Department of Medicine

Researcher : Au CL

List of Research Outputs

Lam B., Ip M.S.M., Sam K., Au C.L., Tsang K.W.T., Lam W.K., Cooke M.S., One year efficacy of oral appliance in treating sleep apnoea has no correlation with the change in cross section of the upper airway, 6th World Congress on Sleep Apnoea, Sydney, Australia. 2000, 93: 119.

Researcher : Au WY

List of Research Outputs

Au W.Y., Horsman D.E., Viswanatha D.S., Klasa R.J., Connors J.M., Gascoyne R.D., 8q24 re-arrangements in blastic transformation of mantle cell lymphoma., Haematologica. 2000, 85: 1225-7.

Au W.Y., Chow W.S., Lam K.S.L., Cockram C.S., Ko T.C., Kwong Y.L., Acute leukemia in acromegalic patients, British Journal of Haematology. 2000, 110: 871-3.

Au W.Y., Ho C.M., Lie A.K.W., Sun J., Zheng L., Liang R.H.S., Lam W.K., Tsang K.W.T., Ciliary assessment in bone marrow transplantation patients., Bone Marrow Transplantation. 2001, 27: 1147-51.

Au W.Y., Jim M.H., Lam A.K.Y., Kwong Y.L., Digital gangrene and a mass in the heart., Archives of Internal Medicine. 2001, 161: 270-1.

Au W.Y., Lie A.K.W., Kwong Y.L., Lee C.K., Chim J.C.S., Leung A.Y.H., Liang R.H.S., Donor lymphocyte infusion (DLI) for leukemia relapse: the Queen Mary Hosptial Experience., The Hong Kong Society of Haematology Annual Open Scientific Meeting & The 4th Joint Shanghai-Hong Kong Haematology Meeting 2000.. 2000, 12.

Au W.Y., Lo C.M., Hawkins B.R., Ma E.S.K., Lie A.K.W., Kwong Y.L., Evans' syndrome and chronic graft versus host disease after liver transplantation., Transplantation. 2001, 72: 527-528.

Au W.Y., Chim J.C.S., Liang R.H.S., Kwong Y.L., Fludarabine, mitoxantrone and dexamethasone (FND) in indolent lymphoid malignancies., Blood. 2000, 96: 233b.

Au W.Y., Lie A.K.W., Liang R.H.S., Lam C.C.K., Kwong Y.L., Fulminant late onset cold hemagglutinin disease after allogeneic bone marrow transplantation., Haematologica. 2000, 85: E10.

Au W.Y., Lie A.K.W., Shek T.W.H., Fulminant molluscum contagiosum and concomitant leukemia cutis after bone marrow transplantation for chronic myeloid leukemia., British Journal of Dermatology. 2000, 144: 1097.

Au W.Y., Ma E.S.K., Kwong Y.L., Ng I.O.L., Hawkins B.R., Wan T.S.K., Liu C.L., Fan S.T., Lo C.M., Graft versus host disease after liver transplantation: documentation by FISH and HLA typing., Clinical Transplantation. 2000, 14: 173-176.

Au W.Y., Kwong Y.L., Ma E.S.K., Mak Y.K., Wong K.F., Lei K.I., Ng M.H., Chan J.C.W., Lin S.Y., Lee K.K., Liang R.H.S., Hairy cell leukemia in Hong Kong Chinese: a 12-year retrospective survey, Hematological Oncology. 2000, 18: 155-159.

Au W.Y., Lie A.K.W., Lee C.K., Leung A.Y.H., Liang R.H.S., Kwong Y.L., ICE chemotherapy plus peripheral blood stem cell (PBSC) for post-BMT relapse of leukemia., International Society of Hematology. 2000.

Au W.Y., Lie A.K.W., Siu L.L., Liang R.H.S., Chim J.C.S., Leung A.Y.H., Kwong Y.L., Intensive chemotherapy with peripheral blood stem cell (PBSC) support in the treatment of leukemia relapse after allogeneic bone marrow transplantation: clinical results and chimerism findings, The Hong Kong Practitioner. 2001, 23(Suppl): 48.

Au W.Y., Shek T.W.H., Kwong Y.L., Intravascular lymphoma and Epstein Barr virus in Chinese., American Journal of Surgery Pathology. 2000, 24: 309-10.

Au W.Y., Ho W.K., Shek T.W.H., Kwong Y.L., Isolated primary granulocytic sarcoma of the nasopharynx., American Journal of Hematology. 2001, 67: 273-4.

Au W.Y., Man C., Lam C.C.K., Ma E.S.K., Wan T.S., Kwong Y.L., Late onset t-MDS after treatment for acute promyelocytic leukemia, Human Pathology. 2001, 32: 126-9.

Au W.Y., Shek T.W.H., Gascoyne R.D., Kwong Y.L., Leukaemic infiltration of an adenocarcinoma effusion., British Journal of Haematology. 2001, 112: 412.

Au W.Y., Shek T.W.H., Ma E.S.K., Leung G., Ooi C.G.C., Liang R.H.S., Kwong Y.L., Meningeal granulocytic sarcoma (chloroma) in essential thrombocythemia., Journal of Clinical Oncology. 2000, 18: 3996-7.

Au W.Y., Chan G.C.F., Chim J.C.S., Liang R.H.S., Lie A.K.W., Leung A.Y.H., Kwong Y.L., Sustained and repeated response of relapsed acute promyelocytic leukemia (APL) to arsenic therapy., The Hong Kong Practitioner. 2001, 23(Suppl): 49.

Au W.Y., Lie A.K.W., Ma E.S.K., Leung A.Y.H., Siu L.L.P., Kwong Y.L., Therapy related myelodysplastic syndrome of recipient origin after allogeneic bone marrow transplantation for acute lymphoblastic leukemia, British Journal of Haematology. 2001, 112: 424-426.

Au W.Y., Lam C.C.K., Ma E.S.K., Man C.M.S., Wan T.S.K., Kwong Y.L., Therapy-related myelodysplastic syndrome after eradication of acute promyelocytic leukemia: Cytogenetic and molecular features, Human Pathology. 2000, 32(1): 126-129.

Au W.Y., Choy C.K.W., Ng W.M., Kwong Y.L., Treatment of subcutaneous panniculitis T cell lymphoma with fludarabine., British Journal of Dermatology. 2000, 43: 408-11.

Au W.Y., Lam C.C.K., Chan E.C., Kwong Y.L., Two novel mutations in a Chinese family with Factor VII deficiency., British Journal of Haematology. 2000, 111: 143-5.

Au W.Y., Ma E.S.K., Ooi C.G.C., Liang R.H.S., Kwong Y.L., Unusual manifestations of acute leukemia: central nervous system relapse of acute promyelocytic leukemia after arsenic treatment., Journal of Clinical Oncology. 2000, 18: 3435-7.

Chen W.Y.W., Wong K.Y., Au W.Y., Liang R.H.S., Srivastava G., BCL10 somatic mutations rarely occur in gastric lymphoma: detection of high frequency of polymorphisms in BCL10 coding region, Cancer Genetics and Cytogenetics. 2001, 127: 184-187.

Chen Y.W., Wong K.Y., Au W.Y., Liang R.H.S., Srivastava G., BCL10 mutations rarely occur in B-cell non-Hodgkin's lymphoma of gastric origin- detection of high frequency of polymorphisms in BCL10 coding region, Proceedings at the 7th Hong Kong International Cancer Congress, Hong Kong, 7-9 December. 2000.

Chim J.C.S., Au W.Y., Ooi C.G.C., Muscle Lymphoma: An MR Imaging Appraisal., Lancet. 2001, 357: 132.

Chim J.C.S., Au W.Y., Shek T.W.H., Ho J., Choy C.K.W., Ma E.S.K., Tung H.M., Liang R.H.S., Kwong Y.L., Primary CD56+ lymphomas of the gastrointestinal tract., Cancer. 2001, 91: 525-533.

Kwong Y.L., Au W.Y., Chim J.C.S., Pang A.W.K., Suen C., Liang R.H.S., Arsenic trioxide and idarubicin induced remissions in relapsed acute promyelocytic leukaemia : clinicopathological and molecular features of a pilot study., American Journal of Hematology. 2001, 66: 274-279.

Kwong Y.L., Au W.Y., Extramedullary relapses at uncommon sites after allogeneic stem cell transplantation., Bone Marrow Transplant. 2000, 26: 1134-35.

Leung A.Y.H., Chim J.C.S., Kwong Y.L., Lie A.K.W., Au W.Y., Liang R.H.S., Retrospective studies of 230 Chinese adults with chronic idiopathic thrombocytopenia purpura., The Hong Kong Society of Haematology Annual Open Scientific Meeting & The 4th Joint Shanghai-Hong Kong Haematology Meeting 2000.. 2000, 19.

Leung A.Y.H., Lie A.K.W., Kwong Y.L., Yuen K.Y., Au W.Y., Wong K.K., Kwok J.S.Y., Lee T.L., Cheng V.C.C., Liang R.H.S., The 23-valent polysaccharide pneumococcal vaccination is not useful in BMT patients at risk of pneumococcal bacteremic sepsis., 7th Hong Kong International Cancer Congress.. 2000.

Leung A.Y.H., Lie A.K.W., Kwong Y.L., Yuen K.Y., Au W.Y., Wong K.K., Kwok J.S.Y., Cheng V.C.C., Liang R.H.S., The 23-valent polysaccharide pneumococcal vaccination is not useful in BMT patients at risk of pneumococcal bacteremic sepsis, The Hong Kong Practitioner. 2001, 23(Suppl): 53.

Leung A.Y.H., Lie A.K.W., Au W.Y., Hawkins B.R., Kwong Y.L., Liang R.H.S., Unmanipulated bone marrow transplantation from one HLA locus mismatched siblings carries high transplant-related mortality in Chinese patients, Haematologica. 2001, 86: 518-22.

Leung K.F.S., Au W.Y., Chan A.Y.Y., Chan L.C., Waye J.S., Chui D.H.K., Ma E.S.K., Haemoglobin Q-Thailand and hereditary spherocytosis in a Chinese family, Clinical & Laboratory Haematology. 2001, 23(1): 53-55.

Liang R.H.S., Yu C.M., Au W.Y., Choy C.K.W., Kwong Y.L., Non-Hodgkins lymphoma involving the heart : metastatic lymphoma to the heart manifesting as intra-cavitary masses., Journal of Clinical Oncology. 2000, 18: 1998-1999.

Lie A.K.W., Au W.Y., Siu L.L., Liang R.H.S., Leung A.Y.H., Kwong Y.L., Intensive chemotherapy with peripheral blood stem cell support for leukaemia relapse after allogeneic bone marrow transplantation., 7th Asian Pacific BMT group meeting, Bangkok.. 2000, 130-131.

Lie A.K.W., Leung A.Y.H., Au W.Y., Hawkins B.R., Liang R.H.S., Unmanipulated bone marrow transplantation from one HLA antigen mismatched siblings carries high transplant-related mortality compared with the HLA-identical counterparts., 7th Hong Kong International Cancer Congress.. 2000.

Lie A.K.W., Leung A.Y.H., Au W.Y., Hawkins B.R., Kwong Y.L., Liang R.H.S., Unmanipulated bone marrow transplantation from one-antigen mismatched sibling carries high transplant-related mortality compared with the HLA-identical counterparts, The Hong Kong Practitioner. 2001, 23(Suppl): 50.

Ma E.S.K., Au W.Y., Chan A.Y.Y., Chan L.C., Clinical phenotype of triplicated a-globin genes and heterozygosity for b⁰-thalassemia in Chinese subjects, International Journal of Molecular Medicine. 2001, 8: 171-175.

Ma E.S.K., Au W.Y., Wan T.S.K., Kwong Y.L., Chan L.C., Translocation (15;17)(q22;q21) not associated with acute promyelocytic leukemia and negative for PML/RARa rearrangement, Haematologica. 2000, 85(7): 768-769.

Shek T.W.H., Ma E.S.K., Au W.Y., Nodal plasmacytoma with significant paraproteinaemia, Leukemia & Lymphoma. 2001, 40: 425-428.

Wan T.S.K., Ma E.S.K., Chan L.C., Au W.Y., Association between der(Y)t(Y;1)(q12;q12) and myelodysplastic syndrome, Cancer Genetics and Cytogenetics. 2001, 124: 84-85.

Wan T.S.K., Ma E.S.K., Au W.Y., Chan L.C., Derivative (1;18)(q10;q10): a recurrent and novel unbalanced translocation involving 1q in myeloid disorders, Cancer Genetics and Cytogenetics. 2001, 128: 35-38.

Researcher : Chan CK

List of Research Outputs

Wong B.C.Y., Wong W.M., Wang W.H., Tang V.S.Y., Young J., Lai K.C., Yuen S.T., Leung S.Y., Hu H.C., Chan C.K., Hui W.M., Lam S.K., An evaluation of invasive and non-invasive tests for the diagnosis of Helicobacter pylori infection in Chinese, Alimentary Pharmacology and Therapeutics. 2000, 15(4): 505-511.

Wong B.C.Y., Chan C.K., Wong K.W., Wong W.M., Yuen M.F., Lai K.C., Hu H.C., Lau G.K.K., Lai C.L., Lam S.K., Evaluation of a new referral system for the management of dyspepsia in Hong Kong: role of open-access upper endoscopy., Journal of Gastroenterology & Hepatology. 2000, 15(11): 1251-1256.

Wong B.C.Y., Wong K.W., Chan C.K., Wong W.M., Yuen M.F., Lai K.C., Hu H.C., Lau G., Lai C.L., Lam S.K., Evaluation of new referral system for the management of dyspepsia in Hong Kong: Role of open access uper endoscopy, Journal of Gastroenterology and Hepatology. 2000, 15: 1251-1256.

Wong B.C.Y., Wong W.M., Wang W.H., Fung F.M.Y., Lai K.C., Chu K.M., Yuen S.T., Leung S.Y., Hu H.C., Yuen M.F., Lau G., Chan C.K., Lam S.K., One-week Ranitidine Bismuth Citrate-based triple therapy for the eradication of Helicobacter pylori in Hong Kong with high prevalence of metronidazole resistance, Alimentary Pharmoacology and Therapeutics. 2001, 15: 403-409.

Wong B.C.Y., Wang W.H., Lau G., Wong W.M., Fung F.M.Y., Kung N.N.S., Chu K.M., Lai K.C., Hu H.C., Hu F.L., Liu X.G., Chan C.K., Yuen M.F., Hui W.M., Lam S.K., Three-day lansoprazole quadruple therapy for Helicobacter pylori-positive duodenal ulcers: a randomized contolled study [Oral presentation, 6th Medical Research Conference, Department of Medicine, 13-14 January], The Hong Kong Practitioner. 2001, 23 (2-suppl): 18.

Wong W.M., Wong B.C.Y., Wong K.W., Fung F.M.Y., Lai K.C., Hu H.C., Yuen S.T., Leung S.Y., Lau G.K.K., Lai C.L., Chan C.K., Go R., Lam S.K., ¹³C-urea breath test without a test meal is highly accurate for the detection of Helicobacter pylori infection in Chinese, Alimentary Pharmacology and Therapeutics. 2000, 14: 1353-1358.

Researcher : Chan DTM

Project Title:	The effects of glucose, TGF-Beta, and heparin on the expression of proteoglycans and extracellular matrix molecules by human peritoneal mesothelial cells
Investigator(s):	Prof. Chan D.T.M. , Dr. Chu S.M., Dr. Li F.K., Prof. Wong Y.C., Dr. Yung S.
Department:	Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	December 1998
Completion Date:	November 2000

Abstract:

To determine and characterise the profile of ECM components synthesized and secretes by HPMC; to identify changes in the synthesis and secretion of ECM molecules, in particular the PGs perlecan and decorin by HPMC cultured in the presence of different glycaemic conditions and TGF-beta; to determine the effects of heparin and neutralising antibodies to TGF-beta on PG and ECM protein synthesis by HPMC; to examine the ultrastructural changes within the peritoneum of patients maintained on CAPD with reference to ECM components in particular PGs.

Project Title:	Modification of cell adhesion and stress fibre organisation by human peritoneal mesothelial cells in response to hyperglycaemia
Investigator(s):	Prof. Chan D.T.M. , Dr. Yung S.S.Y.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	July 1999

Abstract:

To examine the synthesis and expression of ECM proteins, integrins, and focal adhesion components by HPMC in culture under physiological glucose concentration; to identify the changes in the synthesis and expression of ECM proteins, integrins, and adhesion components at elevated glucose concentrations or in the presence of dialysis fluid from PD patients; to examine the relatinship between changes identified under section (2) and cell attachment, spreading, and proliferation.

Project Title:	Binding of anti-DNA immunoglobulins from patients wth lupus nephritis to human proximal renal tubular epithelial cells (HPTC) and their effects on HPTC expression of RANTES, MCP-1, TGF-Beta1, and C3
Investigator(s):	Prof. Chan D.T.M. , Dr. Tang S.C.W., Dr. Yung S.S.Y.
Department:	Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	September 1999

Abstract:

To determine the mechanisms of interaction between anti-DNA antibodies and human proximal renal tubular epithelial cells; to determine the effects of anti-DNA antibodies on human proximal renal tubular epithelial cell expression of pro-inflammatory and pro-fibrotic cytokines and growth factors, namely RANTES, MCP-1, TGF-beta1, and C3.

Project Title:	Modulation of human mesangial cell hyaluronan synthesis and degradation by anti-DNA antibodies in SLE
Investigator(s):	Prof. Chan D.T.M. , Dr. Yung S.S.Y.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	November 2000

Abstract:

To isolate anti-DNA antibodies from patients during both inactive and active SLE; to examine the effects of anti-DNA antibodies on HMC HA synthesis and degradation; to investigate the role of HA and its fragments in pro-inflammatory cytokine stimulation and cell proliferation.

List of Research Outputs

Chan D.T.M., Efficacy of mycophenolate mofetil in patients with diffuse proliferative lupus nephritis, The New England Journal of Medicine. 2000, 344 (5): 375.

Chan D.T.M., Lok A.S., Lai C.L., Cheng I.K.P., Lai K.N., Hepatitis C after renal transplantation, Transplantation Proceedings. 2000, 32(7): 1799-1800.

Chan D.T.M., Li F.K., Chan Y.Y., Lai K.N., Long-term effects of 1.1% amino acid dialysate in Chinese CAPD patients, Abstracts of the 10th International Congress on Nutrition and Metabolism in Renal Disease. July 4-6, Lyon, France, 2000, 38.

Chan D.T.M., Ho S.K.N., Fang G.X., Cheng I.K.P., Lai K.N., Longitudinal profile of HBV DNA in renal allograft recipients, Abstracts of the Congress of the International Society of Transplantation. August 27-31,Rome, Italy, 2000.

Chan D.T.M., Organ transplantation - the Hong Kong perspective, Asian Hosp Healthcare Management. Asian Hospital Federation, 2001, 6: 64-65.

Chan D.T.M., Li F.K., Tang C.S.O., Wong R.W.S., Fang G.X., Ji Y.L., Lau W.C.S., Wong A.K.M., Tong M.K.L., Chan K.W., Lai K.N., for the Hong Kong-Guangzhou Nephrology Study Group. Efficacy of Mycophenolate Mofetil in patients with diffuse proliferative lupus nephritis, The New England Journal of Medicine. 2000, 343 (16): 1156-1162.

Ho S.K., Li F.K., Lai K.N., Chan D.T.M., Comparison of the CMV brite turbo assay and the digene hybrid capture CMV DNA (Version 2.0) assay for quantitation of cytomegalovirus in renal transplant recipients, Journal of Clinical Microbiology. 2000, 38(10): 3743-3745.

Ho S.K.N., Chan D.T.M., An overview of assays for serum HBV DNA, Clinical Laboratory. 2000, 46: 609-614.

Ip E.W.K., Lau Y.L., Chan S.Y., Mok C.C., Chan D.T.M., Tong K.K., Lau W.C.S., Mannose-binding lectin and rheumatoid arthritis in southern Chinese, Arthritis and Rheumatism. 2000, 43(8): 1679-1687.

Kwong Y.L., Lam C.C.K., Chan D.T.M., Post transplantation lymphoproliferative disease of natural killer cell lineage : clinicopathological and molecular features., British Journal of Haematology. 2000, 110: 197-202.

Lai K.N., Li F.K., Lan H.Y., Tang S.C.W., Tsang A.W., Chan D.T.M., Leung J.C.K., Expression of aquaporin-1 in human peritoneal mesothelial cells and its upregulation by glucose in vitro, Journal of American Society of Nephrology. 2001, 12(5): 1036-1045.

Lai K.N., Ho S.K., Leung J.C.K., Tang S.C.W., Chan D.T.M., Li F.K., Increased survival of mesothelial cells from the peritoneum in peritoneal dialysis fluid, Cell Biology International. 2001, 25(5): 445-450.

Lam M.F., Li F.K., Choy C.B.Y., Tang S.C.W., Lo W.K., Lui S.L., Chu S.M., Tam P.C., Chan D.T.M., Lai K.N., The impact of the establishment of a multiorgan transplantation program on cold ischemia time and delayed graft function in renal transplantation, Transplantation Proceedings. 2000, 32(7): 1611-1612.

