| Researcher : Chan VWY |
| List of Research Outputs |
| Chan V.W.Y., Yip H.K.F., So K.F., Wu W., Neuroprotective effects of extracts from american ginsengs, ginkgo biloba and St. John's wort on striatal dopaminergic neruons against 1-methyl-4-phenyl-1,2,4,6-tetrahydropyridine-induced toxicity, Society for Neuroscience Abstracts. 2000, 26: P1877. |
| Researcher : Chang RCC |
| List of Research Outputs |
| Chang R.C.C., Stadlin A., Tsang D., Effects of tumor necrosis factor alpha on taurine uptake in cultured rat astrocytes, Neurochemistry International. 2001, 38: 249-254. |
| Chang R.C.C., Jiang L., Hudson P., Abel H., Hong J.S., Expression of neural cell adhesion molecules (NCAM) on cultured microglia, Society of Neuroscience. 2000, 26 Part 2: p1944. |
| Chang R.C.C., Suen K.C., Ma E.C.H., Hugon J., Expression of phosphorylated eukaryotic initiation factor 2 alpha in neuronal apoptosis b-amyloid toxicity, Society of Neuroscience. 2001, 27: No.772.12. |
| Chang R.C.C., Hudson P., Wilson B., Liu B., Abel H., Hemperly J., Hong J.S., Immune modulatory effects of neural cell adhesion molecules on lipopolysaccharide-induced nitric oxide production by cultured glia, Molecular Brain Research. 2000, 81: 197-201. |
| Chang R.C.C., Chen W., Hudson P., Wilson B., Han S.K., Hong J.S., Neurons reduce glial responses to lipopolysaccharide (LPS) and prevent injury of microglial cells from over-activation by LPS, Journal of Neurochemistry. 2001, 76: 1042-1049. |
| Chang R.C.C., Chen W., Hudson P., Wilson B., Han D.S.K., Hong J.S., Roles of neurons in the responses of glia to immune stimulant in neurodegenerative diseases, Neuroscience Letter. 2001, 313 Suppl. 1: s4. |
| Cooper C.L., Liu B., Wilson B., Tomasino K., Chang R.C.C., Han D.S., Hong J.S., Neurons survive interferong-primed microglial activation by high-dose LPS, Society of Neuroscience. 2001, 27: No.862.5. |
| Elyaman W., Chang R.C.C., Hugon J., The mood stabilizer agents, lithium and valproate, inhibit staurosporine-induced apoptosis and eukaryotic initiation factor-2 alpha phosphorylation in SH-SY5Y mneuroblastoma cells, Society of Neuroscience. 2001, 27: No.772.8. |
| Jeohn G.H., Wilson B., Chang R.C.C., Liu B., Hudson P., Hong J.S., p38 kinase contributes to LPS-induced neurotoxicity in primary midbrain neuron-glia cultures, Society of Neuroscience. 2000, 26 Part 2: p1944. |
| Jiang L., Chang R.C.C., Jeohn G.H., Hong J.S., Roles of p38 kinase pathway in the activation of the LTR-promoter of human immunodeficiency virus in microglia, Society of Neuroscience. 2000, 26 Part 2: p1945. |
| Liu B., Yang S., Wilson B., Wang J., Chang R.C.C., Femtomolar concentrations of dynorphins protect midbrain dopaminergic neurons against inflammation-mediated degeneration, Society of Neuroscience. 2000, 26 Part 2: p1944. |
| Suen K.C., Chang R.C.C., Ma E.C.H., Elyaman W., Hugon J., Calcium could mediate the hyperphosphorylation of eukaryotic initiation factor 2 alpha in neurons induced by b amyloid peptide 25-35, Society of Neuroscience. 2001, 27: No.428.9. |
| Researcher : Cheung A |
| Project Title: | Role of HPV infection in human esophageal squamous cell carcinoma |
| Investigator(s): | Dr. Cheung A.L.M. , Dr. Poon C.S.P., Dr. Tsao G.S.W. |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | September 1999 |
| Abstract: |
| To study the histological pattern of HPV infection in human esophageal squamous cell carcinomas by in situ hybridization; to determine if HPV infection can be detected in the normal esophageal epithelium adjacent to the cancerous lesions; to determine if there is integration of HPV DNA in the host genome of esophageal squamous cell carcinomas; to study and compare the profiles of genetic alterations, in particular the pattern of loss of heterozygosity (allelotypes) in HPV-positive and -negative esophageal squamouns cell carcinomas. |
| Project Title: | Mechanism of downregulation of E-cadherin in human oesophageal cancer |
| Investigator(s): | Dr. Cheung A.L.M. , Dr. Tsao G.S.W. |
| Source(s) of Funding: | RGC Fundable Projects (Block Grant Funded) |
| Start Date: | May 2000 |
| Completion Date: | April 2001 |
| Abstract: |
| To determine the role of methylation in the regulation of E-cadherin gene in oesophageal cancer; to study the transcription regulation of E-cadherin expression using promoter-luciferase reporter gene assay; to determine the role of deletion and mutation in the inactivation of E-cadherin expression in esophageal cancer. |
| List of Research Outputs |
| Cheung A., Graf A.H., Hauser-Kronberger C., Dandachi N., Dietze O., Tubbs R.R., Pettay J., Hacker G.W., Localising rare molecules in cells and tissues, XIth International Congress of Histochemistry and Cytochemistry, 3-8 September 2000, University of York, UK. 2000, 111-112. |
| Graf A.-.H., Cheung A., Hauser-Kronberger C., Dandachi N., Tubbs R.R., Dietze O., Hacker G.W., Clinical relevance of HPV 16/18 testing methods in cervical squamous cell carcinoma, Applied Immunohistochemistry and Molecular Morphology. 2001, 8(4): 300-309. |
| Hacker G.W., Cheung A., Tubbs R.R., Hauser-Kronberger C., Dietze O., Graf A.-.H., Tyramide signal-amplified gold-silver and gold-gold in situ hybridisation: single copy sensitivity for virus detection, Cellular and Molecular Biology Congress. 2001, 46: 80. |
| Hauser-Kronberger C., Cheung A., Dandachi N., Dietze O., Tubbs R.R., Hacker G.W., In situ hybridisation with tyramide signal-amplification (TSA TM) in combination with various fluorochromes and chromogens, XIth International Congress of Histochemistry and Cytochemistry, 3-8 September 2000, University of York, UK. 2000, 40-41. |
| Lo K.F., Yuen P.W., Liu Y., Wang X., Cheung A., Wong Y.C., Tsao G.S.W., Down regulation of hemidesmosomal proteins in nasopharyngeal carinoma cells, Cancer Letters. 2001, 163: 117-124. |
| Si H., Tsao G.S.W., Lam A.K.Y., Srivastava G., Liu Y., Wong Y.C., Shen Z.Y., Cheung A., E-cadherin expression is commonly downregulated by CpG island hypemethylation in esophageal carcinoma cells, Cancers Letters. 2001, 173: 71-78. |
| Si H., Liu Y., Tsao G.S.W., Cheung A., Hypermethylation of the e-cadherin promotor region in esophageal carcinoma, 7th Hong Kong International Cancer Congress, December 7-9, 2000. 12.1. |
| Wang X., Jin D., Wong Y.C., Cheung A., Chun C.S., Lo K.F., Liu Y., Tsao G.S.W., Correlation of defective mitotic checkpoint with aberrantly reduced expression of MAD2 protein in nasopharyngeal carcinoma cells, Carcinogenesis. 2001, 21 No.12: 2293-2297. |
| Researcher : Cheung MPL |
| List of Research Outputs |
| Chen H., Cheung M.P.L., Chow P.H., O W.S., The study of relationship between male accessory sex gland secretions and sperm DNA damage in the golden hamster, Biology of Reproduction. 2000, 62 Suppl.1: No.121. |
| Researcher : Cheung ZHY |
| List of Research Outputs |
| Cheung Z.H.Y., So K.F., Yip H.K.F., Wu W., Mixture of American ginseng extract, ginkgo biloba extract and St. John's wort extract enhances the survival of axotomized retinal ganglion cells, Society for Neuroscience Abstracts. 2000, 26: P. 331. |
| So K.F., Cheung Z.H.Y., Yip H.K.F., Wu W., Regeneration of axotomized retinal ganglion cells is promoted by a mixture of american ginseng extract, ginkgo biloba extract and St. John's wort extract, Society for Neuroscience Abstracts. 2000, 26: P.2128. |
| Researcher : Dominy NJ |
| List of Research Outputs |
| Dominy N.J., Lucas P.W., Chimpanzees and sensory cues for fig selection, 3rd International Symposium-Workshop on Frugivores and Seed Dispersal, August 6-11, 2000, Hotel Fazenda Fonte Colina Verde, Sao Pedro, SP - Brazil. 2000, 113. |
| Dominy N.J., Lucas P.W., Ecological importance of trichromatic vision to primates, Nature. 2001, 410: 383-386. |
| Dominy N.J., Leaf colour as an indicator of food quality to anthropoid primates, The XVIIIth Congress of the International Primatological Society. 2001, 45. |
| Dominy N.J., Mechanical criteria of fruit selection: figs and primates in Kibale Forest, Uganda, Plant Biomechanics 2000. Proceedings of the 3rd Plant Biomechanics Conference Freiburg-Badenweiler, August 27th to September 2. 2000, 522-528. |
| Dominy N.J., Lucas P.W., Osorio D., Yamashita N., The sensory ecology of primate food perception, Evol. Anthrop.. 2001, 10: 176-186. |
| Lucas P.W., Dominy N.J., Yamashita N., Essackjee H.C., Osorio D., Darvell B.W., A physiochemical field kit for ecological studies, 3rd International Symposium-Workshop on Frugivores and Seed Dispersal, August 6-11, 2000, Hotel Fazenda Fonte Colina Verde, Sao Pedro, SP - Brazil. 2000, 208. |
