Dept of Physiology, HKU Address
About Us Staff Undergraduate Postgraduate Research Course Material Publications

Lee, Hon Cheung,  Ph.D.

Chronological Listing of Papers on Cyclic ADP-Ribose and NAADP
       

Middle of List

 

 

 

 

 

 

End of List

 

 

 

 

 

 

Back to H.C. Lee Page

  1. Clapper, D.L. and Lee, H.C. (1985) Inositol trisphosphate induces Ca+2- release from non-mitochondrial stores in sea urchin egg homogenates. J. Biol. Chem. 260, 13947-13954.
  2. Clapper, D.L., Walseth, T.F., Dargie, P.J. and Lee, H.C. (1987) Pyridine nucleotide metabolites stimulate calcium release from sea urchin egg microsomes desensitized to inositol trisphosphate. J. Biol. Chem. 262, 9561-9568.
  3. Lee, H.C., Walseth, T.F., Bratt, G.T., Hayes, R.N., and Clapper, D.L. (1989) Structural determination of a cyclic metabolite of NAD+ with intracellular Ca+2 mobilizing activity. J. Biol. Chem. 264, 1608-1615.
  4. Yang, C.M. and Lee, H.C. (1989) Effects of sulfhydryl reagents on 3H-inositol trisphosphate binding to dog cerebellar membranes. J. Receptor Res. 9, 159-169.
  5. Rusinko, N. and Lee, H.C. (1989) Widespread occurrence in animal tissues of an enzyme catalyzing the conversion of NAD+ into a cyclic metabolite with intracellular Ca+2 mobilizing activity. J. Biol. Chem. 264,11725-11731.
  6. Dargie, P.J., Agre, M.C., and Lee, H.C. (1990) Comparison of Ca+2 mobilizing activities of cyclic ADP-ribose and inositol trisphosphate. Cell Regulation 1, 279-290.
  7. Lee, H.C. (1991) Specific binding of cyclic ADP-ribose to calcium-storing microsomes from sea urchin eggs. J. Biol. Chem. 266, 2276-2281.
  8. Lee, H.C. and Aarhus, R (1991) ADP-ribosyl cyclase: an enzyme that cyclizes NAD+ into a calcium-mobilizing metabolite. Cell Regulation 2, 203-209. Journal Cover.
  9. Walseth, T. F., Aarhus, R., Zeleznikar, R.J. Jr., and Lee, H.C. (1991) Determination of endogenous levels of cyclic ADP-ribose in rat tissues. Biochim. Biophys. Acta 1094, 113-120.
  10. Galione, A., Lee, H.C. and Busa, W.B. (1991) Ca+2 -induced Ca+2 release in sea urchin egg homogenates and its modulation by cyclic ADP-ribose. Science 253, 1143-1146.
  11. Koshiyama, H., Lee, H.C. and Tashjian, A.H. Jr. (1991) Novel mechanism of intracellular calcium release in pituitary cells. J. Biol. Chem. 266, 16985-16988.
  12. States, D.J., Walseth, T.F. and Lee, H.C. (1992) Similarities in amino acid sequences of Aplysia ADP-ribosyl cyclase and human lymphocyte antigen CD38. Trends Biochem. Sci. 17, 495.
  13. Lee, H.C. (1993) Potentiation of calcium- and caffeine-induced calcium release by cyclic ADP-ribose. J. Biol. Chem. 268, 293-299.
  14. Lee, H.C. and Aarhus, R. (1993) Wide distribution of an enzyme that catalyzes the hydrolysis of cyclic ADP-ribose. Biochim. Biophys. Acta 1164, 68-74.
  15. Walseth, T.F. and Lee, H.C. (1993) Synthesis and characterization of antagonists of cyclic ADP-ribose. Biochim. Biophys. Acta 1178, 235-242.
  16. Lee, H.C., Aarhus, R. and Walseth, T.F. (1993) Calcium mobilization by dual receptors during fertilization of sea urchin eggs. Science 261, 352-355.
  17. Lee, H.C., Zocchi, E., Guida, L., Franco, L., Benatti, U., and De Flora, A. (1993) Production and hydrolysis of cyclic ADP-ribose at the outer surface of human erythrocytes. Biochem. Biophys. Res. Commun. 191, 639-645.