Leung J.C.K., Tang S.C.W., Lam M.F., Chan D.T.M., Lai K.N., Charge-dependent binding of polymeric IgA1 to human mesangial cells in IgA nephropathy, Kidney International. 2001, 59(1): 277-285.

Li F.K., Chan D.T.M., Lai K.N., Alloimmune hemolysis after renal transplantation, American Journal of Nephrology. 2000, 20(6): 473-475.

Li F.K., Lui S.L., Lai K.N., Chan D.T.M., Current issues in renal transplantation: immunology and immunosuppression, Medical Progress. 2000, 27: 19-26.

Li F.K., Lui S.L., Lai K.N., Chan D.T.M., Current issues in renal transplantation, Medical Progress. 2000, 27(9): 13-18.

Li F.K., To C.H., Leung J.C.K., Chan D.T.M., Lai K.N., Electrophysiology and glucose transport of human peritoneal mesothelial cells: implications for peritoneal dialysis, Peritoneal Dialysis International. 2001, 21(2): 115-121.

Li F.K., Ho S.K.N., Chan D.T.M., Lai K.N., Significance of monocytic cytokines on the immune responsiveness of renal transplant recipients. [33rd Annual Meeting and 2000 Renal Week, American Society of Nephrology, October 10-16, 2000, Toronto, Ontario, Canada], Journal of American Society of Nephrology. 2000, 11: 476A-477A.

Li F.K., Chan D.T.M., Lai K.N., Significance of transmesothelial ionic and molecular transport in pertioneal dialysis, International Society of Nephrology: 2nd Conference on Forefront in Nephrology. 2000.

Lui S.L., Loretta Chan Y.Y., Zhang X.H., Zhu W., Chan D.T.M., Fung P.C.W., Lai K.N., Effect of mycophenolate mofetil on nitric oxide production and inducible nitric oxide synthase gene expression during renal ischaemia-reperfusion injury, Nephrology Dialysis Transplantation. 2001, 16: 1-6.

Lui S.L., Luk W.K., Cheung C.Y., Chan D.T.M., Lai K.N., Peiris J.S.M., Nosocomial outbreak of parvovirus B19 infection in a renal transplant unit, Transplantation. 2001, 71(1): 59-64.

Siu C.W., Chan D.T.M., Li F.K., Choy C.B.Y., Lui S.L., Lo C.Y., Tang S.C.W., Lo W.K., Lai K.N., Association between anti-thymocyte globulin administration and cytomegalic virus infection and/or CMV disease in cadaveric renal allograft recipients, Transplantation Proceedings. 2000, 32(7): 1932-1934.

Tang S.C.W., Tso W.K., Li J.H., Li C.L., Chan D.T.M., Lai K.N., Clinical outcome following percutaneous transluminal angioplasty for transplant renal artery stenoses, Transplantation Proceedings. 2000, 32(7): 1889-1891.

Tang S.C.W., Chan D.T.M., Lui S.L., Li F.K., Lo W.K., Lai K.N., Risk factors for avascular bone necrosis after renal transplantation, Transplantation Proceedings. 2000, 32(7): 1873-1875.

Tang S.C.W., Lai K.N., Chan D.T.M., Lan H.Y., Ho S.K., Sacks S.H., Transferrin but not albumin mediates stimulation of complement C3 biosynthesis in human proximal tubular epithelial cells, American Journal of Kidney Diseases. 2001, 37(1): 94-103.

Researcher : Chan HHL

Project Title:	Laser therapy of hypertrophic scar
Investigator(s):	Dr. Chan H.H.L. , Dr. Chan E.S.Y., Dr. Lau J.W.Y.
Department:	Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	December 1999

Abstract:

To assess the role of pulsed dye laser therapy in: a) treatment of chronic hypertrophic burn scars among Asian patients; b) prevent the formation of hypertrophic burn scar among Asian patients.

Project Title:	An in vitro model to look at the effect of sub-lethal lasers damage on human melanocytic expression of p16ink-4a
Investigator(s):	Dr. Chan H.H.L. , Prof. Lai K.N., Mr. Leung J.C.K.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	September 2000

Abstract:

To assess the sub-lethal effect of Q-switched Alexandrite and Q-switched Nd:YAG (1064nm) laser in p16 expression of normal melanocytic and melanoma cell lines.

Project Title:	The role of epidermal cooling in improving the outcome of laser therapy in the treatment of Nevus of Ota
Investigator(s):	Dr. Chan H.H.L. , Dr. Lam L.K.
Department:	Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	December 2000

Abstract:

To assess whether epidermal cooling would reduce pain, swelling, complications but improve clinical response and reduce the number of session required for laser treatment for Nevus of Ota.

List of Research Outputs

Chan H.H.L., Leung S.C., Ying S.Y., Lai C.F., Kono T., Chua K.H., Ho W.S., A retrospective analysis of complications of treatment of nevus of Ota with the Q-switched Alexandrite (QS Alex) and Q-switched Neodymium: Yttrium-Aluminum-Garnet (QS Nd-YAG) lasers, The Hong Kong Practitioner. 2001, 2: p 38.

Chan H.H.L., Leung R.S., Ying S.Y., Lai C.F., Kono T., Chua J.K., Ho W.S., A retrospective study looking at the complications of Q-switched Alexandrite (QS Alex) and Q-switched Neodymium: Yttrium-Aluminum-Garnet (QS Nd-YAG) lasers in the treatment of nevus of Ota, Dermatol Surg. 2000, 26: 1000-1006.

Chan H.H.L., Fung K.K., Ying S.Y., Kono T., An in vivo trail comparing the use of different types of 532nm Neodymium: Yttrium-Aluminum-Garnet (QS Nd-YAG) lasers in the treatment of facial lentigines in oriential patients., The Hong Kong Practitioner. 2001, 2: p 40.

Chan H.H.L., Ying S.Y., Ho W.S., Kono T., King W., An in vivo trial comparing the clinical efficacy and complications of Q-switched 755nm Alexandrite (QS Alex) and Q-switched 1064nm Neodymium: Yttrium-Aluminum-Garnet (QS Nd-YAG) lasers in the treatment of nevus of Ota., The Hong Kong Practitioner. 2001, 2: p 39.

Chan H.H.L., Ying S.Y., Ho W.S., Kono T., King W.W., An in vivo trial comparing the clinical efficacy and complications of Q-switched Alexandrite (QS Alex) and Q-switched 1064nm Neodymium: Yttrium-Aluminum-Garnet (QS 1064 Nd-YAG) lasers in the treatment of Nevus of Ota, Dermatol Surg. 2000, 26: 919-922.

Chan H.H.L., Fung W.K.K., Ying S.Y., Kono T., An in vivo trial comparing the use of different types of 532 nm Neodymium: Yttrium-Aluminum-Garnet (Nd-YAG) lasers in the treatment of facial lentigines in oriental patients, Dermatol Surg. 2000, 26: 743-749.

Chan H.H.L., Cosmetic Laser Surgery in Asians, Proceeding of the International Conference on skin therapy update2001. Singapore. 24-27 May,. 2001, p 59.

Chan H.H.L., Dermatological Emergency, The Hong Kong Allergy Convention, 12-14 January. 2001.

Chan H.H.L., Ying S.Y., Ho W.S., Diode laser and long pulsed Nd-YAG laser in hair removal among Chinese patient, Japanese Journal of Dermatology. 2001, 111: P233.

Chan H.H.L., Ying S.Y., Ho W.S., Wong D.S., Lam L.K., Diode laser and long pulsed Nd-YAG laser in hair removal among Chinese patient, Lasers of Surgery and Medicine. 2001, S13: 198.

Chan H.H.L., Laser Surgery in the Chinese, Proceeding of the Annual Scientific Meeting of the Hong Kong Society of Dermatology and Venereology. 2000.

Chan H.H.L., Lasers Surgery in Asians, The American Academy of Dermatology Annual Meeting, Washington. 2-7 March. 2001.

Chan H.H.L., Lam L.K., Wong D.S., Leung R.S., Ying S.Y., Lai C.F., Ho W.S., Chua J.K., Nevus of Ota: a new classification based upon the response to laser treatment, Lasers of Surgery and Medicine. 2001, 28: 267-72.

Chan H.H.L., Lam L.K., Wong S.Y., Leung S.C., Ying S.Y., Lai C.F., Ho W.S., Chua K.H., Nevus of Ota: a new classification based upon the response to laser treatment, The Hong Kong Practitioner. 2001, 2: p 38.

Chan H.H.L., Leung R.S.C., Ying S.Y., Lai C.F., Chua J., Kono T., Recurrence of nevus of Ota after successful treatment with Q-switched lasers, Archives of Dermatology. 2000, 136: 1175-1176.

Chan H.H.L., Woo J., Chan W.M., Hjelm M., Teledermatology in Hong Kong: a cost effective method to provide service to the elderly patients living in institutions, International Journal of Dermatology. 2000, 39: 774-778.

Chan H.H.L., Woo J., Chan W.M., Hjelm M., Teledermatology in Hong Kong: a cost effective method to provide service to the elderly patients living in instiututions, The Hong Kong Practitioner. 2001, 2: p 11.

Chan H.H.L., The pathogenesis of atopic eczema, The Hong Kong Allergy Convention, 12-14 January. 2001.

Chan H.H.L., The use of Q-switched lasers in the treatment of nevus of Ota, 6th Sino-Japan Joint Meeting of Dermatology. 15-17 September,. 2000.

Chan H.H.L., The use of laser in the treatment of naevus of Ota, Proceeding of the International Conference on skin therapy update 2001. Singapore. 24-27, May. 2001, p 123.

Chan H.H.L., Chan E., Kono T., Ying S.Y., Ho W.S., The use of variable pulse width frequency double Neodymium: YAG 532nm laser in the treatment of port wine stain in Chinese., The Hong Kong Practitioner. 2001, 2: p 39.

Chan H.H.L., Chan E., Kono T., Ying S.Y., Ho W.S., The use of variable pulse width frequency double neodymium: YAG 532 nm laser in the treatment of port wine stain in Chinese, Dermatol Surg. 2000, 26: 657-661.

Chan H.H.L., Pei A., Van Krevel C., Wong G.W.K., Lai C.K.W., Validation of the Chinese translated version of ISAAC core question for atopic eczema, Clinical and Experimental Allergy. 2001, 31: 903-907.

Chan H.H.L., Pei A., Van Krevel C., Wong W.K., Lai K.W., Validation of the Chinese translated version of ISAAC core questions for atopic eczema, The Hong Kong Practitioner. 2001, 2: p 11.

Chan H.H.L., Pei A., Van Krevel C., Wong G.W., Validation of the translated version of ISAAC core questions for atopic eczema, Japanese Journal of Dermatology. 2001, 111: P21.

Ho W.S., Ying S.Y., Chan H.H.L., A study of burn injuries in the elderly in a regional burn center, Burns. 2001, 27: 382-5.

Kono T., Nozaki M., Chan H.H.L., Mikashima Y., A retrospective study looking at the use of long-term complications of Q-switched ruby laser in the treatment of nevus of Ota, Japanese Journal of Dermatology. 2001, 111: p239.

Kono T., Nozaki M., Chan H.H.L., Combined laser (normal mode ruby laser and QS ruby laser) treatment on congenital hairy melanocytic nevi, Lasers of Surgery and Medicine. 2001, S13: 244.

Kono T., Nozaki M., Chan H.H.L., Diode laser assisted hair removal in Asians: a restrospective study of 101 Japanese patients, Lasers of Surgery and Medicine. 2001, S13: 245.

Lam A.Y., Chan H.H.L., Wong D.S., Lam L.K., Ho W.S., The use of Q-switched Alexandrite laser in the treatment of acquired bilateral nevus of Ota like macules, Japanese Journal of Dermatology. 2001, 111: P245.

Lam A.Y., Chan H.H.L., Wong D.S., Lam L.K., Ho W.S., The use of Q-switched Alexandrite laser in the treatment of acquired bilateral nevus of Ota like macules, Lasers of Surgery and Medicine. 2001, S13: 248.

Lam Y.M., Chan H.H.L., Wong S.Y., Lam L.K., Ho W.S., The use of Q-switched Alexandrite (QS Alex) laser in the treatment of acquired bilateral nevus of Ota-like macules (ABNOM), The Hong Kong Practitioner. 2001, 2: p 40.

Pei A., Chan H.H.L., Ho K.M., The effectiveness of wet wrap dressings using 1% mometasone furoate and 0.005% fluticasone proprionate ointments in the treatment of moderate-to-severe atopic dermatitis in children, The Hong Kong Practitioner. 2001, 2: p 10.

Pei A.Y., Chan H.H.L., Leung T.F., Leukotriene-receptor antagonist for the treatment of atopic dermatitis., Pediatr Allergy Immunol. 2001, 12(3): 154-8.

Yeung C.K., Au W.Y., Trendal-Smith N., Chan H.H.L., Panniculitis heralding blastic transformation of myelofibrosis, British Journal of Dermatology. 2001, 144: 905-906.

Ying S.Y., Ho W.S., Chan H.H.L., Toxic epidermolysis necrosis, Burns. 2001, 27: 372-5.

Researcher : Chan JCK

Project Title:	Application of the APACHE II and III prognostic scoring methods in the 14-bed Intensive Care Unit at Queen Mary Hospital
Investigator(s):	Dr. Chan J.C.K. , Prof. Lam W.K.
Department:	Medicine
Source(s) of Funding:	Health Services Research Fund
Start Date:	July 1995

Abstract:

To evaluate the usefulness of the APACHE II and III prognostic scoring methods in the 14-bed ICU at Queen Mary Hospital; to compare our ICU performance in terms of actual mortality with the predicted mortality based on the APACHE II predictive equation; to correlate the APACHE II and III severity scores. As the mortality prediction equation for APACHE III is only commercially available, a close correlation between APACHE II and III scores would support using the APACHE II scoring and prediction method as the standard method rather than financially investing in the APACHE III system.

Project Title:	Application of the APACHE II and III prognostic scoring methods in the 14-bed Intensive Care Unit at Queen Mary Hospital
Investigator(s):	Dr. Chan J.C.K. , Prof. Lam W.K.
Department:	Medicine
Source(s) of Funding:	Queen Mary Hospital Charitable Trust Training and Research Assistance Scheme
Start Date:	July 1995

Abstract:

List of Research Outputs

Ang M.F., Lie A.K.W., Chan J.C.K., Liang R.H.S., Kwong Y.L., Ex vivo expansion of peripheral blood haematopoietic stem cells: preclinical studies, The Hong Kong Practitioner. 2000, 22(Suppl): 11.

Kwong Y.L., Lie A.K.W., Chan J.C.K., Liang R.H.S., Changes in haematopoiesis in bone marrows primed with haematopoietic growth factors before allogeneic bone marrow transplantation: an interim analysis, The Hong Kong Practitioner. 2000, 22(Suppl): 43.

Lo C.M., Fan S.T., Liu C.L., Lai C.L., Lau G.K.K., Yong B.H., Ng I.O.L., Young K., Chan J.C.K., Wong J., Liver transplantation in Hong Kong - a wider application., Transplantation Proceedings. 2000, 32(7): 2141.

Researcher : Chan JCW

List of Research Outputs

Wat N.M.S., Lo C.Y., Lam Y.K., Chan J.C.W., Lam K.S.L., Germline mutation analysis in Hong Kong Chinese families with multiple endocrine neoplasia type 2., 11th International Congress of Endocrinology, Sydney, Australia. 2000.

Researcher : Chan KW

List of Research Outputs

Chan D.T.M., Li F.K., Tang C.S.O., Wong R.W.S., Fang G.X., Ji Y.L., Lau W.C.S., Wong A.K.M., Tong M.K.L., Chan K.W., Lai K.N., for the Hong Kong-Guangzhou Nephrology Study Group. Efficacy of Mycophenolate Mofetil in patients with diffuse proliferative lupus nephritis, The New England Journal of Medicine. 2000, 343 (16): 1156-1162.

Researcher : Chan LY

List of Research Outputs

Chan L.Y., Fong D.Y.T., Lam C.L.K., Chan-Yeung M., Say J., Yan C.P.K., Leung R., Ooi C.G.C., Ip M.S.M., Lam W.K., Tsang K.W.T., Validation of the Hong Kong Chinese Version of St. George's Respiratory Questionnaire (SGRQ), Medical Research Conference 13-14 January 2001. Hong Kong.

Cheung B.M.Y., Tsang K.W.T., Leung Y.H., Chan L.Y., Kumana C.R., Plasma adrenomedullin level is markedly elevated in bronchiectasis, Hong Kong Practitioner. 2000, 22 (Suppl): 4.

Lam W.K., Chan L.Y., Leung R., Fung P.C.W., Zheng L., Lam C.L., Shum I.H.Y., Ho J.C.M., Ip S., Ip M.S.M., Tsang K.W.T., Exhaled nitric oxide levels in steady state bronchiectasis : a prospective study, European Respiratory Journal. 2000, 16 (Suppl 1): 399S.

Lam W.K., Chan L.Y., Fung P.C.W., Zheng L., Shum I.H.Y., Leung R., Ho J.C.M., Ip S., Wang J., Ip M.S.M., Tsang K.W.T., Is there a correlation between nitric oxide (NO) in exhaled air, sputum, serum, saliva and urine of bronchiectatic patients?, European Respiratory Journal. 2000, 16(Suppl 31): 399S.

Tsang K.W.T., Shum H.Y.I., Ho J.C.M., Leung Y.H., Taylor G., Zheng L., Tipoe G.L., Chan L.Y., Fung P.C.W., Lam W.K., Downregulation of endothelin (ET)-1 and interleukin (IL)-8 expression in human respiratory mucosa by Pseudomonas aeruginosa pyocyanin and 1-hydroxy-phenazine, Hong Kong Practitioner. 2001, 23 Suppl 2: 67.

Tsang K.W.T., Ip S.K., Leung Y.H., Tipoe G.L., Chan L.Y., Shum H.Y.I., Zheng L., Yan C.P.K., Fung P.C.W., Lam W.K., Exhaled NO: effects of age, gender and body size, American Journal of Respiratory and Critical Care Medicine. 2001, 163 (5): A50.

Tsang K.W.T., Ip M.S.M., Fung P.C.W., Zheng L., Shum H.Y.I., Leung Y.H., Chan L.Y., Tipoe G.L., Ooi C.G.C., Ho J.C.M., Lam W.K., Pseudomonas aeruginosa infection is associated with reduced exhaled NO in bronchiectasis, American Journal of Respiratory and Critical Care Medicine. 2001, 163 (5): A671.

Tsang K.W.T., Ip S.K., Fung P.C.W., Ooi C.G.C., Shum H.Y.I., Leung Y.H., Chan L.Y., Tipoe G.L., Zheng L., Ip M.S.M., Ho J.C.M., Chan M.M.W., Lam W.K., Pseudomonas aeruginosa infection is associated with reduced exhaled NO in bronchiectasis, Hong Kong Practitioner. 2001, 23 Suppl 2: 30.

Tsang K.W.T., Leung Y.H., Taylor G., Tipoe G.L., Chan L.Y., Shum H.Y.I., Fung P.C.W., Lam W.K., Pseudomonas aeruginosa pyocyanin and 1-hydroxyphenazine downregulate endothelin-1 and interleukin-8 expression in human respiratory mucosa, American Journal of Respiratory and Critical Care Medicine. 2001, 163 (5): A671.

Tsang K.W.T., Ip S.K., Leung Y.H., Tipoe G.L., Chan L.Y., Shum H.Y.I., Zheng L., Yan C.P.K., Fung P.C.W., Lam W.K., The effects of gender on exhaled NO production among volunteers, Hong Kong Practitioner. 2001, 23 Suppl 2: 28.

Researcher : Chan MMW

Project Title:	Genetic and environmental risk factors and their interaction in the pathogenesis of lung cancer in Hong Kong
Investigator(s):	Prof. Chan M.M.W. , Prof. Lam W.K., Dr. Tan-Un K.C.
Department:	Medicine
Source(s) of Funding:	Anti-Cancer Society of Hong Kong
Start Date:	July 2000
Completion Date:	June 2001

Abstract:

To determine the environmental risk factors such as occupational and other domestic exposures and diet and their interaction with various polymorphisms of genes responsible for cytochrome P450 and glutathione-s-transferase systems which are important in controlling the oxidant-antioxidant balance in the body.

Project Title:	Transmission of tuberculosis in Hong Kong using both molecular and conventional epidemiological methods
Investigator(s):	Prof. Chan M.M.W. , Dr. Kam K.M., Dr. Tam C.M.
Department:	Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	September 2000

Abstract:

To conduct a molecular and conventional epidemiological study on all bacteriologically proven active cases of tuberculosis in Hong Kong Island over a period of 24 consecutive months.

Project Title:	Genetic and dietary factors in the pathogenesis of chronic obstructive pulmonary disease (COPD)-pilot study
Investigator(s):	Prof. Chan M.M.W. , Prof. Ip M.S.M., Dr. Tan-Un K.C.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	February 2001

Abstract:

To determine the prevalence of glutathione S-transferase (enzymes important for anti-oxidation) GSTT1, GSTM1, and GSTP1 polymorphisms in patients with COPD and controls.