| Lucas P.W., Beta T., Darvell B.W., Dominy N.J., Essackjee H.C., Lee P.K.D., Osorio D., Ramsden L., Yamashita N., Yuen T.D.B., Field kit to characterize physical, chemical and spatial aspects of potential foods of primates, Folia Primatol. 2001, 72: 11-15. |
| Lucas P.W., Beta T., Darvell B.W., Dominy N.J., Essackjee H.C., Osorio D., Ramsden L., Yamashita N., Measuring the physicochemical properties of the foods of primates in the field, The XVIIIth Congress of the International Primatological Society, January 7-12, 2001. 53. |
| Lucas P.W., Turner I.M., Dominy N.J., Yamashita N., Mechanical defences to herbivory, Annals of Botany. 2000, 86: 913-920. |
| Researcher : Elyaman W |
| List of Research Outputs |
| Elyaman W., Terro F., Wong N.S., Hugon J., N-methyl-D-Aspartate receptor blockade-mediated apoptosis induced GSK activation and increase of TAU phosphorylation in newborn rats, Federation of Asian-Oceanian Neuroscience Societies (FAONS) Symposium 2000 and the 20th Scientific Meeting of the Hong Kong Society of Neurosciences. 2000. |
| Elyaman W., Chang R.C.C., Hugon J., The mood stabilizer agents, lithium and valproate, inhibit staurosporine-induced apoptosis and eukaryotic initiation factor-2 alpha phosphorylation in SH-SY5Y mneuroblastoma cells, Society of Neuroscience. 2001, 27: No.772.8. |
| Suen K.C., Chang R.C.C., Ma E.C.H., Elyaman W., Hugon J., Calcium could mediate the hyperphosphorylation of eukaryotic initiation factor 2 alpha in neurons induced by b amyloid peptide 25-35, Society of Neuroscience. 2001, 27: No.428.9. |
| Researcher : Hugon J |
| Project Title: | PKR and chaperone (grp78, p58) gene expression in cellular and transgenic models of alzheimer's disease |
| Investigator(s): | Prof. Hugon J. , Dr. Tsao G.S.W. |
| Source(s) of Funding: | RGC Fundable Projects (Block Grant Funded) |
| Start Date: | May 2000 |
| Abstract: |
| To analysis PKR and chaperone protein expressing will be conducted in cellular and transgenic models of AD which are now readily available. |
| Project Title: | Molecular control of Inositol 1,4,5-triphosphate receptors (IP3R) in cellular models of Alzheimer's disease |
| Investigator(s): | Prof. Hugon J. |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | October 2000 |
| Abstract: |
| Alzheimer's disease (AD) is a frequent neurodegenerative disorder characterized by the progressive occurrence of memory disturbances slowly evolving to a complete cognitive impairment with behavioural anomalies. The project aims to use models to attenuate neuronal apoptosis by modulating IP3R gene expression and IP3R activity. Regulating IP3R could be one of the base for neuroprotection and could present a new therapeutic target to decrease the evolution of this disease in affected patients. |
| Project Title: | Role of calmodulin-dependent protein kinase II in neural cell apoptosis and tau phosphorylation |
| Investigator(s): | Prof. Hugon J. |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | May 2001 |
| Abstract: |
| To analyse during neuronal apoptosis induced by calcium influx, the role of CaMK II in tau phosphorylation and neuroprotection and the links with the activation of the AkT/PkB anti-apoptotic signaling pathway. |
| List of Research Outputs |
| Battu S., Elyaman W., Hugon J., Cardot P.J.P., Cortical cell elution by sedimentation field-flow fractionation, Biochimica et Biophysica-Acta. 2001, 25215: 1-8. |
| Chang R.C.C., Suen K.C., Ma E.C.H., Hugon J., Expression of phosphorylated eukaryotic initiation factor 2 alpha in neuronal apoptosis b-amyloid toxicity, Society of Neuroscience. 2001, 27: No.772.12. |
| Elyaman W., Terro F., Wong N.S., Hugon J., N-methyl-D-Aspartate receptor blockade-mediated apoptosis induced GSK activation and increase of TAU phosphorylation in newborn rats, Federation of Asian-Oceanian Neuroscience Societies (FAONS) Symposium 2000 and the 20th Scientific Meeting of the Hong Kong Society of Neurosciences. 2000. |
| Elyaman W., Chang R.C.C., Hugon J., The mood stabilizer agents, lithium and valproate, inhibit staurosporine-induced apoptosis and eukaryotic initiation factor-2 alpha phosphorylation in SH-SY5Y mneuroblastoma cells, Society of Neuroscience. 2001, 27: No.772.8. |
| Hugon J., Terro F., Esclaire F., Yardin C., Markers of apoptosis and models of programmed cell death in Alzheimer's disease, Journal of Neural Transmission. 2000, 59 Suppl: 125-131. |
| Hugon J., Ludolph A., Kuncl R.W., Pharmacotherapy of ALS and its scientific basis, In: Ralph W. Kuncl, Motor Neuron Disease. W. B. Saunders, 2001, 115-132. |
| Hugon J., Ludolph A.C., Spencer P.S., b-N-Oxalylamino-L-Alanine, In: P. S. Spencer, H. H. Schaumburg, A. C. Ludolph, Experimental and Clinical Neurotoxicology. Oxford, 2000, Second Edition: 925-938. |
| Suen K.C., Chang R.C.C., Ma E.C.H., Elyaman W., Hugon J., Calcium could mediate the hyperphosphorylation of eukaryotic initiation factor 2 alpha in neurons induced by b amyloid peptide 25-35, Society of Neuroscience. 2001, 27: No.428.9. |
| Yardin C., Terro F., Marquet P., Esclaire F., Hugon J., The apoptosis-inducing toxin brefeldin A is taken up and secondarily released by neurons, Neuroscience Research Communications. 2001, 27 No.2: 125-133. |
| Researcher : Ji JZ |
| List of Research Outputs |
| Ji J.Z., So K.F., Yip H.K.F., Lee V.W.H., Ciliary neurotrophic factor prevents the death of retinal ganglion cells in a rat glaucoma model, Society for Neuroscience Abstracts. 2000, 26: P.329. |
| Researcher : Lai KW |
| List of Research Outputs |
| Lai K.W., Cheng L.Y.L., Tsang B.K., O W.S., Galactosemia and rat granulosa cell apoptosis, Biology of Reproduction. 2000, 62 Suppl.1: No.287. |
| Researcher : Lee DTW |
| List of Research Outputs |
| Ouyang X., Wang X., Lee D.T.W., Tsao G.S.W., Wong Y.C., Up-regulation of TRPM-2, MMP-7 and ID-1 during sex hormone-induced prostate carcinogenesis in the Noble rat, Carcinogenesis. 2001, 22 No. 6: 965-973. |
| Tam N.N.C., Chung S.S.M., Lee D.T.W., Wong Y.C., Aberrant expression of hepatocyte growth factor and its receptor, c-Met, during sex hormone-induced prostatic carcinogenesis in the Noble rat, Carcinogenesis. 2000, 21(12): 2183-2191. |
| Wong Y.C., Wang Y.Z., Lee J.S.K., Tam N.N.C., Lee D.T.W., Changes in serum and tissue zinc levels in sex hormone-induced prostatic carcinogenesis in the noble rat, Tumor Biology. 2000, 21: 328-336. |
| Researcher : Lee VWH |
| List of Research Outputs |
| Lee V.W.H., Mok K.H., Nerve fibre layer measurement of the Hong Kong Chinese population by scanning laser polarimetry, Eye. 2000, 14: 371-374. |
| Mok K.H., Lee V.W.H., Nerve fiber analyzer and short-wavelength automated perimetry in glaucoma suspects, Ophthalmology. 2000, 107 No.12: 1-4. |
| Mok K.H., Lee V.W.H., Synechial angle closure attern in chinese chronic primary angle-closure glaucoma patients, Journal of Glaucoma. 2001, 10: 427-428. |
| Researcher : Leung KM |
| List of Research Outputs |
| Jin Y., Tipoe G.L., Liong E.C., Lau T.H.Y., Fung P.C.W., Leung K.M., Overexpression of BMP-2/4,-5 and BMPPR-IA associated with oral epithelium, European Journal of Cancer, Oral Oncology. 2001, 37: 225-233. |
| Researcher : Liu Y |
| List of Research Outputs |
| Fung L.F., Lo K.F., Yuen P.W., Liu Y., Wang X., Tsao G.S.W., Differential gene expression in nasopharyngeal carcinoma cells, Life Sciences. 2000, 67: 923-936. |
| Liu Y., Wang X., Cao L., Yang X.H., Wong Y.C., Chan C.K., Tsao G.S.W., Biological properties of latent membrane protein-1 (LMP-1) expression in nasopharyngeal epithelial cells, AACR 91st Ann Meeting. 2000, 41: 317-318. |
| Lo K.F., Yuen P.W., Liu Y., Wang X., Cheung A., Wong Y.C., Tsao G.S.W., Down regulation of hemidesmosomal proteins in nasopharyngeal carinoma cells, Cancer Letters. 2001, 163: 117-124. |
| Lo K.F., Liu Y., Wang X., Wong Y.C., Lee C.K.F., Huang D.P., Tsao G.S.W., Identification of downstream target genes of latent membrane protein 1 in nasopharyngeal carcinoma cells by suppression subtractive hybridization, Biochimica et Biophysica Acta. 2001, 1520: 131-140. |
| Si H., Tsao G.S.W., Lam A.K.Y., Srivastava G., Liu Y., Wong Y.C., Shen Z.Y., Cheung A., E-cadherin expression is commonly downregulated by CpG island hypemethylation in esophageal carcinoma cells, Cancers Letters. 2001, 173: 71-78. |
| Si H., Liu Y., Tsao G.S.W., Cheung A., Hypermethylation of the e-cadherin promotor region in esophageal carcinoma, 7th Hong Kong International Cancer Congress, December 7-9, 2000. 12.1. |
| Tsao G.S.W., Wong N., Wang X., Liu Y., Wan T.S.K., Fung L.F., Lancaster W.D., Gregoire L., Wong Y.C., Nonrandom chromosomal imbalances in human ovarian surface epithelial cells immortalized by HPV16-E6E7 viral oncogenes, Cancer Genetics and Cytogenetics. 2001, 130: 141-149. |