  18. Howard, M., Grimaldi, J.C., Bazan, J.F., Lund, F.E., Santos-Argumedo, L., Parkhouse, R.M.E., Walseth, T.F. and Lee, H.C. (1993) Formation and hydrolysis of cyclic ADP-ribose catalyzed by lymphocyte antigen CD38. Science 262, 1056-1059.
  19. Walseth, T. F., Aarhus, R., Kerr, J. A. and Lee, H.C. (1993) Identification of cyclic ADP-ribose binding proteins by photoaffinity labeling. J. Biol. Chem. 268, 26686-26691.
  20. Zocchi, E., Franco, L., Guida, L., Benatti, U., Bargellesi, A., Malavasi, F., Lee, H.C., and De Flora, A. (1993) A single protein immunologically identified as CD38 displays NAD+ glycohydrolase, ADP-ribosyl cyclase and cyclic ADP-ribose hydrolase activities at the outer surface of human erythrocytes. Biochem. Biophys. Res. Commun. 196, 1459-1465.
  21. Lee, H.C., Aarhus, R. and Levitt, D. (1994) The crystal structure of cyclic ADP-ribose. Nature Structural Biology 1, 143-144.
  22. Lee, H.C. (1994) A signaling pathway involving cyclic ADP-ribose, cyclic GMP and nitric oxide. News in Physiol. Sci. 9, 134-138.
  23. Lee, H.C., Galione, A. and Walseth, T.F. (1994) Cyclic ADP-ribose: Metabolism and calcium mobilizing function. In "Vitamins and Hormones". Edited by G. Litwack, Academic Press, Orlando, Fl., Vol. 48, p.199-254.
  24. Lee, H.C., Aarhus, R., Graeff, R., Gurnack, M.E. and Walseth, T.F. (1994) Cyclic ADP-ribose activation of the ryanodine receptor is mediated by calmodulin. Nature 370, 307-309.
  25. Lee, H.C. (1994) Cyclic ADP-ribose: A new member of a super family of signaling cyclic nucleotides. Cellular Signalling 6, 591-600.
  26. Lee, H.C. (1994) Cyclic ADP-ribose: A calcium mobilizing metabolite of NAD+. Mol. Cell. Biochem. 138, 229-235.
  27. Graeff, R., Walseth, T.F., Fryxell, K., Branton, D. and Lee, H.C. (1994) Enzymatic synthesis of cyclic GDP-ribose. A procedure for distinguishing enzymes with ADP-ribosyl cyclase activity. J. Biol. Chem. 269, 30260-30267.
  28. Graeff, R.M., Mehta, K. and Lee, H.C. (1994) GDP-ribosyl cyclase activity as a measure for CD38 induction by retinoic acid in HL-60 cells. Biochem. Biophys. Res. Commun. 205, 722-727.
  29. Graeff, R., Podein, R.J., Aarhus, R. and Lee, H.C. (1995) Magnesium ions but not ATP inhibit cyclic ADP-ribose-induced calcium release. Biochem. Biophys. Res. Commun. 206, 786-791.
  30. Baumgarten, L.B., Lee, H.C. and Villereal, M.L. (1995) Multiple intracellular Ca+2 pools exist in human foreskin fibroblast cells. The effect of BK on release and filling of the non-cytosolic Ca+2 pools. Cell Calcium 17, 41-52.
  31. Lee, H.C. and Aarhus, R. (1995) A derivative of NADP mobilizes calcium stores insensitive to inositol trisphosphate and cyclic ADP-ribose. J. Biol. Chem. 270, 2152-2157.
  32. Aarhus, R., Gee, K, and Lee, H.C. (1995) Caged cyclic ADP-ribose. Synthesis and use. J. Biol. Chem. 270, 7745-7749.
  33. Beers, K.W., Chini, E.N., Lee, H.C. and Dousa, T.P. (1995) Metabolism of cyclic ADP-ribose in opossum kidney renal epithelial cells. Am. J. Physiol. 268, C741-C746.
  34. Lee, H.C., Aarhus, R. and Graeff, R. (1995) Sensitization of the calcium-induced calcium release by cyclic ADP-ribose and calmodulin. J. Biol. Chem. 270, 9060-9066.
  35. Fryxell, K.B., O'Donoghue, K., Graeff, R.M., Lee, H.C. and Branton, W.D. (1995) Functional expression of soluble forms of human CD38 in E. coli and Picjia Pastoris. Protein Expression and Purification 6, 329-336.
