Dr YAN Hoi Ning, Helen | hyan@pathology.hku.hk

Awards and Honors

The Fellow and Students Day Workshop Award, Endocrine Society Annual Meeting (2007)

The American Society for Cell Biology 45th Annual Meeting Pre-doctoral Student Travel Award (2005)

Recent Publication Lists

Yan H. H. N., Mruk D. D., Lee W. M. and Cheng C. Y. Blood-testis barrier dynamics are regulated by testosterone and cytokines via their differential effects on the kinetics of protein endocytosis and recycling in Sertoli cells. FASEB J. 2008 (In press)

Yan H. H. N., Mruk D. D. and Cheng C. Y. Junction restructuring and spermatogenesis: the biology, regulation, and implication in male contraceptive development. Curr Top Dev Biol. 2008 80:57-92. Review.

Yan H. H. N., Mruk D. D., Lee W. M. and Cheng C. Y. Ectoplasmic specialization: a friend or a foe of spermatogenesis? Bioessays. 2007 29:36-48. Review.

Yan H. H. N., Mruk D. D., Lee W. M., and Cheng C. Y. Cross-talk between tight and anchoring junctions – lesson from the testis. In Molecular Mechanisms in Spermatogenesis, Eds Cheng CY. Austin, TX, USA: Landes Bioscience. 2007. (in press)

Lie P. P., Xia W., Wang C. Q., Mruk D. D., Yan H. H. N., Wong C. H., Lee W. M., Cheng C. Y. Dynamin II interacts with the cadherin- and occludin-based protein complexes at the blood-testis barrier in adult rat testes. J Endocrinol. 2006 191:571-86.

Li M. W., Xia W., Mruk D. D., Wang C. Q., Yan H. H. N., Siu M. K., Lui W. Y., Lee W. M., Cheng C. Y.Tumor necrosis factor {alpha} reversibly disrupts the blood-testis barrier and impairs Sertoli-germ cell adhesion in the seminiferous epithelium of adult rat testes. J Endocrinol. 2006 190:313-29.

Yan H. H. N., Cheng C. Y. Laminin alpha 3 forms a complex with beta3 and gamma3 chains that serves as the ligand for alpha 6beta1-integrin at the apical ectoplasmic specialization in adult rat testes. J Biol Chem. 2006 281:17286-303

Yan H. H. N., Cheng C. Y. Blood-testis barrier dynamics are regulated by an engagement/disengagement mechanism between tight and adherens junctions via peripheral adaptors. Proc Natl Acad Sci U S A. 2005 102:11722-7.