathology
The University of Hong Kong

1:00 PM, Thursday, July 21, 2011
Lecture Theatre
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04111061

RESEARCH POSTGRADUATE STUDENTS (RPGS) RETREAT

Date: 15th July, 2011
Time: 1:00PM – 5:35PM
Venue: Pathology Lecture Theatre
University Pathology Building
Queen Mary Hospital

***********
PROGRAMME (20-min presentation + 5-min discussion)
1:00PM Opening Remarks

1:10PM CHAN Wing Lim Wallace - 2nd Yr MPhil student of Dr. John Nicholls
Protein Interaction of SARS-CoV and the host

1:35PM SO King Yan, Leo - 2nd Yr MPhil student of Dr. John Nicholls
Dynamics of the Mammalian Nuclear Proteome during Influenza Viral Infection Using SICAC-Based Quantitative Proteomics

2:00PM LUI Wing Chi Winnie - 2nd Yr PhD student of Dr. Ray Ng
Epigenetic alterations in MLL-rearranged leukemogenesis

2:25PM MA Wei - 2nd Yr PhD student of Professor Irene Ng
RhoE is underexpressed in hepatocellular carcinoma and suppresses cell motility and invasiveness

2:50PM TSUI Yu Man - 2nd Yr PhD student of Professor Irene Ng
Functional characterization of Dishevelled 2 in HCC

3:15PM Tea Break

3:30PM FAN Ngo Yin Dorothy – 2nd Yr PhD student of Dr. Jack Wong
Identification of non-histone protein target of histone lysine methyltransferase SUV39H1

3:55PM AU Leung Kuen, Sandy – 4th Yr PhD student of Dr. Jack Wong
Enhancer of zeste homolog 2 (EZH2) epigenetically silences multiple tumor suppressor miRNAs to promote liver cancer metastasis

4:20PM MAK Chun Yin Victor - 3rd Yr PhD student of Professor Annie Cheung
Molecular studies on ASPP and FBI-1 in gestational trophoblastic disease

4:45PM LAU Lai Yee - 3rd Yr PhD student of Professor US Khoo
Identification of microRNAs associated with tamoxifen resistance in breast cancer

5:10PM CHEN Jie - 4thYr PhD student of Professor US Khoo
The interaction of FOXO3a and miR-221/222 in breast cancer

5:35PM Prize giving & closing remarks by Adjudicator:
Dr. Maria Mercedes Garcia-Barcelo
(Assistant Professor, Department of Surgery, HKU)

For any further enquiries, please email Ms Irene Tong

A Technology Seminar

Introduction to Roche cobas genomics & oncology portfolio

by

Mr Brian Earp
International Business Leader
Genomics and Oncology
Roche Molecular System

1:00 - 2:00 PM, Tuesday, July 12, 2011
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

A Seminar

Colorectal Cancer: From Genetics to Epigenetics

by

Dr Chan Tsun Leung, Chris
Assistant Professor
Department of Pathology
The University of Hong Kong

1:00 PM, Thursday, June 30, 2011
Lecture Theatre
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04111051

A Seminar

Molecular Dissection and Targeting of Leukemic Stem Cells

by

Professor So Chi Wai, Eric
Professor and Chair in Leukaemia Biology Head
Leukaemia and Stem Cell Biology Group
Department of Haematological Medicine
King's College London, The University of London
United Kingdom

5:00 PM, Thursday, June 23, 2011
Lecture Theatre
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04111041

A Seminar

Update on Thalassemia Research in Thailand

by

Professor Suthat FUCHAROEN
Thalassemia Research Center
Institute of Science and Technology for Research and
Development Mahidol University, Thailand

11:30 AM, Thursday, May 26, 2011
Lecture Theatre
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04111031

A Seminar

Phosphorylation of DLC1 Tumor Suppressor:
Its Functional Impact

by

Dr Yam Wai Ping, Judy
Assistant Professor
Department of Pathology
The University of Hong Kong
 

1:00 PM, Thursday, May 19, 2011
Lecture Theatre
University Pathology Building
Queen Mary Hospital
 
All are welcome
 
MLT CPD code: 04111021

A Seminar

Lung Cancer - the Evolving Paradigm

by

Dr Wong Pik, Maria
Associate Professor
Department of Pathology
The University of Hong Kong

1:00 PM, Thursday, May 12, 2011
Lecture Theatre
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04111011

A Seminar

Diagnosing Beta Thalassaemia Trait in
Iron Deficient Patients - The Wait is Over

by

Dr So Chi Chiu, Jason
Associate Professor
Department of Pathology
The University of Hong Kong
 
1:00 PM, Thursday, April 28, 2011
Lecture Theatre
University Pathology Building
Queen Mary Hospital
 
All are welcome

MLT CPD code: 04101451

A Seminar
 

Demystifying Medical Humanities -
Why It matters to Medicine and Society
 

by
 

Professor Chan Li Chong
Chair Professor and Head
Department of Pathology
The University of Hong Kong
 
(Professor Chan is also Co-ordinator of the
Task Force in Medical Humanities, LKS Faculty of Medicine, and
Co-director of the Centre for the Humanities and Medicine, HKU)

 
1:00 PM, Thursday, April 21, 2011
Lecture Theatre
University Pathology Building
Queen Mary Hospital
 
All are welcome
 
MLT CPD code: 04101441

Jointly organized by

Department of Medicine

&

Department of Pathology
The University of Hong Kong

A Seminar

Epigenetic Regulation of Hepatic Stellate Cells:
New Target for Liver Fibrosis?

by

Professor Hide Tsukamoto
Professor of Pathology
Director of Southern California Research Center for ALPD and Cirrhosis
Keck School of Medicine, University of Southern California, USA

4:30 PM, Tuesday, April 19, 2011
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04101421

A Seminar

Biomarker & Target of Liver Cancer

by

Professor Wang Hong-Yang
Academician of Chinese Academy of Engineering
Professor & Director
International Cooperation Laboratory on Signal Transduction
Eastern Hepatobiliary Surgery Institute / Hospital, Shanghai
State Key Laboratory of Oncogenes and related Genes
Shanghai Cancer Institute, Renji Hospital
Shanghai Jiaotong University School of Medicine