| Wang X., Jin D., Wong Y.C., Cheung A., Chun C.S., Lo K.F., Liu Y., Tsao G.S.W., Correlation of defective mitotic checkpoint with aberrantly reduced expression of MAD2 protein in nasopharyngeal carcinoma cells, Carcinogenesis. 2001, 21 No.12: 2293-2297. |
| Wang X., Wang J., Wong S.C.H., Chow L.S.N., Nicholls J.M., Wong Y.C., Liu Y., Kwong D.L.W., Sham J.S.T., Tsao G.S.W., Cytotoxic effect of gossypol on colon carcinoma cells, Life Sciences. 2000, 67: 2663-2671. |
| Researcher : Lo KF |
| List of Research Outputs |
| Fung L.F., Lo K.F., Yuen P.W., Liu Y., Wang X., Tsao G.S.W., Differential gene expression in nasopharyngeal carcinoma cells, Life Sciences. 2000, 67: 923-936. |
| Lo K.F., Yuen P.W., Liu Y., Wang X., Cheung A., Wong Y.C., Tsao G.S.W., Down regulation of hemidesmosomal proteins in nasopharyngeal carinoma cells, Cancer Letters. 2001, 163: 117-124. |
| Lo K.F., Liu Y., Wang X., Wong Y.C., Lee C.K.F., Huang D.P., Tsao G.S.W., Identification of downstream target genes of latent membrane protein 1 in nasopharyngeal carcinoma cells by suppression subtractive hybridization, Biochimica et Biophysica Acta. 2001, 1520: 131-140. |
| Wang X., Jin D., Wong Y.C., Cheung A., Chun C.S., Lo K.F., Liu Y., Tsao G.S.W., Correlation of defective mitotic checkpoint with aberrantly reduced expression of MAD2 protein in nasopharyngeal carcinoma cells, Carcinogenesis. 2001, 21 No.12: 2293-2297. |
| Wang X., Masters J.R.W., Wong Y.C., Lo K.F., Tsao G.S.W., Mechanism of differential sensitivity to cisplatin in nasopharyngeal carcinoma cells, Anti-Cancer Research. 2001, 21: 403-408. |
| Researcher : Lucas PW |
| Project Title: | The importance of colour vision for foraging strategies of primates and their relationship to the evolution of trichromatic colour vision |
| Investigator(s): | Prof. Lucas P.W. |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | January 1998 |
| Abstract: |
| To study potential plant foods through the eyes of primates to spot the crucial advantages of trichromatism for feeding. |
| Project Title: | The importance of colour vision for foraging strategies of primates and their relationship to the evolution of trichromatic colour vision |
| Investigator(s): | Prof. Lucas P.W. |
| Source(s) of Funding: | VC's Strategic Research Initiatives |
| Start Date: | January 1998 |
| Abstract: |
| To study potential plant foods through the eyes of primates to spot the crucial advantages of trichromatism for feeding. |
| List of Research Outputs |
| Agrawal K.R., Lucas P.W., Bruce I.C., The effects of food fragmentation index on mandibular closing angle in human mastication, Archives of Oral Biology. 2000, 45: 577-584. |
| Dominy N.J., Lucas P.W., Chimpanzees and sensory cues for fig selection, 3rd International Symposium-Workshop on Frugivores and Seed Dispersal, August 6-11, 2000, Hotel Fazenda Fonte Colina Verde, Sao Pedro, SP - Brazil. 2000, 113. |
| Dominy N.J., Lucas P.W., Ecological importance of trichromatic vision to primates, Nature. 2001, 410: 383-386. |
| Dominy N.J., Lucas P.W., Osorio D., Yamashita N., The sensory ecology of primate food perception, Evol. Anthrop.. 2001, 10: 176-186. |
| Lucas P.W., Dominy N.J., Yamashita N., Essackjee H.C., Osorio D., Darvell B.W., A physiochemical field kit for ecological studies, 3rd International Symposium-Workshop on Frugivores and Seed Dispersal, August 6-11, 2000, Hotel Fazenda Fonte Colina Verde, Sao Pedro, SP - Brazil. 2000, 208. |
| Lucas P.W., Darvell B.W., Lee K.D., Yamashita N., Yuen D.B., A portable mechanical field tester for ecological studies, Plant Biomechanics 2000. Proceedings of the 3rd Plant Biomechanics Conference Freiburg-Badenweiler, August 27th to September 2. 2000, 541-545. |
| Lucas P.W., Beta T., Darvell B.W., Dominy N.J., Essackjee H.C., Lee P.K.D., Osorio D., Ramsden L., Yamashita N., Yuen T.D.B., Field kit to characterize physical, chemical and spatial aspects of potential foods of primates, Folia Primatol. 2001, 72: 11-15. |
| Lucas P.W., Peters C.R., Function of postcanine tooth shape in mammals, In: M. F. Teaford, M. M. Smith and M. Ferguson, Development, Function and Evolution of Teeth. Cambridge, Cambridge University Press, 2000, 482-489. |
| Lucas P.W., Beta T., Darvell B.W., Dominy N.J., Essackjee H.C., Osorio D., Ramsden L., Yamashita N., Measuring the physicochemical properties of the foods of primates in the field, The XVIIIth Congress of the International Primatological Society, January 7-12, 2001. 53. |
| Lucas P.W., Turner I.M., Dominy N.J., Yamashita N., Mechanical defences to herbivory, Annals of Botany. 2000, 86: 913-920. |
| Prinz J.F., Lucas P.W., 'The first bite of the cherry' Intra-oral manipulation prior to the first bite in humans, Journal of Oral Rehabilitation. 2001, 28: 614-617. |
| Prinz J.F., Lucas P.W., Saliva tannin interactions, Journal of Oral Rehabilitation. 2000, 27: 991-994. |
| Turner J., Lucas P.W., Becker P., Wong S.C., Young J.W.H., Chung M.F., Tyree M.T., Tree leaf form in Burnei: a health forest and a mixed dipterocarp forest compared, Biotropica. 2000, 32(1): 53-61. |
| Researcher : Ma ECH |
| List of Research Outputs |
| Chang R.C.C., Suen K.C., Ma E.C.H., Hugon J., Expression of phosphorylated eukaryotic initiation factor 2 alpha in neuronal apoptosis b-amyloid toxicity, Society of Neuroscience. 2001, 27: No.772.12. |
| Suen K.C., Chang R.C.C., Ma E.C.H., Elyaman W., Hugon J., Calcium could mediate the hyperphosphorylation of eukaryotic initiation factor 2 alpha in neurons induced by b amyloid peptide 25-35, Society of Neuroscience. 2001, 27: No.428.9. |
| Researcher : Mok KH |
| List of Research Outputs |
| Lee V.W.H., Mok K.H., Nerve fibre layer measurement of the Hong Kong Chinese population by scanning laser polarimetry, Eye. 2000, 14: 371-374. |
| Mok K.H., Lee V.W.H., Nerve fiber analyzer and short-wavelength automated perimetry in glaucoma suspects, Ophthalmology. 2000, 107 No.12: 1-4. |
| Mok K.H., Lee V.W.H., Synechial angle closure attern in chinese chronic primary angle-closure glaucoma patients, Journal of Glaucoma. 2001, 10: 427-428. |
| Researcher : O WS |
| Project Title: | The ampullary gland, ventral prostate and embryogenesis |
| Investigator(s): | Dr. O W.S. , Dr. Cheong P.P.H. |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | July 1996 |
| Abstract: |
| To use a hamster model to investigate the effect of ampullary gland and ventral prostate gland secretions on fertilization and early embryogenesis. |
| Project Title: | Assessment of testicular, epididymal and ejaculated human sperm after intraceptoplasmic sperm injection into hamster oocytes |
| Investigator(s): | Dr. O W.S. , Dr. Cheng L.Y.L., Dr. Yeung W.S.B. |
| Source(s) of Funding: | Faculty Development Fund for Faculty of Medicine |
| Start Date: | November 1998 |
| Abstract: |
| To determine the function of testicular, epididymal and ejaculated sperm to activate oocytes after ICSI; to compare the genomic integrity of sperms. |
| Project Title: | Effect of male accessory sex gland secretions on the oxidative stress, functional competence and genomic integrity of hamster spermatozoa |
| Investigator(s): | Dr. O W.S. , Dr. Cheong P.P.H. |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | July 1999 |
| Completion Date: | June 2001 |
| Abstract: |
| To investigate: 1) the relationship of ASG secretion on the oxidative stress on the sperm; 2) the correlation of ROS with the fertilizing ability of the sperm with/without exposure to ASG; 3) analyse the genomic integrity of sperm before and after fertilization with an ovum. |
| Project Title: | Galactosemia and folliculogenesis - molecular mechanism of ovarian failure |
| Investigator(s): | Dr. O W.S. |
| Source(s) of Funding: | RGC Fundable Projects (Block Grant Funded) |
| Start Date: | February 2000 |
| Completion Date: | February 2001 |
| Abstract: |
| To focus on the molecular mechanisms leading to ovarian failure especially on how the genes that regulate apoptosis and inhibitors of apoptosis proteins are expressed. |
| Project Title: | Effects of male accessory sex gland secretions on the oxidative stress, functional competence and genomic integrity of hamster spermatozoa |
| Investigator(s): | Dr. O W.S. , Dr. Chow P.H. |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | September 2000 |
| Abstract: |
| To test the hypothesis that defects in oocyte activation is the consequence of damage to sperm which are not exposed to accessory sex glands (ASG) secretions at the time of mating. Results of this study will give insight into the mechanism of functioning of male ASG, and hence the treatment of human infertility and assisted conception procedures in cases associated with oxidative stress. |