List of Research Outputs

Chan H., Lai C.K.W., Wong G.W.K., Standford A., Pare P.D., Chan M.M.W., IL-4 receptor and IL-4 promoter polymorphisms among Hong Kong schoolchildren, American Journal of Respiratory and Critical Care Medicine. 2001, 161: A202.

Chan K.N., Ip M.S.M., Law B., Wu A.Y.Y., Chan M.M.W., Tsang K.W.T., Lee S.L., Chan E., Siu E., Lam W.K., Effectiveness of an asthma education program, American Journal of Respiratory and Critical Care Medicine. 2000, 161: A320.

Chan M.M.W., Becker A., Ferguson A., Dimich-Ward H., Watson W., Manfreda J., ACompliance and effectiveness of intervention measures 12 months after the cessation of the program in a primary prevention of asthma study, American Journal of Respiratory and Critical Care Medicine. 2000, 161: A620.

Chan M.M.W., Air pollution and health, Hong Kong Medical Journal. 2000, 6: 390-398.

Chan M.M.W., Malo J.L., Epidemiology of occupational asthma:, In: Busse W and Holgate S., Asthma and Rhinits. Blackwell Science Inc., 2000, 43-55.

Chan M.M.W., Noertjojo K., Chan S.L., Tam C.M., Factors associated with default from tuberculosis treatment in Hong Kong, American Journal of Respiratory and Critical Care Medicine. 2000, 161: A642.

Chan M.M.W., Indoor allergens, In: Fitzgerald M, Ernst P, Boulet LP, O'Byrne BC, Evidence-based asthma. Dekker Inc, Hamilton, 2001, 81-86.

Chan M.M.W., Noertjojo K., Chan S.L., Tam C.M., Report: Evaluation of tuberculosis and its management in Hong Kong, 2000.

Chan M.M.W., Noertjojo K., Tam C.M., Chan S.L., Tan J., Sex differences in tuberculosis in Hong Kong, American Journal of Respiratory and Critical Care Medicine. 2001, 161: A99.

Chan M.M.W., Spirometry and measures of bronchial responsiveness, International Journal of Tuberculosis and Lung Diseases. 2000, 4: 633-638.

Chan M.M.W., Dimich-Ward H., Ferguson A., Manfreda J., Watson W., Becker A., The Pediatric Forum: Asthma, Breastfeeding and hypoallergenic formula, Arch Pediatr Adolescent Med. 2001, 155: 203-4.

Chan M.M.W., Tuberculosis control in Hong Kong. Are we doing enough?, Hong Kong Thoracic Society Newsletter. 2000, 10: 24-28.

Chan M.M.W., Noertjojo K., Chan S.L., Tam C.M., Tuberculosis in the elderly in Hong Kong, American Journal of Respiratory and Critical Care Medicine. 2000, 161: A225.

Chan M.M.W., What is "Air Pollution Index" and its relation to human health?, Hong Kong Thoracic Society Newsletter. 2000, 10.

Chan M.M.W., In: Awarded the Alice Hamilton Award of the American Indusrial Hygiene Association for "Major and lasting contribution to Occupational Health" for the year 2000, 2000.

Dik N., Chan M.M.W., Ecklake M.R., Sweet L., Bowie D., Anthonisen N.R., Tate R.B., Manfreda J., Nasal allergies in Canada, American Journal of Respiratory and Critical Care Medicine. 2001, 161: A191.

Dimich-Ward H., Debuncio A., Dittrick M., Ferguson A., Becker A., Manfreda J., Watson W., Chan M.M.W., Respiratory symptom changes for parents of infants enrolled in a primary prevention of asthma study, American Journal of Respiratory and Critical Care Medicine. 2001, 161: A884.

Hegele R.G., Ahmad H.Y., Becker A., Dimich-Ward H., Ferguson A., Manfreda J., Watson W., Chan M.M.W., The association between respiratory viruses and symptoms in 2-week-old infants at high risk for asthma and allergy, Journal of Pediatrics. 2001, 138: 831-7.

Ho J.C.M., Tsang K.W.T., Lam B., Lam C.L., Wang J., Ip S., Yan C.P.K., Ip M.S.M., Chan M.M.W., Lam W.K., A multicentre Asian trial of docetaxel and cisplatinin advanced non-small cell lung cancer, Hong Kong Practitioner. 2001, 23 Suppl 2: 29.

Ho J.C.M., Tsang K.W.T., Chan M.M.W., Occupational and interstitial lung diseases, Clinical Respiratory Medicine. 2000, 2nd edition: 122-142.

Ip M.S.M., Lam B., Ip T.Y., Mok W.Y.W., Tsang K.W.T., Chan M.M.W., Lam W.K., Vascular risk profile in obstructive sleep apnoea, 10th European Respiratory Society Annual Congress, Florence, Italy. Aug - Sep 2000. 161: 274s(P1959).

Johnson A., Dimich-Ward H., Manfreada J., Becklake M., Ernst P., Sears M., Sweet L., Bowie D., Chan M.M.W., Occupational asthma in adults in six Canadian communities, American Journal of Respiratory and Critical Care Medicine. 2000, 162: 2058-62.

Joos L., Zhu S., Becker A., Chan M.M.W., Baldini M., Martinez F., Pare P., Standford A., Polymorphisms of the CD14 and TGF beta1 gene in a cohort of infants at high risk of allergic disorders, American Journal of Respiratory and Critical Care Medicine. 2000, 161: A928.

Malo J.L., Chan M.M.W., Specific Problems: Occupational asthma, In: O'Byrne P. and Saunders W.B., Manual of asthma management. 2001, 2nd edition: 443-452.

Manfreda J., Becklake M.R., Sears M., Chan M.M.W., Dimich-Ward H., Siersted H., Ernst P., Sweet L., Van Til L., Bowie D., Anthonisen N.R., Tate R.B., Prevalence of asthma symptoms among adults aged 20-44 years in Canada, Canadian Medical Association Journal. 2001, 164: 995-1001.

Noertjojo K., Tam C.M., Chan S.L., Chan M.M.W., Extrapulmonary tuberculosis in Hong Kong, American Journal of Respiratory and Critical Care Medicine. 2001, 163: A99.

Noertjojo K., Tam C.M., Chan S.L., Tan J., Chan M.M.W., Risk factors associated with mortality of tuberculosis in Hong Kong, American Journal of Respiratory and Critical Care Medicine. 2000, 161: A296.

Obata J., Chan H., Dittrick M., Chan M.M.W., Occupational asthma due to African Cherry Wood (Makore) Dust, Internal Medicine. 2000, 39: 947-949.

Sandford A., Zhu S., Becker A., Chan M.M.W., Pare P., Polymorphisms in the CCR5 and IL-4 receptor alpha genes are not associated with increased risk for allergic disease, American Journal of Respiratory and Critical Care Medicine. 2000, 161: A929.

Tsang K.W.T., Ip S.K., Fung P.C.W., Ooi C.G.C., Shum H.Y.I., Leung Y.H., Chan L.Y., Tipoe G.L., Zheng L., Ip M.S.M., Ho J.C.M., Chan M.M.W., Lam W.K., Pseudomonas aeruginosa infection is associated with reduced exhaled NO in bronchiectasis, Hong Kong Practitioner. 2001, 23 Suppl 2: 30.

Vedal S., Brumm J., Brauer M., Tsui M., Tong K.K., Wong Y.K., Petkau J., Chan M.M.W., Acute effects of air pollution on asthma emergency room visits in Hong Kong, American Journal of Respiratory and Critical Care Medicine. 2001, 161: A562.

Wong G.W.K., Chan H., Standford A., Pare P.D., Lai C.K.W., Chan M.M.W., Beta-2 adrenergic receptor polymorphisms in Hong Kong school children, In: Am J Respir Crit Care Med, 2001, 161: A202.

Wymer M., Chan M.M.W., Kennedy S., Kasteel K., Dimich-Ward H., A comparison of respiratory symptoms between physiotherapists and radiographers, In: Am J Respir Crit Care Med, 2000, 161: A167.

Researcher : Chan TK

List of Research Outputs

Chan V.N.Y., Yam I.Y.L., Yip P.C., Au P., Shing M.K., Li C.K., Chan T.K., Single nucleotide polymorphisms (SNPs) of the factor IX gene for linkage analysis in the southern Chinese population, British Journal of Haematology. 2000, 111(2): 540-543.

Chen F.E., Ooi C.G.C., Ha S.Y., Cheung B.M.Y., Todd D., Liang R.H.S., Chan T.K., Chan V.N.Y., Genetic and clinical features of hemoglobin H disease in Chinese patients, New England Journal of Medicine. 2000, 343(8): 544-550.

Chen F.E., Ooi C.G.C., Ha S.Y., Cheung B.M.Y., Todd D., Liang R.H.S., Chan T.K., Chan V.N.Y., Genetics and clinical features of Hemoglobin H disease in Chinese patients, New England Journal of Medicine. 2000, 343(8): 544-550.

Leung A.Y.H., Lam C.C.K., Chan T.K., Hemighost cell in acute hepatitis A., American Journal of Medicine. 2001, 111(1): 81-2.

Researcher : Chan VNY

Project Title:	Application of DNA technology in genetic diseases and blood cancers
Investigator(s):	Prof. Chan V.N.Y. , Prof. Chan T.K., Dr. Chiu E.K.W., Prof. Kwong Y.L., Prof. Liang R.H.S., Prof. Wong V.C.N.
Department:	Medicine
Source(s) of Funding:	Croucher Foundation
Start Date:	September 1993

Abstract:

Studies in the molecular biology of other neurogenetic diseases: spinal muscular atrophy (SMA) and fragile X syndrome; development of simpler techniques in the diagnosis of thalassaemia and haemophilias; application of fluorescent-in-situ hybridization to (a) prenatal diagnosis and (b) detection of minimal disease in blood cancers; detection of mixed chimerism after bone marrow transplantation as early detection of engraftment and/or relapse.

Project Title:	Linkage of genetic locus/loci in the human genome to idiopathic scoliosis
Investigator(s):	Prof. Chan V.N.Y. , Dr. Lu D., Prof. Luk K.D.K.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	July 1998
Completion Date:	March 2001

Abstract:

To link the genetic locus/loci to the phenotype by use of panels of fluorescent-based microsatelite markers of the human genome.

Project Title:	Prenatal diagnosis of alpha thalassemia by quantitative PCR
Investigator(s):	Prof. Chan V.N.Y.
Department:	Medicine
Source(s) of Funding:	RGC Fundable Projects (Block Grant Funded)
Start Date:	May 2000
Completion Date:	April 2001

Abstract:

To study a method of providing a result for the prenatal diagnosis within 3-4 hours of fetal sampling.

List of Research Outputs

Chan V.N.Y., Honorary Fellowship, Hong Kong College of Physicians. 2001.

Chan V.N.Y., Honorary Fellowship, Royal College of Physicians, London. 2001.

Chan V.N.Y., Invited Symposium Speaker, 3rd HUGO Pacific Meeting and 4th Asia-Pacific Conference on Human Genetics, Shanghai, October 2000. 2000.

Chan V.N.Y., Member of International Advisory Board, 4th HUGO Pacific Meeting and 5th Asia Pacific Conference on Human Genetics, Thailand, October 2002. 2001.

Chan V.N.Y., Prenatal Diagnosis of Common Genetic Diseases, The 3rd HUGO Pacific Meeting and the 4th Asia-Pacific Conference on Human Genetics, Shanghai, China. 2000.

Chan V.N.Y., Prenatal diagnosis of common genetic diseases, The 3rd HUGO Pacific Meerting and 4th Asia-Pacific Conference on Human Genetics, Shanghai, October 2000.

Chan V.N.Y., Yam I.Y.L., Yip P.C., Au P., Shing M.K., Li C.K., Chan T.K., Single nucleotide polymorphisms (SNPs) of the factor IX gene for linkage analysis in the southern Chinese population, British Journal of Haematology. 2000, 111(2): 540-543.

Chen F.E., Ooi C.G.C., Ha S.Y., Cheung B.M.Y., Todd D., Liang R.H.S., Chan T.K., Chan V.N.Y., Genetic and clinical features of hemoglobin H disease in Chinese patients, New England Journal of Medicine. 2000, 343(8): 544-550.

Chen F.E., Ooi C.G.C., Ha S.Y., Cheung B.M.Y., Todd D., Liang R.H.S., Chan T.K., Chan V.N.Y., Genetics and clinical features of Hemoglobin H disease in Chinese patients, New England Journal of Medicine. 2000, 343(8): 544-550.

Kung A.W.C., Lau K.S., Chan V.N.Y., Genetic Mapping for thyrotoxic Hypokalemic Periodic Paralysis (TPP), The Endocrine Society's 83rd Annual Meeting, USA, June 2001.

Kung A.W.C., Lau K.S., Chan V.N.Y., Genetic mapping for thyrotoxic hypokalemic periodic paralysis (TPP), The Endocrine Society USA. 83rd annual meeting.. 2001, P1-578.

Siu L.L., Chan V.N.Y., Chan J.K., Wong K.F., Liang R.H.S., Kwong Y.L., Consistent patterns of allelic loss in natural killer cell lymphoma, American Journal of Pathology. 2000, 157(6): 1803-1809.

Siu L.L.P., Chan V.N.Y., Chan J.K.C., Wong K.F., Liang R.H.S., Kwong Y.L., Consistent patterns of allelic loss in natural killer cell lymphoma, American Journal of Pathology. 2000, 157(6): 1803-1809.

Wong V.C.N., Chan V.N.Y., Molecular genetic study of a childhood form of spinal muscular atrophy, Journal of Child Neurology. 2001, 16(4): 291-294.

Xu J., Chan V.N.Y., Zhang W., Lam K.S.L., High Frequency of Mutations in the Hepatocyte Nuclear Factor-1 alpha in Chinese Subjects with Familial Early-Onset Type 2 Diabetes: Identificatioin and Functional Analysis, 61st Scientific Sessions, American Diabetes Association, June 22-26, 2001, Philadelphia, Pennsylvania, USA. 2001.

Xu J., Chan V.N.Y., Zhang W., Lam K.S.L., High frequency of mutations in the hepatocyte nuclear factor-1aGene identification and functional analysis, 61st American Diabetes Association meeting, Philadelphia, USA. 2001, 1019-P.

Xu J., Chan V.N.Y., Lam K.S.L., Mutations in the Hepatocyte Nuclear Factor-1 Alpha Gene in Southern Chinese Subjects with Early-Onset Type 2 Diabetes, 3rd HUGO-Pacific Meeting, Shanghai, China, October 18-21, 2000.

Xu J., Zhang W., Chan V.N.Y., Lam K.S.L., Mutations in the Hepatocyte Nuclear Factor-1 alpha Gene in Chinese Subjects with Familial Early-Onset Type 2 Diabetes: Identification and Functional Analysis, Semi-final of the 7th Challenge Cup Competition, April 27, 2001, The University of Hong Kong. 2001.

Xu J., Chan V.N.Y., Lam K.S.L., Mutations in the Hepatocyte Nuclear Factor-1 alpha Gene in Southern Chinese Subjects with Early-Onset Type 2 Diabetes, 6th Medical Research Conference, Department of Medicine, The University of Hong Kong, Jan 13-14, 2001.

Xu J., Chan V.N.Y., Lam K.S.L., The Hepatocyte Nuclear Factor-1 alpha Gene Plays a Significant Role in Southern Chinese Subjects With Early-Onset Type 2 Diabetes, 5th Research Postgraduate Symposium, The University of Hong Kong, December 7-9, 2000.

Researcher : Chan WK

List of Research Outputs

Ren Y., Wu A.Y.Y., Chan W.K., Lau W.C.S., Increased apoptotic blood neutrophils and macrophages and decreased clearance of apoptotic neutrophils in systemic lupus erythematosus, Hong Kong Practitioner. The Hong Kong Practitioner, 2001, 23(2) supple: 31.

Tong T.K., Yeung J.S.L., Yang D., Wu A.Y.Y., Chan W.K., Chiu P.K.Y., Tang W.M., Lau W.C.S., Effects of triptolide, an active ingredient of trypterygium Wilfordii Hook F (Thunder God Vine, a traditional Chinese herb), on rheumatoid synovial fibroblast function, Hong Kong Practitioner. The Hong Kong Practitioner, 2001, 23(2) Supple: 33.

Wu A.Y.Y., Chan W.K., Chik S.C.C., Lau W.C.S., B cell apoptosis in systemic lupus erythematosus, J Allergy Clin Immunol. 2000, 105 (1 pt2): S78.

Wu A.Y.Y., Chan W.K., Chik S.C.C., Lau W.C.S., Preliminary study on the effect of triptolide in an animal model of contact dermatitis, J Allergy Clin Immunol. 2001, 107 (2 pt2): 372.

Researcher : Chan WM

List of Research Outputs

Cheng V.C.C., Yuen K.Y., Chan W.M., Wong S.S.Y., Ma E.S.K., Chan R.M.T., Immunorestitution disease involving the innate and adaptive response, Clinical Infectious Diseases. 2000, 30(6): 882-892.

Researcher : Chan YL

List of Research Outputs

Researcher : Chan YY

List of Research Outputs

Chan D.T.M., Li F.K., Chan Y.Y., Lai K.N., Long-term effects of 1.1% amino acid dialysate in Chinese CAPD patients, Abstracts of the 10th International Congress on Nutrition and Metabolism in Renal Disease. July 4-6, Lyon, France, 2000, 38.

Researcher : Chau J

List of Research Outputs

Yu C.M., Deng J.C., Chau J., Wang S., Lam K.B., Ho Y.Y., Chiu S.Y., Lau C.P., Combination of angiotensin converting enzyme inhibitor and irbesartan for the treatment of heart failure, The Hong Kong Practitioner. 2001, 23 no. 2: 1.

Yu C.M., Chau J., McGhee S.M., Cheung B.M.Y., Lau C.P., Li L.S.W., Short course cardiac rehabilitation programme improves long-term quality of life in patients with acute myocardial infarction an dafter coronary angioplasty: a highly cost-effectiveness therapy, Journal of the American College of Cardiology. 50th Annual Scientific Session, Orlando, Florida, March 18-21, 2001. 2001, 1214-7.

Researcher : Chau MC

List of Research Outputs

Fan K., Lee K.L.F., Yu C.M., Tse H.F., Chau M.C., Lau C.P., Chronic threshold testing of biventricular pacing in heart failure - analysis of QRS characteristics with biventricular, left and right ventricular pacing (Abstract), Pacing and Clinical Electrophysiology. 2001, 24(4) Part II: 765.

Fan K., Lee K.L.F., Chow W.H., Chau M.C., Kwok O.H., Chan C.W.S., Lau C.P., Roles of left atrial mechanical dilatation and pre-existing atrial fibrillation in patients with chronic atrial fibrillation and mitral valve disease (Abstract), Pacing and Clinical Electrophysiology. 2001, 24(4) Part II: 93.

Lee K.L.F., Fan K., Tse H.F., Chau M.C., Yu C.M., Lau C.P., Chronic biventricular pacing is assoicated with a decrease in ventricular vulnerability to develop ventricular fibrillation in heart failure patients (Abstract), Pacing and Clinical Electrophysiology. 2001, 24(4) Part II: 509.

Yu C.M., Lau C.P., Tse H.F., Tang M.O., Yang H., Chau M.C., Fan K., Lee K.L.F., Hill M.R.S., Reverse remodeling of the left ventricle after biventricular pacing in patients with advanced heart failure is related to intraventricular resynchronization: a mechanistic study by tissue doppler imaging, Journal of the American College of Cardiology. 2001, B57-1.

Researcher : Chen S

List of Research Outputs

Chen S., Cheung R.T.F., Effects of exogenous neuropeptide Y and neuropeptide Y-Y1 receptor antagonist on focal cerebral ischemia in the rat, Society for Neuroscience Abstracts. 2000, 26: 772.

Chen S., Pei Z., Fung P.C.W., Cheung R.T.F., Neuropeptide Y and related compounds can modulate nitric oxide production during focal cerebral ischemia in the rat. An electron paramagnetic resonance study, 7th Hong Kong International Cancer Congress and 5th Research Postgraduate Symposium, 7 to 9 December 2000. 2.3.

Cheung R.T.F., Chen S., Neuropeptide Y-Y1 receptor antagonist protects against focal cerebral ischemia in the rat, Stroke. 2000, 31: 2859.

Pei Z., Chen S., Fung P.C.W., Cheung R.T.F., Melatonin abolishes the increase in nitric oxide production during cerebral ischemia in the rat, 7th Hong Kong International Cancer Congress and 5th Research Postgraduate Symposium, 7 to 9 December 2000. 2.12.

Researcher : Chen WH

Project Title:	A randomized placebo-controlled trial to test whether abciximab can reduce in-stent restonosis in diabetic patients after intra coronary stenting
Investigator(s):	Dr. Chen W.H. , Prof. Lau C.P., Dr. Lau Y.K., Dr. Leung W.S.
Department:	Medicine
Source(s) of Funding:	Eli Lilly Asia Inc.
Start Date:	January 2001

Abstract:

To investigate whether abciximab can reduce in-stent restenosis in diabetic patients after intra coronary stenting.