  36. Lee, H.C. (1995) Cyclic ADP-ribose: A mediator of a calcium signaling pathway. In "Ryanodine Receptors". Edited by V. Sorrentino, CRC Series on Pharmacology and Toxicology. CRC Press, Boca Raton, Fl. Chapter 3, pp. 31-50.
  37. Lee, H.C., Graeff, R. and Walseth, T.F. (1995) Cyclic ADP-ribose and its metabolic enzymes. Biochimie 77, 345-355.
  38. Aarhus, R., Graeff, R.M., Dickey, D.M., Walseth, T.F. and Lee, H.C. (1995) ADP-ribosyl cyclase and CD38 catalyze the synthesis of a calcium mobilizing metabolite from NADP. J. Biol. Chem. 270, 30327-30334.
  39. Graeff, R.M., Walseth, T.F., Hill, H.K. and Lee, H.C. (1996) Fluorescent analogs of cyclic ADP-ribose. Synthesis, spectral characterizations and use. Biochemistry 35, 379-386.
  40. Willmott, N., Sethi, J., Walseth, T.F., Lee, H.C., White, A.M., and Galione, A. (1996) Nitric oxide induced mobilization of intracellular calcium via the cyclic ADP-ribose signalling pathway. J. Biol. Chem. 271, 3699-3705.
  41. Prasad, G.S., Levitt, D.G., Lee, H.C., Stout, C.D. (1996) Preliminary crystallographic studies of ADP-ribosyl cyclase from Aplysia california. Proteins 24, 138-140.
  42. Lee, H.C. (1996) Modulator and messenger functions of cyclic ADP-ribose in calcium signaling. Recent Prog. Hormone Res. 52, 357-391.
  43. Aarhus, R., Dickey, D.M., Graeff, R.M., Gee, K.R., Walseth, T.F. and Lee, H.C. (1996) Activation and Inactivation of Ca2+ Release by NAADP. J. Biol. Chem. 271, 8513-8516.
  44. Lee, H.C. (1996) Cyclic ADP-ribose and calcium signaling in eggs. Biol. Signals 5, 101-110.
  45. Prasad, G.S., McRee, D.E., Stura, E.A., Levitt, D.G., Lee, H.C., Stout, C.D. (1996) Crystal structure of Aplysia ADP-ribosyl cyclase, a homolog of the bifunctional ectozyme CD38. Nature Struct. Biol. 3, 957-964.  Journal Cover.
  46. Graeff, R.M., Walseth, T.F. and Lee, H.C. (1997) A radio-immunoassay for measuring endogenous levels of cyclic ADP-ribose in tissues. Meth. Enzymol. 280, 230-241.
  47. Munshi, C.B. Fryxell, K.B., Lee, H.C. and Branton, W.D. (1997) Large scale production of human CD38 in yeast by fermentation. Meth. Enzymol. 280, 318-330.
  48. Lee, H.C., Graeff, R.M., Munshi, C.B., Walseth, T.F. and Aarhus, R. (1997) Large scale purification of Aplysia ADP-ribosyl cyclase and measurment of its activity by a fluorimetric assay. Meth. Enzymol. 280, 331-340.
  49. Walseth, T.F., Aarhus, R., Gurnack, M.E., Wong, L., Breitinger, H.-G. A., Gee, K.R., and Lee, H.C. (1997) Preparation of cyclic ADP-ribose antagonists and caged cyclic ADP-ribose. Meth. Enzymol. 280, 294-305.
  50. Walseth, T.F., Wong, L., Graeff, R.M. and Lee, H.C. (1997) A bioassay for determining endogenous levels of cyclic ADP-ribose. Meth. Enzymol. 280, 287-294.
  51. Lee, H.C., Aarhus, R., Gee, K. and Kestner, T (1997) Caged NAADP. Synthesis and Use. J. Biol. Chem. 272, 4172-4178.
  52. Lee, H.C., Graeff, R.M. and Walseth, T.F. (1997) ADP-ribosyl cyclase and CD38: Multi-functional enzymes in calcium signaling. Adv. Exp. Med. Biol. 419, 411-419.
  53. De Flora, A., Guida, L., Franco, L., Zocchi, E., Bruzzone, S., Benatti, U., Damonte, G. and Lee, H.C. (1997) CD38 and ADP-ribosyl cyclase catalyze the synthesis of a dimeric ADP-ribose that potentiates the calcium-mobilizing activity of cyclic ADP-ribose. J. Biol. Chem. 272, 12945-12951.