| List of Research Outputs |
| Basir Ghazala S., Lam T.P.W., Chau M.T., Ng E.H.Y., O W.S., Ho P.C., Colour doppler anaylysis of peri-implantation utero-ovarian haemodynamics in women with excessive high oestradiol concentrations after ovarian stimulation, Human Reproduction. 2001, 16: 2114-2117. |
| Basir Ghazala S., Lam T.P.W., O W.S., Ho P.C., Haemodynamic evaluation of tubal and male factors of infertility in natural and ovarian stimulation cycles, Journal of Assisted Reproduction and Genetics. 2001, 18: 125-128. |
| Basir Ghazala S., O W.S., Ng E.H.Y., Ho P.C., Morphometric analysis of peri-implantation endometrium in patients having excessively high oestradiol concentrations after ovarian stimulation, Human Reproduction. 2001, 16(3): 435-440. |
| Chan O.C., Chow P.H., O W.S., total ablation of paternal accessory sex glands curtails developmental potential in preimplantation embryos in the golden hamster, Anatomy and Embryology. 2001, 204: 117-122. |
| Chen H., Cheung M.P.L., Chow P.H., O W.S., The study of relationship between male accessory sex gland secretions and sperm DNA damage in the golden hamster, Biology of Reproduction. 2000, 62 Suppl.1: No.121. |
| Jiang H.Y., O W.S., Lee K.H., Tang P.L., Chow P.H., Ablation of paternal accessory sex glands is detrimental to embryo development during implantation, Anatomy and Embryology. 2001, 203: 255-263. |
| Jiang H.Y., Lee K.H., Schneider C., O W.S., Tang P.L., Chow P.H., The growth arrest specific gene (gas6) protein is expressed in abnormal embryos sired by male golden hamsters with accessory sex glands removed, Anatomy and Embryology. 2001, 203: 343-355. |
| Lai K.W., Cheng L.Y.L., Tsang B.K., O W.S., Galactosemia and rat granulosa cell apoptosis, Biology of Reproduction. 2000, 62 Suppl.1: No.287. |
| O W.S., Wang Y.F., Tsang B.K., Is x-linked inhibitor of apoptosis protein (Xiap) a determinant of ovarian failure in galactosemic rats, Biology of Reproduction. 2000, 62 Suppl.1: No.286. |
| Researcher : Ouyang X |
| List of Research Outputs |
| Ouyang X., Wang X., Lee D.T.W., Tsao G.S.W., Wong Y.C., Up-regulation of TRPM-2, MMP-7 and ID-1 during sex hormone-induced prostate carcinogenesis in the Noble rat, Carcinogenesis. 2001, 22 No. 6: 965-973. |
| Researcher : Si H |
| List of Research Outputs |
| Si H., Tsao G.S.W., Lam A.K.Y., Srivastava G., Liu Y., Wong Y.C., Shen Z.Y., Cheung A., E-cadherin expression is commonly downregulated by CpG island hypemethylation in esophageal carcinoma cells, Cancers Letters. 2001, 173: 71-78. |
| Si H., Liu Y., Tsao G.S.W., Cheung A., Hypermethylation of the e-cadherin promotor region in esophageal carcinoma, 7th Hong Kong International Cancer Congress, December 7-9, 2000. 12.1. |
| Researcher : So KF |
| Project Title: | Effect of ciliary neurotrophic factor on enhancing axonal regeneration across the crush site of the optic nerve |
| Investigator(s): | Prof. So K.F. , Dr. Yip H.K.F. |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | July 1999 |
| Completion Date: | June 2001 |
| Abstract: |
| To examine if administration of ciliary neurotrophic factor (CNTF) into the vitreous of the eye can enhance regeneration of retinal axons in the optic nerve following a crush injury. |
| Project Title: | Neuroprotection in a rat experimental glaucoma model |
| Investigator(s): | Prof. So K.F. |
| Source(s) of Funding: | RGC Fundable Projects (Block Grant Funded) |
| Start Date: | November 2000 |
| Abstract: |
| To develop an animal model of glaucoma with increased intraocular pressure by blocking the outflow of the aqueous humor with laser photocoagulation of the episcleral and limbal veins. |
| List of Research Outputs |
| Chan V.W.Y., Yip H.K.F., So K.F., Wu W., Neuroprotective effects of extracts from american ginsengs, ginkgo biloba and St. John's wort on striatal dopaminergic neruons against 1-methyl-4-phenyl-1,2,4,6-tetrahydropyridine-induced toxicity, Society for Neuroscience Abstracts. 2000, 26: P1877. |
| Chan Y.M., Wu W., Yip H.K.F., So K.F., Oppenheim R.W., Caspase inhibitors rescue spinal motoneurons after root avulsion in neonatal rats, Society for Neuroscience Abstracts. 2000, 26: P.326. |
| Chau C.H., Shum D.K.Y., So K.F., Chan Y.S., Effects of chondroitin sulfate supplements on regeneration of bridged sciatic nerves, Society for Neuroscience Abstracts. 2000, 26: P. 2126. |
| Cheung Z.H.Y., So K.F., Yip H.K.F., Wu W., Mixture of American ginseng extract, ginkgo biloba extract and St. John's wort extract enhances the survival of axotomized retinal ganglion cells, Society for Neuroscience Abstracts. 2000, 26: P. 331. |
| Ji J.Z., So K.F., Yip H.K.F., Lee V.W.H., Ciliary neurotrophic factor prevents the death of retinal ganglion cells in a rat glaucoma model, Society for Neuroscience Abstracts. 2000, 26: P.329. |
| Schneider G.E., You S.W., So K.F., Carter D.A., Khan F., Ellis-Behnke R., Okobi A., Visual function due to regeneration of optic nerve or optic tract through peripheral nerve homografts, Society for Neuroscience Abstracts. 2000, 26: P. 611. |
| So K.F., Cheung Z.H.Y., Yip H.K.F., Wu W., Regeneration of axotomized retinal ganglion cells is promoted by a mixture of american ginseng extract, ginkgo biloba extract and St. John's wort extract, Society for Neuroscience Abstracts. 2000, 26: P.2128. |
| So K.F., Regeneration of the optic nerve, In: W. Q. Cai and Li, H.B., Developmental Neurobiology. Beijing, China, Chinese Scientific Press, 2000, 284-296. |
| So K.F., Yip H.K.F., The use of peripheral nerve transplants to enhance axonal regeneration in CNS neurons, In: N. A. Ingoglia and M. Murray, Axonal Regeneration in the Central Nervous System. 2001, 20: 505-528. |
| Yick L.W., Wu W., So K.F., Yip H.K.F., Shum D.K.Y., Chondroitinase ABC promotes axonal regeneration of Clarke's neurons after spinal cord injury, NeuroReport. 2000, 11 No.5: 1063-1067. |
| You S.W., So K.F., Yip H.K.F., Effect of distance of axotomy on axonal regeneration of retinal ganglion cells into a normal or pre-degenerated peripheral nerve graft in adult hamsters, Acta Anatomica Sinica. 2001, 23 No. 1: 26-29. |
| You S.W., So K.F., Yip H.K.F., Ju G., Nitric oxide and nitric oxide synthase in traumatic nerve injury, Chinese Journal of Neuroscience. 2000, 16: 166-169. |
| Researcher : Suen KC |
| List of Research Outputs |
| Chang R.C.C., Suen K.C., Ma E.C.H., Hugon J., Expression of phosphorylated eukaryotic initiation factor 2 alpha in neuronal apoptosis b-amyloid toxicity, Society of Neuroscience. 2001, 27: No.772.12. |
| Suen K.C., Chang R.C.C., Ma E.C.H., Elyaman W., Hugon J., Calcium could mediate the hyperphosphorylation of eukaryotic initiation factor 2 alpha in neurons induced by b amyloid peptide 25-35, Society of Neuroscience. 2001, 27: No.428.9. |
| Researcher : Tipoe GL |
| Project Title: | Surgical reconstruction of intraoral defects using an in vitro autologous human compound muscosal graft |
| Investigator(s): | Dr. Tipoe G.L. , Prof. Cheung L.K. |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | July 1998 |
| Completion Date: | November 2000 |
| Abstract: |
| To use such cell culture techniques to amplify cell populations from oral muscosal biopsies for the production of human living oral mucosal equivalents consisting both connective tissue and epithelial components which will be used to replace the conventional split thickness skin in standard oral surgical procedures such as oncological reconstructive surgery, reconstruction of dental implants and pre-prosthetic surgery. |
| Project Title: | Green tea polyphenols down-regulate inducible nitric oxide synthase production in chemical induced hepatoxicity in vivo |
| Investigator(s): | Dr. Tipoe G.L. , Dr. Cheung A.L.M., Prof. Fung P.C.W. |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | July 1999 |
| Abstract: |
| To document the extent of morphological alterations induced by CCL4 toxicity and the protective effect of GTPs in mouse liver; to quantify the expression of iNOS protein in the control and the different experimental groups; to determine the expression of co-factor (Nuclear Factor alpha-beta) and mRNA iNOS; to clarify the role of nitric oxide in CCL4 liver injury and the action of GTPs in protecting the liver against CCL4 toxicity. |
| Project Title: | Green tea polyphenols modulate the effects of chemical-induced hepatoxicity in vivo |
| Investigator(s): | Dr. Tipoe G.L. , Prof. Fung P.C.W., Dr. Leung F.C.C. |
| Source(s) of Funding: | RGC Fundable Projects (Block Grant Funded) |
| Start Date: | February 2000 |
