Dr SIU Kwan Yee, Michelle 
Research Assistant Professor
Research
Studies of the molecular and cellular mechanisms that contribute to the pathogenesis of gynaecological cancers
- Signaling pathways of metastasis-related genes (e.g. p21-activated kinases, Paks) that are involved in ovarian and endometrial carcinogenesis.
- Role of folate and folate receptor in gynaecological cancers
Major Research Grants
Cancer Research Grant, The Hong Kong Anti-Cancer Society
- p21-activated kinase 4: a prognostic and therapeutic target for ovarian carcinomas? (2007)
American Institute for Cancer Research-Post-doctoral Award
- Effects of folate and folate receptor on ovarian and endometrial cancer: an in vitro study (2006)
Awards & Honors
Avon Foundation-AACR International Scholar-in-Training Award, The American Association for Cancer Research, USA (2006)
Predoctoral Student Travel Award, The American Society for Cell Biology, USA (2002)
Recent Publication List:
Click here for detail publication list on PubMed
Liao XY, Xue WC, Shen DH, Ngan HY, Siu MKY, Cheung ANY. p63 expression in ovarian tumours: a marker for Brenner tumours but not transitional cell carcinomas. Histopathology 2007, 51(4):447-483.
Cheung ANY, Siu MKY, Au CW, Chan HY, Wong ES. Follicle Stimulating Hormone can act on Receptors of Other Growth Hormones. Carcinogenesis 2007, 28(9):2060-2061.
Siu MKY , Cheng CY. Extracellular matrix and its role in spermatogenesis. In Molecular Mechanisms in Spermatogenesis, Eds Cheng CY. Austin, TX, USA: Landes Bioscience. 2007. (in press)
Siu MKY , Wong CH, Lee WM and Cheng CY. Sertoli-germ cell anchoring junction dynamics in the testis are regulated by an interplay of lipid and protein kinasesJ Biol Chem 2005, 280:25029-25047.
Wong CH, Mruk DD, Siu MKY, and Cheng CY. Blood-testis barrier dynamics are regulated by az-macroglobulin via the c-Jun N-terminal protein kinase pathway. Endocrinology 2005, 146:1893-1908.
Siu MKY and Cheng CY. Dynamic cross-talk between cells and the extracellular matrix in the testis. BioEssays 2004, 26:978-992.
Siu MKY , Cheng CY. Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis. Biol Reprod2004, 71: cover page and 375-391.
Siu MKY and Cheng CY. Interactions of proteases, protease inhibitors, and the b1 integrin/laminin g3 protein complex in the regulation of ectoplasmic specialization dynamics in the rat testis. Biol Reprod 2004, 70:945-964.
Siu MKY , Mruk DD, Lee WM and Cheng CY. Adhering junction dynamics in the testis are regulated by an interplay of β1-integrin and focal adhesion complex-associated proteins. Endocrinology2003, 144:2141-2163.
Siu MKY, Lee WM and Cheng CY. The interplay of collagen IV, tumor necrosis factor-a, gelatinase B (matrix metalloprotease-9) and tissue inhibitor of metalloproteases-1 in the basal lamina regulates Sertoli cell tight junction dynamics in the rat testis. Endocrinology 2003, 144:371-387.