Project Title:	A randomized placebo-controlled trial to test whether abciximab can reduce in-stent restonosis in diabetic patients after intra coronary stenting
Investigator(s):	Dr. Chen W.H. , Prof. Lau C.P., Dr. Lau Y.K., Dr. Leung W.S.
Department:	Medicine
Source(s) of Funding:	Guidant Hong Kong Ltd.
Start Date:	January 2001

Abstract:

To investigate whether abciximab can reduce in-stent restenosis in diabetic patients after intra coronary stenting.

Project Title:	A pilot study to evaluate the safety and efficacy of reperfusion therapy using abciximab and intravenous enoxaparin in patients older than 75 years with acute myocardial infarction
Investigator(s):	Dr. Chen W.H. , Prof. Lau C.P.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	June 2001

Abstract:

To evaluate the efficacy and safety of a reperfusion therapy using a combination of abciximab and intravenous enoxaparin in patients age 75 years or older with acute myocardial infarction.

List of Research Outputs

Chen W.H., Lau C.P., Lau Y.K., Lam R.W.F., Li P.Y., Ma E., Yu C.M., Ng W., Safety, Efficacy, and Pharmacokinetics of the Use of Enoxaparin in Chinese Patients Undergoing Percutaneous Coronary Intervention., HK College of Cardilogy, 9th Annual Scientific Congress. 2001, 9: 75.

Chen W.H., Lau Y.K., Lee P.Y., Mok T.M., Evora M., Lau C.P., Streptokinase is ineffective in restoring early myocardial reperfusion in Asian patients wiht acute myocardial infarction, The Hong Kong Practitioner. 2001, 23: 6.

Chen W.H., Lau C.P., Lau Y.K., Lam R.W.F., Lee P.Y., Ma E., Yu C.M., Ng W., The use of enoxaparin in Chinese patients undergoing percutaneous coronary intervention: observations on safety, efficacy, and pharmacokinetics from a pilot study, The Hong Kong Practitioner. 2001, 23: 6.

Chen W.H., Thrombolytic therapy for acute myocardiaqlo infarction in the elderly, Journal of the Hong Kong College of Cardiology. 2001, 9: 39-40.

Chen W.H., advances in anti-thrombotic treatment, Journal of the Hong Kong College of Cardiology. 2001, 9: 59-63.

Researcher : Cheng IKP

List of Research Outputs

Chan D.T.M., Lok A.S., Lai C.L., Cheng I.K.P., Lai K.N., Hepatitis C after renal transplantation, Transplantation Proceedings. 2000, 32(7): 1799-1800.

Chan D.T.M., Ho S.K.N., Fang G.X., Cheng I.K.P., Lai K.N., Longitudinal profile of HBV DNA in renal allograft recipients, Abstracts of the Congress of the International Society of Transplantation. August 27-31,Rome, Italy, 2000.

Researcher : Cheung BMY

Project Title:	Cost implications of new guidelines on cholesterol reduction in patients with coronary heart disease
Investigator(s):	Dr. Cheung B.M.Y. , Prof. Kumana C.R., Prof. Lau C.P.
Department:	Medicine
Source(s) of Funding:	Health Services Research Fund
Start Date:	June 1996

Abstract:

To compile a database of patients with coronary heart disease under the care of the Division of Cardiology of Queen Mary Hospital and identify those requiring lipid-lowering therapy; to analyse the costs, benefits, and cost-effectiveness of treating hypercholesterolaemia in coronary heart disease patients using statins; to assess the cost-effectiveness of dietary classes and interviews.

Project Title:	Prevalence of hypertension in close relatives of hypertensive patients
Investigator(s):	Dr. Cheung B.M.Y.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	July 1997

Abstract:

To determine the prevalence of hypertension in the close relatives of hypertensive patients, and thereby identifying the pattern of inheritance of hypertension.

Project Title:	Cost-effectiveness of low salt diet in lowering blood pressure in Hong Kong Chinese
Investigator(s):	Dr. Cheung B.M.Y. , Prof. Lau C.P., Dr. McGhee S.M., Ms Ng P.P.Y.
Department:	Medicine
Source(s) of Funding:	Health Services Research Fund
Start Date:	April 1998

Abstract:

To investigate the relationship between blood pressure and sodium intake in the general population; to compare the effectiveness of dietary salt reduction with conventional treatment in lowering blood pressure; to compare cost of low salt diet and standard drug therapy.

Project Title:	The role of adrenomedullin in inflammatory diseases of the airways - asthma and bronchiectasis
Investigator(s):	Dr. Cheung B.M.Y. , Prof. Ip M.S.M., Prof. Kumana C.R., Dr. Tsang K.W.T.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	July 1998

Abstract:

To test the hypothesis that adrenomedullin level in plasma or sputum in patients with asthma and bronchiectasis reflects inflammatory activity in the airways.

Project Title:	Angiotensin-converting enzyme, bradykinin and endothelial function
Investigator(s):	Dr. Cheung B.M.Y. , Prof. Fung P.C.W., Prof. He G.W., Dr. Tan K.C.B., Dr. Tsang K.W.T.
Department:	Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	December 1999

Abstract:

To confirm the relationship between angiotensin-converting enzyme (ACE) genotype, ACE inhibition and bradykinin level; to assess the relationship between bradykinin level and endothelial function (production of nitric oxide and flow-mediated dilatation); to assess the influence of ACE genotype on endothelial function in vitro and in vivo.

Project Title:	The role of adrenomedullin in inflammation
Investigator(s):	Dr. Cheung B.M.Y. , Dr. Lan H.Y., Prof. Lau W.C.S., Prof. Tang F., Dr. Tsang K.W.T.
Department:	Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	October 2000

Abstract:

To investigate whether human adrenomedullin (AM) is an inflammatory or anti-inflammatory cytokine in vitro and in vivo. For patients with systemic lupus erythematosus (SLE), the project will study the changes in AM level during relapses and remissions, and after immunosuppressive therapy. The research will lead to new strategies to treat systemic inflammatory conditions, and pave way for the development of anti-inflammatory and immunosuppressive agents with fewer adverse effects.

Project Title:	Plasma homocysteine and cardiovascular risk in Hong Kong Chinese
Investigator(s):	Dr. Cheung B.M.Y. , Prof. Lau C.P., Dr. O K.
Department:	Medicine
Source(s) of Funding:	RGC Fundable Projects (Block Grant Funded)
Start Date:	November 2000

Abstract:

To set up a homocysteine (HCY) assay; to determine a reference range for men and women; to measure HCY in patients who have developed or are at risk from cardiovascular disease.

List of Research Outputs

Chau J., Cheung B.M.Y., McGhee S.M., Lauder I.J., Lau C.P., Kumana C.R., Cost-effectiveness and cost-utility of statins inpatients with CHD and average cholesterol levels applied to Hong Kong, The Hong Kong Practitioner. 2001, 23: 9.

Chen F.E., Ooi C.G.C., Ha S.Y., Cheung B.M.Y., Todd D., Liang R.H.S., Chan T.K., Chan V.N.Y., Genetic and clinical features of hemoglobin H disease in Chinese patients, New England Journal of Medicine. 2000, 343(8): 544-550.

Chen F.E., Ooi C.G.C., Ha S.Y., Cheung B.M.Y., Todd D., Liang R.H.S., Chan T.K., Chan V.N.Y., Genetics and clinical features of Hemoglobin H disease in Chinese patients, New England Journal of Medicine. 2000, 343(8): 544-550.

Cheung B.M.Y., A middle-aged man with hypertension, diabetes mellitus and hypercholesterolaemia, Cardiovascular Risk Factor Digest. 2000, 3 (2): 8.

Cheung B.M.Y., Leung Y.H., Lau C.P., Kumana C.R., Angiotensin-converting enzyme genotypes in hypertensive patients with left ventricular hypertrophy, American Journal of Hypertension. 2000, 13(4) II: 74A.

Cheung B.M.Y., Leung Y.H., Lau C.P., Kumana C.R., Angiotensin-converting enzyme genotypes in hypertensive patients with left ventricular hypertrophy, Hong Kong Practitioner. 2000, 22 (Suppl): 35.

Cheung B.M.Y., Kumana C.R., Association studies of genetic polymorphisms and complex disease (letter), Lancet. 2000, 355: 1277.

Cheung B.M.Y., Law C.Y., Ho G.Y.Y., Ng P.P.Y., Kumana C.R., Lau C.P., Change in ambulatory blood pressure in hypertensive patients is related to sodium intake, 9th Annual Scientific Congress of the Hong Kong College of Cardiology, Hong Kong. 2001.

Cheung B.M.Y., Clinical Challenge - hypertension, Hong Kong Practitioner. 2000, 22: 262-3.

Cheung B.M.Y., Kumana C.R., Dementia and statins (letter), Lancet. 2001, 257: 880.

Cheung B.M.Y., Ho P.C., Lau C.P., Diastolic blood pressure is related to sodium intake in hypertensive Chinese, Quarterly Journal of Medicine. 2000, 93: 163-168.

Cheung B.M.Y., Cheung A.H.K., Ho P.C., Lau C.P., Kumana C.R., Drug utlisation in a hypertension outpatient clinic 1996-1999, Hong Kong Practitioner. 2000, 22 (Suppl): 4.

Cheung B.M.Y., Law C.Y., Ho G.Y.Y., Ng P.P.Y., Kumana C.R., Lau C.P., Efficacy of non-pharmacological treatment of hypertension, American Journal of Hypertension. 2001, 14: 141a.

Cheung B.M.Y., Cheung A.H.K., Ng P., Kumana C.R., Lau C.P., Efficacy of non-pharmacological treatment of hypertension, Journal of Hypertension. 2000, 18: S97.

Cheung B.M.Y., Cheung A.H.K., Ng P., Kumana C.R., Lau C.P., Efficacy of non-pharmacological treatment of hypertension, Journal of the Hong Kong College of Cardiology. 2000, 8: 86.

Cheung B.M.Y., Chow V., O K., Lau C.P., Elevated plasma homocysteine is associated with ischaemic heart disease in Hong Kong Chinese, The Hong Kong Practitioner. 2001, 23: 7.

Cheung B.M.Y., Leung Y.H., Lau C.P., Frequency of angiotensin-converting enzyme genotypes in hypertensive patients with left ventricular hypertrophy, Journal of the Renin-Angiotensin-Aldosterone System (JRAAS). 2000, 1: 82.

Cheung B.M.Y., Cheung A.H.K., Lau C.P., Kumana C.R., Hypertension in relatives is associaed with obesity, Hong Kong Practitioner. 2000, 22 (Suppl): 5.

Cheung B.M.Y., Cheung A.H.K., Lau C.P., Kumana C.R., Is systolic blood pressure related to potassium excretion?, American Journal of Hypertension. 2000, 13(4)II: 169A.

Cheung B.M.Y., Tse H.F., Kumana C.R., Lau C.P., Left ventricular mass is related to blood pressure and body weight, The Hong Kong Practitioner. 2001, 23: 10.

Cheung B.M.Y., Law C.Y., Ho G.Y.Y., Ng P.P.Y., Kumana C.R., Lau C.P., Non-Pharmacological treatment of hypertension, The Hong Kong Practitioner. 2001, 23: 8.

Cheung B.M.Y., Cheung A.H.K., Lau C.P., Kumana C.R., Obesity is a predictor of hypertension in relatives, Journal of Hypertension. 2000, 18: S126.

Cheung B.M.Y., Lau W.C.S., Leung Y.H., Tong K.K., Kumana C.R., Plasma adrenomedullin level in systemic lupus erythematosus, Rheumatology. 2000, 39: 804-5.

Cheung B.M.Y., Tsang K.W.T., Leung Y.H., Chan L.Y., Kumana C.R., Plasma adrenomedullin level is markedly elevated in bronchiectasis, Hong Kong Practitioner. 2000, 22 (Suppl): 4.

Cheung B.M.Y., Leung Y.H., Cheung A.H.K., Tsang K.W.T., Lau C.P., Kumana C.R., Plasma bradykinin level and angiotensin-converting enzyme gene polymorphism in hypertensive patients, Hong Kong Practitioner. 2000, 22 (Suppl): 35.

Cheung B.M.Y., Tam S.C.F., Cheung A.H.K., Ng P.P.Y., Kumana C.R., Lau C.P., Plasma renin and aldosterone in Chinese hypertensive patients, 2nd International Forum on Angiotensin II Receptor Antagonists, Monte-Carlo. 2001.

Cheung B.M.Y., Tam S.C.F., Ng P.P.Y., Kumana C.R., Lau C.P., Plasma renin and aldosterone in patients with essential hypertension, 9th Annual Scientific Congress of the Hong Kong College of Cardiology, Hong Kong. 2001.

Cheung B.M.Y., Tam S.C.F., Ng P.P.Y., Kumana C.R., Lau C.P., Plasma renin and aldosterone in patients with hypertension before treatment, The Hong Kong Practitioner. 2001, 23: 8.

Cheung B.M.Y., Prevalence and consequences of hypertension in Hong Kong, New in Circulation. 2001, 1: 1-3.

Cheung B.M.Y., Ho P.C., Lau C.P., Randomised placebo-controlled study of the effect of fosinopril on left ventricular mass in untreated hypertensive patients: final results, Hong Kong Practitioner. 2000, 22 (Suppl): 34.

Cheung B.M.Y., Law C.Y., Ho G.Y.Y., Ng P.P.Y., McGhee S.M., Kumana C.R., Lau C.P., Reducing sodium intake reduces ambulatory blood pressure in hypertensive patients, American Journal of Hypertension. 2001, 14: 143-144A.

Cheung B.M.Y., Law C.Y., Ho G.Y.Y., Ng P.P.Y., McGhee S.M., Kumana C.R., Lau C.P., Reducing sodium intake reduces ambulatory blood pressure in hypertensive patients, Hong Kong Practitioner. 2001, 23 (Suppl 2): 9.

Cheung B.M.Y., Law C.Y., Ho G.Y.Y., Ng P.P.Y., McGhee S.M., Kumana C.R., Lau C.P., Reducing sodium intake reduces ambulatory blood pressure inhypertensive patients, The Hong Kong Practitioner. 2001, 23: 9.

Cheung B.M.Y., Kumana C.R., Should decisions on treatment be based on absolute benefit rather than absolute risk?, New Zealand Medical Journal. 2001, 114: 214-5.

Cheung B.M.Y., The new millennium from an Asian perspective, Medical Progress. 2000, 27 (1): 1.

Cheung B.M.Y., Kumana C.R., Treatment those at risk or treating those who benefit?, Medical Progress. 2001, 28: 8-9.

Cheung B.M.Y., Lam T.C., Law C.Y., Kumana C.R., Lau C.P., Waist circumference and cardiovascular risk in patients with essential hypertension, 9th Annual Scientific Congress of the Hong Kong College of Cardiology, Hong Kong. 2001.

Lam Y.M., Tse H.F., Lau C.P., Cheung B.M.Y., Kumana C.R., Does low dose amiodarone effective for ventricular rate control in patients wiht cronic atiral fibrillation?, Europace. 2000, Supp 1: D137.

Li N., Kumana C.R., Cheung B.M.Y., Fan S.T., Liu C.L., Age affects blood pressure and heart rate following IV diazepam, VII World Conference on Clinical Pharmacology & Therapeutics 4th Congress of the European Association for Clinical Pharmacology & Therapeutics. 2001.

Tse H.F., Lam Y.M., Lau C.P., Cheung B.M.Y., Kumana C.R., Comparison of digoxin versus low-dose amiodarone for ventricular rate control in patients with chronic atrial fibrilation, Clin Exp Pharmacol Physiol. 2001, 28: 446-450.

Tse H.F., Cheung B.M.Y., Chan J.K.F., Lau C.P., Long term reliability of serial echocardiographic measurement in detecting regression of left ventricular hypertrophy: comparison with magnetic resonance imaging, The Hong Kong Practitioner. 2001, 23 (2): 3.

Yu C.M., Chau J., McGhee S.M., Cheung B.M.Y., Lau C.P., Li L.S.W., Short course cardiac rehabilitation programme improves long-term quality of life in patients with acute myocardial infarction an dafter coronary angioplasty: a highly cost-effectiveness therapy, Journal of the American College of Cardiology. 50th Annual Scientific Session, Orlando, Florida, March 18-21, 2001. 2001, 1214-7.

Researcher : Cheung RTF

Project Title:	Effect of intravenous infusion of neuropeptide Y on the infarct volume following transient or permanent middle cerebral artery occlusion in the rat
Investigator(s):	Dr. Cheung R.T.F.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	July 1999
Completion Date:	June 2001

Abstract:

To study the effects of intravenous infusion of neuropeptide Y following focal cerebralischaemia.

Project Title:	Homocysteine and folate in Chinese stroke patients
Investigator(s):	Dr. Cheung R.T.F.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	November 2000

Abstract:

To determine the serum level of folate and plasma level of homocysteine among Chinese patients with different types of stroke; to correlate the serum level of folate and plasma level of homcysteine with carotid artery atherosclerosis in Chinese patients with different types of stroke.

List of Research Outputs

Chen S., Cheung R.T.F., Effects of exogenous neuropeptide Y and neuropeptide Y-Y1 receptor antagonist on focal cerebral ischemia in the rat, Society for Neuroscience Abstracts. 2000, 26: 772.

Chen S., Pei Z., Fung P.C.W., Cheung R.T.F., Neuropeptide Y and related compounds can modulate nitric oxide production during focal cerebral ischemia in the rat. An electron paramagnetic resonance study, 7th Hong Kong International Cancer Congress and 5th Research Postgraduate Symposium, 7 to 9 December 2000. 2.3.

Cheng P.W., Lee T.Y., Cheung R.T.F., Assessment of chronic ischaemia of middle cerebral artery territories in pre-occlusive or occluded carotid artery with CT perfusion, First Symposium on CT and MR Brain Perfusion, Giessen, Germany. 2000, A6.

Cheung R.T.F., Cheng P.W., Wong W.C., Lee T.Y., A CT perfusion study of cerebrovascular status and reserve in patients with carotid artery disease, Stroke. 2000, 31: 2772.

Cheung R.T.F., Acute management of stroke, Treatment Update in Common Diseases I, Frontiers in Clinical Medicine, The Hong Kong Medical Forum, the Hong Kong Convention and Exhibition Centre, July 2, 2000. 2000.

Cheung R.T.F., CT perfusion study in acute stroke management, Radiology VI (Neuroradiology), Radiology 2000 Hong Kong International Congress on Science and The People & 8th Annual Scientific Meeting of the Hong Kong College of Radiologists, August 13, 2000. 2000.

Cheung R.T.F., Cerebrovascular disease - advances in management, Hong Kong Medical Journal. 2001, 7: 58-66.

Cheung R.T.F., Chairman of Organizing Committee and Chairman of a Symposium, The 2000 Annual Scientific Meeting of the Hong Kong Neurological Society. 2000.

Cheung R.T.F., Clopidogrel and thrombotic thrombocytopenic purpura, The New England Journal of Medicine. 2000, 343: 1192.

Cheung R.T.F., Fasting serum level of cholesterol and triglyceride of stroke patients in Hong Kong, Stroke. 2000, 31: 2797.

Cheung R.T.F., Hong Kong patient's knowledge of stroke does not influence time to hospital presentation, Stroke. 2000, 31: 2843.

Cheung R.T.F., Ischemic preconditioning and tolerance in human brain, Stroke. 2000, 31: 2272-2273.

Cheung R.T.F., Pei Z., Pang S.F., Melatonin protects against focal cerebral ischemia in the rat, Stroke. 2000, 31: 2859.

Cheung R.T.F., Member of Organizing Comittee, Hong Kong Stroke Workshop 2000.

Cheung R.T.F., Member of Organizing Committee & Chairman of a Session, First International Symposium on CT and MR Brain Perfusion. Giessen, Germany, 2000.

Cheung R.T.F., Chen S., Neuropeptide Y-Y1 receptor antagonist protects against focal cerebral ischemia in the rat, Stroke. 2000, 31: 2859.

Cheung R.T.F., Patients' knowledge of stroke does not influence time to hospital presentation, Stroke. 2001, 32: 365.

Cheung R.T.F., Recent Advances in Stroke, The Federation's Anniversary Scientific Meeting 2000, the Federation of the Medical Societies of Hong Kong, Hospital Authority Building, October 22 , 2000. 2000.

Cheung R.T.F., Li L.S.W., Leung K.P., Stroke prevention in atrial fibrillation among Hong Kong Chinese, Cerebrovascular Diseases. 2001, 11: 353-354.

Cheung R.T.F., Hachinski V., The insula and cerebrogenic sudden death, Archives of Neurology. 2000, 57: 1685-1688.

Fong G.C.Y., Fong K.Y., Ho W.Y., Mak W., Tsang K.L., Chan K.H., Cheung R.T.F., Ho S.L., Postictal psychosis related regional cerebral hyperperfusion., Journal of Neurology Neurosurgery & Psychiatry.. 2000, 68: 100-101.

Ho D.S.W., Wang Y., Chui M., Ho S.L., Cheung R.T.F., Epileptic seizures attributed to cerebral hyperperfusion after percutaneous transluminal angioplasty and stenting of the internal carotid artery, Cerebrovascular Diseases. 2000, 10: 374-379.