| Completion Date: | February 2001 |
| Abstract: |
| To determine whether GTPs antioxidant property could prevent liver cell damage in mice against carbon tetrachloride [CCL4] induced toxicity; to investigate whether GTPs act via transcriptional factors (Nuclear Factor alpha-beta and Activator Protein-1) , thereby regulating inducible nitric oxide (iNOS), inducible cyclooxygenase (COX 2) and endothelin-1 (ET-1) genes that eventually modulate nitric oxide production. |
| Project Title: | Nitric oxide expression in stable bronchiectasis |
| Investigator(s): | Dr. Tipoe G.L. , Prof. Lam W.K., Dr. Tsang K.W.T. |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | February 2001 |
| Abstract: |
| To evaluate the expression of inducible iNOS, eNOS and COX-2 proteins and mRNAs in the bronchial biopsies of control and bronchiectasis subjects; to evaluate the effects of pyocyannin on the expression of iNOS, eNOS and COX-2 proteins in human respiratory epithelium in vitro; to determine the expression of transcriptional nuclear factor kappa beta in bronchial biopsies obtained from control and bronchiectasis subjects as well as in nasal cells i n vitro; to correlate the expressions of iNOS, eNOS, COX-2 and NFk?]in bronchial biopsies withthe clinical parameters that include 24hour psutum volume, number of bronchiectatic lobes, lung function indices and exacerbation frequency. |
| List of Research Outputs |
| Ho J.C., Chan K.N., Hu W.H., Lam W.K., Zheng L., Tipoe G.L., Sun J., Leung R., Tsang K.W.T., The effect of aging on nasal mucociliary clearance, beat frequency, and ultrastructure of respiratory cilia, American Journal of Respiratory and Critical Care Medicine. 2001, 163: 983-988. |
| Ho J.C., Chan K.N., Hu W.H., Lam W.K., Zheng L., Tipoe G.L., Sun J., Leung Y.H., Tsang K.W.T., The effect of aging on nasal mucocilliary clearance, beat frequency, and ultrastructure of respiratory cilia, American Journal of Respiratory and Critical Care Medicine. 2001, 163 (3): 983-988. |
| Ho J.C.M., Lam W.K., Hu W., Leung R., Sun J.Z., Tipoe G.L., Zheng I., Chu L.W., Tsang K.W.T., The effects of aging on respiratory ciliary function and electron microscopic abnormalities, American Journal of Respiratory and Critical Care Medicine. 2000, 161: A123. |
| Jin Y., Lu H.B., Li Y., Tipoe G.L., Analysis of the expression of BMP-2,3,4,5 and in nerve sheath tumors of maxillofacial region, West China Journal of Stomatology. 2000, 18: 307-309. |
| Jin Y., Tipoe G.L., Lau T.Y.H., Expression of BMP-2/4, -5 and BMPR-1A receptor in normal, benign and malignant lesions of oral epithelium, Chinese Journal of Histochemistry and Cytochemistry. 2001, 10: 21-26. |
| Jin Y., Tipoe G.L., Liong E.C., Lau T.H.Y., Fung P.C.W., Leung K.M., Overexpression of BMP-2/4,-5 and BMPPR-IA associated with oral epithelium, European Journal of Cancer, Oral Oncology. 2001, 37: 225-233. |
| Jin Y., Tipoe G.L., Liong E.C., Lau T.Y.H., Fung P.C.W., Overexpression of BMP-2/4,-5 and BMPR-IA was Associated with Malignancy of Oral Epithelia, Oral Oncology. 2000, 37: 225-233. |
| Jin Y., Lu H.B., Liong E., Lau T.Y.H., Tipoe G.L., Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors, Histology and Histopathology. 2001, 16: 1013-1019. |
| Ma Y., Jin Y., Sun Q.M., Li Y., Tipoe G.L., Quantitative analysis of expession of cyclin D1 and CDK4 in normal, inflammatory and malignant epithelia of cheek mucosa, Journal of Fourth Military Medical University. 2001, 22: 262-264. |
| Nie X., Jin Y., Zhang H., Tipoe G.L., Expression of small GTP binding protein in TC10 in facial nucleus following injury, Journal of Practical Stomatology. 2001, 17: 175-178. |
| Nie X., Jin Y., Tipoe G.L., Upregulation of CNTFR in facial motor neurons following facial nerve regeneration in rat and the regulated role of TGF-!b, BMP-2, Journal of Comprehensive Stomatology. 2001, 17: 170-172. |
| Tsang K.W.T., Shum H.Y.I., Ho J.C.M., Leung Y.H., Taylor G., Zheng L., Tipoe G.L., Chan L.Y., Fung P.C.W., Lam W.K., Downregulation of endothelin (ET)-1 and interleukin (IL)-8 expression in human respiratory mucosa by Pseudomonas aeruginosa pyocyanin and 1-hydroxy-phenazine, Hong Kong Practitioner. 2001, 23 Suppl 2: 67. |
| Tsang K.W.T., Ip S.K., Leung Y.H., Tipoe G.L., Chan L.Y., Shum H.Y.I., Zheng L., Yan C.P.K., Fung P.C.W., Lam W.K., Exhaled NO: effects of age, gender and body size, American Journal of Respiratory and Critical Care Medicine. 2001, 163 (5): A50. |
| Tsang K.W.T., Ip M.S.M., Fung P.C.W., Zheng L., Shum H.Y.I., Leung Y.H., Chan L.Y., Tipoe G.L., Ooi C.G.C., Ho J.C.M., Lam W.K., Pseudomonas aeruginosa infection is associated with reduced exhaled NO in bronchiectasis, American Journal of Respiratory and Critical Care Medicine. 2001, 163 (5): A671. |
| Tsang K.W.T., Ip S.K., Fung P.C.W., Ooi C.G.C., Shum H.Y.I., Leung Y.H., Chan L.Y., Tipoe G.L., Zheng L., Ip M.S.M., Ho J.C.M., Chan M.M.W., Lam W.K., Pseudomonas aeruginosa infection is associated with reduced exhaled NO in bronchiectasis, Hong Kong Practitioner. 2001, 23 Suppl 2: 30. |
| Tsang K.W.T., Leung Y.H., Taylor G., Tipoe G.L., Chan L.Y., Shum H.Y.I., Fung P.C.W., Lam W.K., Pseudomonas aeruginosa pyocyanin and 1-hydroxyphenazine downregulate endothelin-1 and interleukin-8 expression in human respiratory mucosa, American Journal of Respiratory and Critical Care Medicine. 2001, 163 (5): A671. |
| Tsang K.W.T., Ip S.K., Leung Y.H., Tipoe G.L., Chan L.Y., Shum H.Y.I., Zheng L., Yan C.P.K., Fung P.C.W., Lam W.K., The effects of gender on exhaled NO production among volunteers, Hong Kong Practitioner. 2001, 23 Suppl 2: 28. |
| Yu C.M., Tipoe G.L., Lai K.W.H., Lau C.P., The effect of combination of angiotensin-converting enzyme inhibitor and angiotensin receptor antagonist on inflammatory cellular infiltration and myocardial interstitial fibrosis after acute myocardial infarction, Journal of American College of Cardiology. 2001, 38(4): 1207-1215. |
| Zheng L., Tipoe G.L., Lam W.K., Ho J.C.M., Shum H.Y.I., Ooi G.C., Leung Y.H., Tsang K.W.T., Endothelin-1 in stable bronchiectasis, European Respiratory Journal. 2000, 16: 146-149. |
| Zheng L., Shum H., Tipoe G.L., Leung R., Lam W.K., Ooi C.G.C., Tsang K.W., Macrophages, neutrophils and tumor necrosis factor-alpha expression in bronchiectatic airways in vivo, Respiratory Medicine. 2001, 95: 792-798. |
| Zheng L., Lam W.K., Shum H.Y.I., Tipoe G.L., Yan C., Ip M.S.M., Tsang K.W.T., Overexpression of metalloproteinase-8 and -9 in bronchiectatic airways in vivo, The Hong Kong Practitioner. 2001, 2: 64. |
| Zheng L., Tipoe G.L., Lam W.K., Leung Y.H., Ho J.C., Ooi G.C., Shum H.Y.I., Tsang K.W.T., Up-regulation of circulating adhesion molecules in bronchiectasis, European Respiratory Journal. 2000, 16: 691-696. |
| Researcher : Tsao GSW |
| Project Title: | Telomerase activation in nasopharyngeal carcinomas |
| Investigator(s): | Dr. Tsao G.S.W. , Dr. Nicholls J.M., Prof. Sham J.S.T., Prof. Wei W.I. |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | September 1997 |
| Abstract: |
| To evaluate the clinical significance of telomerase activation and its potential application as malignant marker for nasopharyngeal carcinoma (NPC). |
| Project Title: | Construction and characterization of suppression subtractive cDNA libraries from microdissected tissues of cancerous and non-cancerous nasopharyngeal epithelial tissues |
| Investigator(s): | Dr. Tsao G.S.W. , Dr. Yuen P.W. |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | July 1999 |
| Completion Date: | June 2001 |
| Abstract: |
| To microdissect cancerous and non-cancerous nasopharnygeal epithelial tissues using laser-captured microdissection techniques; to construct differential expressed cDNA libraries specific for cancerous and non-cancerous nasopharyngeal epithelial tissues by a PCR based subtractive hybridization method; to characterize the differentially expressed cDNA in nasopharyngeal carcinoma and non-cancerous nasopharyngeal tissues by direct sequencing of the differentially expressed cDNA clones in the subtractive hybridization libraries; to identify potential oncogenes and tumour suppressor genes involved in the pathogenesis of nasopharyngeal carcinoma. |
| Project Title: | Molecular basis of chromosomal aberrations in immortalized nasopharyngeal epithelial cells |
| Investigator(s): | Dr. Tsao G.S.W. , Dr. Jin D.Y. |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | November 2000 |
| Abstract: |
| To identify non-random chromosome aberrations in immortalized nasopharyngeal epithelial cells; to study the mitotic checkpoint regulation of nasopharyngeal epithelial cells before and after immortalization; to study the telomere dynamics and telomerase activation during immortalization of nasopharyngeal epithelial cells. |