1:00 PM, Friday, April 8, 2011
Lecture Theatre
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04101431

Jointly organized by

Department of Pathology
&
Department of Biochemistry
The University of Hong Kong

A Seminar

WASP, WIP and Podosome Dynamics

by

Professor Gareth E Jones
Head, Cell Motility & Cytoskeleton Section
Randall Division of Cell & Molecular Biophysics
King’s College School of Biomedical Sciences
United Kingdom

5:00 PM, Wednesday, March 23, 2011
Lecture Theatre 4, Cheung Kung Hai Conference Centre
G/F, William MW Mong Block
Li Ka Shing Faculty of Medicine

All are welcome

MLT CPD code: 04101411

Jointly organized by

Department of Pathology
&
Centre for Cancer Research
The University of Hong Kong

A Seminar

PAK4 and Cancer Cell Migration

by

Dr Claire Wells
Cell Biology & Imaging Section
Division of Cancer Studies
King’s College School of Medicine
United Kingdom

1:00 PM, Wednesday, March 23, 2011
Lecture Theatre
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04101401

A Seminar

Roles of B Cells in Autoimmunity

by

Dr Liwei Lu
Associate Professor
Department of Pathology
The University of Hong Kong

1:00 PM, Thursday, March 17, 2011
Lecture Theatre
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04101391

A Seminar

Cancer Stem Cells Switch Between Two Distinct Phenotypes
in Squamous Cell Carcinoma

by

Dr Adrian Biddle
Post-doctoral Fellow
Barts and The London School of Medicine and Dentistry
Queen Mary, University of London
United Kingdom

1:00 PM, Tuesday, March 8, 2011
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04101381

A Seminar

Killing Them, Killing Us

A Reflection on Judicial Execution and the Medical Profession

by

Dr Beh Swan Lip, Philip
Associate Professor
Department of Pathology
The University of Hong Kong

1:00 PM, Thursday, March 3, 2011
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04101371

A Seminar

Phosphatase and Tensin Homolog (PTEN)
in Hepatocellular Carcinoma and Its Implications
in Cancer Metastasis

by

Dr Sze Man Fong, Karen
Post-doctoral Fellow
Department of Pathology
The University of Hong Kong

1:00 PM, Thursday, January 27, 2011
Room 004 (Venue changed)
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04101341

Joint Seminar
Departments of Chemistry & Pathology

Understanding Protein
Misfolding Diseases Using Proteomics

Professor John R. YATES III
Department of Chemical Physiology
The Scripps Research Institute
California, U.S.A.

5:00 PM, January 25, 2011 (Tuesday) Pathology
Lecture Theatre, 1/F.,
University Pathology Building
Queen Mary Hospital
Pokfulam, Hong Kong

All are welcome

A Seminar

Retinoic Acid Receptor Responder 3 Expression
in Colorectal Cancer

by

Dr Yan Hoi Ning, Helen
Post-doctoral Fellow
Department of Pathology
The University of Hong Kong

1:00 PM, Thursday, January 20, 2011
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04101331

A Seminar

Gene Expression Programme of
Colon Crypt and Pathways Involved in Intestinal Stem Cell Regulation

by

Professor Leung Suet Yi
Department of Pathology
The University of Hong Kong

1:00 PM, Thursday, January 6, 2011
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04101321

A Seminar

Post-translational Regulations of Tumor Suppressor Deleted
in Liver Cancer 1 (DLC1) in Cancers

by

Dr Ko Chi Fat, Frankie
Post-doctoral Fellow
Department of Pathology
The University of Hong Kong

1:00 PM, Thursday, December 23, 2010
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04101301

A Seminar

Does Hepatitis B x Antigen Promote the Appearance
of Liver Cancer Stem Cells?

by

Mark Feitelson, Ph.D.
Professor of Biology
Associate Director
Temple Biotechnology Center
College of Science and Technology
Temple University, USA

12:00 PM, Monday, December 20, 2010
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04101311

A Seminar

Controlling Seasonal and Pandemic Influenza:
Transmission, Pathogenesis and New Therapeutic Strategies

by

Dr Chan Wan Yi, Renee
Post-doctoral Fellow
Department of Pathology
& Department of Microbiology
The University of Hong Kong

1:00 PM, Thursday, December 9, 2010
Lecture Theatre
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04101291

A Seminar

Study of Translation Initiation Efficiency Differentially
Affects the Translation of Breast Cancer Associated Gene Isoforms

by

Dr Cheung Yuen Nei
Post-doctoral Fellow
Department of Pathology
The University of Hong Kong

1:00 PM, Thursday, November 25, 2010
Lecture Theatre
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04101281

A Seminar

Epigenetic Regulation of AKAP12 in Human Hepatocarcinogenesis

by

Dr Odilia Popanda
Senior Scientist
German Cancer Research Center (DKFZ)
Germany

1:00 PM, Tuesday, November 16, 2010
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04101271

Jointly organized by

Department of Pathology
The University of Hong Kong

and

The Royal College of Pathologists of Australasia


A Seminar

A Historical Lecture on Stem Cell Regeneration and the Myth of Prometheus

by

Professor John Rasko
RCPA Visiting Professor
and
Professor, Department of Cell and Molecular Therapies
Royal Prince Alfred Hospital & Centenary Institute
Sydney, Australia

5:30PM, Wednesday, November 3, 2010
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04101251

A Seminar

Alterations in Wnt Signaling Pathway in Hepatocellular Carcinoma

by

Dr Tung Kwok Kwan, Edmund
Post-doctoral Fellow
Department of Pathology
The University of Hong Kong

1:00 PM, Thursday, October 21, 2010
Lecture Theatre
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04101231

A Seminar

Genetic Abnormalities of NF-kB Regulators in DLBCL

by

Dr Chen Yun Wen, Wendy
Post-doctoral Fellow
Department of Pathology
The University of Hong Kong

1:00 PM, Thursday, October 14, 2010
Lecture Theatre
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04101221