    54.  

    Top of List 

    End of List

    Back to H.C. Lee Page

  54. Lee, H.C. and Aarhus, R. (1997) Structural determinants of nicotinic acid adenine dinucleotide phosphate important for its calcium-mobilizing activity. J. Biol. Chem. 272, 20378-20383.
  55. Lee, H.C. (1997) Mechanisms of calcium signaling by cyclic ADP-ribose and NAADP. Physiol. Rev. 77, 1133-1164.
  56. Munshi, C. and Lee H.C. (1997) High-level expression of recombinant Aplysia ADP-ribosyl cyclase in pichia pastoris by fermentation. Prot. Expr. Purif. 11, 104-110.
  57. Wu, Y., Kuzma, J., Marechal, E., Graeff, R., Lee, H.C., Foster, R. and Chua, N.H. (1997) Abscisic acid signaling through cyclic ADP-ribose in plant. Science 278, 2126-2130.
  58. Lee, H.C. (1998) Calcium signaling by cyclic ADP-ribose and NAADP. A decade of exploration. Cell Biochem. Biophys. 28, 1-17.  Journal Cover.
  59. Dickey, D.M., Aarhus, R., T.F. Walseth and Lee, H.C. (1998) Thio-NADP is not an antagonist of NAADP. Cell Biochem. Biophys. 28, 63-73.
  60. Graeff, R.M., Franco, L. De Flora, A. and Lee, H.C. (1998) Cyclic GMP dependent and independent effects on the synthesis of the calcium messengers cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate. J. Biol. Chem. 273, 118-125.
  61. Hussain, A.M.M., Lee, H.C. and Chang, C.F. (1998) Functional expression of secreted mouse BST-1 in yeast. Prot. Expr. Purif. 12, 133-137.
  62. Albrieux, M., Lee, H.C., Villaz, M. (1998) Calcium signaling by cyclic ADP-ribose, NAADP and inositol trisphosphate are involved in distinctfunctions in ascidian oocytes. J. Biol. Chem. 273, 14566-14574.
  63. Gee, K.R. and Lee, H.C. (1998) Characterization and application of the photogeneration of the calcium mobilizers cyclic ADP-ribose and NAADP from caged analogs. Meth. Enzymol. 291, Chap. 22, 403-415.
  64. Sauve, A., Munshi, C., Lee, H.C. and Schramm, V.L. (1998) The reaction mechanism for CD38. A single intermediate is responsible for cyclization, hydrolysis and base-exchange chemistries. Biochemistry 37, 13239-13249.
  65. Lee, H.C. and Aarhus, R. (1998) Fluorescent analogs of NAADP with calcium mobilizing activity. Biochim. Biophys. Acta 1425, 263-271.
  66. Munshi, C., Baumann, C., Levitt, D., Bloomfield, V. A. and Lee, H.C. (1998) The homo-dimeric form of ADP-ribosyl cyclase in solution. Biochim. Biophys. Acta 1388, 428-436.
  67. Lee, H.C., Munshi, C. and Graeff, R.M. (1999) Structure and activity of cyclic ADP-ribose, NAADP and their metabolic enzymes. Mol. Cell. Biochem. 193, 89-98.
  68. Lee, H.C. (1999) A unified mechanism for enzymatic synthesis of two calcium messengers, cyclic ADP-ribose and NAADP. Biol. Chem. 380, 785-793.  Journal Cover.
  69. Munshi, C., Thiel, D.J., Mathews, I.I. Aarhus, R., Walseth, T. F. and Lee, H.C. (1999) Characterization of the active site of ADP-ribosyl cyclase. J. Biol. Chem. 274, 30770-30777.