| List of Research Outputs |
| Chow V.W.H., Yuen P.W., Lam K.Y., Tsao G.S.W., Ho W.K., Wei W.I., A comparative study of the clinicopathological significance of E-cadherin and catenins (a, b, g) expression in the surgical management of oral tongue carcinoma, Journal of Cancer Research and Clinical Oncology. 2001, 127: 59-63. |
| Fong P.Y., Tsao G.S.W., Cheung A.N.Y., Differential gene expression in gestational trophoblastic disease using cDNA array, 7th Hong Kong International Cancer Congress, Hong Kong, 7-9 December. 2000, 10.9. |
| Fong P.Y., Tsao G.S.W., Ngan H.Y.S., Chiu P.M., Cheung A.N.Y., Profiling of differentially expressed genes in persistent gestational trophoblastic disease by complementary DNA expression array, 5th International Symposium on the Impact of Cancer Biotechnology on Predictive Oncology and Therapy, Geneva, Switzerland, 28-31 October. 2000, 24(1): S-188(453 P113). |
| Fung L.F., Lo K.F., Yuen P.W., Liu Y., Wang X., Tsao G.S.W., Differential gene expression in nasopharyngeal carcinoma cells, Life Sciences. 2000, 67: 923-936. |
| Liu Y., Wang X., Cao L., Yang X.H., Wong Y.C., Chan C.K., Tsao G.S.W., Biological properties of latent membrane protein-1 (LMP-1) expression in nasopharyngeal epithelial cells, AACR 91st Ann Meeting. 2000, 41: 317-318. |
| Lo K.F., Yuen P.W., Liu Y., Wang X., Cheung A., Wong Y.C., Tsao G.S.W., Down regulation of hemidesmosomal proteins in nasopharyngeal carinoma cells, Cancer Letters. 2001, 163: 117-124. |
| Lo K.F., Liu Y., Wang X., Wong Y.C., Lee C.K.F., Huang D.P., Tsao G.S.W., Identification of downstream target genes of latent membrane protein 1 in nasopharyngeal carcinoma cells by suppression subtractive hybridization, Biochimica et Biophysica Acta. 2001, 1520: 131-140. |
| Ouyang X., Wang X., Lee D.T.W., Tsao G.S.W., Wong Y.C., Up-regulation of TRPM-2, MMP-7 and ID-1 during sex hormone-induced prostate carcinogenesis in the Noble rat, Carcinogenesis. 2001, 22 No. 6: 965-973. |
| Si H., Tsao G.S.W., Lam A.K.Y., Srivastava G., Liu Y., Wong Y.C., Shen Z.Y., Cheung A., E-cadherin expression is commonly downregulated by CpG island hypemethylation in esophageal carcinoma cells, Cancers Letters. 2001, 173: 71-78. |
| Si H., Liu Y., Tsao G.S.W., Cheung A., Hypermethylation of the e-cadherin promotor region in esophageal carcinoma, 7th Hong Kong International Cancer Congress, December 7-9, 2000. 12.1. |
| Tsao G.S.W., Wong N., Wang X., Liu Y., Wan T.S.K., Fung L.F., Lancaster W.D., Gregoire L., Wong Y.C., Nonrandom chromosomal imbalances in human ovarian surface epithelial cells immortalized by HPV16-E6E7 viral oncogenes, Cancer Genetics and Cytogenetics. 2001, 130: 141-149. |
| Wang X., Jin D., Wong Y.C., Cheung A., Chun C.S., Lo K.F., Liu Y., Tsao G.S.W., Correlation of defective mitotic checkpoint with aberrantly reduced expression of MAD2 protein in nasopharyngeal carcinoma cells, Carcinogenesis. 2001, 21 No.12: 2293-2297. |
| Wang X., Wang J., Wong S.C.H., Chow L.S.N., Nicholls J.M., Wong Y.C., Liu Y., Kwong D.L.W., Sham J.S.T., Tsao G.S.W., Cytotoxic effect of gossypol on colon carcinoma cells, Life Sciences. 2000, 67: 2663-2671. |
| Wang X., Masters J.R.W., Wong Y.C., Lo K.F., Tsao G.S.W., Mechanism of differential sensitivity to cisplatin in nasopharyngeal carcinoma cells, Anti-Cancer Research. 2001, 21: 403-408. |
| Wong Y.C., Xie W., Tsao G.S.W., Structural changes and alteration in expression of TGF-b1 and its receptors in prostatic intraepithelial neoplasia (PIN) in the ventral prostate of noble rats, The Prostate. 2000, 45: 289-298. |
| Xie B., Tsao G.S.W., Wong Y.C., Sex hormone-induced mammary carcinogenesis in the female Noble rats: expression of Bc1-2 and Bax in hormonal mammary carcinogenesis, Breast cancer Research and Treatment. 2000, 61: 45-57. |
| Xie W., Wong Y.C., Tsao G.S.W., Correlation of increased apoptosis and proliferation with development of prostatic intraepithelial neoplasis (PIN) in ventral prostate of the Noble rat, The Prostate. 2000, 44: 31-39. |
| Yang X.H., Sham J.S.T., Ng M.H., Tsao G.S.W., Zhang D.K., Lowe S.W., Cao L., LMP1 of Epstein-Barr virus induces the proliferation of mouse embryonic fibroblast cells and transforms MEF cells in cooperation with a p16 insensitive CDK4 mutant, Journal of Virology. USA, 2000, 74(2): 883-891. |
| Researcher : Wang X |
| List of Research Outputs |
| Fung L.F., Lo K.F., Yuen P.W., Liu Y., Wang X., Tsao G.S.W., Differential gene expression in nasopharyngeal carcinoma cells, Life Sciences. 2000, 67: 923-936. |
| Liu Y., Wang X., Cao L., Yang X.H., Wong Y.C., Chan C.K., Tsao G.S.W., Biological properties of latent membrane protein-1 (LMP-1) expression in nasopharyngeal epithelial cells, AACR 91st Ann Meeting. 2000, 41: 317-318. |
| Lo K.F., Yuen P.W., Liu Y., Wang X., Cheung A., Wong Y.C., Tsao G.S.W., Down regulation of hemidesmosomal proteins in nasopharyngeal carinoma cells, Cancer Letters. 2001, 163: 117-124. |
| Lo K.F., Liu Y., Wang X., Wong Y.C., Lee C.K.F., Huang D.P., Tsao G.S.W., Identification of downstream target genes of latent membrane protein 1 in nasopharyngeal carcinoma cells by suppression subtractive hybridization, Biochimica et Biophysica Acta. 2001, 1520: 131-140. |
| Ouyang X., Wang X., Lee D.T.W., Tsao G.S.W., Wong Y.C., Up-regulation of TRPM-2, MMP-7 and ID-1 during sex hormone-induced prostate carcinogenesis in the Noble rat, Carcinogenesis. 2001, 22 No. 6: 965-973. |
| Tsao G.S.W., Wong N., Wang X., Liu Y., Wan T.S.K., Fung L.F., Lancaster W.D., Gregoire L., Wong Y.C., Nonrandom chromosomal imbalances in human ovarian surface epithelial cells immortalized by HPV16-E6E7 viral oncogenes, Cancer Genetics and Cytogenetics. 2001, 130: 141-149. |
| Wang X., Jin D., Wong Y.C., Cheung A., Chun C.S., Lo K.F., Liu Y., Tsao G.S.W., Correlation of defective mitotic checkpoint with aberrantly reduced expression of MAD2 protein in nasopharyngeal carcinoma cells, Carcinogenesis. 2001, 21 No.12: 2293-2297. |
| Wang X., Wang J., Wong S.C.H., Chow L.S.N., Nicholls J.M., Wong Y.C., Liu Y., Kwong D.L.W., Sham J.S.T., Tsao G.S.W., Cytotoxic effect of gossypol on colon carcinoma cells, Life Sciences. 2000, 67: 2663-2671. |
| Wang X., Masters J.R.W., Wong Y.C., Lo K.F., Tsao G.S.W., Mechanism of differential sensitivity to cisplatin in nasopharyngeal carcinoma cells, Anti-Cancer Research. 2001, 21: 403-408. |
| Researcher : Wong YC |
| Project Title: | Role of IGF-1 and VEGF in sex hormone induced prostate carcinogenesis |
| Investigator(s): | Prof. Wong Y.C. , Dr. Cheung A.L.M., Dr. Sheng H.P. |
| Source(s) of Funding: | Medical Faculty Research Grant Fund |
| Start Date: | November 1998 |
| Abstract: |
| To further examine the role of IGF-1 system and to confirm by in situ hybridization (ISH) the existence of mRNA for IGF-1 and its receptors in dysplastic and carcinoma cells; to establish the expression pattern of VEGF and its receptors during initiation, and progression to carcinoma and to establish whether an autocrine loop exists in this rat prostate cancer by ISH. |
| Project Title: | Suicide gene therapy of sex hormone-induced mammary tumour in the Noble rat |
| Investigator(s): | Prof. Wong Y.C. |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | July 1999 |
| Abstract: |
| To investigate the suitability and efficacy of HSV1-TK/GCV suicide gene for mammary tumour therapy. |
| Project Title: | The role of stromal smooth muscle-epithelial interactions in sex hormone-induced prostate carcinogenesis |
| Investigator(s): | Prof. Wong Y.C. |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | September 1999 |
| Abstract: |
| To determine the changes of prostatic stromal SM cells in relation to altered epithelial phenotype during sex hormone-induced prostate carcinogenesis; to correlate the stromal SM cells de-differentiation and E-cadherin and beta-catenin system in prostatiic epithelial aberrations; to analyze the epithelial regulatory factors which control the differentiation of stromal SM cells using an in vitro system. |
| Project Title: | The role of androgens in breast carcinogenesis |
| Investigator(s): | Prof. Wong Y.C. , Dr. Ke Y.Q., Dr. Tsao G.S.W. |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | October 2000 |
| Abstract: |
| To establish the mechanism of androgen actions by examining several factors involved in the cross talk between the epithelium and stroma during the process of mammary carcinogenesis; to further refine and characterize these factors at protein and mRNA levels; to examine changes in expression patterns of several oncogenes and tumour suppressor genes as well as the role of apoptosis in hormonal carcinogenesis; and finally to examine the genes affected during the early process of hormonal carcinogenesis. |