A Seminar

Making and Breaking the Link -
How Changes to a Receptor Can Influence Influenza Virus Infection

by

Dr John Nicholls
Associate Professor
Department of Pathology
The University of Hong Kong

1:00 PM, Thursday, September 30, 2010
Lecture Theatre
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04101211

A Seminar

Epigenetic Modifying Enzymes in
Leukaemia Initiation and Drug Response

by

Professor So Chi Wai, Eric
Professor and Chair in Leukaemia Biology
Head, Leukaemia and Stem Cell Biology Group
Department of Haematological Medicine
King's College London, The University of London, UK

5:00 PM, Monday, September 13, 2010
Lecture Theatre
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04101191

A Seminar

Development of Stem Cell & Regenerative Medicine in HK:
Heart Regeneration as a Case Study

by

Professor Ronald Li
Director
Stem Cell & Regenerative Medicine Consortium (SCRMC)
Li Ka Shing Faculty of Medicine
The University of Hong Kong

1:00 PM, Thursday, September 9, 2010
Lecture Theatre
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04101201

Jointly organized by

The Hong Kong College of Pathologists

and

Department of Pathology
The University of Hong Kong

A Seminar

Histopathology External Quality Assurance (EQA) Schemes and
their role in revalidation

by

Dr Raymond McMahon
Senior Lecturer in Pathology
The University of Manchester
and
Honorary Consultant Pathologist
Central Manchester and
Manchester Children's University Hospitals NHS Trust

5:00 - 6:00 PM
Monday, September 6, 2010
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

HKCPath - 1 CME point
MLT Board - 1 CPD point (Code: 04101181)

A

Identifying Hepatocellular Carcinoma Susceptible Loci
via Genome-wide Association Analysis

by

Dr Chan Yuen Kwong, Kelvin
Research Assistant Professor
Department of Pathology
The University of Hong Kong

1:00 PM, Thursday, August 19, 2010
Lecture Theatre
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04101171

A Seminar

The Tumor Suppressor DLC1 -
from Focal Adhesions to Nucleus

by

Dr Chan Lo Kong
Post-doctoral Fellow
Department of Pathology
The University of Hong Kong

1:00 PM, Thursday, August 12, 2010
Lecture Theatre
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04101161

A Seminar

MicroRNA-616 Induces Androgen-independent Growth of Prostate Cancer Cells
Through Suppression of TFPI-2 Expression

by

Dr Ma Kwai Yee, Stephanie
Research Assistant Professor
Department of Pathology
The University of Hong Kong

1:00 PM, Thursday, July 29, 2010
Lecture Theatre
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04101151

Department of Pathology, HKU

RESEARCH POSTGRADUATE STUDENTS (RPGS) RETREAT

Date: July 16, 2010 (Friday)

Time: 2:00 – 5:30 pm

Venue: Lecture Theatre, University Pathology Building,
Queen Mary Hospital

***********

PROGRAMME (20 min presentation + 5 min discussion)

2:00 pm - Opening remarks

2:10 pm - ‘Epigenetic dysregulation of miR-9 in hepatocellular carcinoma’
by Ms TAM Hoy Kam (2nd Yr MPhil student of Dr Jack Wong)

2:35 pm - ‘Population differences in genomic alterations of sporadic basal cell carcinoma of the skin’
by Ms LAU Kin Chong (2nd Yr PhD student of Professor Ching-Wan Lam)

3:00 pm - ‘Identification of microRNAs associated with tamoxifen resistance in breast cancer’
by Ms LAU Lai Yee (2nd Yr PhD student of Professor Ui-Soon Khoo)

3:25 pm - ‘Novel function of BAFF in the induction of IL-10-producing regulatory B cells’
by Ms YANG Min (2nd Yr PhD student of Dr Liwei Lu)

3:50 pm - Coffee/Tea break

4:10 pm - ‘Frequent upregulation of Enhancer of Zeste Homolog 2 was implicated in Deleted in Liver Cancer 1 gene silencing and HCC progression’
by Ms AU Leung Kuen (3rd Yr PhD student of Dr Jack Wong)

4:35 pm - ‘Caveolin-1 promotes hepatocellular carcinoma tumourigenesis migration and invasion via MET-ERK1/2 pathway’
by Ms TSE Yuk Ting (3rd Yr PhD student of Dr Judy Yam)

5:00 pm - Inspirational talk for current RPGs by
Dr Stephanie Kwai-Yee Ma
a recipient of the Li Ka Shing Prize for her PhD thesis (2006-2007)

5:15 pm - Prize giving & closing remarks by Adjudicators:-

Professor Xin-Yuan Guan (Department of Clinical Oncology, HKU)
Dr. Alice Sze-Tsai Wong (Department of Biological Sciences, HKU)

For any further enquiries, please contact Ms Irene Tong
at 2255 3967 or by e-mail at irene.tong@pathology.hku.hk

All are welcome

Department of Pathology

&

Centre for Reproduction, Development and Growth
The University of Hong Kong

Presents

A seminar

Induced Pluripotent Stem Cell Therapy for Human Diseases, Are We There Yet?

by

Professor Yupo Ma
Haematopathologist and Medical Director of Flow Cytometry
Department of Pathology
Stony Brook University Medical Center, USA

4:00 PM, Friday, June 25, 2010
Lecture Theatre 4, Cheung Kung Hai Conference Centre
G/F, William MW Mong Block
Li Ka Shing Faculty of Medicine

All are welcome

MLT CPD code: 04101141

A Seminar

Using Clinical Outcomes Data to Improve Patient Care

by

Professor Laurie W Shroyer
Vice Chair for Research and Professor, Department of Surgery
Assistant Dean for Educational Research
Stony Brook University, School of Medicine, USA

5:30 PM, Thursday, June 24, 2010
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04101131

Department of Pathology

&

Centre for Cancer Research
The University of Hong Kong

Presents

A seminar

Molecular Diagnoses of Cervical Neoplasia:
Biomarker Discovery and Validation

by

Professor Kenneth R Shroyer
Chairman, Department of Pathology
Stony Brook University Medical Center, USA

