Professor CHEUNG NY Annie
anycheun@pathology.hku.hk
Professor
MBBS HK; MD HK; FRCPath; FHKCPath; FIAC; FHKAM (Pathology)
To better women’s health
Clinical Services
- Director (Molecular Pathology), University Pathology Laboratory, The University of Hong Kong
- Pathologist in charge, Cervical Cytology Screening Laboratory, The University of Hong Kong
Medical Education
- Chairman, Quality Assurance Committee
- Co-Programme Director, the China Programme, Institute for Medicine and Health Sciences Education
Community Services
- Chief Examiner, Anatomical Pathology, Hong Kong College of Pathologists
- President, Hong Kong Society of Colposcopy & Cervical Pathology
- Regional Representative, Asian Oceania Research on Genital Infections and Neoplasia
Research Description
Studies on gynaecological cancers
- Molecular cytogenetic study of gynaecological tumours by chromosome in situ hybridization and comparative genomic hybridization
- Genetic and epigenetic alterations in oncogenes involved in endometrial and ovarian carcinogenesis
- Genetic susceptibility to gynaecological cancers including single nucleotide polymorphisms study
- Clinico-pathological and molecular biological study of cervical cytology for cervical cancer screening
- Role of stem cells in gynaecological cancers
Studies on Gestational Trophoblastic Diseases (GTD) including hydatidiform mole, choriocarcinoma and placental site trophoblastic tumour
- The role of oncogenes, tumour suppressor genes and growth factors in GTD and placenta including differential expression studies by cDNA array and suppressive subtractive hybridization
- Epigenetic alterations in GTD
- Clinical significance of proliferative and apoptotic activities in GTD
- Molecular cytogenetic study of GTD by chromosome in situ hybridization, genotyping and comparative genomic hybridization
- Mitochondrial DNA alterations in GTD
- Role of stem cells in GTD
Major Rersearch Grants
RGC - Competitive Earmarked Research Grants
- Stem cell related genes in gestational trophoblastic diseases (2004)
- Akt and p21-activated kinase signaling pathways in gestational trophoblastic disease (2006)
- VOE grant on Centre for Research into Circulating Fetal Nucleic Acids (CUHK/HKU) (2007, Co-investigator)
SK Yee Foundation
- HPV detection - an adjunct to triage of atypical cervical cytology in screening for risk of cervical cance (2006)
Research Fund for the Control of Infections Diseases & Health and Health Services Research Fund
- Cervical cancer screening by enhanced cervical cytology – Application of novel markers (2006)
Integrated Human Papilloma Virus Analysis as Adjunct for Triage of Atypical Cervical Cytology (2007)
Awards and Honors
Best Teachers Award (Medical Society, H.K.U.S.U.) (1996)
Faculty Teaching Medal (2002)
University Teaching Fellow (2005)
Sir Patrick Manson Gold Medal 1998-1999 for outstanding M.D. thesis
Award for Innovative Excellence in Teaching, Learning & Technology in 17th International Conference on College Teaching and Learning (2006)
Scholar-in-Training Awards for postgraduate students and fellow by the American Association for Cancer Research (2003, 2004, 2006)
Selected Publications
Click here for detail publication list on PubMed
Cheung AN . Molecular Targets in Gynaecological Cancer. Pathology 2007; 29(1):26-45. Review.
Liao XY, Xue WC, Shen DH, Ngan HY, Siu MK, Cheung AN. p63 expression in ovarian tumours: a marker for Brenner tumours but not transitional cell carcinomas. Histopathology 2007, 51(4):477-483.
Yang CQ, Chan KY, Ngan HY, Khoo US, Chiu PM, Chan QK, Xue WC, Cheung AN. Single nucleotide polymorphisms of follicle-stimulating hormone receptor are associated with ovarian cancer susceptibility. Carcinogenesis 2006, 27:1502.
Feng HC, Tsao SW, Ngan HY, Kwan HS, Shih SM, Xue WC, Chiu PM, Chan KW, Cheung AN . Differential gene expression identified in complete hydatidiform mole by combining suppression subtractive hybridization and cDNA microarray. Placenta 2006, 27:521-526.
Chan SF, Chan KY, Chen YX, Poon LL, Cheung AN, et al. Homozygous L-SIGN (CD209L) plays a protective role in SARS coronavirus infection. Nat Genet 2006, 38(1):38-46.
Feng HC, Tsao SW, Ngan HY, Xue WC, Chiu PM, Cheung AN. Differential expression of insulin-like growth factor binding protein 1 and ferritin light polypeptide in gestational trophoblastic neoplasia: combined cDNA suppression subtractive hybridization and microarray study. Cancer 2005, 1;104(11):2409-2416.
Chan QYK, Khoo US, Ngan HYS, Yang CQ, Xue WC, Chan KYK, Chiu PM, Ip PPC, Cheung AN. Single Nucleotide Polymorphism of Pi-class Glutathione-S-Transferase and Susceptibility to Endometrial Carcinoma. Clin Cancer Res2005, 11:2981-2985.
Shen DH, Chan KYK, Khoo US, Ngan HYS, Xue WC, Chiu PM, Ip P, Cheung AN. Epigenetic and genetic alterations of p33ING1b in ovarian cancer. Carcinogenesis 2005, 26:855-863.
Fong PY, Xue WC, Ngan HYS, Chan KYK, Khoo US, Tsao SW, Chiu PM, Man LS, Cheung AN. Mcl-1 expression in gestational trophoblastic disease correlates with clinical outcome: a differential expression study. Cancer 2005, 103:268-276.
Cheung AN , Khoo US, Lai CYL, et al. Metastatic trophoblastic disease following initial diagnosis of partial hydatidiform mole: genotyping and chromosome in situ hybridization analysis. Cancer 2004, 100:1411-1417.
Chiu PM, Liu WS, Ngan HYS, Khoo US, Cheung AN. Detection of mitochondrial mutations in gestational trophoblastic diseases. Hum Mutat2003, 22:177.