Ho D.S.W., Wang Y., Chui M., Wang Y., Ho S.L., Cheung R.T.F., Intracarotid Abciximab injection to abort impending ischemic stroke during carotid angioplasty, Cerebrovascular Diseases. 2001, 11: 300-304.

Ho H.T.S., Pei Z., Pang S.F., Cheung R.T.F., Melatonin pretreatment protects against focal cerebral ischemia in the rat, Society for Neuroscience Abstracts. 2000, 26: 767.

Lee N., Cheung R.T.F., A non-alcoholic case of Wernicke's encephalopathy, Hong Kong Practitioner. 2000, 22: 457-461.

Lee T.Y., Cheng P.W., Cheung R.T.F., Silver B.H., Lee D.H., Gulka I.B., CT perfusion study on vascular reserve in cerebrovascular disease patients using diamox challenge, Radiology. 2000, 217 Supplement: 555.

Li L.S.W., Chiu K., Leung K.P., Cheung R.T.F., Ho S.L., Prediction of dysphagic recovery after stroke, Neurological Journal of South East Asia. 2001, 5: 78.

Li L.S.W., Chiu K., Leung K.P., Cheung R.T.F., Ho S.L., Prediction of recovery of swallowing disorder in stroke patients after rehabilitation, Hong Kong Practitioner. 2001, 23 (suppl 2): 24.

Li L.S.W., Leung K.P., Cheung R.T.F., Lee T., Kwok T.H., Ho C.T.K., Ho S.L., Remission of post-stroke alien hand syndrome during rehabilitation., International Society of Physical and Rehabilitation Medicine. Amsterdam, Netherlands., International Society of Physical and Rehabilitation Medicin, 2001.

Mak W., Mok K.Y., Tsoi T.H., Cheung R.T.F., Ho S.L., Chang C.M., Cerebral venous thrombosis in Hong Kong, Cerebrovascular Diseases. 2001, 11: 282-283.

Mak W., Cheng P.W., Cheung R.T.F., Leukoencephalopathy following chemotherapy for colonic carcinoma, Clinical Radiology. 2001, 56: 333-335.

Ooi C.G.C., Tsang K.W.T., Cheung R.T.F., Lam W.K., Fok C.Y.M., Ng F.M.L., Chan F.L., Ngan H., Lung volume measurement in chronic obstructive pulmonary disease: Application of helical computed tomography., Journal of the Hong Kong College of Radiologists. 2000, 4: 53-58.

Pei Z., Chen S., Fung P.C.W., Cheung R.T.F., Melatonin abolishes the increase in nitric oxide production during cerebral ischemia in the rat, 7th Hong Kong International Cancer Congress and 5th Research Postgraduate Symposium, 7 to 9 December 2000. 2.12.

Pei Z., Fung P.C.W., Cheung R.T.F., Melatonin protects against focal cerebral ischemia in rats via inhibition of ischemia-induced overproduction of nitric oxide, Hong Kong Practitioner. 2001, 23 (suppl 2): 63.

Pei Z., Pang S.F., Cheung R.T.F., Repeated doses of melatonin protects against focal cerebral ischemia in the rat, Society for Neuroscience Abstracts. 2000, 26: 767.

Researcher : Chik SCC

List of Research Outputs

Wu A.Y.Y., Chan W.K., Chik S.C.C., Lau W.C.S., B cell apoptosis in systemic lupus erythematosus, J Allergy Clin Immunol. 2000, 105 (1 pt2): S78.

Wu A.Y.Y., Chan W.K., Chik S.C.C., Lau W.C.S., Preliminary study on the effect of triptolide in an animal model of contact dermatitis, J Allergy Clin Immunol. 2001, 107 (2 pt2): 372.

Researcher : Chim JCS

List of Research Outputs

Au W.Y., Lie A.K.W., Kwong Y.L., Lee C.K., Chim J.C.S., Leung A.Y.H., Liang R.H.S., Donor lymphocyte infusion (DLI) for leukemia relapse: the Queen Mary Hosptial Experience., The Hong Kong Society of Haematology Annual Open Scientific Meeting & The 4th Joint Shanghai-Hong Kong Haematology Meeting 2000.. 2000, 12.

Au W.Y., Chim J.C.S., Liang R.H.S., Kwong Y.L., Fludarabine, mitoxantrone and dexamethasone (FND) in indolent lymphoid malignancies., Blood. 2000, 96: 233b.

Au W.Y., Lie A.K.W., Siu L.L., Liang R.H.S., Chim J.C.S., Leung A.Y.H., Kwong Y.L., Intensive chemotherapy with peripheral blood stem cell (PBSC) support in the treatment of leukemia relapse after allogeneic bone marrow transplantation: clinical results and chimerism findings, The Hong Kong Practitioner. 2001, 23(Suppl): 48.

Au W.Y., Chan G.C.F., Chim J.C.S., Liang R.H.S., Lie A.K.W., Leung A.Y.H., Kwong Y.L., Sustained and repeated response of relapsed acute promyelocytic leukemia (APL) to arsenic therapy., The Hong Kong Practitioner. 2001, 23(Suppl): 49.

Chim J.C.S., Au W.Y., Ooi C.G.C., Clinical picture: Muscle lymphoma., The Lancet. 2001, 357: 1320.

Chim J.C.S., Ma E.S.K., Giant pronormoblasts in parvovirus-associated pure red cell aplasia, American Journal of Hematology. 2000, 65(4): 289.

Chim J.C.S., Choy C.K.W., Ooi C.G.C., Chung L.P., Wong K.K., Liang R.H.S., Intravascular lymphomatosis of the lung., Journal of Clinical Oncology. 2000, 18: 3733-3735.

Chim J.C.S., Trendall-Smith N.J., Metastatic malignant melanoma: a BM diagnosis., British Journal of Haematology. 2001, 112: 2.

Chim J.C.S., Au W.Y., Ooi C.G.C., Muscle Lymphoma: An MR Imaging Appraisal., Lancet. 2001, 357: 132.

Chim J.C.S., Choy P.T., Kwong Y.L., Negative gallium scan in Castleman's disease., Haematologica. 2001, 86: 442-3.

Chim J.C.S., Shek T.W.H., Ho J., Liang R.H.S., Kwong Y.L., Primary CD56+ gastrointestinal lymphoma., Cancer. 2001, 91: 525-533.

Chim J.C.S., Au W.Y., Shek T.W.H., Ho J., Choy C.K.W., Ma E.S.K., Tung H.M., Liang R.H.S., Kwong Y.L., Primary CD56+ lymphomas of the gastrointestinal tract., Cancer. 2001, 91: 525-533.

Chim J.C.S., Choy C.K.W., Ooi C.G.C., Liang R.H.S., Primary Hepatic Lymphoma., Leukemia & Lymphoma. 2000.

Chim J.C.S., Ng I.O.L., Trendell-Smith N.J., Liang R.H.S., Primary extramedullary plasmacytoma of the lacrimal gland, Leukemia and Lymphoma. 2001, 42(4): 831-834.

Chim J.C.S., Choy C.K.W., Ooi C.G.C., Srivastava G., Liang R.H.S., Primary skeletal muscle lymphoma., American Journal of Medicine. 2001.

Chim J.C.S., Ma E.S.K., Serous degeneration of the bone marrow., Haematologica. 2001, 86: 558.

Chim J.C.S., Kwong Y.L., Shek W.E., Ma E.S.K., Ooi C.G.C., Splenic rupture as the presenting symptom of blastic crises in a patient with Philadelphia-negative bcr-alb-positive ET., American Journal of Hematology. 2000, 70-71.

Chim J.C.S., Shek T.W.H., Ma E.S.K., Kwong Y.L., Spontaneous Splenic rupture in Ph- +ve ET, American Journal of Hematology. 2001, 66: 70-71.

Chim J.C.S., Choy C.B.Y., Ooi C.G.C., Chung L.P., Wong K.K., Liang R.H.S., Two unusual lymphomas. Case 2: pulmonary intravascular lymphomatosis., Journal of Clinical Oncology. 2000, 18(21): 3733-3775.

Chim J.C.S., Tam C., Liang R.H.S., Kwong Y.L., p15 and p16 gene methylation in adult acute leukemia : lack of prognostic significance., Cancer. 2001, 91: 2222-2229.

Chim J.C.S., Liang R.H.S., Tam C., Kwong Y.L., p15 and p16 promotor methylation in acute promyelocytic leukemia., Journal of Clinical Oncology. 2001, 19: 2033-2040.

Ho P.L., Chim J.C.S., Yuen K.Y., Splenic tuberculosis presenting with pyrexia of unknown origin., Scandinavian Journal of Infectious Diseases. 2000, 32: 700-701.

Kwong Y.L., Au W.Y., Chim J.C.S., Pang A.W.K., Suen C., Liang R.H.S., Arsenic trioxide and idarubicin induced remissions in relapsed acute promyelocytic leukaemia : clinicopathological and molecular features of a pilot study., American Journal of Hematology. 2001, 66: 274-279.

Leung A.Y.H., Hawkins B.R., Chim J.C.S., Kwong Y.L., Liang R.H.S., Genetics analysis of HLA-typing in Chinese patients with idiopathic thrombocytopenic purpura, Haematologica. 2001, 86: 221-222.

Leung A.Y.H., Chim J.C.S., Kwong Y.L., Lie A.K.W., Au W.Y., Liang R.H.S., Retrospective studies of 230 Chinese adults with chronic idiopathic thrombocytopenia purpura., The Hong Kong Society of Haematology Annual Open Scientific Meeting & The 4th Joint Shanghai-Hong Kong Haematology Meeting 2000.. 2000, 19.

Ooi C.G.C., Chim J.C.S., Khong P.L., Lie A.K.W., Tsang K.W.T., Liang R.H.S., Radiologic manifestations of extramedullary leukemic relapse., Journal of the Hong Kong College of Radiologists. 2000, 3: 265.

Ooi C.G.C., Chim J.C.S., Khong P.L., Au W.Y., Lie A.K.W., Tsang K.W.T., Kwong Y.L., Radiologic manifestations of granulocytic sarcoma in adult leukemia, American Journal of Roentgenology. 2001, 176: 1427-1431.

Researcher : Choi CY

List of Research Outputs

Choi C.Y., Fung P.C.W., Lie A.K.W., Leung R., Liang R.H.S., Nitrite/nitrate levels in patients after stem cell transplant., The Hong Kong Practitioner. 2001, 23(Suppl): 57.

Researcher : Choo CK

Project Title:	IL2-mediated gene delivery into IL-2 receptor expressing cells
Investigator(s):	Dr. Choo C.K. , Prof. Kwong Y.L.
Department:	Medicine
Source(s) of Funding:	RGC Fundable Projects (Block Grant Funded)
Start Date:	May 2000

Abstract:

To establish the fusion protein as an effective DNA delivery vehicle for gene therapy in IL-2 expressing cells.

List of Research Outputs

Choo C.K., Ling M.T., Suen C.K.M., Chan K.W., Kwong Y.L., Retrovirus-mediated delivery of HPV16 E7 antisense RNA inhibited tumorigenicity of CaSki cells, Gynecologic Oncology. 2000, 78: 293-301.

Researcher : Chow CH

List of Research Outputs

Leung A.Y.H., Chow C.H., Kwong Y.L., Lie A.K.W., Fung T.K., Chow W.H., Yip A.S.B., Liang R.H.S., Genetic polymorphism at exon 4 of cytochrome P450CYP2C9 in Chinese patients might determine the warfarin dose requirement., 42nd Annual Meeting of the American Society of Hematology. San Francisco.. 2000.

Researcher : Choy CBY

List of Research Outputs

Chim J.C.S., Choy C.B.Y., Ooi C.G.C., Chung L.P., Wong K.K., Liang R.H.S., Two unusual lymphomas. Case 2: pulmonary intravascular lymphomatosis., Journal of Clinical Oncology. 2000, 18(21): 3733-3775.

Lam M.F., Li F.K., Choy C.B.Y., Tang S.C.W., Lo W.K., Lui S.L., Chu S.M., Tam P.C., Chan D.T.M., Lai K.N., The impact of the establishment of a multiorgan transplantation program on cold ischemia time and delayed graft function in renal transplantation, Transplantation Proceedings. 2000, 32(7): 1611-1612.

Siu C.W., Chan D.T.M., Li F.K., Choy C.B.Y., Lui S.L., Lo C.Y., Tang S.C.W., Lo W.K., Lai K.N., Association between anti-thymocyte globulin administration and cytomegalic virus infection and/or CMV disease in cadaveric renal allograft recipients, Transplantation Proceedings. 2000, 32(7): 1932-1934.

Researcher : Chu LW

Project Title:	Fall and fall-related injuries in community-dwelling elderly persons in Hong Kong - a study on risk factors, functional decline and health services utilization after falls
Investigator(s):	Dr. Chu L.W. , Prof. Chi I.
Department:	Medicine
Source(s) of Funding:	Health Services Research Fund
Start Date:	March 1998

Abstract:

To investigate the risk factors associated with repeated falls; to investigate the risk factors associated with a single (isolated) falls; to investigate the effect of falls in relation to functional decline, mortality, nursing home placement and health services utilizations: in a sample of community-dwelling elderly population in Hong Kong.

List of Research Outputs

Chu L.W., Lam K.S.L., Tam S.C.F., Hu W., Hui S.L., Chin A., Chiu K.C., Ng P., A randomised controlled trial of low dose recombinant human growth hormone in the treatment of malnourished elderly patients., Journal of Clinical Endocrinology & Metabolism. 2001, 86: 1913-1920.

Chu L.W., Chiu K.C., Hui S.L., Yu G.K.K., Tsui W.J.C., Lee P.W.H., The reliability and validity of the Alzeimer's Diseases Assessment Scale Cognitive Subscale (ADAS-Cog) among Chinese Elderly in Hong Kong, Annals Academy of Medicine Singapore. 2000.

Ho J.C.M., Lam W.K., Hu W., Leung R., Sun J.Z., Tipoe G.L., Zheng I., Chu L.W., Tsang K.W.T., The effects of aging on respiratory ciliary function and electron microscopic abnormalities, American Journal of Respiratory and Critical Care Medicine. 2000, 161: A123.

Kung A.W.C., Yeung S.C., Chu L.W., The efficacy and tolerability of alendronate in postmenopausal Chinese women. A randomised placebo-controlled study., Calcified Tissue International. 2000, 67: 286-290.

Researcher : Chu MY

List of Research Outputs

Chu M.Y., Outcome measures in chronic arthritis in Hong Kong: Comparison of the AIMS2 (Chinese) and WHO quality of life - Brief Form (WHOQOL-BREF) (HK), In: MY Chu, PKY Chiu, CS Lau, RWS Wong, The Hong Kong Practitioner 2000; 22(2) (Supple):25. 2000.

Chu M.Y., Chiu P.K.Y., Wong R.W.S., Lau W.C.S., Validity and reliability of a Chinese version of the arthritis impact measurement scales 2 (CAIMS2), Arthritis and Rheumatism 2000:(43(9):S177:663. Arthritis and Rheumatism, 2001, 43(9): S177:663.

Researcher : Feng Z

Project Title:	The role of isoenzymes of cyclooxygenase COX-1 and COX-2 in MPTP treated animal model for Parkinson's disease
Investigator(s):	Dr. Feng Z.H. , Dr. Ho S.L., Prof. Langenbach R.
Department:	Medicine
Source(s) of Funding:	RGC Fundable Projects (Block Grant Funded)
Start Date:	May 2000
Completion Date:	April 2001

Abstract:

To investigate the role of COX isoenzymes in Parkinson's disease.

Project Title:	The effects of antisense treatment of human Catechol-O-methyltransferase in the COX-2 knockout mice after MPTP exposure
Investigator(s):	Dr. Feng Z.H.
Department:	Medicine
Source(s) of Funding:	RGC Fundable Projects (Block Grant Funded)
Start Date:	October 2000

Abstract:

To explore a new method to attenuate the translation of COMT to increase the dopamine supply in the brain using antisense oligonucleotides.

List of Research Outputs

Feng Z., Guan X., Ho S.L., Ramsden R.B., Jiang H., Tang T., Sham J.S.T., Different expressions of human Catechol-O-methyltransferase gene are correlated with the phosphorylation of cyclic AMP regulatory element binding protein., European Journal of Neuroscience. 2000, 12(suppl 11): 402.

Feng Z., Kong L.Y., Qi Q.P., Ho S.L., Tiao N.Y., Bing G.Y., Han Y.F., Induction of unspliced cfos messenger RNA in rodent brain by kainic acid and lipopolysaccharide., Neuroscience Letters. 2001, 305: 17-20.

Jiang H., Feng Z., Ramsden D.B., Ho S.L., Effects of estrogen on human Catechol-O-methyltransferase gene, 6th International Congress of Parkinson's Disease and Movem. Barcelona, Spain., 2000.

Researcher : Fung FMY

List of Research Outputs

Wang W.H., Wong B.C.Y., Berg D.E., Fung F.M.Y., Lai K.C., Wong W.M., Wong K.W., Cho C.H., Lam S.K., Mixed genotype and metronidazole susceptibility patterns of Helicobacter pylori in Hong Kong, Gastroenterology. 2000, 118:4 (suppl 2): A503.

Wong B.C.Y., Wang W., Berg D.E., Fung F.M.Y., Wong K.W., Wong W.M., Lai K.C., Cho C.H., Hui W.M., Lam S.K., High prevalence of mixed infections by Helicobacter pylori in Hong Kong: metronidazole sensitivity and overall genotype, Alimentary Pharmacology and Therapeutics. 2000, 15: 493-503.

Wong B.C.Y., Wong W.M., Wang W.H., Fung F.M.Y., Lai K.C., Chu K.M., Yuen S.T., Leung S.Y., Hu H.C., Yuen M.F., Lau G., Chan C.K., Lam S.K., One-week Ranitidine Bismuth Citrate-based triple therapy for the eradication of Helicobacter pylori in Hong Kong with high prevalence of metronidazole resistance, Alimentary Pharmoacology and Therapeutics. 2001, 15: 403-409.

Wong B.C.Y., Wang W.H., Lau G., Wong W.M., Fung F.M.Y., Kung N.N.S., Chu K.M., Lai K.C., Hu H.C., Hu F.L., Liu X.G., Chan C.K., Yuen M.F., Hui W.M., Lam S.K., Three-day lansoprazole quadruple therapy for Helicobacter pylori-positive duodenal ulcers: a randomized contolled study [Oral presentation, 6th Medical Research Conference, Department of Medicine, 13-14 January], The Hong Kong Practitioner. 2001, 23 (2-suppl): 18.

Wong W.M., Wong B.C.Y., Wong K.W., Li T.M., Cheung K.L., Fung F.M.Y., Xia H.H.X., Lam S.K., Low dose 13C-Urea breath test with citrate is equally reliable for the detection of Helicobacter pylori infection in Chinese [6th Medical Research Conference, Department of Medicine, University of Hong Kong, 13-14 January], The Hong Kong Practitioner. 2001, 23 (2-suppl): 19.

Researcher : Fung PCW

Project Title:	Making superoxide microsensor for in vivo and in vitro studies in biomedical science
Investigator(s):	Prof. Fung P.C.W.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	November 2000

Abstract:

To buildup superoxide micro-sensor by making chemically modified electrode of size down to ~10microM; to measure superoxide generation in diseased organs (ischemia/reperfusion, inflammatory, dysfunctional) of animal models in vivo.

List of Research Outputs

Chen S., Pei Z., Fung P.C.W., Cheung R.T.F., Neuropeptide Y and related compounds can modulate nitric oxide production during focal cerebral ischemia in the rat. An electron paramagnetic resonance study, 7th Hong Kong International Cancer Congress and 5th Research Postgraduate Symposium, 7 to 9 December 2000. 2.3.

Choi C.Y., Fung P.C.W., Lie A.K.W., Leung R., Liang R.H.S., Nitrite/nitrate levels in patients after stem cell transplant., The Hong Kong Practitioner. 2001, 23(Suppl): 57.

Fung M.L., Ye J.S., Fung P.C.W., Acute hypoxia elevates nitric oxide generation in rat carotid body in vitro, 6^th Medical Research Conference, Department of Medicine, HKU. 2001.

Fung P.C.W., Lam S.K., Diseases, Nitric Oxide and Related Potent Therapy, Medical Progress. 2001, 19-22.

Fung P.C.W., The roles played by nitric oxide in acute and chronical hepatitis of animal model, Journal of Gastroenterology & Hepatology (Supplement), September 2000. Liver Diseases in the New Millennium, Shanghai, September 23-26, 2000. 15: s11.

Guo W.H., Chan K.L., Fung P.C.W., Chan K.W., Tam P.K.H., Nitric oxide protects segmental intestinal grafts from ischaemia and reperfusion I/R injury, Transplantation Proceedings. 2000, 32: 1297-1298.

Ip M.S.M., Lam B., Cheng S., Zheng L., Tsang K.W.T., Fung P.C.W., Lam W.K., Circulating nitic oxide is suppressed in obstruvtive sleep apnea and is reversed by nCPAP, American Journal of Respiratory and Critical Care Medicine. 2000, 162: 2166-2171.