4:00 PM, Thursday, June 24, 2010
Lecture Theatre 4, Cheung Kung Hai Conference Centre
G/F, William MW Mong Block
Li Ka Shing Faculty of Medicine

All are welcome

MLT CPD code: 04101121

A Seminar

Clinical Applications of Stem Cells in Cardiovascular Diseases

by

Professor Tse Hung Fat
William MW Mong Professor in Cardiology Academic Chief,
Cardiology Division, Department of Medicine
The University of Hong Kong

1:00 PM, Thursday, June 10, 2010
Lecture Theatre
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04101111

A Seminar

The Art of Science and the Science of Art

by

Dr Lam Lai Kwan, Queenie
Research Assistant Professor
Department of Pathology
The University of Hong Kong

1:00 PM, Thursday, May 28, 2010 (Date changed)
Lecture Theatre
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04101101

A Seminar

Identification of Liver Cancer Stem Cells Using
a Chemoresistant Animal Model

by

Dr Lee Kin Wah, Terence
Research Assistant Professor
Department of Pathology
The University of Hong Kong

1:00 PM, Thursday, May 20, 2010
Lecture Theatre
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04101091

The Department of Pathology
will host a reception to display and share
posters we presented at the recently held
American Association for Cancer Research (AACR)
Annual 2010 Meeting at Washington DC., USA

You are cordially invited to attend our poster sharing session for research exchange and potential collaboration.
Poster authors will be present to answer questions and queries.

Date: May 19, 2010 (Wednesday)

Time: 5:00PM - 6:00PM

Venue: 1/F, University Pathology Building, Queen Mary Hospital

Light refreshment will be served

All are welcome

********************

Posters to be presented:

1. CD24 is a functional marker that mediates liver tumor initiation via regulation of Nanog

2. Dysregulated expression of stem cell transcription factor Nanog in development and progress of ovarian cancers

3. Deleted in Liver Cancer 1 (DLC1) is a negative regulator of metastasis and deregulated by kinase phosphorylation in hepatocellular carcinoma

4. Dysregulated expression and function of Plexin-B1 in ovarian cancers

5. Examination of eIF4E level in human breast cancer and study the role of eIF4 in regulating translation of various splice variants of breast cancer genes

6. iASPP and Chemoresistance in ovarian Cancers - Effects on Paclitaxel-mediated mitotic catastrophe

7. Isolation, expansion and characterization of CD44 positive cells as tumor-initiating/stem/progenitor cells in non-small cell lung cancer

8. microRNA-616 induces androgen-independent growth of prostate cancer cells through suppression of TFPI-2 expression

9. Molecular features and functional consequence of CD44 activation by a novel recurrent IGH translocation t(11;14) (p13;q32) in mature B- cell lymphoid neoplasm

10. Nuclear targeted Deleted in Liver Cancer 1 exhibited reduced tumor suppressive function both in vitro and in vivo

11. Nucleophosmin (Theronine 234) is a novel mediator of tumor metastasis

12. Retinoic acid receptor responder 3 expression suppresses colorectal cancer cell growth in vitro and is a stage-independent prognostic marker in colorectal cancer patients in vivo

13. The Role of CpG Island Methylator Phenotype 2 (CIMP2) in Early Onset Colorectal Cancer Patients

14. Serum level of DKK1 as a marker for predicting tumor recurrence of hepatocellular carcinoma

A Seminar

MicroRNA-139 Antagonizes ROCK2 in Liver Cancer Metastasis

by

Dr Wong Chun Ming, Jack
Research Assistant Professor
Department of Pathology
The University of Hong Kong

1:00 PM, Wednesday, May 5, 2010
(date revised)
Lecture Theatre
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04101081

A Seminar

Isolation and Characterization of Cancer Stem Cells in
Non-small Cell Lung Cancer

by

Dr Leung Lai Han, Elaine
Post-doctoral Fellow
Department of Pathology
The University of Hong Kong

1:00 PM, Tuesday, March 30, 2010
Lecture Theatre
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04101071

A Seminar

Molecular Classification of Diffuse Large B-cell Lymphoma

by

Dr Choi Wai Lap, William
Assistant Professor
Department of Pathology
The University of Hong Kong

1:00 PM, Thursday, March 25, 2010
Lecture Theatre
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04101061

Jointly organized by

Department of Pathology
The University of Hong Kong

&

The Hong Kong Society for Immunology

A Seminar

Inflammation as Novel Strategy for Tumor Immune-editing

by

Professor Limin Zheng
Director for Tumor Biotherapy
Cancer Center Vice Dean at School of Life Sciences
Sun Yat-Sen (Zhong-Shan) University, China

5:00 PM, Wednesday, March 10, 2010
Lecture Theatre
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04101051

A Seminar

Reversible Epigenetic Silencing of CD44 During B Cell Development

by

Professor Gopesh Srivastava
Department of Pathology
The University of Hong Kong

1:00 PM, Thursday, March 4, 2010
Lecture Theatre
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04101041

A Seminar

Paradoxical Impact of Two Different Folate Transporters
in Ovarian and Endometrial Cancers

by

Dr Siu Kwan Yee, Michelle
Research Assistant Professor
Department of Pathology
The University of Hong Kong

1:00 PM, Thursday, February 25, 2010
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04101031

Department of Pathology
The University of Hong Kong

A Seminar

Aberrant DNA Methylation in MLL-rearranged Leukaemia

by

Dr Ray Ng
Research Assistant Professor
Department of Pathology
The University of Hong Kong

1:00 PM, Thursday, February 4, 2010
(Postponded from January 21, 2010)
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04101011

Department of Pathology
The University of Hong Kong

A Seminar

Melamine and Beyond

by

Professor Lam Ching Wan
Department of Pathology
The University of Hong Kong

1:00 PM, Thursday, January 28, 2010
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04101021

A Seminar

2B or Not To Be: A 45-year saga of Montreal Platelet Syndrome

by

Professor POON Man Chiu
Professor, Departments of Medicine, Pediatrics, Oncology
Faculty of Medicine, University of Calgary, Canada