| List of Research Outputs |
| Liu Y., Wang X., Cao L., Yang X.H., Wong Y.C., Chan C.K., Tsao G.S.W., Biological properties of latent membrane protein-1 (LMP-1) expression in nasopharyngeal epithelial cells, AACR 91st Ann Meeting. 2000, 41: 317-318. |
| Lo K.F., Yuen P.W., Liu Y., Wang X., Cheung A., Wong Y.C., Tsao G.S.W., Down regulation of hemidesmosomal proteins in nasopharyngeal carinoma cells, Cancer Letters. 2001, 163: 117-124. |
| Lo K.F., Liu Y., Wang X., Wong Y.C., Lee C.K.F., Huang D.P., Tsao G.S.W., Identification of downstream target genes of latent membrane protein 1 in nasopharyngeal carcinoma cells by suppression subtractive hybridization, Biochimica et Biophysica Acta. 2001, 1520: 131-140. |
| Man K., Lo C.M., Ng I.O.L., Wong Y.C., Qin L., Fan S.T., Wong J., Liver transplantation in rats using small-for-size grafts - a study of hemodynamic and morphological changes, Archives of Surgery. 2001, 136: 280-285. |
| Ouyang X., Wang X., Lee D.T.W., Tsao G.S.W., Wong Y.C., Up-regulation of TRPM-2, MMP-7 and ID-1 during sex hormone-induced prostate carcinogenesis in the Noble rat, Carcinogenesis. 2001, 22 No. 6: 965-973. |
| Si H., Tsao G.S.W., Lam A.K.Y., Srivastava G., Liu Y., Wong Y.C., Shen Z.Y., Cheung A., E-cadherin expression is commonly downregulated by CpG island hypemethylation in esophageal carcinoma cells, Cancers Letters. 2001, 173: 71-78. |
| Tam N.N.C., Chung S.S.M., Lee D.T.W., Wong Y.C., Aberrant expression of hepatocyte growth factor and its receptor, c-Met, during sex hormone-induced prostatic carcinogenesis in the Noble rat, Carcinogenesis. 2000, 21(12): 2183-2191. |
| Tsao G.S.W., Wong N., Wang X., Liu Y., Wan T.S.K., Fung L.F., Lancaster W.D., Gregoire L., Wong Y.C., Nonrandom chromosomal imbalances in human ovarian surface epithelial cells immortalized by HPV16-E6E7 viral oncogenes, Cancer Genetics and Cytogenetics. 2001, 130: 141-149. |
| Wang X., Jin D., Wong Y.C., Cheung A., Chun C.S., Lo K.F., Liu Y., Tsao G.S.W., Correlation of defective mitotic checkpoint with aberrantly reduced expression of MAD2 protein in nasopharyngeal carcinoma cells, Carcinogenesis. 2001, 21 No.12: 2293-2297. |
| Wang X., Wang J., Wong S.C.H., Chow L.S.N., Nicholls J.M., Wong Y.C., Liu Y., Kwong D.L.W., Sham J.S.T., Tsao G.S.W., Cytotoxic effect of gossypol on colon carcinoma cells, Life Sciences. 2000, 67: 2663-2671. |
| Wang X., Masters J.R.W., Wong Y.C., Lo K.F., Tsao G.S.W., Mechanism of differential sensitivity to cisplatin in nasopharyngeal carcinoma cells, Anti-Cancer Research. 2001, 21: 403-408. |
| Wong Y.C., Tam N.N.C., Changes in expression of hepatocyte growth factor and its receptor, c-met, in sex hormone-induced prostate carcinogenesis in the Noble rat, Chinese Journal Histochem Cytochem. 2000, 9 Suppl.: 9-10. |
| Wong Y.C., Wang Y.Z., Lee J.S.K., Tam N.N.C., Lee D.T.W., Changes in serum and tissue zinc levels in sex hormone-induced prostatic carcinogenesis in the noble rat, Tumor Biology. 2000, 21: 328-336. |
| Wong Y.C., Wang Y.Z., Growth factors and epithelial-stromal interactions in prostate cancer development, International Review of Cytology. 2000, 199: 65-116. |
| Wong Y.C., Xie W., Tsao G.S.W., Structural changes and alteration in expression of TGF-b1 and its receptors in prostatic intraepithelial neoplasia (PIN) in the ventral prostate of noble rats, The Prostate. 2000, 45: 289-298. |
| Wong Y.C., Xie B., The role of androgens in breast carcinogenesis, Acta Anatomica Sinica. 2000, 31 Suppl.: 1-4. |
| Xie B., Tsao G.S.W., Wong Y.C., Sex hormone-induced mammary carcinogenesis in the female Noble rats: expression of Bc1-2 and Bax in hormonal mammary carcinogenesis, Breast cancer Research and Treatment. 2000, 61: 45-57. |
| Xie W., Wong Y.C., Tsao G.S.W., Correlation of increased apoptosis and proliferation with development of prostatic intraepithelial neoplasis (PIN) in ventral prostate of the Noble rat, The Prostate. 2000, 44: 31-39. |
| Researcher : Wu W |
| Project Title: | Degeneration of motor neuron in adult rat spinal cord: mechanism and prevention |
| Investigator(s): | Dr. Wu W.T. |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | January 1998 |
| Abstract: |
| To find a cure for paralysis associated with spinal cord injury and other adult onset neuronal degenerative diseases. |
| Project Title: | Effect of delayed transplantation of a peripheral nerve (PN) graft on motoneuron survival and regeneration after spinal root avulsion |
| Investigator(s): | Dr. Wu W.T. |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | July 1998 |
| Abstract: |
| To hypothesize whether a delayed implantation of PN graft can prevent the dealth of motoneurons and enhance their regeneration. The study will also determine the best post-injury time for PN graft transplantation. |
| Project Title: | Effect of delayed transplantation of a peripheral nerve (PN) graft on motoneuron survival and regeneration after spinal root avulsion |
| Investigator(s): | Dr. Wu W.T. |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | July 1998 |
| Abstract: |
| To hypothesize whether a delayed implantation of PN graft can prevent the dealth of motoneurons and enhance their regeneration. The study will also determine the best post-injury time for PN graft transplantation. |
| Project Title: | Long-term effects of a single dose of brain-derived neurotrophic factor (BDNF) on motoneuron survival following spinal root avulsion in the adult rat |
| Investigator(s): | Dr. Wu W.T. |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | July 1999 |
| Abstract: |
| To investigate whether treatment with a single dose of brain-derived neurotrophic factor (BDNF) could prevent motoneuron degeneration after spinal root avulsion in adult rat. |
| Project Title: | Re-implantation of ventral root following spinal root avulsion - a new microsurgical technique for regeneration of injured motoneurons |
| Investigator(s): | Dr. Wu W.T. |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | December 1999 |
| Abstract: |
| To investigate whether spinal montoneurons could survive and regenerate if the ventral root is re-implanted into the spinal cord after root avulsion and to determine how many injured motoneurons could regenerate through the re-implanted ventral root and reach the target muscles. |
| List of Research Outputs |
| Chan V.W.Y., Yip H.K.F., So K.F., Wu W., Neuroprotective effects of extracts from american ginsengs, ginkgo biloba and St. John's wort on striatal dopaminergic neruons against 1-methyl-4-phenyl-1,2,4,6-tetrahydropyridine-induced toxicity, Society for Neuroscience Abstracts. 2000, 26: P1877. |
| Chan Y.M., Wu W., Yip H.K.F., So K.F., Oppenheim R.W., Caspase inhibitors rescue spinal motoneurons after root avulsion in neonatal rats, Society for Neuroscience Abstracts. 2000, 26: P.326. |
| Cheung Z.H.Y., So K.F., Yip H.K.F., Wu W., Mixture of American ginseng extract, ginkgo biloba extract and St. John's wort extract enhances the survival of axotomized retinal ganglion cells, Society for Neuroscience Abstracts. 2000, 26: P. 331. |
| So K.F., Cheung Z.H.Y., Yip H.K.F., Wu W., Regeneration of axotomized retinal ganglion cells is promoted by a mixture of american ginseng extract, ginkgo biloba extract and St. John's wort extract, Society for Neuroscience Abstracts. 2000, 26: P.2128. |
| Yick L.W., Wu W., So K.F., Yip H.K.F., Shum D.K.Y., Chondroitinase ABC promotes axonal regeneration of Clarke's neurons after spinal cord injury, NeuroReport. 2000, 11 No.5: 1063-1067. |
| Researcher : Yamashita N |
| List of Research Outputs |
| Dominy N.J., Lucas P.W., Osorio D., Yamashita N., The sensory ecology of primate food perception, Evol. Anthrop.. 2001, 10: 176-186. |
| Lucas P.W., Dominy N.J., Yamashita N., Essackjee H.C., Osorio D., Darvell B.W., A physiochemical field kit for ecological studies, 3rd International Symposium-Workshop on Frugivores and Seed Dispersal, August 6-11, 2000, Hotel Fazenda Fonte Colina Verde, Sao Pedro, SP - Brazil. 2000, 208. |
| Lucas P.W., Darvell B.W., Lee K.D., Yamashita N., Yuen D.B., A portable mechanical field tester for ecological studies, Plant Biomechanics 2000. Proceedings of the 3rd Plant Biomechanics Conference Freiburg-Badenweiler, August 27th to September 2. 2000, 541-545. |
| Lucas P.W., Beta T., Darvell B.W., Dominy N.J., Essackjee H.C., Lee P.K.D., Osorio D., Ramsden L., Yamashita N., Yuen T.D.B., Field kit to characterize physical, chemical and spatial aspects of potential foods of primates, Folia Primatol. 2001, 72: 11-15. |