  70. Wong, L., Aarhus, R., Lee, H.C. and Walseth, T.F. (1999) Cyclic 3-deaza-adenosine diphosphoribose: A potent and stable analog of cyclic ADP-ribose. Biochim. Biophys. Acta 1472, 555-564.
  71. Lee, H.C. (2000) Enzymatic functions and structures of CD38 and homologs. In "Chemical Immunology", Edited by K. Mehta and F. Malavasi, Karger Publishers, Vol. 75, 39-59.
  72. Lee, H.C. (2000) NAADP: An emerging calcium signaling molecule. J. Memb. Biol. 173, 1-8.
  73. Lee, H.C. (2000) Multiple calcium stores: Separate but interacting. Science's STKE http://www.stke.org/cgi/content/full/OC_sigtrans;2000/40/pe1
  74. Munshi, C., Aarhus, R., Graeff, R., Walseth, T.F., Levitt, D. and Lee, H.C. (2000) Identification of the enzymatic active site of CD38 by site-directed mutagenesis. J. Biol. Chem. 275, 21566-21571
  75. Khoo, K.M., Han, M.K., Park, J.B., Chae, S.W., Kim, U.H., Lee, H.C. Bay, B.H. and Chang, C.F. (2000) Localization of the cyclic ADP-ribose dependent calcium signaling pathway in hepatocyte nucleus. J. Biol. Chem. 275, 24807-24817.
  76. Alamgir, M.M.H, Lee, H.C. and Chang, C.F. (2000) Modulation of CD157 expression and its functional evaluation in multi-lineage myeloid differentiation of promyelocytic cell lines. Eur. J. Cell Biol. 79, 697-706.
  77. Lee, H.C. and Aarhus, R. (2000) Functional visualization of the separate but interacting calcium stores sensitive to NAADP and cyclic ADP-ribose. J. Cell. Sci.113, 4413-4420.
  78. White, T.A., Johnson, S., Walseth, T.F., Lee, H.C., Graeff, R.M., Munshi, C.B., Prakash, Y.S., Sieck, G.C. and Kannan, M.S (2000) Subcellular localization of cyclic ADP-ribosyl cyclase and cyclic ADP-ribose hydrolase activities in porcine airway smooth muscle. Biochim. Biophys. Acta 1498, 64-71.
  79. Lee, H.C. (2001) Physiological functions of cyclic ADP-ribose and NAADP as calcium messengers. Ann. Rev. Pharmacol. Toxicol. 41, 317-345.
  80. Munshi, C. and Lee, H.C. (2001) Recent advances in the structure and mechanism of Aplysia ADP-ribosyl cyclase and human CD38. Curr. Top. Biochem. Res. 3, 121-129.
  81. Graeff, R., Munshi, C., Aarhus, R. Johns, M. and Lee, H.C. (2001) A single residue at the active site of CD38 determines its NAD cyclizing and hydrolyzing activities. J. Biol. Chem. 276, 12169-12173.
  82. Graeff, R. and Lee, H.C. (2002) A novel cycling assay for cellular cyclic ADP-ribose with nanomolar sensitivity. Biochem. J. 361, 379-384. 
  83. Lee, H.C. (2002) Calcium signaling mediated by cyclic ADP-ribose and NAADP: Roles in cellular response to stress. In Sensing, Signalling and Cell Adaptation. K.B. Storey and J.M. Storey (eds), vol. 3, pp. 91-104, Elsevier.
  84. Graeff, R. and Lee, H.C. (2002) A novel cycling assay for NAADP with nanomolar sensitivity. Biochem. J. 367, 163-168.
  85. Lee, H.C. (2002) Cyclic ADP-ribose and NAADP. A story of two calcium messengers. In Cyclic ADP-Ribose and NAADP. Structures, Metabolism and Functions. Lee, H.C. (ed), pp. 1-21, Dordrecht: Kluwer.