1:00 PM, Thursday, November 19, 2009
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04091211

A Seminar

ROCK and Rho and Molecular Pathology of Liver Cancer

by

Professor Irene Ng
Loke Yew Professor in Pathology
Department of Pathology
The University of Hong Kong

1:00 PM, Thursday, November 12, 2009
Lecture Theatre
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04091201

A Seminar

Ancient Mystery, Modern Technology and Controversies

by

Dr Shan Yuan
Assistant Medical Director of Transfusion Medicine
and
Assistant Clinical Professor
Department of Pathology and Laboratory Medicine
David Geffen School of Medicine at UCLA, USA

1:00 PM, Wednesday, October 28, 2009
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code04091181

A seminar jointly organized by

The Hong Kong College of Pathologists
and
Department of Pathology
The University of Hong Kong

Molecular Pathology of Colorectal Neoplasia

by

Dr Raymond McMahon
Senior Lecturer in Pathology
The University of Manchester and
Honorary Consultant Pathologist
Central Manchester and
Manchester Children’s University Hospitals NHS Trust

5:30 – 6:30 PM, Monday, September 28, 2009
G004, Conference Room
University Pathology Building, Queen Mary Hospital
Pokfulam Road, Hong Kong

All are welcome

HKCPath - 1 CME point
MLT Board - 1 CPD point (code: 04091191)

THE DEPARTMENT OF PATHOLOGY,
THE UNIVERSITY OF HONG KONG
AND
THE HONG KONG FORENSIC SCIENCE SOCIETY

PRESENTS A PUBLIC LECTURE

“THE DEATH OF PRINCESS DIANA”

by

PROFESSOR PETER VANEZIS, OBE
 M.B., Ch.B., (Path).M.D., Ph.D., F.R.C.Path., F.R.C.P. (Glasg.),
F.F.F.L.M., D.M.J.

on

21 AUGUST 2009 (6.30 – 8 PM)

at

Room ADC 306
HKU SPACE
Admiralty Center
Queensway, Hong Kong.

ALL ARE WELCOME AND ATTENDANCE IS FREE OF CHARGE.  SEATS ARE HOWEVER LIMITED, PLEASE REGISTER YOUR SEAT BY EMAILING philipbeh@pathology.hku.hk

Abstract

On 31st August 1997, Diana, Princess of Wales died as a result of injuries sustained in a car crash in the Pont de l’Alma road tunnel in Paris. Her companion Dodi Al-Fayed and the driver of the car, Henri Paul, were pronounced dead at the scene of the accident. The bodyguard, Trevor Rees-Jones, was the only occupant to survive the crash. There was a  universal outpouring of grief at her death which has rarely been witnessed in modern times. Her death became the subject was of an intensive investigation which lasted for over ten years until the inquest in 2008. Since February 1998, Dodi's father, Mohamed Al-Fayed (the owner of the Hôtel Ritz for which Paul worked) has claimed that the crash was a result of a conspiracy and has since contended that the crash was orchestrated by MI6. Fayed's claims that the crash was a result of a conspiracy were dismissed by a French judicial investigation and Operation Paget, a Metropolitan police inquiry that concluded in 2006. An inquest headed by Lord Justice Scott Baker into the deaths of Princess Diana and Dodi Fayed began at the Royal Courts of Justice London on 2 October 2007 and was a continuation of the original inquest that began in 2004. A jury decided on 7 April 2008 that Diana had been unlawfully killed by the grossly negligent driving of chauffeur Henri Paul and paparazzi photographers.

This lecture explores the circumstances surrounding her tragic death and discusses the claim that she may have been murdered or whether in fact her death was in reality, just a tragic accident.

A Seminar

Molecular Markers for
Cervical Cancer Detection

by

Professor Annie Cheung
Department of Pathology
The University of Hong Kong

1:00 PM, Thursday, August 6, 2009
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04091171

A Seminar

Jointly organized by

Department of Pathology
The University of Hong Kong
&
The Hong Kong Society for Immunology


Regulation of B Cell Development in Gut Associated Lymphoid Tissue

by

Dr Michael JH Ratcliffe
Professor and Chair
Department of Immunology
University of Toronto

5:00 PM, Friday, July 3, 2009
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04091161

A Seminar

EGFR Mutations and Targets of Therapy
in Non-small Cell Lung Cancer

by

Dr Wong Pik, Maria
Associate Professor
Department of Pathology
The University of Hong Kong

1:00 PM, Thursday, June 25, 2009
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04091151

A Seminar

Update of the BRCA Genes in Breast
and Ovarian Cancer with
Clinico-Pathologic Considerations

by

Dr Khoo Ui Soon
Associate Professor
Department of Pathology
The University of Hong Kong

1:00 PM, Thursday, June 18, 2009
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04091141

A Seminar

Of Viruses and Cells:
A Network of Dynamic Interactions

by

Dr Roberto Bruzzone
Chief Executive Officer, HKU-Pasteur Research Centre
Visiting Professor, Li Ka Shing Faculty of Medicine
The University of Hong Kong

1:00 PM, Thursday, June 4, 2009
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04091111

Department of Pathology
and
Centre for Cancer Research

jointly present

A Seminar

“Somatic mutations in human cancer:
Genome-wide characterization of structural rearrangements
and on to whole genome sequencing”

by

Dr. P. Andrew Futreal
Co-director of the Cancer Genome Project,
The Wellcome Trust Sanger Institute

1:00 PM, Friday, May 22, 2009
Lecture Theatre, University Pathology Building
Queen Mary Hospital Compound
Pokfulam Road, Hong Kong

All are welcome

Biosketch: Dr. Futreal received his PhD in Pathology from the University of North Carolina in 1993. He then was an Assistant Professor at Duke University in the Departments of Surgery, Gynecologic Oncology and Genetics before moving to the to the UK in 2000 to start the Cancer Genome Project with Mike Stratton and Richard Wooster. He is currently Co-Director of the Cancer Genome Project with Mike Stratton and a Senior Investigator at the Wellcome Trust Sanger Institute. His research background includes work on identification of BRCA1 and BRCA2 as well as investigations into the somatic genetics of breast and gynaecological malignancies. His current research areas are using genome-based approaches to investigate the somatic genetics of human cancer - including high-throughput sequencing and array-based methods. This work has lead to the identification of BRAF as a new human cancer gene, and other progress including identification of ERBB2 mutations in lung cancer, FBXW7 and PTEN mutations in T-cell leukaemia, identification of chemo-resistance mechanisms in glioblastoma and identifying mutations implicating the histone modification machinery in solid tumours. His work also focuses on investigating the translation of basic research findings with a focus on applying somatic cancer genetics to clinical oncology problems.