| Lucas P.W., Beta T., Darvell B.W., Dominy N.J., Essackjee H.C., Osorio D., Ramsden L., Yamashita N., Measuring the physicochemical properties of the foods of primates in the field, The XVIIIth Congress of the International Primatological Society, January 7-12, 2001. 53. |
| Lucas P.W., Turner I.M., Dominy N.J., Yamashita N., Mechanical defences to herbivory, Annals of Botany. 2000, 86: 913-920. |
| Yamashita N., Blanchard M., Sequeira G., A comparative study of physico-chemical food properties and colour in two lemur species, The XVIIIth Congress of the International Primatological Society, January 7-12, 2001. 44. |
| Yamashita N., Mechanical thresholds as a criterion for food selection in two prosimian primate species, Plant Biomechanics 2000. Proceedings of the 3rd Plant Biomechanics Conference Freiburg-Badenweiler, August 27th to September 2nd, 2000. 2000, 590-595. |
| Researcher : Yick LW |
| List of Research Outputs |
| Yick L.W., Wu W., So K.F., Yip H.K.F., Shum D.K.Y., Chondroitinase ABC promotes axonal regeneration of Clarke's neurons after spinal cord injury, NeuroReport. 2000, 11 No.5: 1063-1067. |
| Researcher : Yip HKF |
| Project Title: | Expression of cell adhesion molecules in the retinal and optic nerve of the adult mouse following axonal injury and intravitreal transplantation of a peripheral nerve graft |
| Investigator(s): | Dr. Yip H.K.F. , Dr. Schachner M., Prof. So K.F. |
| Source(s) of Funding: | Germany/Hong Kong Joint Research Scheme |
| Start Date: | January 1997 |
| Abstract: |
| To elucidate the effect of intravitreal transplantation of a peripheral nerve (PN) graft on the expression of specific cell adhesion molecules in the retina and optic nerve of the adult mouse and their roles in the axonal regrowth of axotomized retinal ganglion cells will also be assessed. |
| Project Title: | Study of cell adhesion molecules in mediating regeneration of retinal ganglion cell axons severed in the optic nerve of the adult mouse with an intravitreal peripheral nerve graft |
| Investigator(s): | Dr. Yip H.K.F. , Prof. Schachner M., Prof. So K.F. |
| Source(s) of Funding: | Germany/Hong Kong Joint Research Scheme |
| Start Date: | September 1998 |
| Abstract: |
| 1. To study the temporal and spatial expression of cell adhesion molecules (N-CAM, L1, CHL1, tenascin-C, and tenascin-R) in the retina and the lesioned adult mouse optic nerve following intravitreal transplant of a peripheral nerve graft or dissociated Schwann cells. The role of these cell adhesion molecules in the axonal regrowth of axotomized retinal ganglion cells will also be examined. Thus we will analyze the localization of the messenger RNAs (mRNAs) of these molecules in the adult retina and optic nerve by in situ hybridization, and the localization of the cell adhesion proteins in the crushed adult mouse optic nerve by ligh and electron microscopic immunocytochemistry. 2. To study whether the regulation of cell adhesion molecule expression can be attributed to an identified neurotrophic factor, known to be released by the PN grafts. The effects of intraocular administration of neurotrophins (NGF, NT-3, NT-4/5, and BDNF) and/or other neurotrophic factors (FGF-2, TGF-b and CNTF) on the expression of these cell adhesion molecules will be examined. |
| Project Title: | Study of cell adhesion molecules in mediating regeneration of retinal ganglion cell axons severed in the optic nerve of the adult mouse with an intravitreal peripheral nerve graft |
| Investigator(s): | Dr. Yip H.K.F. , Prof. Schachner M., Prof. So K.F. |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | September 1998 |
| Abstract: |
| 1. To study the temporal and spatial expression of cell adhesion molecules (N-CAM, L1, CHL1, tenascin-C, and tenascin-R) in the retina and the lesioned adult mouse optic nerve following intravitreal transplant of a peripheral nerve graft or dissociated Schwann cells. The role of these cell adhesion molecules in the axonal regrowth of axotomized retinal ganglion cells will also be examined. Thus we will analyze the localization of the messenger RNAs (mRNAs) of these molecules in the adult retina and optic nerve by in situ hybridization, and the localization of the cell adhesion proteins in the crushed adult mouse optic nerve by ligh and electron microscopic immunocytochemistry. 2. To study whether the regulation of cell adhesion molecule expression can be attributed to an identified neurotrophic factor, known to be released by the PN grafts. The effects of intraocular administration of neurotrophins (NGF, NT-3, NT-4/5, and BDNF) and/or other neurotrophic factors (FGF-2, TGF-b and CNTF) on the expression of these cell adhesion molecules will be examined. |
| Project Title: | The use of estrogen in MPTP-induced parkinsonism animal model |
| Investigator(s): | Dr. Yip H.K.F. , Dr. Feng Z.H., Dr. Ho S.L. |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | July 1999 |
| Abstract: |
| To study potential neuroprotective effects of estrogen in retired breeder C57/B1 mice following MPTP exposure, which can induce apoptosis (programmed cell death) in this model for testing neurotoxins in PD; to explore whether estrogen can prevent apoptosis, and the extent and mechanism by which it confers neuroprotection, and whether the estrogenic effects on COMT gene and protein expression can contribute to this neuroprotection. |
| List of Research Outputs |
| Chan V.W.Y., Yip H.K.F., So K.F., Wu W., Neuroprotective effects of extracts from american ginsengs, ginkgo biloba and St. John's wort on striatal dopaminergic neruons against 1-methyl-4-phenyl-1,2,4,6-tetrahydropyridine-induced toxicity, Society for Neuroscience Abstracts. 2000, 26: P1877. |
| Chan Y.M., Wu W., Yip H.K.F., So K.F., Oppenheim R.W., Caspase inhibitors rescue spinal motoneurons after root avulsion in neonatal rats, Society for Neuroscience Abstracts. 2000, 26: P.326. |
| Cheung Z.H.Y., So K.F., Yip H.K.F., Wu W., Mixture of American ginseng extract, ginkgo biloba extract and St. John's wort extract enhances the survival of axotomized retinal ganglion cells, Society for Neuroscience Abstracts. 2000, 26: P. 331. |
| Ji J.Z., So K.F., Yip H.K.F., Lee V.W.H., Ciliary neurotrophic factor prevents the death of retinal ganglion cells in a rat glaucoma model, Society for Neuroscience Abstracts. 2000, 26: P.329. |
| Pang P.K.T., Shan J.J., Yip H.K.F., Chen C.F., Watanabe H., Natural medicine development: problems and solutions, Proceedings of the International Symposium of the Medicinal Resources Research Center, Wonkwang University, August 17, 2000. |
| So K.F., Cheung Z.H.Y., Yip H.K.F., Wu W., Regeneration of axotomized retinal ganglion cells is promoted by a mixture of american ginseng extract, ginkgo biloba extract and St. John's wort extract, Society for Neuroscience Abstracts. 2000, 26: P.2128. |
| So K.F., Yip H.K.F., The use of peripheral nerve transplants to enhance axonal regeneration in CNS neurons, In: N. A. Ingoglia and M. Murray, Axonal Regeneration in the Central Nervous System. 2001, 20: 505-528. |
| Yick L.W., Wu W., So K.F., Yip H.K.F., Shum D.K.Y., Chondroitinase ABC promotes axonal regeneration of Clarke's neurons after spinal cord injury, NeuroReport. 2000, 11 No.5: 1063-1067. |
| You S.W., So K.F., Yip H.K.F., Effect of distance of axotomy on axonal regeneration of retinal ganglion cells into a normal or pre-degenerated peripheral nerve graft in adult hamsters, Acta Anatomica Sinica. 2001, 23 No. 1: 26-29. |
| You S.W., So K.F., Yip H.K.F., Ju G., Nitric oxide and nitric oxide synthase in traumatic nerve injury, Chinese Journal of Neuroscience. 2000, 16: 166-169. |
| Ph.D. thesis - | The Effects of CNTF and BDNF on c-Jun Expression, Survival and Regeneration of Axotomized Retinal Ganglion Cells in Adult Golden Hamsters |
Research postgraduate student: TAM Ngai Chung, Neville
| Ph.D. thesis - | Cellular Mechanisms of Hormonal Carcinogenesis in the Prostate Gland of the Noble Rat |
Research postgraduate student: XIE Wen
| Ph.D. thesis - | Morphological and Functional Studies of the Ventral Prostate During the Development of Prostatic Intraepithelial Neoplasia in the Noble Rats |
Research postgraduate student: LAM Wai Yuan, Leon
| MPhil. thesis - | Neuroprotection of Low Energy Laser on Retinal Ganglion Cells Survival after Optic Nerve Injury |
Research postgraduate student: LAU Yue Huen
| MPhil. thesis - | Ultrastructural and Stereological Investigation of the Effects of Hexamethylene Bisacetamide on Human Colon Carcinoma LoVo Cells In Vitro |
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