  86. Lee, H.C., Munshi C.B. and Graeff, R. (2002) ADP-ribosyl cyclases-A family of cADPR and NAADP metabolizing enzymes. In Cyclic ADP-Ribose and NAADP. Structures, Metabolism and Functions. Lee, H.C. (ed), pp. 23-43, Dordrecht: Kluwer.
  87. Munshi C.B. and Lee, H.C. (2002) A yeast expression system of high efficiency for producing recombinant enzymes. In Cyclic ADP-Ribose and NAADP. Structures, Metabolism and Functions. Lee, H.C. (ed), pp. 81-99, Dordrecht: Kluwer.
  88. Graeff, R. and Lee, H.C. (2002) Novel cycling assays for cADPR and NAADP. In Cyclic ADP-Ribose and NAADP. Structures, Metabolism and Functions. Lee, H.C. (ed), pp. 101-120, Dordrecht: Kluwer.
  89. Walseth T.F. and Lee, H.C. (2002) Pharmacology of cyclic ADP-ribose and NAADP. Synthesis and properties of analogs. In Cyclic ADP-Ribose and NAADP. Structures, Metabolism and Functions. Lee, H.C. (ed), pp. 121-142, Dordrecht: Kluwer.
  90. Lee, H.C. (2002) Separate but interacting calcium stores. In Cyclic ADP-Ribose and NAADP. Structures, Metabolism and Functions. Lee, H.C. (ed), pp. 143-166, Dordrecht: Kluwer.
  91. Munshi, C.B., Graeff R. and Lee, H.C. (2002) Evidence for a causal role of CD38 expression in granulocytic differentiation of human HL-60 cells. J. Biol. Chem. 277, 49453-49458.
  92. Lee, H.C. (2003) Calcium signaling: NAADP ascends as a new messenger. Curr. Biol. 13, R186-R188.
  93. Graeff, R. and Lee, H.C. (2003) High throughput fluorescence-based assays for cyclic ADP-ribose, NAADP and their metabolic enzymes. Comb. Chem. High Throughput Screen 6, 183-194.
  94. Bruzzone, S., De Flora, A., Graeff, R. and Lee, H.C. (2003) Cyclic ADP-ribose is a second messenger in the lipopolysaccharide-stimulated proliferation of human blood mononuclear cells. Biochem. J. 375, 395-403.
  95. Li, P.L., Lee, H.C., Nelson, M.T., Meininger, G.A. and Van Breemen, C. (2003) Novel Ca2+ signaling mechanisms in vascular myocytes: Symposium overview. Acta Physiol. Scand. 179, 339-352.
  96. Lee, H.C. (2004) Multiplicity of Ca2+ messengers and Ca2+ stores: A perspective from cyclic ADP-ribose and NAADP. Curr. Mol. Med. 4, 227-237.
  97. Love, M.L., Szebenyi, D.M.E., Kriksunov, I.A., Thiel, D.J., Munshi, C., Graeff, R., Lee, H.C., Hao, Q. (2004) ADP-ribosyl cyclase: Crystal structures reveal a covalent intermediate. Structure 12, 477-486.
  98. Yalcintepe, L., Albeniz, I., Adin-Cinar, S., Tiryaki, D., Bermek, E., Graeff, M.R., and Lee, H.C. (2005) Nuclear CD38 in retinoic acid-induced HL-60 cells. Exp. Cell Res. 303, 14-21.
  99. Bai, N., Lee, H.C. and Laher I. (2005) Emerging role of cyclic ADP-ribose in smooth muscle. Pharmacol. Therapeutics. 105, 189-207.
  100. Liu, Q., Kriksunov, I.A., Graeff, R., Munshi, C. Lee, H.C. and Hao, Q. (2005) Crystal structure of the human CD38 extracellular domain. Structure 13, 1331-1339.  Journal Cover.
  101. Lee, H.C. (2005) Nicotinic acid adenine dinucleotide phosphate (NAADP)-mediated calcium signaling. J. Biol. Chem. 280, 33693-33696.