MLT CPD code: 04091121

A Seminar

Study of Foetal Haemoglobin in Chinese

by

Dr So Chi Chiu, Jason
Associate Professor
Department of Pathology
The University of Hong Kong

1:00 PM, Thursday, May 21, 2009
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04091101

A Seminar

Control of Fetal Haemoglobin Expression –
Implications for the Beta Haemoglobin Disorders

by

Professor Swee Lay THEIN
Professor of Molecular Haematology
Head of Division of Gene and Cell Based Therapy
Kings College London School of Medicine /
Kings College Hospital
United Kingdom

1:00 PM, Friday, May 8, 2009
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04091071

A Seminar

Autoimmune Arthritis and Its Experimental Therapy by Gene Silencing

by

Dr Liwei Lu
Associate Professor
Department of Pathology
The University of Hong Kong

1:00 PM, Thursday, May 7, 2009
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04091091

A Seminar

Pernicious Anemia:
Pathogenesis and Diagnostic Approach

by

Professor Ban-Hock TOH
Head, Autoimmunity Laboratory
Centre for Inflammatory Diseases
Department of Medicine, Southern Clinical School
Faculty of Medicine, Nursing and Health Sciences
Monash University, Victoria, Australia

1:00 PM, Monday, May 4, 2009
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code:04091081

A Seminar

Subcellular Localization of DLC1
and Its Functional Significance

by

Dr Yam Wai Ping, Judy
Assistant Professor
Department of Pathology
The University of Hong Kong

1:00 PM, Thursday, April 9, 2009
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04091061

A Seminar on Automated Image Analysis

Introduction to Automated Image Analysis in Histological Sections

- GenieTM Histology Pattern Recognition System

- Microvessel Density Analysis

by

Mr Scott Spear
Application Specialist
Aperio Technologies, Inc

Monday, April 6th, 2009
4:30PM – 6:00PM
Lecture Theatre, 1/F,
University Pathology Building
Queen Mary Hospital Compound

All are welcome

by

Dr Yan Hoi Ning, Helen
Post-doctoral Fellow
Department of Pathology
The University of Hong Kong

1:00 PM, Thursday, March 19, 2009
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04091051

University Pathology Laboratory
Department of Pathology
The University of Hong Kong

on

Thursday, March 12, 2009

6:00pm – 6:15pm
Welcome address by Professor LC Chan
Room 134, Lecture Theatre
University Pathology Building
Queen Mary Hospital Compound

6:15pm – 6:45pm
Tour of University Pathology Laboratory
Room 129, University Pathology Building
Queen Mary Hospital Compound

6:45pm – 7:30pm
Cocktail reception
1/F, University Pathology Building
Queen Mary Hospital Compound

All are welcome

Brochure available here

For further information,
please contact Ms Lily Fung at 2855-4875

by

Professor Si LOK
Scientific Director
Genome Research Centre
Li Ka Shing Faculty of Medicine
The University of Hong Kong

1:00 PM, Thursday, March 12, 2009
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code:04091041

Jointly organised by
Department of Anatomy, Department of Pathology
and Centre for Cancer Research
The University of Hong Kong

New Core Imaging Facilities and their Applications
in Research and Education

- live cell imaging using the spinning disc confocal microscope

- microscopic slide scanning and web-based virtual microscopy

- tissue microarray and automated image analysis
(nuclear, membrane and cytoplasmic staining quantification)

Speakers:
Professor George SW Tsao
Department of Anatomy
The University of Hong Kong

Dr US Khoo
Department of Pathology
The University of Hong Kong

Professor SY Leung
Department of Pathology
The University of Hong Kong

4:30PM – 5:45PM, Friday, 6 March 2009
Lecture Theatre 1, Cheung Kung Hai Conference Centre,
G/F, William MW Mong Block, Li Ka Shing Faculty of Medicine

All are welcome

Prostate Cancer with a Twist, and a bit more

by

Dr Chan Kwok Wah
Associate Professor
Department of Pathology
The University of Hong Kong

1:00 PM, Thursday, February 26, 2009
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code:04091031

What do we know about Homicides in Hong Kong?

by

Dr Philip Beh
Associate Professor
Department of Pathology
The University of Hong Kong

1:00 PM, Thursday, February 19, 2009
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code:04091021

Mitotic checkpoint signaling in cancers –
is it MAD?

by

Dr Sze Man Fong, Karen
Post-doctoral Fellow
Department of Pathology
The University of Hong Kong

1:00 PM, Thursday, January 22, 2009
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code:04091011

Influenza Receptors and
Seeds of Confusion

by

Dr John Nicholls
Associate Professor
Department of Pathology
The University of Hong Kong

1:00 PM, Tuesday, December 30, 2008
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code:04081251

A Seminar

Actin Turnover Dynamics in Cells

by

Dr Hao Yuan KUEH
Department of Systems Biology
Harvard Medical School, USA

1:00 PM, Tuesday, December 16, 2008
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04081241

Epimutations, mismatch repair and colorectal cancer

by

Professor Robyn Ward
Professor and Chair of Medicine
Prince of Wales Clinical School
University of New South Wales, Sydney
and
Director of Area Cancer Services
South East Sydney and Illawarra Area Health Service

1:00 PM, Tuesday, December 9, 2008
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code:04081231

by

Dr Chan Tsun Leung, Chris
Assistant Professor
Department of Pathology
The University of Hong Kong

1:00 PM, Thursday, December 4, 2008
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code:04081221