Jin Y., Tipoe G.L., Liong E.C., Lau T.H.Y., Fung P.C.W., Leung K.M., Overexpression of BMP-2/4,-5 and BMPPR-IA associated with oral epithelium, European Journal of Cancer, Oral Oncology. 2001, 37: 225-233.

Jin Y., Tipoe G.L., Liong E.C., Lau T.Y.H., Fung P.C.W., Overexpression of BMP-2/4,-5 and BMPR-IA was Associated with Malignancy of Oral Epithelia, Oral Oncology. 2000, 37: 225-233.

Lam W.K., Chan L.Y., Leung R., Fung P.C.W., Zheng L., Lam C.L., Shum I.H.Y., Ho J.C.M., Ip S., Ip M.S.M., Tsang K.W.T., Exhaled nitric oxide levels in steady state bronchiectasis : a prospective study, European Respiratory Journal. 2000, 16 (Suppl 1): 399S.

Lam W.K., Chan L.Y., Fung P.C.W., Zheng L., Shum I.H.Y., Leung R., Ho J.C.M., Ip S., Wang J., Ip M.S.M., Tsang K.W.T., Is there a correlation between nitric oxide (NO) in exhaled air, sputum, serum, saliva and urine of bronchiectatic patients?, European Respiratory Journal. 2000, 16(Suppl 31): 399S.

Lan X.R., Hui W.C., Chen Y.X., Wong B.C.Y., Metz C., Bucala R., Fung P.C.W., Lam S.K., Lan H.Y., Macrophage migration inhibitory factor is an important medicator in gastric inflammatory disease [Oral presentation, 6th Medical Research Conference, Department of Medicine, University of Hong Kong, 13-14 January], The Hong Kong Practitioner. 2001, 23 (2-suppl): 45.

Lui S.L., Loretta Chan Y.Y., Zhang X.H., Zhu W., Chan D.T.M., Fung P.C.W., Lai K.N., Effect of mycophenolate mofetil on nitric oxide production and inducible nitric oxide synthase gene expression during renal ischaemia-reperfusion injury, Nephrology Dialysis Transplantation. 2001, 16: 1-6.

Mok M.Y., Wong W.Y., Ooi C.G.C., Lam Y.M., Tse H.F., Chan S., Tsang K.W.T., Fung P.C.W., Wong R.W.S., Lau W.C.S., Exhaled and serum nitric oxide measurement in patients with systemic sclerosis complicated by interstitial lung involvement, Hong Kong Practitioner. The Hong Kong Practitioner, 2001, 23 (2) Supple: 68.

Pei Z., Chen S., Fung P.C.W., Cheung R.T.F., Melatonin abolishes the increase in nitric oxide production during cerebral ischemia in the rat, 7th Hong Kong International Cancer Congress and 5th Research Postgraduate Symposium, 7 to 9 December 2000. 2.12.

Pei Z., Fung P.C.W., Cheung R.T.F., Melatonin protects against focal cerebral ischemia in rats via inhibition of ischemia-induced overproduction of nitric oxide, Hong Kong Practitioner. 2001, 23 (suppl 2): 63.

Peng Y., Kok K.H., Xu R.H., Kwok K., Tay D., Fung P.C.W., Kung H., Lin M.C., Maternal cold inducible RNA binding protein is required for embryonic kidney formation in Xenopus laevis, Federation of European Biochemical Societies Letters. 2000, 482: 37-43.

Tsang K.W.T., Shum H.Y.I., Ho J.C.M., Leung Y.H., Taylor G., Zheng L., Tipoe G.L., Chan L.Y., Fung P.C.W., Lam W.K., Downregulation of endothelin (ET)-1 and interleukin (IL)-8 expression in human respiratory mucosa by Pseudomonas aeruginosa pyocyanin and 1-hydroxy-phenazine, Hong Kong Practitioner. 2001, 23 Suppl 2: 67.

Tsang K.W.T., Ip S.K., Leung Y.H., Tipoe G.L., Chan L.Y., Shum H.Y.I., Zheng L., Yan C.P.K., Fung P.C.W., Lam W.K., Exhaled NO: effects of age, gender and body size, American Journal of Respiratory and Critical Care Medicine. 2001, 163 (5): A50.

Tsang K.W.T., Ip M.S.M., Fung P.C.W., Zheng L., Shum H.Y.I., Leung Y.H., Chan L.Y., Tipoe G.L., Ooi C.G.C., Ho J.C.M., Lam W.K., Pseudomonas aeruginosa infection is associated with reduced exhaled NO in bronchiectasis, American Journal of Respiratory and Critical Care Medicine. 2001, 163 (5): A671.

Tsang K.W.T., Ip S.K., Fung P.C.W., Ooi C.G.C., Shum H.Y.I., Leung Y.H., Chan L.Y., Tipoe G.L., Zheng L., Ip M.S.M., Ho J.C.M., Chan M.M.W., Lam W.K., Pseudomonas aeruginosa infection is associated with reduced exhaled NO in bronchiectasis, Hong Kong Practitioner. 2001, 23 Suppl 2: 30.

Tsang K.W.T., Leung Y.H., Taylor G., Tipoe G.L., Chan L.Y., Shum H.Y.I., Fung P.C.W., Lam W.K., Pseudomonas aeruginosa pyocyanin and 1-hydroxyphenazine downregulate endothelin-1 and interleukin-8 expression in human respiratory mucosa, American Journal of Respiratory and Critical Care Medicine. 2001, 163 (5): A671.

Tsang K.W.T., Ip S.K., Leung Y.H., Tipoe G.L., Chan L.Y., Shum H.Y.I., Zheng L., Yan C.P.K., Fung P.C.W., Lam W.K., The effects of gender on exhaled NO production among volunteers, Hong Kong Practitioner. 2001, 23 Suppl 2: 28.

Wang Y., Ho D.S.W., Gao R.L., Shen W.F., Du Z.M., Hou Y.Q., Fung P.C.W., Experience with Gianturco-Roubin II Stenting in 132 Patients: Good Acute Results but Suboptimal Long-Term Outcome, Chinese Medical Journal. 2001.

Wong G.W., Kok K.H., Kwok K.H., Fung P.C.W., Knoops B., Kung H., Lin M.C., Antioxidant enzymes protect Xenopus laevis embryos against alcohol-induced neural injury, 7^th Annual Meeting of The Oxygen Society, San Diego, USA, Nov 16-20. 2000.

Zhu W., Fung P.C.W., The Roles Played by Crucial Free Radicals like Lipid Free Radicals, Nitric Oxide, Enzymes NOS and NADPH in CC14-Induced Acute Liver Injury of Mice, Free Radical Biology & Medicine. 2000, 29: 870-880.

Researcher : Fung TK

List of Research Outputs

Leung A.Y.H., Chow C.H., Kwong Y.L., Lie A.K.W., Fung T.K., Chow W.H., Yip A.S.B., Liang R.H.S., Genetic polymorphism at exon 4 of cytochrome P450CYP2C9 in Chinese patients might determine the warfarin dose requirement., 42nd Annual Meeting of the American Society of Hematology. San Francisco.. 2000.

Researcher : Ho DSW

List of Research Outputs

Ho D.S.W., Wang Y., Chui M., Ho S.L., Cheung R.T.F., Epileptic seizures attributed to cerebral hyperperfusion after percutaneous transluminal angioplasty and stenting of the internal carotid artery, Cerebrovascular Diseases. 2000, 10: 374-379.

Ho D.S.W., Wang Y., Chui M., Wang Y., Ho S.L., Cheung R.T.F., Intracarotid Abciximab injection to abort impending ischemic stroke during carotid angioplasty, Cerebrovascular Diseases. 2001, 11: 300-304.

Ho D.S.W., Wang Y., Wang Y.Q., Zhang R.Y., Chui M., Multivessel Spasm During Coronary and Peripheral Angiography, In: Ho DSW Wang Y Wang YQ Zhang RY Chui M, The Journal of Invasive Cardiology. 2001, 13: 320-322.

Ho D.S.W., Renal Angioplasty: Why, Whom, When, In: Ho DSW, ACTA Cardiologica Sinica, Taiwan. 2001, 17:suppl: 52-53.

Wang Y., Ho D.S.W., Gao R.L., Shen W.F., Du Z.M., Hou Y.Q., Fung P.C.W., Experience with Gianturco-Roubin II Stenting in 132 Patients: Good Acute Results but Suboptimal Long-Term Outcome, Chinese Medical Journal. 2001.

Wholey M.H., Wholey M., Mathias K., Roubin G.S., Diethrich E.B., Henry M., Bailey S., Bergeron P., Dorros G., Eles G., Gaines P., Gomez C.R., Gray B., Guimaraens J., Higashida R., Ho D.S.W., Katzen B., Kambara A., Kumar V., Laborde J.C., Leon M., Lim M., Londero H., Mesa J., Global Experience in Cervical Carotid Artery Stent Placement, Catheterization and Cardiovascular Interventions. New York, USA, Wiley-Liss, 2001, 50: 1522-1946.

Researcher : Ho ECM

List of Research Outputs

Ho E.C.M., Lam K.S.L., Chung S.S.M., Chung S.K., Aldose reductase-deficient mice are alleviated from the depletion of GSH in the peripheral nerve and MNCV deficit associated with diabetes, 61st American Diabetes Association meeting, Philadelphia, USA. 2001, 238OR.

Ho E.C.M., Lam K.S.L., Chung S.S.M., Chung S.K., Aldose reductase-deficient mice are protected from motor nerve conduction deficit associated with diabetes, 13^th Annual Scientific Meeting of the Hong Kong Society of Endocrinology, Metabolism and Reproduction, December 3. 2000.

Ho E.C.M., Lam K.S.L., Chung S.S.M., Chung S.K., Aldose reductase-deficient mice are protected from reduction of nerve conduction associated with diabetes, Fifth Diabetic Neuropathy Satellite to the International Diabetes Federation Congress 2000, San Jose, Costa Rica, October 31 - November 4. 2000.

Researcher : Ho JCS

List of Research Outputs

Ho J.C.S., Lam W.K., Ooi C.G.C., Lam B., Tsang K.W.T., Lymphoepithelioma-like carcinoma of the lung., Respiratory Medicine. 2000, 94(10): 943-947.

Researcher : Ho PC

List of Research Outputs

Cheung B.M.Y., Ho P.C., Lau C.P., Diastolic blood pressure is related to sodium intake in hypertensive Chinese, Quarterly Journal of Medicine. 2000, 93: 163-168.

Cheung B.M.Y., Cheung A.H.K., Ho P.C., Lau C.P., Kumana C.R., Drug utlisation in a hypertension outpatient clinic 1996-1999, Hong Kong Practitioner. 2000, 22 (Suppl): 4.

Cheung B.M.Y., Ho P.C., Lau C.P., Randomised placebo-controlled study of the effect of fosinopril on left ventricular mass in untreated hypertensive patients: final results, Hong Kong Practitioner. 2000, 22 (Suppl): 34.

Ho P.C., Tse H.F., Lau C.P., Hettrick D.A., Mehra R., Effects of different atrioventricular intervals during dual-site right atrial pacing on left atrial mechanical function, Pacing and Clinical Electrophysiology. 2000, 23: 1748-1751.

Yu C.M., Lau C.P., Yang H., Wang Q., Lee S.W.L., Chan R.H.W., Lam L., Lam Y.M., Lee P.Y., Jim M.H., Ng W., Tse H.F., Lee K.L.F., Ho P.C., Lam R.W.F., "Isolated" left ventricular diastolic dysfunction - The condition need to be redefined, The Hong Kong Practitioner. 2001, 23 no. 2: 1.

Researcher : Ho SL

Project Title:	Differential expressed genes with estrogen in human glial cells after MPTP-induced neurotoxicity
Investigator(s):	Dr. Ho S.L. , Dr. Feng Z.H.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	July 1999

Abstract:

To explore the molecular mechanisms by which estrogen produces its neuroprotective effects in our homogenous human glial cell line by determining the differential gene expression using a combination of subtractive hybridization and selective gene product amplification technique.

Project Title:	Estrogenic modulation of human catecholamine-O-methyltransferase (COMT): its relevance in Parkinson's disease (PD)
Investigator(s):	Dr. Ho S.L. , Dr. Feng Z.H., Dr. Ramsden D.B., Dr. Yip H.K.F.
Department:	Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	September 2000

Abstract:

Parkinson's disease (PD) is characterized by neurodegeneration that leads to dopamine depletion. The cause is unknown, and gender differences appeared in PD. The present study will explore the role of estrogen, specifically, the hypothesis that estrogen-mediated COMT inhibition being a contributory factor to the gender and menstrual-related differences in PD.

List of Research Outputs

Feng Z., Guan X., Ho S.L., Ramsden R.B., Jiang H., Tang T., Sham J.S.T., Different expressions of human Catechol-O-methyltransferase gene are correlated with the phosphorylation of cyclic AMP regulatory element binding protein., European Journal of Neuroscience. 2000, 12(suppl 11): 402.

Feng Z., Kong L.Y., Qi Q.P., Ho S.L., Tiao N.Y., Bing G.Y., Han Y.F., Induction of unspliced cfos messenger RNA in rodent brain by kainic acid and lipopolysaccharide., Neuroscience Letters. 2001, 305: 17-20.

Fong G.C.Y., Fong K.Y., Ho W.Y., Mak W., Tsang K.L., Chan K.H., Cheung R.T.F., Ho S.L., Postictal psychosis related regional cerebral hyperperfusion., Journal of Neurology Neurosurgery & Psychiatry.. 2000, 68: 100-101.

Ho D.S.W., Wang Y., Chui M., Ho S.L., Cheung R.T.F., Epileptic seizures attributed to cerebral hyperperfusion after percutaneous transluminal angioplasty and stenting of the internal carotid artery, Cerebrovascular Diseases. 2000, 10: 374-379.

Ho D.S.W., Wang Y., Chui M., Wang Y., Ho S.L., Cheung R.T.F., Intracarotid Abciximab injection to abort impending ischemic stroke during carotid angioplasty, Cerebrovascular Diseases. 2001, 11: 300-304.

Ho S.L., Cheng P.W., Wong W.C., A case-controlled MRI/MRA study of neurovascular contact in hemifacial spasm., Neurology. Neurology, 2000, 55: 156.

Jiang H., Feng Z., Ramsden D.B., Ho S.L., Effects of estrogen on human Catechol-O-methyltransferase gene, 6th International Congress of Parkinson's Disease and Movem. Barcelona, Spain., 2000.

Li L.S.W., Chiu K., Leung K.P., Cheung R.T.F., Ho S.L., Prediction of dysphagic recovery after stroke, Neurological Journal of South East Asia. 2001, 5: 78.

Li L.S.W., Chiu K., Leung K.P., Cheung R.T.F., Ho S.L., Prediction of recovery of swallowing disorder in stroke patients after rehabilitation, Hong Kong Practitioner. 2001, 23 (suppl 2): 24.

Li L.S.W., Leung K.P., Cheung R.T.F., Lee T., Kwok T.H., Ho C.T.K., Ho S.L., Remission of post-stroke alien hand syndrome during rehabilitation., International Society of Physical and Rehabilitation Medicine. Amsterdam, Netherlands., International Society of Physical and Rehabilitation Medicin, 2001.

Mak W., Mok K.Y., Tsoi T.H., Cheung R.T.F., Ho S.L., Chang C.M., Cerebral venous thrombosis in Hong Kong, Cerebrovascular Diseases. 2001, 11: 282-283.

Mak W., Ho S.L., Impact of Molecular Biology on Clinical Neurology, Hong Kong Medical Journal. Hong Kong, Hong Kong Medical Journal, 2001, 7: 40-49.

Pow E.H.N., Leung K.C.M., Mcmillan A.S., Wong M.C.M., Li L.S.W., Ho S.L., Oral stereognosis in stroke and Parkinson's disease: a comparison of partially dentate and edentulous individuals, Clinical Oral Investigations. Germany, 2001, 5: 112-117.

Ramsden D.B., Parsons R.B., Ho S.L., Xie T., Waring R.H., Williams A.C., Further studies in xenobiotic metabolism and Parkinson's disease. In: Parkinson's disease. Advances in Neurology., In: D Calne, S Calne, Eds, Philadelphia, Lippincott Williams and Wilkins, 2000, 86: 105-113.

Tsang K.L., Ho S.L., Lo S.K., Estrogen improves motor disability in postmenopausal women with Parkinson's disease associated with motor fluctuations, Neurology. 2000, 54(12): 2292-2298.

Tsang K.L., Hung K.N., Ho S.L., Subthalamic nucleus deep brain stimulation in idiopathic Parkinson's disease; a regional hospital experience in Hong Kong, 4th International Congress of Parkinson's Disease.. Helsinki, Finland., 2001.

Tsang K.L., Ho S.L., Surgical treatment of Parkinson's Disease: an update, Neurology. Medical Progress, 2001, 28(6): 9-14.

Tsang K.L., Jiang H., Ramsden D.B., Ho S.L., The use of estrogen in the treatment of Parkinson's disease. Parkinsonism & Related Disorders, Parkinsonism & Related Disorders. 2001, 8(2): 133-137.

Wong P.C.M., Diehl R.L., Ho S.L., Li L.S.W., Tsang K.L., Perception of Cantonese Parkinsonian Speech., Journal of the Acoustical Society of America,. 2001, 109(5): 2314.

Researcher : Hu HC

Project Title:	A study to validate a symptom severity questionnaire for patents with functional dyspepsia
Investigator(s):	Dr. Hu W.H.C. , Dr. Lam C.L.K.
Department:	Medicine
Source(s) of Funding:	Health Services Research Fund
Start Date:	October 1998

Abstract:

To develop and validate an instrument to measure the severity of symptoms in patients with functional dyspepsia.

List of Research Outputs

Tsang K.W.T., Lam W.K., Chan K.N., Hu H.C., Wu A.Y.Y., Kwok E.N.L., Zheng L., Wong B.C.Y., Lam S.K., Helicobacter pylori sero-prevalence in asthma, Respiratory Medicine. 2000, 94: 756-60.

Wong B.C.Y., Wong W.M., Wang W.H., Tang V.S.Y., Young J., Lai K.C., Yuen S.T., Leung S.Y., Hu H.C., Chan C.K., Hui W.M., Lam S.K., An evaluation of invasive and non-invasive tests for the diagnosis of Helicobacter pylori infection in Chinese, Alimentary Pharmacology and Therapeutics. 2000, 15(4): 505-511.

Wong B.C.Y., Chan C.K., Wong K.W., Wong W.M., Yuen M.F., Lai K.C., Hu H.C., Lau G.K.K., Lai C.L., Lam S.K., Evaluation of a new referral system for the management of dyspepsia in Hong Kong: role of open-access upper endoscopy., Journal of Gastroenterology & Hepatology. 2000, 15(11): 1251-1256.

Wong B.C.Y., Wong K.W., Chan C.K., Wong W.M., Yuen M.F., Lai K.C., Hu H.C., Lau G., Lai C.L., Lam S.K., Evaluation of new referral system for the management of dyspepsia in Hong Kong: Role of open access uper endoscopy, Journal of Gastroenterology and Hepatology. 2000, 15: 1251-1256.

Wong B.C.Y., Wong W.M., Wang W.H., Fung F.M.Y., Lai K.C., Chu K.M., Yuen S.T., Leung S.Y., Hu H.C., Yuen M.F., Lau G., Chan C.K., Lam S.K., One-week Ranitidine Bismuth Citrate-based triple therapy for the eradication of Helicobacter pylori in Hong Kong with high prevalence of metronidazole resistance, Alimentary Pharmoacology and Therapeutics. 2001, 15: 403-409.

Wong B.C.Y., Wang W.H., Lau G., Wong W.M., Fung F.M.Y., Kung N.N.S., Chu K.M., Lai K.C., Hu H.C., Hu F.L., Liu X.G., Chan C.K., Yuen M.F., Hui W.M., Lam S.K., Three-day lansoprazole quadruple therapy for Helicobacter pylori-positive duodenal ulcers: a randomized contolled study [Oral presentation, 6th Medical Research Conference, Department of Medicine, 13-14 January], The Hong Kong Practitioner. 2001, 23 (2-suppl): 18.

Wong W.M., Wong B.C.Y., Wong K.W., Fung F.M.Y., Lai K.C., Hu H.C., Yuen S.T., Leung S.Y., Lau G.K.K., Lai C.L., Chan C.K., Go R., Lam S.K., ¹³C-urea breath test without a test meal is highly accurate for the detection of Helicobacter pylori infection in Chinese, Alimentary Pharmacology and Therapeutics. 2000, 14: 1353-1358.

Researcher : Hui SL

List of Research Outputs

Chu L.W., Lam K.S.L., Tam S.C.F., Hu W., Hui S.L., Chin A., Chiu K.C., Ng P., A randomised controlled trial of low dose recombinant human growth hormone in the treatment of malnourished elderly patients., Journal of Clinical Endocrinology & Metabolism. 2001, 86: 1913-1920.