  102. Graeff, R., Liu, Q., Kriksunov, I.A., Hao, Q. and Lee, H.C. (2006) Acidic residues at the active sites of CD38 and ADP-ribosyl cyclase determine NAADP synthesis and hydrolysis activities. J. Biol. Chem. 281, 28951-28957.
  103. Liu, Q., Kriksunov, I.A., Graeff, R., Munshi, C. Lee, H.C. and Hao, Q. (2006) Structural basis for the mechanistic understanding human CD38 controlled multiple catalysis. J. Biol. Chem. 281, 32861-32869.
  104. Lee, H.C. (2006) Structure and enzymatic functions of human CD38. Mol. Med. 12, 317-323.  Journal Cover.
  105. Liu, Q., Kriksunov, I.A., Graeff, R., Lee, H.C. and Hao, Q. (2007) Structural basis for formation and hydrolysis of calcium messenger cyclic ADP-ribose by human CD38. J. Biol. Chem. 282, 5853-5861.
  106. Liu, Q., Kriksunov, I.A., Moreau, C., Graeff, R., Potter, B.V.L. Lee, H.C. and Hao, Q. (2007) Catalysis associated conformational changes revealed by human CD38 complexed with a non-hydrolysable substrate analog. J. Biol. Chem. 282, 24825-24832.
  107. Bezin, S., Charpentier, G., Lee, H.C., Baux, G., Fossier, P. and Cancela, J.-M. (2008) Regulation of nuclear Ca2+ signalling by translocation of the Ca2+ messenger synthesizing enzyme ADP-ribosyl cyclase during neuronal depolarization. J. Biol. Chem. 283: 27859- 27870.
  108. Liu, Q., Kriksunov, I.A., Jiang, H., Graeff, R. Lin, H., Lee, H.C., Hao, Q. (2008) Covalent and non-covalent intermediates of the calcium signaling enzyme CD38. Chem. Biol., 15, 1068-1078.
  109. Guse, A.H. and Lee, H.C. (2008) NAADP: A universal Ca2+ trigger. Science Signaling 1: re10.  http://stke.sciencemag.org/cgi/reprint/sigtrans;1/44/re10.pdf
  110. Davis, L.C., Morgan, A.J., Ruas, M.,  Wong, J.L., Graeff, R.M., Poustka, A.J., Lee, H.C., Wessel, G.M., Parrington, J. and Galione, A. (2008) Ca2+ signalling via second messenger release from intra-organelle synthesis sites. Curr. Biol. 18, 1612–1618.
  111. Liu, Q., Kriksunov, I.A., Wang, Z., Graeff, R., Lee, H.C., Hao, Q. (2008) Hierarchical and helical self-assembly of ADP-ribosyl cyclase into large-scale protein microtubes. J. Phys. Chem. B 112, 14682–14686.
  112. Liu, Q., Graeff, R., Kriksunov, I.A., Lam, C.M.C., Lee, H.C. and Hao, Q. (2008) Conformational closure of the catalytic site of human CD38 induced by calcium. Biochemistry 47, 13966-13973.
  113. Jiang, H., Congleton, J., Liu, Q., Merchant, P.U., Malavasi, F., Lee, H.C., Hao, Q., Yen, A. and Lin, H. (2009) Mechanism-based small molecule probes for labeling CD38 on live cells. J. Am. Chem. Soc. 131, 1658-1659.
  114. Lam, C.M.C., Yeung, P.K.K., Lee, H.C. and Wong, J.T.Y. (2009) Cyclic ADP-ribose links metabolism to multiple fission in the dinoflagellate Crypthecodinium cohnii. Cell Calcium, 45, 346-357.
  115. Graeff, R., Liu, Q., Kriksunov, I.A., Kotaka, M., Oppenheimer, N., Hao, Q. and Lee, H.C. (2009) Mechanism of cyclizing NAD to cyclic ADP-ribose by ADP-ribosyl cyclase and CD38. J. Biol. Chem. 284, 27629-27636. Selected as top 1% of papers published by JBC.  Journal Cover.