Proteasome inhibitor bortezomib-induced
cell death in natural killer-cell leukemia
and lymphoma: a preclinical evaluation
and a mechanistic study

by

Dr Shen Lijun
Post-doctoral Fellow
Center for Cancer Research
The University of Hong Kong

1:00 PM, Thursday, November 27, 2008
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code:04081201

The molecular basis of hereditary diffuse gastric cancer
and its clinical management

by

Dr Parry Guilford
Cancer Genetics Laboratory
University of Otago
Dunedin, New Zealand

4:00 PM, Tuesday, November 25, 2008
Lecture Theatre
1/F, University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code:04081211

29th - 31st October 2008

Jointly Organised
by

DEPARTMENT OF PATHOLOGY
THE UNIVERSITY OF HONG KONG

and

KATHARINE DORMANDY HAEMOPHILIA CENTRE
ROYAL FREE HOSPITAL, UK

Details
Program
Application Form

Modulators of reactive oxygen species generation
and BRAF-signaling in cancers

by

Dr Yeung Ho Yee, Bonnie
Post-doctoral Fellow
Department of Pathology, HKU

1:00 PM, Thursday, October 23, 2008
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code:0408181

Colorectal cancer - gene expression profiling, genetics, epigenetics,
pathways of cancer development and prevention

by

Professor SY Leung
Department of Pathology
The University of Hong Kong

1:00 PM, Thursday, October 16, 2008
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code:0408171

EGFR and Src - potential drug targets
in treating non-small cell lung cancer

by

Dr Leung Lai Han, Elaine
Post-doctoral Fellow
Department of Pathology, HKU

1:00 PM, Thursday, September 25, 2008
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code:0408161

by

Dr Lam Lai Kwan, Queenie
Post-doctoral Fellow
Department of Pathology, HKU

1:00 PM, Thursday, September 11, 2008
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code:0408151

by

Professor Benjamin K. Tsang
Director, Reproductive Biology Unit
Professor of Obstetrics & Gynecology and Cellular & Molecular Medicine, University of Ottawa Senior Scientist, Chronic Disease Program Ottawa Health Research Institute, Canada

2:30 PM, Tuesday, September 2, 2008
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 0408141

A Seminar

Bone Marrow-derived Mesenchymal Stem Cells
in Tissue Repair/Regeneration

by

Professor Yaojiong Wu
Professor, School of Medicine
Shenzhen University


12:00 Noon, Thursday, August 14, 2008
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 0408131

Gastric Lymphoma:
Disorder Deriving from Differentiation Arrest of Mature B-cells

by

Dr Chen Yun Wen, Wendy
Post-doctoral Fellow
Department of Pathology, HKU

1:00 PM, Thursday, July 31, 2008
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code:0408121

Carboxypeptidase E: a surprising link between
prohormone processing enzyme and tumor metastasis

by

Dr Lee Kin Wah, Terence
Research Assistant Professor
Department of Pathology, HKU

1:00 PM, Thursday, July 17, 2008
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04081111

The Impact of Epigenetic Alterations in Liver Carcinogenesis

by

Dr Wong Chun Ming, Jack
Research Assistant Professor
Department of Pathology, HKU

1:00 PM, Monday, June 30, 2008
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code:04081101

Granulin-epithelin Precursor: a potential cancer therapeutic target

by

Dr Ip Ying Chi, Jovian
Post-doctoral Fellow
Department of Pathology, HKU

1:00 PM, Thursday, June 26, 2008
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code:04081091

A Seminar

The Role of Phytocompounds in
Immunoenhancement and Cancer Abatement

by

Professor Sandra Miller
Department of Anatomy and Cell Biology
McGill University, Canada

4:00 PM, Tuesday, April 29, 2008
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code:04081061

Contribution of Genetic Variants to Disease Risk

by

Dr Kelvin YK Chan
Research Assistant Professor
Department of Pathology, HKU

1:00 PM, Thursday, April 24, 2008
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code:04081051

DEPARTMENT OF PATHOLOGY
THE UNIVERSITY OF HONG KONG

Presents

The Inaugural Hou Pao-Chang Distinguished Lecture

The Fates of the Injured Cell

by



Professor Andrew H Wyllie
Head of Department of Pathology, University of Cambridge
Honorary Consultant, Addenbrooke’s Hospital, Cambridge
United Kingdom

April 8, 2008
5.30PM (Cocktail Reception at 6.30PM)
Venue: Lecture Theatre 4,
Cheung Kung Hai Conference Centre,
G/F, William MW Mong Block,
Li Ka Shing Faculty of Medicine,
The University of Hong Kong,
21 Sassoon Road, Pokfulam

All are welcome

For further information, please feel free to contact
Miss Noven Lau at noven@pathology.hku.hk or (Tel) 2855-4882

Abstract

Multicellular organisms devote many different, genetically-defined pathways to their responses to injury. Some of these are shared by unicellular organisms (e.g. the heat shock, unfolded protein and autophagy responses). Others (including apoptosis) are widely employed by multicellular organisms, in which they also participate in the shaping of tissues and organs in normal development. Deficiency in these pathways carries high biological costs that include cancer, disorders of immunoregulation, and degenerative diseases of the CNS. This lecture focuses on the activation of apoptosis in cells that have been exposed to ionising radiation, a circumstance in which they receive double-strand DNA breaks. It discusses how injury signals are coupled to the apoptosis effector mechanism, how the threshold for activating cell death may be modified, and how, following injury, the death sentence may be repealed by the intra-nuclear particles called PML bodies. Finally, it seeks to indicate the relevance of these cellular reactions to human carcinogenesis.