Researcher : Hui WC

List of Research Outputs

Lan X.R., Hui W.C., Chen Y.X., Wong B.C.Y., Metz C., Bucala R., Fung P.C.W., Lam S.K., Lan H.Y., Macrophage migration inhibitory factor is an important medicator in gastric inflammatory disease [Oral presentation, 6th Medical Research Conference, Department of Medicine, University of Hong Kong, 13-14 January], The Hong Kong Practitioner. 2001, 23 (2-suppl): 45.

Researcher : Hui WM

List of Research Outputs

Chan A.O.O., Lam S.K., Chu K.M., Lam C.M., Kwok E.N.L., Leung S.Y., Yuen S.T., Law S.Y., Hui W.M., Lai K.C., Wong B.C.Y., Hu W.C.H., Lai C.L., Wong J., Soluble E-cadherin is a valid prognostic marker in gastric carcinoma., Gut. 2001, 48(6): 808-811.

Chan A.O.O., Lam S.K., Chu K.M., Lam C.M., Kwok E., Leung S.Y., Yuen S.T., Law S.Y.K., Hui W.M., Lai C.L., Wong C.Y., Hu H.C., Lai C.L., Wong J., Soluble E-cadherin is a valid prognostic marker in gastric carcinoma, Gut. 2001, 48: 808-811.

Lai K.C., Lam S.K., Hui W.M., Wong C.Y., Chu K.M., Wong W.M., Chan O.O., Lai C.L., Lau K.K., Yuen M.F., Chan C.K., Lansoprazole reduces ulcer relapse after eradication of Helicobacter pylori in NSAIDs users, Gastroenterology. 2000, 118(Supp 2): A251.

Wang W.P., Fan X.M., Lam S.K., Cho C.H., Lin M.C., Kung H., Hui W.M., Wong B.C.Y., Inhibition of 12-lipoxygenase induced apoptosis in human gastric cancer cells, Proceedings, Second Joint Scientific Meeing, Hong Kong Society of Gastroenterology, Hong Kong Society of Digestive Endosocpy, Hong Kong Society for Colopractology,2 September. 2000.

Wong B.C.Y., Wong W.M., Wang W.H., Tang V.S.Y., Young J., Lai K.C., Yuen S.T., Leung S.Y., Hu H.C., Chan C.K., Hui W.M., Lam S.K., An evaluation of invasive and non-invasive tests for the diagnosis of Helicobacter pylori infection in Chinese, Alimentary Pharmacology and Therapeutics. 2000, 15(4): 505-511.

Wong B.C.Y., Wang W., Berg D.E., Fung F.M.Y., Wong K.W., Wong W.M., Lai K.C., Cho C.H., Hui W.M., Lam S.K., High prevalence of mixed infections by Helicobacter pylori in Hong Kong: metronidazole sensitivity and overall genotype, Alimentary Pharmacology and Therapeutics. 2000, 15: 493-503.

Wong B.C.Y., Wang W.H., Lau G., Wong W.M., Fung F.M.Y., Kung N.N.S., Chu K.M., Lai K.C., Hu H.C., Hu F.L., Liu X.G., Chan C.K., Yuen M.F., Hui W.M., Lam S.K., Three-day lansoprazole quadruple therapy for Helicobacter pylori-positive duodenal ulcers: a randomized contolled study [Oral presentation, 6th Medical Research Conference, Department of Medicine, 13-14 January], The Hong Kong Practitioner. 2001, 23 (2-suppl): 18.

Zhou X.M., Lai K.C., Lam S.K., Zhang H.B., Lan X.R., Fan X.M., Hui W.M., Fan D.M., Wong B.C.Y., Induced gastric mucosal apoptosis in Helicobacter pylori positive patients taking low lose aspirin: a 6-month case-control study, Proceedings, Second Joint Scientific Meeting, Hong Kong Society of Gastroenterology, Hong Kong Society of Digestive Endoscopy, Hong Kong Society for Coloproctology, 2 September. 2000.

Researcher : Ip MSM

Project Title:	Role of cytokines and adhesion molecules in the inflammatory response of bronchiectasis
Investigator(s):	Prof. Ip M.S.M. , Prof. Lam W.K., Dr. Shum D.K.Y., Dr. Tsang K.W.T.
Department:	Medicine
Source(s) of Funding:	Lee Wing Tat Cardiothoracic Research and Education Fund
Start Date:	January 1996

Abstract:

To study the profile and actions of cytokines and cell adhesion molecules in the chronic and acute on chronic inflammatory response in bronchiectasis.

Project Title:	The interaction of airway secretions and bronchial epithelial cells in the regulation of airway inflammation in bronchiectasis
Investigator(s):	Prof. Ip M.S.M. , Prof. Lam W.K., Dr. Tsang K.W.T.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	July 1998

Abstract:

To evaluate pro-inflammatory cytokine release (IL-6, IL-8, GM-CSF) by bronchial epithelial cells in the context of chronic bronchial infection; to evaluate the modification of this release by drugs.

Project Title:	Role of nitric oxide and endothelin in the regulation of haemodynamic homeostasis in obstructive sleep apnoea
Investigator(s):	Prof. Ip M.S.M. , Prof. Fung P.C.W., Prof. Lam W.K., Dr. Tsang K.W.T., Dr. Zheng L.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	July 1999
Completion Date:	August 2000

Abstract:

To investigate the possible roles of nitric oxide and endothelin in the regulation of blood pressure in OSA.

Project Title:	The role of cell adhesion molecule in persistent neutrophil recruitment in bronchiectasis and in-vitro evaluation of modulating effect of therapeutic agents
Investigator(s):	Prof. Ip M.S.M. , Prof. Lam W.K., Dr. Tsang K.W.T., Dr. Zheng L.
Department:	Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	September 1999

Abstract:

To investigate the mechanisms by which neutrophils are persistently recruited into the airways of patients with idiopathic diffuse bronchiectasis, focussing on aspects of neutrophil cell adhesion molecule expression by endothelial cells and epithelial cells in the context of the biological mileau of patients; to examine the modulatory effects of drugs on the above mechanisms.

Project Title:	Randomised controlled study of the effectiveness of treatment in mild to moderate sleep apnoea
Investigator(s):	Prof. Ip M.S.M. , Prof. Cooke M.S., Prof. Karlberg J.P.E., Prof. Lam W.K., Dr. Lam C.L.K., Dr. Tsang K.W.T., Dr. Yam L.Y.C.
Department:	Medicine
Source(s) of Funding:	Health Services Research Fund
Start Date:	December 1999

Abstract:

To evaluate the effectiveness of active treatment (with nasal continuous positive airway pressure or oral appliance) versus conservative management only in patients with mild to moderate sleep apnoea

Project Title:	Development of a mouse model of obstructive sleep apnoea (OSA) for future basic research work on vascular pathogenesis in OSA
Investigator(s):	Prof. Ip M.S.M. , Prof. Fung P.C.W.
Department:	Medicine
Source(s) of Funding:	RGC Fundable Projects (Block Grant Funded)
Start Date:	November 2000

Abstract:

To develop a mouse model of obstructive sleep apnea which can be utilized for investigation of various basic pathological mechanisms in the condition; to develop methodology for monitoring the activity of brain wave, blood gaseous exchange and haemodynamics in the mouse model.

Project Title:	Study of the mechanisms of vascular homeostasis in obstructive sleep apnoea
Investigator(s):	Prof. Ip M.S.M. , Prof. Kwong Y.L., Prof. Lam W.K., Dr. Tsang K.W.T., Dr. Tse H.F.
Department:	Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	December 2000

Abstract:

To evaluate some basic mechanisms with a study protocol that examines changes in vascular mediators, platelet activity, vascular reactivity and haemodynamic/breathing profile during sleep in obstructive sleep apnoea (OSA) subjects compared to normal controls as well as in OSA subjects before and after treatment with nasal continuous positive airway pressure (nCPAP).

List of Research Outputs

Chan K.N., Ip M.S.M., Law B., Wu A.Y.Y., Chan M.M.W., Tsang K.W.T., Lee S.L., Chan E., Siu E., Lam W.K., Effectiveness of an asthma education program, American Journal of Respiratory and Critical Care Medicine. 2000, 161: A320.

Chan L.Y., Fong D.Y.T., Lam C.L.K., Chan-Yeung M., Say J., Yan C.P.K., Leung R., Ooi C.G.C., Ip M.S.M., Lam W.K., Tsang K.W.T., Validation of the Hong Kong Chinese Version of St. George's Respiratory Questionnaire (SGRQ), Medical Research Conference 13-14 January 2001. Hong Kong.

Cheung Y.B., Karlberg J.P.E., Low L.C.K., Ip M.S.M., Letter to the editor - Birth weight and adult lung function in China, Thorax. 2001, 56: 85.

Ho J.C.M., Tsang K.W.T., Lam B., Lam C.L., Wang J., Ip S., Yan C.P.K., Ip M.S.M., Chan M.M.W., Lam W.K., A multicentre Asian trial of docetaxel and cisplatinin advanced non-small cell lung cancer, Hong Kong Practitioner. 2001, 23 Suppl 2: 29.

Ho J.C.M., Lam W.K., Ip M.S.M., Nguyer T., Tsang K.W.T., Phase II trial of taxotere and cisplatin in advanced non-small cell lung cancer, Lung Cancer. 2000, 29(Suppl 1): 44 (abst 141).

Ip M.S.M., Lam B., Lauder I.J., Tsang K.W.T., Chung K.F., Mok W.Y.W., Lam W.K., A community study of sleep disordered breathing in middle-aged Chinese men in Hong Kong, Chest. 2001, 119: 62-69.

Ip M.S.M., Lam B., Cheng S., Zheng L., Tsang K.W.T., Fung P.C.W., Lam W.K., Circulating nitic oxide is suppressed in obstruvtive sleep apnea and is reversed by nCPAP, American Journal of Respiratory and Critical Care Medicine. 2000, 162: 2166-2171.

Ip M.S.M., Curriculum design, Universitas 21 - Deans' Meeting, Singapore. 2000.

Ip M.S.M., Wat N.M.S., Tan K.C.B., Peh W.C.G., Ho J.C.M., Lam K.S.L., Effect of a somatostatin analogue on sleep apnea in acromegaly - correlation with CT cephalometry and hormonal activity, ENDO 2000, Toronto, Canada. June 2000.

Ip M.S.M., End of life decision making, Joint Annual Scientific Meeting of the Australasian College of Physicians & Hong Kong College of Anasthaseia, Hong Kong. 2001.

Ip M.S.M., Highlights of research in respiratory medicine - Hong Kong perspective, National Congress on Respiratory Disease, Chinese Thoracic Society (Chinese Medical Association), Nanjing, China. 2000.

Ip M.S.M., Medical Education Reform: The Hong Kong Experience, Workshop on Medical Curriculum Reform, West China University of Medical Sciences, Chengdu, China. 2000.

Ip M.S.M., Obstructive sleep apnoea and vascular risks, Department of Medicine, National University Hospital, National University of Singapore. 2000.

Ip M.S.M., Obstructive sleep apnoea and vascular risks, Joint Shanghai-Hong Kong Medical Forum, Shanghai Rui Jin Hospital and Dept of Medicine, HKU, Shanghai, China. 2000.

Ip M.S.M., Obstructive sleep apnoea, Joint Annual Scientific Meeting of the Australasian College of Physicians & Hong Kong College of Anasthaesia, Hong Kong. 2001.

Ip M.S.M., Report from Hong Kong, First Workshop on Epidemiological Survey of COPD and alpha-1-antitrypson deficiency in Asian Pacific region, Juntendo University, School of Medicine, Tokyo, Japan. 2000.

Ip M.S.M., Respiratory physiology in sleep disorders, 2nd International Meeting on Respiratory Care, Indonesia. 2000.

Ip M.S.M., Lam K.S.L., Ho C.M., Tsang K.W.T., Lam W.K., Serum leptin and vascular risk factors in obstructive sleep apnoea, Chest. 2000, 118: 582-586.

Ip M.S.M., Sleep apnoea and hypertension - relevance in clinical practice in Asian communities, Journal of American Medical Association (S.E. Asia). 2000, 16(5): 5-6.

Ip M.S.M., Sleep disordered breathing in critical care, 2nd International Meeting on Respiratory Care, Indonesia. 2000.

Ip M.S.M., Syndrome Z - does it exist, Fourth Beijing-Hong Kong Medical Exchange - Diabetes and the Metabolic Syndrome. Beijing July. 2000, Programme & Abstracts: 20.

Ip M.S.M., The Z syndrome - does it exist?, Beijing-Hong Kong Medical Exchange, China Medical Association and Hong Kong Medical Association. Beijing, China. 2000.

Ip M.S.M., Sam K., Cooke M.S., Lam B., The effects and predictors of success of an oral appliance in the treatment of mild to moderate obstructive sleep apnoea, 10th European Respiratory Society Annual Congress, Florance Italy. Aug-Sep 2000. European Respiratory Journal. 2000, 161: 418s(P2979).

Ip M.S.M., Lam B., Ip T.Y., Mok W.Y.W., Tsang K.W.T., Chan M.M.W., Lam W.K., Vascular risk profile in obstructive sleep apnoea, 10th European Respiratory Society Annual Congress, Florence, Italy. Aug - Sep 2000. 161: 274s(P1959).

Kumana C.R., Kou M., Lauder I.J., Ip M.S.M., Lam W.K., Increasing use of inhaled steroids associated with declining asthma mortality, Journal of Asthma. NY, USA, Marcel Dekker, 2001, 38: 161-167.

Lam B., Tsang K.W.T., Lam W.K., Ip M.S.M., Nasal pressure sensor has no better correlation with arousal index than thermistor, Abstract Book of World Congress on Sleep Apnoea. 2000, 13.

Lam B., Ip M.S.M., Sam K., Au C.L., Tsang K.W.T., Lam W.K., Cooke M.S., One year efficacy of oral appliance in treating sleep apnoea has no correlation with the change in cross section of the upper airway, 6th World Congress on Sleep Apnoea, Sydney, Australia. 2000, 93: 119.

Lam C.L., Lam W.K., Tsang K.W.T., Ip M.S.M., Characteristics of young Chinese patients (less than 40 years of age) having carcinoma of lung compared to patients of older age group, Lung Cancer. 2000, 29(Suppl 1): 237 (abst 815).

Lam C.L., Lam W.K., Ip M.S.M., Tsang K.W.T., Lam B., Ho J.C.M., Ip S., Wang J., The use of gemcitabine and cisplatin Chinese patients with advanced non-small cell lung carcinoma (NSCLC), Medical Research Conference, University Department of Medicine, Hong Kong. 2001, 23(Suppl 2): 24 (G-RM-1).

Lam O.B., Ooi C.G.C., Sam K., Lam W.K., Ip M.S.M., Upper airway change after oral appliance in obstructive sleep apnoea patients - difference exist in good and poor responders., Journal of the Japanese Respiratory Society. 2001, 39(S-2): 80.

Lam W.K., Tsang K.W.T., Ip M.S.M., Bronchiectasis : conventional and new, innovative medical treatments, 2nd International Meeting on Respiratory Care (RESPINA 2000), Jakarta, Indonesia. 2000, P.77: T11-1.

Lam W.K., Tsang K.W.T., Ip M.S.M., Chemotherapy for advanced non-small cell lung cancer : role of paclitaxel and gemcitabine, Hong Kong Medical Journal. 2000, 5: 180-186.

Lam W.K., Ho J.C.M., Lam B., Ip M.S.M., Tsang K.W.T., Chemotherapy for stage IIIB and stage IV non-small cell lung cancer (NSCLC) - Hong Kong experience, 9th World Conference on Lung Cancer (Tokyo, Japan 2000) Satellite Symposium - Recent Trends in the Management of Lung Cancer. 2000, abstract: p, 5.

Lam W.K., Chan L.Y., Leung R., Fung P.C.W., Zheng L., Lam C.L., Shum I.H.Y., Ho J.C.M., Ip S., Ip M.S.M., Tsang K.W.T., Exhaled nitric oxide levels in steady state bronchiectasis : a prospective study, European Respiratory Journal. 2000, 16 (Suppl 1): 399S.

Lam W.K., Wong M.P., Lung M.L., Tsang K.W.T., Ip M.S.M., Fu K.H., Chiu S.W., Yew W.W., Genetic changes in non-smoking Chinese women with lung cancer, Lung Cancer. 2000, 29(Suppl 2): 65.

Lam W.K., Chan L.Y., Fung P.C.W., Zheng L., Shum I.H.Y., Leung R., Ho J.C.M., Ip S., Wang J., Ip M.S.M., Tsang K.W.T., Is there a correlation between nitric oxide (NO) in exhaled air, sputum, serum, saliva and urine of bronchiectatic patients?, European Respiratory Journal. 2000, 16(Suppl 31): 399S.

Ng J.K.F., Ip M.S.M., Ho E.T.F., Gong Z., Xiong Y., Coagulation and cytokine profile after major hepatobiliary surgery in Chinese Patients, Hepatogastroenterology. Greece, 2000, 47: 1067-1071.

Peh W., Ip M.S.M., Chu F., Chung K.F., Computed tomographic cephalometric analysis of Chinese patients with obstructive sleep apnoea, Australasian Radiology. 2000, 44: 417-423.

Shum D.K.Y., Chan C.H., Ip M.S.M., Neutrophil-mediated degradation of lung proteoglycans: stimulation by TNF-a in sputum of patients with bronchiectasis, American Journal of Respiratory and Critical Care Medicine. 2000, 162: 1925-1931.

Tsang K.W.T., Ip M.S.M., Ho P.L., Opportunistic Pulmonary Infections, Clinical Respiratory Medicine. 2000, 2nd edition: 91-103.

Tsang K.W.T., Ip M.S.M., Fung P.C.W., Zheng L., Shum H.Y.I., Leung Y.H., Chan L.Y., Tipoe G.L., Ooi C.G.C., Ho J.C.M., Lam W.K., Pseudomonas aeruginosa infection is associated with reduced exhaled NO in bronchiectasis, American Journal of Respiratory and Critical Care Medicine. 2001, 163 (5): A671.

Tsang K.W.T., Ip S.K., Fung P.C.W., Ooi C.G.C., Shum H.Y.I., Leung Y.H., Chan L.Y., Tipoe G.L., Zheng L., Ip M.S.M., Ho J.C.M., Chan M.M.W., Lam W.K., Pseudomonas aeruginosa infection is associated with reduced exhaled NO in bronchiectasis, Hong Kong Practitioner. 2001, 23 Suppl 2: 30.

Wang J., Lam W.K., Ho J.C.M., Ip M.S.M., Tsang K.W.T., Paclitaxel and carboplatin in advanced non-small cell lung carcer (NSCLC), Hong Kong experience, Medical Research Conference, University Department of Medicine, Hong Kong. 2001, 23(Suppl 2): 25 (G-RM-3).

Zheng L., Lam W.K., Shum H.Y.I., Tipoe G.L., Yan C., Ip M.S.M., Tsang K.W.T., Overexpression of metalloproteinase-8 and -9 in bronchiectatic airways in vivo, The Hong Kong Practitioner. 2001, 2: 64.

Researcher : Ip TY

List of Research Outputs

Ip M.S.M., Lam B., Ip T.Y., Mok W.Y.W., Tsang K.W.T., Chan M.M.W., Lam W.K., Vascular risk profile in obstructive sleep apnoea, 10th European Respiratory Society Annual Congress, Florence, Italy. Aug - Sep 2000. 161: 274s(P1959).

Researcher : Jiang X

List of Research Outputs

Jiang X., Wong B.C.Y., Yuen S.T., Jiang S.H., Cho C.H., Lai K.C., Lin M.C., Kung H., Lam S.K., Arsenic trioxide induces apoptosis in human gastric cancer cells through up-regulation of P53 and activation of caspase-3, International Journal of Cancer. 2001, 91: 173-179.

Jiang X., Lam S.K., Lin M.C., Cho C.H., Lai K.C., Kung H., Yang D., Wong B.C.Y., P53 status determines nuclear factor-kappa B response in Triptolide-induced apoptosis in gastric cancer [Poster presentation, 92nd Annual meeting of the American Association of Cancer Research], Proceedings of American Association of Cancer Research Annual Meeting. 2001, 42: 659.

Jiang X., Lam S.K., Lin M.C., Cho C.H., Lai K.C., Kung H., Yang D., Wong B.C.Y., p53 status determines nuclear factor-kappa B response in Triptolide-induced apoptosis in gastric cancer (poster presentation), 92nd Annual meeting of the American Association of Cancer Research (March 24-28, 2001) Proceedings of American Association of Cancer Research Annual Meeting. 2001, 42: 659.

Jiang X., Lam S.K., Lin M.C., Cho C.H., Lai K.C., Kung H., Yang D., Wong B.C.Y., p53 status determines nuclear factor-kb response in triptolide-induced apoptosis in gastric cancer, The 92nd Annual meeting of the American Association for Cancer Research, New Orleans, USA, March 24-28. 2001.

Wong B.C.Y., Jiang X., Zhu G.H., Lin M.C., Kung H., Lam S.K., Chemoprevention of gastric cancer through modulation of Protein Kinase C by non-steroidal anti-inflammatory drugs, 5th International Symposium on Predictive Oncology and Therapy. Impact of Biotechnology on Cancer Diagnostic & Prognostic Indicators, organised by the International Society for Preventive Oncology, Geneva, Switzerland, October 28-31. 2000.

