Head of Pharmacology, The University of Hong Kong.
Head

Professor Paul M Vanhoutte
M.D. Gent, Ph.D. Antwerp, D.H.C. mult.


Professor Paul M Vanhoutte
Contact me

  • Editor-in Chief, Journal of Cardiovascular Pharmacology President
  • International Union of Pharmacology (IUPHAR) Director
  • Bio-pharmaceutical Development Centre, the University of Hong Kong
  •   - Bio pharmaceutical Development Centre, HKU - 

Research Interests :  
  • Cardiovascular pharmacology and therapeutics in particular endothelium-dependent relaxations, hyperpolarizations and contractions.




Professor Paul M Vanhoutte's laboratory and his research associates


Selected Publications :

  • J G De Mey and P M Vanhoutte (1982) Heterogeneous Behavior of the Canine Arterial and Venous Wall - Importance of the Endothelium. Cir Res 51: 439-337.
  • L Olmos, J Mombouli, S, Illiano, and P M Vanhoutte (1995) cGMP mediates the desensitization to bradykinin in isolated canine coronary arteries. Am J Physiol 268 (Heart Circ Physiol 37): H865-H870
  • G M Rubanyi and P M Vanhoutte (1986) Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor. Am J Physiol 250 (Heart Circ Physiol 19): H822-H827.
  • C Boulanger, H Hendrickson, R R Lorenz and P M Vanhoutte (1989) Release of different relaxing factors by cultured porcine endothelial cells. Cir Res 64: 1070-1078
  • H Shimokawa & P M Vanhoutte (1989) Impaired endothelium-dependent relaxation to aggregating platelets and related vasoactive substances in porcine coronary arteries in hypercholesterolemia and atherosclerosis. Cir Res 64: 900-914.
  • T Ge, H Hughes, D C Junquero, K K Wu, P M Vanhoutte, C M Boulanger (1995) Endothelium-dependent contractions are associated with both augmented expression of prostaglandin H synthese-1 and hypersensivity to prostaglandin H2 in the SHR aorta. Circ Res 76:1003-1010.
  • P Sansilvestri-Morel, A Rupin, S Jaisson, J Fabiani, T J Vrebeuren, P M Vanhoutte (2002) Synthesis of collagen is dysregulated in cultured fibroblasts derived from skin of subjects with varicose veins as it is in venous smooth muscle cells. Circulation 106: 479-483.
  • J Quignard, M Feletou, C Thollon, J Vilaine, J Duhault & P M Vanhoutte (1999) Potassium ions and endothelium-derived hyperpolarizing factor in guinea-pig carotid and porcine coronary arteries. B J Pharmacology 127:27-34.
  • D Yang, M Feletou, C M Boulanger, H Wu, N Levens, J Zhang & P M Vanhoutte (2002) Oxygen-derived free radicals mediate endothelium-dependent contractions to acetylcholine in aortas from spontaneously hypertensive rats. B J Pharmacology 136: 104-110.
  • D Yang, M Feletou, N Levens, J N Zhang, P M Vanhoutte (2003) A diffusible substance(s) mediates endothelium-dependent contractions in the aorta of SHR. Hypertension 41: 143-148.

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Other Information :

Professor Paul M Vanhoutte has taken up the post of Distinguished Visiting Professor at the Department of Pharmacology from June 2003. Born in Belgium, Professor Vanhoutte obtained his degrees at the University of Ghent (B.S.,M.S., M.D.) and the University of Antwerp (equivalent to Ph.D.). He received his postdoctoral training at the University of Ghent and the Mayo Clinic (Rochester, MN, USA). His academic career started at the University of Ghent (Assist, 196901971), followed by the Mayo Clinic (Research Associate, 1972-1973), the University of Antwerp (Belgium), from Associate Professor to full Professor and Head of the Department of Pharmacology, 1973-1981), again the Mayo Clinic (Professor of Physiology and Pharmacology, 1981-1989) and Baylor College of Medicine (Houston TX, USA, Professor of Medicine, Pharmacology and Physiology and the Director Center for Experimental Therapeutics, 1989-1995). From 1992 to 2002, Dr. Vanhoutte was Vice-President R&D, and Director of Discovery Research at the Institut de Recherches Internationales Servier, in Courbevoie (Paris, France). During his tenure as Director of Discovery Research at Servier, he supervised the discovery and preclinical development of drugs designed for the treatment of cardiovascular diseases, diabetes, obesity, central nervous system disorders, cancer an osteoarthritis.

For details see : www.isihighlycited.com

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-Last update on July 2006-