About the speaker

Professor Andrew Wyllie graduated from Aberdeen University in Medicine in 1967 and completed his PhD there in 1975 under the supervision of Sir Alastair Currie. It was at this time, with Professor John Kerr from the University of Queensland, that his interest in the processes of cell death began. In 1972 he was co-author of the first paper formally describing the process of apoptosis and much of his research since then has been occupied with the cell and molecular biology of this process and its relevance in cancer. A histopathologist by training, he has worked in the Royal Postgraduate Medical School of London and the University of Edinburgh (where he was Head of Department until 1998), before taking up his present post as Professor of Pathology in the University of Cambridge. His current main research interest is the role of apoptosis in the genesis and treatment of human cancer, and colorectal cancer in particular. Apoptosis is now the focus of intense research in many laboratories worldwide and is the subject of thousands of articles. Wyllie’s contribution has been recognised in international awards including the Bertner Award of the M D Anderson Cancer Center, the Canadian Gairdner Foundation International Award and the Scheele Prize of the Swedish Pharmaceutical Society. He is a Fellow of the Royal Society and the Royal Society of Edinburgh, and a member of the Academia Europea and the British Academy of Medical Sciences. Throughout his career, and at present, he has been involved in teaching medical and other undergraduates the basic processes that underlie disease. He is married, with three children.

MLT CPD code:04081041

Molecular Pathology and Clinical Behaviour of Colorectal Cancer

by

Professor Andrew H Wyllie
Head of Department of Pathology, University of Cambridge
Honorary Consultant, Addenbrooke’s Hospital, Cambridge
United Kingdom

12:00 Noon, Wednesday, April 9, 2008
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 04081041

Interferon: a Fight for Supremacy in SARS
and other Emerging Viral Infections

by

Dr Eleanor N Fish, PhD
Canada Research Chair in Women's Health & Immunobiology,
Director, Arthritis & Autoimmunity Research Centre, University Health Network, Division Head, Cell & Molecular Biology, Toronto General Research Institute, Professor, Department of Immunology, University of Toronto

12:00 Noon, Tuesday, March 25, 2008
Lecture Theatre
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code:04081021

Guiding the 'Misguided Immunity' - Functional Conditioning of Dendritic Cells
for DC-Based Tumor Immunotherapy

by

Dr Fang-Ping Huang
Senior Lecturer
Molecular Genetics & Rheumatology Section
Division of Medicine, Imperial College London Hammersmith Hospital, United Kingdom

1:00 PM, Friday, March 14, 2008
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code:04081011

Stem Cells in Leukemia and Lymphoma:
Biology, Animal Models and Future Directions

Date: January 22-24, 2008
Venue: Lecture Theatre, University Pathology Building,
Queen Mary Hospital Compound
Pokfulam Road, Hong Kong

Please click for details

12:00 Noon, Tuesday, December 4, 2007
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code:07041131

12:00 Noon, Thursday, November 29, 2007
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code:07041121

The MLL Recombinome

by

Dr Claus Meyer
Diagnostic Centre of Acute Leukaemia
Johann Wolfgang von Goethe University,
Frankfurt, Germany

1:00 PM, Thursday, October 4, 2007
Lecture Theatre
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 07041111

by

Professor Rolf Marschalek
Institute of Pharmaceutical Biology
Head of Diagnostic Center of Acute Leukemia (DCAL)
Head of The Center for Drug Research,
Development and Safety (ZAFES) Johann Wolfgang Goethe
University of Frankfurt, Germany

1:00 PM, Thursday, September 27, 2007
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 07041101

A Seminar

Molecular Pathology and Genetic Alterations in Hepatocellular Carcinoma

by

Professor Irene Ng
Professor
Department of Pathology
The University of Hong Kong

1:00 PM, Thursday, July 19, 2007
Lecture Theatre
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 07041091

A Seminar

Differential Dosage Response of Human Cancer Cell Lines to Antimitotic Drugs:
from High-throughput Screens to Mechanistic Insights

by

Dr Jade Shi
Post-doctoral Fellow
Department of Systems Biology
Harvard Medical School, USA

1:00 PM, Thursday, May 17, 2007
G004, Conference Room
University Pathology Building
Queen Mary Hospital

Abstract:

Improving selectivity of anticancer drugs is one of the central issues in cancer research. One strategy is to target only dividing cancer cells with antimitotic drugs that perturb cell division, while sparing normal non-dividing cells. However, most currently available antimitotic drugs also cause serious toxicity to normal dividing cells in the bone marrow and gut. Therefore, antimitotic chemotherapy is in urgent need of drugs with higher selectivity for killing cancer cells. This requires exploiting differences in drug response among distinct cell types. Using both quantitative high-throughput phenotypic screens and image- based real-time analysis of dosage response to antimitotic drugs on a panel of human cancer cell lines, my work focuses on characterizing cell type specificity in drug response and identifying its molecular origin. Current results have revealed significant variability between cancer cell lines in their sensitivity to antimitotics, which correlates with both the mechanism of an individual drug and the innate apoptotic response of a specific cell line. The data suggests that the most likely place to find response differences between cell types and therefore to improve the selectivity of antimitotic drugs is in the mitotic stress pathway, which can potentially be targeted by combining antimitotics with stress-modulating agents.

All are welcome

MLT CPD code: 07041061

Human Papilloma Virus:
Updates on Detection and Prevention

by

Professor Annie Cheung
Department of Pathology
The University of Hong Kong


1:00 PM, Thursday, May 10, 2007
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 07041051

Immuno-biology of Intestinal Dendritic Cells

by

Professor G Gordon MacPherson
Reader in Experimental Pathology
Sir William Dunn School of Pathology
University of Oxford, UK

1:00 PM, Tuesday, April 17, 2007
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 07041041

Epidermal Growth Factor Receptor Mutations
and Non-Small Cell Lung Cancer

by

Dr Maria Wong
Clinical Associate Professor
Department of Pathology
The University of Hong Kong

1:00 PM, Thursday, November 23, 2006
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 06041201

Differentiation and Memory Generation
of CD4+ T Cells in Vitro and in Vivo

by

Professor Changyou Wu
Chair, Department of Immunology
Sun Yat Sen University, PR China

1:00 PM, Wednesday, October 25, 2006
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 06041181

Novel Globin Variants – Diagnostic Problems
& Pathogenic Significance

by

Dr Jason So
Clinical Associate Professor
Department of Pathology
The University of Hong Kong

1:00 PM, Thursday, October 19, 2006
G004, Conference Room
University Pathology Building
Queen Mary Hospital

All are welcome

MLT CPD code: 06041171