  116. Liu, Q. Graeff, R., Kriksunov, I.A., Jiang, H., Zhang, B. Potter, B.V. L., Oppenheimer, N., Lin. H., Lee, H.C. and Hao, Q. (2009) Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multi- functional NAD hydrolase. J. Biol. Chem. 284, 27637-27645.

  117. Yue, J.B., Wei, W.J., Lam, C.M.C., Zhao, Y.J., Zhang, L.R., Zhang, L.H. and Lee, H.C. (2009) The CD38/cADPR/Ca2+-pathway promotes cell proliferation and delays NGF-induced differentiation in PC12 cells. J. Biol. Chem. 284, 29335-29242.

  118. Zhang, H.M. Graeff, R., Chen, Z., Zhang, L-G, Zhang, L-H, Lee, H.C. and Hao, Q (2011) Dynamic conformations of the CD38-mediated NAD cyclization captured in a single crystal. J. Mol. Biol. 405, 1070-1078.

  119. Dong, M., Si, Y-Q., Sun, S.-Y., Pu, X.-P., Yang, Z.-J., Zhang, L.-R., Zhang, L.-H., Lam, C.M.C., Leung, C.F.P., Yue, J.B., Zhou, Y.Y., Kriksunov, I.A., Hao, Q., Lee, H.C. (2011) Design, synthesis and biological characterization of novel inhibitors of CD38. Org. Biomol. Chem. 9, 3246-3257.

  120. Zhao, Y.J., Zhang, H.M., Lam, C.M.C., Hao, Q. and Lee, H.C. (2011) Cytosolic CD38 forms intact disulfides and is active in elevating intracellular cyclic ADP-ribose. J. Biol. Chem. 286, 22170-22177.

  121. Lee, H.C. (2011) Unraveling of the NAD cyclizing and calcium signaling functions of human CD38. in Medicinal Chemistry of Nucleic Acids. Zhang, L.H., Chattopadhyaya, J. & Xi, Z. (eds), John Wiley & Sons, Chapter 3, p142-p163.

  122. Lee, H.C. (2011) Cyclic ADP-Ribose and NAADP-fraternal twin messengers for calcium signaling. Science China Life Sci. 54, 699-711.

  123. Tao, R., Sun, H-Y, Lau, C.P., Tse, H.F., Lee, H.C. and Li, G.R. (2011) Cyclic ADP- ribose is a novel regulator of intracellular Ca2+ oscillations in human bone marrow mesenchymal stem cells. J. Cell. Mol. Med.  15, 2684-2696.

  124. Chen, Z., Kwong, A.K.Y., Yang, Z.-J., Zhang, L.R., Lee, H.C. and Zhang, L.H. (2011) Studies on the synthesis of nicotinamide nucleoside and nucleotide analogues and their inhibitions towards CD38 NADase. Heterocycles 83, 2837-2850.

  125. Kwong, A.K.Y.*, Chen, Z.*, Zhang, H.M.*, Leung, F.P.*, Lam, C.M.C., Ding, K.Y., Zhang, L.R., Hao, Q., Zhang, L.H. and Lee, H.C. (2012) Catalysis-based inhibitors of the calcium signaling function of CD38. *Contribute equally. Biochemistry 51, 555-564.

  126. Kotaka, M., Graeff, R., Zhang, L.-H., Lee, H.C. and Hao, Q. (2012) Structural studies of intermediates along the cyclization pathway of Aplysia ADP-ribosyl cyclase. J. Mol. Biol. 415, 514-526.

 

                         

Total Citations: 9,766     h-index: 53      ISI Web of Knowledge

Click Here for other publications on Gastric Acid Secretion and Developmental Biology

Top of List

 

 

 

 

 

 

Middle of List

 

 

 

 

 

 

Back to H.C. Lee Page

 

| Home | About Us | Staff | Undergraduate | Postgraduate | Research | Course Material | Publications |