Researcher : Jiang X

List of Research Outputs

Researcher : Kou M

List of Research Outputs

Kumana C.R., Kou M., Ching T.Y., Kong Y., Ma E., Lee R.A., Cheng C.C., Chiu S.S.S., Seto W.H., Curbing inappropriate vancomycin usage by immediate concurrent feedback, VII World Conference on Clinical Pharmacology & Therapeutics & 4th Congress of the European Association for Clinical Pharmacology & Therapeutics. 2001.

Kumana C.R., Kou M., Lauder I.J., Ip M.S.M., Lam W.K., Increasing use of inhaled steroids associated with declining asthma mortality, Journal of Asthma. NY, USA, Marcel Dekker, 2001, 38: 161-167.

Kumana C.R., Chan M.M.Y., Kou M., Ma J.T.C., Interaction of dietary guar gum with Beta-blockers, In: Bridging Cardiovascular Science & Medicine, October 1999, 2000.

Researcher : Kumana CR

Project Title:	Cyclosporin dosage and co-treatment with diltiazem in renal transplant patients
Investigator(s):	Prof. Kumana C.R. , Prof. Chan D.T.M., Prof. Janus E.D., Dr. Lauder I.J., Dr. Li C.S., Dr. Tong M.K.L., Prof. Walley T.
Department:	Medicine
Source(s) of Funding:	Health Services Research Fund
Start Date:	November 1997

Abstract:

To determine whether in renal transplant patients, co-treatment with diltiazem results in a clinically and statistically significant reduction in cyclosporin (Neoral-R) dosage requirement and improved overall cost-effectiveness of treatment.

Project Title:	Cyclosporin dosage and co-treatment with diltiazem in renal transplant patients
Investigator(s):	Prof. Kumana C.R. , Prof. Chan D.T.M., Prof. Janus E.D., Dr. Lauder I.J., Dr. Li C.S., Dr. Tong M.K.L., Prof. Walley T.
Department:	Medicine
Source(s) of Funding:	Hospital Authority
Start Date:	November 1997

Abstract:

List of Research Outputs

Ambekar C.S., Cheung B., Lee J.S.K., Chan L.C., Liang R.H.S., Kumana C.R., Metabolism of chloramphenicol succinate in human bone marrow, European Journal of Clinical Pharmacology. 2000, 56: 405-409.

Chau J., Cheung B.M.Y., McGhee S.M., Lauder I.J., Lau C.P., Kumana C.R., Cost-effectiveness and cost-utility of statins inpatients with CHD and average cholesterol levels applied to Hong Kong, The Hong Kong Practitioner. 2001, 23: 9.

Cheung B.M.Y., Leung Y.H., Lau C.P., Kumana C.R., Angiotensin-converting enzyme genotypes in hypertensive patients with left ventricular hypertrophy, American Journal of Hypertension. 2000, 13(4) II: 74A.

Cheung B.M.Y., Leung Y.H., Lau C.P., Kumana C.R., Angiotensin-converting enzyme genotypes in hypertensive patients with left ventricular hypertrophy, Hong Kong Practitioner. 2000, 22 (Suppl): 35.

Cheung B.M.Y., Kumana C.R., Association studies of genetic polymorphisms and complex disease (letter), Lancet. 2000, 355: 1277.

Cheung B.M.Y., Law C.Y., Ho G.Y.Y., Ng P.P.Y., Kumana C.R., Lau C.P., Change in ambulatory blood pressure in hypertensive patients is related to sodium intake, 9th Annual Scientific Congress of the Hong Kong College of Cardiology, Hong Kong. 2001.

Cheung B.M.Y., Kumana C.R., Dementia and statins (letter), Lancet. 2001, 257: 880.

Cheung B.M.Y., Cheung A.H.K., Ho P.C., Lau C.P., Kumana C.R., Drug utlisation in a hypertension outpatient clinic 1996-1999, Hong Kong Practitioner. 2000, 22 (Suppl): 4.

Cheung B.M.Y., Law C.Y., Ho G.Y.Y., Ng P.P.Y., Kumana C.R., Lau C.P., Efficacy of non-pharmacological treatment of hypertension, American Journal of Hypertension. 2001, 14: 141a.

Cheung B.M.Y., Cheung A.H.K., Ng P., Kumana C.R., Lau C.P., Efficacy of non-pharmacological treatment of hypertension, Journal of Hypertension. 2000, 18: S97.

Cheung B.M.Y., Cheung A.H.K., Ng P., Kumana C.R., Lau C.P., Efficacy of non-pharmacological treatment of hypertension, Journal of the Hong Kong College of Cardiology. 2000, 8: 86.

Cheung B.M.Y., Cheung A.H.K., Lau C.P., Kumana C.R., Hypertension in relatives is associaed with obesity, Hong Kong Practitioner. 2000, 22 (Suppl): 5.

Cheung B.M.Y., Cheung A.H.K., Lau C.P., Kumana C.R., Is systolic blood pressure related to potassium excretion?, American Journal of Hypertension. 2000, 13(4)II: 169A.

Cheung B.M.Y., Tse H.F., Kumana C.R., Lau C.P., Left ventricular mass is related to blood pressure and body weight, The Hong Kong Practitioner. 2001, 23: 10.

Cheung B.M.Y., Law C.Y., Ho G.Y.Y., Ng P.P.Y., Kumana C.R., Lau C.P., Non-Pharmacological treatment of hypertension, The Hong Kong Practitioner. 2001, 23: 8.

Cheung B.M.Y., Cheung A.H.K., Lau C.P., Kumana C.R., Obesity is a predictor of hypertension in relatives, Journal of Hypertension. 2000, 18: S126.

Cheung B.M.Y., Lau W.C.S., Leung Y.H., Tong K.K., Kumana C.R., Plasma adrenomedullin level in systemic lupus erythematosus, Rheumatology. 2000, 39: 804-5.

Cheung B.M.Y., Tsang K.W.T., Leung Y.H., Chan L.Y., Kumana C.R., Plasma adrenomedullin level is markedly elevated in bronchiectasis, Hong Kong Practitioner. 2000, 22 (Suppl): 4.

Cheung B.M.Y., Leung Y.H., Cheung A.H.K., Tsang K.W.T., Lau C.P., Kumana C.R., Plasma bradykinin level and angiotensin-converting enzyme gene polymorphism in hypertensive patients, Hong Kong Practitioner. 2000, 22 (Suppl): 35.

Cheung B.M.Y., Tam S.C.F., Cheung A.H.K., Ng P.P.Y., Kumana C.R., Lau C.P., Plasma renin and aldosterone in Chinese hypertensive patients, 2nd International Forum on Angiotensin II Receptor Antagonists, Monte-Carlo. 2001.

Cheung B.M.Y., Tam S.C.F., Ng P.P.Y., Kumana C.R., Lau C.P., Plasma renin and aldosterone in patients with essential hypertension, 9th Annual Scientific Congress of the Hong Kong College of Cardiology, Hong Kong. 2001.

Cheung B.M.Y., Tam S.C.F., Ng P.P.Y., Kumana C.R., Lau C.P., Plasma renin and aldosterone in patients with hypertension before treatment, The Hong Kong Practitioner. 2001, 23: 8.

Cheung B.M.Y., Law C.Y., Ho G.Y.Y., Ng P.P.Y., McGhee S.M., Kumana C.R., Lau C.P., Reducing sodium intake reduces ambulatory blood pressure in hypertensive patients, American Journal of Hypertension. 2001, 14: 143-144A.

Cheung B.M.Y., Law C.Y., Ho G.Y.Y., Ng P.P.Y., McGhee S.M., Kumana C.R., Lau C.P., Reducing sodium intake reduces ambulatory blood pressure in hypertensive patients, Hong Kong Practitioner. 2001, 23 (Suppl 2): 9.

Cheung B.M.Y., Law C.Y., Ho G.Y.Y., Ng P.P.Y., McGhee S.M., Kumana C.R., Lau C.P., Reducing sodium intake reduces ambulatory blood pressure inhypertensive patients, The Hong Kong Practitioner. 2001, 23: 9.

Cheung B.M.Y., Kumana C.R., Should decisions on treatment be based on absolute benefit rather than absolute risk?, New Zealand Medical Journal. 2001, 114: 214-5.

Cheung B.M.Y., Kumana C.R., Treatment those at risk or treating those who benefit?, Medical Progress. 2001, 28: 8-9.

Cheung B.M.Y., Lam T.C., Law C.Y., Kumana C.R., Lau C.P., Waist circumference and cardiovascular risk in patients with essential hypertension, 9th Annual Scientific Congress of the Hong Kong College of Cardiology, Hong Kong. 2001.

Kumana C.R., Antibiotic guidelines in hospitals, PD Hinduja National Hospital & Medical Research Centre - Bombay India. 2001.

Kumana C.R., Kou M., Ching T.Y., Kong Y., Ma E., Lee R.A., Cheng C.C., Chiu S.S.S., Seto W.H., Curbing inappropriate vancomycin usage by immediate concurrent feedback, VII World Conference on Clinical Pharmacology & Therapeutics & 4th Congress of the European Association for Clinical Pharmacology & Therapeutics. 2001.

Kumana C.R., Implementing rational antibiotic policies in hospitals, In: 7th Western Pacific Congress on Chemotherapy & Infectious Diseases - Hong Kong, 2001.

Kumana C.R., Kou M., Lauder I.J., Ip M.S.M., Lam W.K., Increasing use of inhaled steroids associated with declining asthma mortality, Journal of Asthma. NY, USA, Marcel Dekker, 2001, 38: 161-167.

Kumana C.R., Chan M.M.Y., Kou M., Ma J.T.C., Interaction of dietary guar gum with Beta-blockers, In: Bridging Cardiovascular Science & Medicine, October 1999, 2000.

Kumana C.R., Rational use of antibiotics, VI HISCON National Conference on Hospital Infection Control - Jaipur, India. 2001.

Lam Y.M., Tse H.F., Lau C.P., Cheung B.M.Y., Kumana C.R., Does low dose amiodarone effective for ventricular rate control in patients wiht cronic atiral fibrillation?, Europace. 2000, Supp 1: D137.

Lee N.L.S., Yuen H., Kumana C.R., Beta-Lactam Antibiotic and Beta-Lactamase Inhibitor Combinations, JAMA. USA, 2001, 285: 386-388.

Li N., Kumana C.R., Cheung B.M.Y., Fan S.T., Liu C.L., Age affects blood pressure and heart rate following IV diazepam, VII World Conference on Clinical Pharmacology & Therapeutics 4th Congress of the European Association for Clinical Pharmacology & Therapeutics. 2001.

Tse H.F., Lam Y.M., Lau C.P., Cheung B.M.Y., Kumana C.R., Comparison of digoxin versus low-dose amiodarone for ventricular rate control in patients with chronic atrial fibrilation, Clin Exp Pharmacol Physiol. 2001, 28: 446-450.

Tse H.F., Kumana C.R., Mercury poisoning by topical facial cream, American Journal of Medicine. 2000, 109: 426.

Researcher : Kung AWC

Project Title:	The production of a transgenic mouse model of autoimmune thyroiditis and the study of induction of tolerance to an organ specific autoantigen in transgenic mice expressing thyroid peroxidase in the thymus
Investigator(s):	Prof. Kung A.W.C. , Dr. Banga J.P., Prof. Chan S.T.H., Dr. Chung S.K.
Department:	Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	November 1994

Abstract:

To analyse the consequence of exposing the thymus to high level expression of an antigen (TPO in the case of AITD) during its development and to study the induction of tolerance by clonal deletion.

Project Title:	To evaluate the characteristics of TSH receptor antibodies and T cell function in Graves' disease during pregnancy
Investigator(s):	Prof. Kung A.W.C. , Dr. Jones B.M.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	July 1998
Completion Date:	January 2001

Abstract:

To characterise TSH receptor antibodies in pregnant women with Graves' Disease during various stages of pregnancy; to evaluate T cell function and cytokines production in pregnant women with Graves' Disease during various stages of pregnancy; to correlate foetal outcome and neonatal thyroid dysfunction with maternal antibody characteristics.

Project Title:	Mapping of the genetic locus / loci for thyrotoxic periodic paralysis
Investigator(s):	Prof. Kung A.W.C. , Prof. Chan V.N.Y.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	July 1999

Abstract:

To determine the genetic cause for thyrotoxic periodic paralysis.

Project Title:	To determine the genetic determinants of bone mass and osteoporosis in southern Chinese women
Investigator(s):	Prof. Kung A.W.C. , Dr. Ho A.Y.Y.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	November 2000

Abstract:

To determine the polymorphic distribution of collagen I-alpha1 gene and transforming growth factor (TGF-beta1) gene in healthy southern Chinese women; to determine the association of collagen I-alpha1 gene and TGF-beta1 gene with bone mineral density and osteoporosis in southern Chinese women.

List of Research Outputs

He M., Tan K.C.B., Li E.T.S., Kung A.W.C., Body fat determination by dual energy X-ray absorptiometry and its relation to body mass index and waist circumference in Hong Kong Chinese., International Journal of Obesity. 2001, 25: 748-752.

Jones B.M., Kwok J.S.Y., Kung A.W.C., Changes in cytokine production during pregnancy in patients with Graves' disease, Thyroid. 2000, 10: 701-707.

Jones B.M., Kwok J.S., Kung A.W.C., Changes in cytokine production during pregnancy inpatients with Graves' Disease, Thyroid. 2000, 10: 701-7.

Kung A.W.C., Lao T.T.H., Chau M.T., Tam S.C.F., Low L.C.K., A prospective study of thyroid nodule development during pregnancy in borderline iodine deficient area., ICE 2000. Sydney, Australia. 2000, P0745.

Kung A.W.C., Lau K.S., Kohn L.D., Characterization of thyroid stimulating blocking antibodies which appeared during transient hypothyroidism after radioactive iodine therapy., Thyroid. 2000, 10: 909-917.

Kung A.W.C., Lau K.S., Kohn L.D., Epitope Mapping of TSH receptor blocking antibodies in Graves' Disease which appeared during pregnancy., ICE 2000 Sydney, Australia. 2000, OR191.

Kung A.W.C., Lau K.S., Chan V.N.Y., Genetic Mapping for thyrotoxic Hypokalemic Periodic Paralysis (TPP), The Endocrine Society's 83rd Annual Meeting, USA, June 2001.

Kung A.W.C., Lau K.S., Chan V.N.Y., Genetic mapping for thyrotoxic hypokalemic periodic paralysis (TPP), The Endocrine Society USA. 83rd annual meeting.. 2001, P1-578.

Kung A.W.C., Genetics & Environnmental Influences on peak bone mass in southern Chinese women, First Annual Meeting of Chinese Osteoporosis & Bone Mineral Society. 2001, A-14.

Kung A.W.C., Ng H.P., Lau K.S., Chung S.K., Altmann D.M., Banga J.P., Identification of a novel pathogenic peptide of mouse thyroid peroxidase (MTPO) and ascertainment of immune tolerance in a transgenic model that ovderexpresses MTPO in the thymus, 12th International Thyroid Congress, Kyoto, Japan. 2000, O-596.

Kung A.W.C., Lao T.T.H., Chau M.T., Tam S.C.F., Low L.C.K., Increased rate of congenital anomalies and adverse fetal outcome even with borderline iodine deficiency, 12th International Thyroid Congress, Kyoto, Japan. 2000, P232.

Kung A.W.C., Yeung S.C., Chu L.W., The efficacy and tolerability of alendronate in postmenopausal Chinese women. A randomised placebo-controlled study., Calcified Tissue International. 2000, 67: 286-290.

Lambrinoudaki I., Kung A.W.C., Steroid-induced Osteoporosis (Review), Chinese Medical Journal. 2000, 113: 681-685.

Lambrinoudanki I., Kung A.W.C., Absence of the high risk 'S' allele associated with osteoporosis at the intronic SP1 binding-site of collagen 1 a 1 gene in a Southern Chinese population., Journal of Endocrinological Investigation. 2001, 24: 499-502.

Lau H.L., Mei J., Kung A.W.C., Estrogen receptor b Gene polymorphisms are associated with higher bone mineral density in premenopausal southern Chinese women., The Endocrine Society USA. 83rd annual meeting. 2001, P3-538.

Lee K.K., Tan K.C.B., Kung A.W.C., Biochemical and behavioral effectiveness of transdermal testosterone replacement therapy in Chinese hypogonadal men., The First Asian Meeting of the International Society for the Study of the Aging Male. Kuala Lumpur, Malaysia. 2001.

Mei J., Yeung S.S.M., Kung A.W.C., High phytoestrogen intake increases bone mineral density in southern Chinese women., The Endocrine Society USA. 83rd annual meeting. 2001, P3-139.

Ng H.P., Banga J.P., Kung A.W.C., Establishment of a mouse model of autoimmune thyroiditis and identification of thyroiditogenic epitope on mouse thyroid peroxidase (MTPO), The Endocrine Society USA. 83rd annual meeting.. 2001, OR8-5.

Researcher : Kwok ENL

List of Research Outputs

Chan A.O.O., Lam S.K., Chu K.M., Lam C.M., Kwok E.N.L., Leung S.Y., Yuen S.T., Law S.Y., Hui W.M., Lai K.C., Wong B.C.Y., Hu W.C.H., Lai C.L., Wong J., Soluble E-cadherin is a valid prognostic marker in gastric carcinoma., Gut. 2001, 48(6): 808-811.

Tsang K.W.T., Lam W.K., Chan K.N., Hu H.C., Wu A.Y.Y., Kwok E.N.L., Zheng L., Wong B.C.Y., Lam S.K., Helicobacter pylori sero-prevalence in asthma, Respiratory Medicine. 2000, 94: 756-60.

Researcher : Kwong YL

Project Title:	Gene therapy for malignant lymphoma
Investigator(s):	Prof. Kwong Y.L. , Prof. Chan V.N.Y.
Department:	Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	December 1996

Abstract:

To develop a gene therapy strategy as a novel treatment modality for lymphoma, using the replication defective adenovirus as the vector for gene delivery.

Project Title:	Provision of purine analogues for the treatment of patients with chronic lymphoid malignancies
Investigator(s):	Prof. Kwong Y.L. , Prof. Liang R.H.S.
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation Grant
Start Date:	July 1997

Abstract:

To provide purine analogues for the treatment of patients with chronic lymphoid malignancies who cannot otherwise afford the drugs.

Project Title:	Comparative genomic hybridization in the detection of genetic alterations in hepatocellular carcinoma
Investigator(s):	Prof. Kwong Y.L. , Prof. Chan V.N.Y., Prof. Lai C.L., Prof. Liang R.H.S.
Department:	Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	January 1998

Abstract:

To identify genetic alternations in hepatocellular carcinoma (HCC) by comparative genomic hybridization.

Project Title:	Patterns of alleleic loss in natural killer cell lymphoma
Investigator(s):	Prof. Kwong Y.L.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	November 2000

Abstract:

To study the definition of the patterns of alleleic loss in natural killer cell lymphoma.

List of Research Outputs

Ang M.F., Lie A.K.W., Chan J.C.K., Liang R.H.S., Kwong Y.L., Ex vivo expansion of peripheral blood haematopoietic stem cells: preclinical studies, The Hong Kong Practitioner. 2000, 22(Suppl): 11.

Au W.Y., Chow W.S., Lam K.S.L., Cockram C.S., Ko T.C., Kwong Y.L., Acute leukemia in acromegalic patients, British Journal of Haematology. 2000, 110: 871-3.

Au W.Y., Kwong Y.L., Ma E.S.K., Aleukemic leukemia masquerading as renal masses: a rare presentation of adult lymphoblastic leukemia, American Journal of Hematology. 2000, 65: 328-329.

Au W.Y., Jim M.H., Lam A.K.Y., Kwong Y.L., Digital gangrene and a mass in the heart., Archives of Internal Medicine. 2001, 161: 270-1.

Au W.Y., Lie A.K.W., Kwong Y.L., Lee C.K., Chim J.C.S., Leung A.Y.H., Liang R.H.S., Donor lymphocyte infusion (DLI) for leukemia relapse: the Queen Mary Hosptial Experience., The Hong Kong Society of Haematology Annual Open Scientific Meeting & The 4th Joint Shanghai-Hong Kong Haematology Meeting 2000.. 2000, 12.

Au W.Y., Lo C.M., Hawkins B.R., Ma E.S.K., Lie A.K.W., Kwong Y.L., Evans' syndrome and chronic graft versus host disease after liver transplantation., Transplantation. 2001, 72: 527-528.

Au W.Y., Chim J.C.S., Liang R.H.S., Kwong Y.L., Fludarabine, mitoxantrone and dexamethasone (FND) in indolent lymphoid malignancies., Blood. 2000, 96: 233b.

Au W.Y., Lie A.K.W., Liang R.H.S., Lam C.C.K., Kwong Y.L., Fulminant late onset cold hemagglutinin disease after allogeneic bone marrow transplantation., Haematologica. 2000, 85: E10.

Au W.Y., Ma E.S.K., Kwong Y.L., Ng I.O.L., Hawkins B.R., Wan T.S.K., Liu C.L., Fan S.T., Lo C.M., Graft versus host disease after liver transplantation: documentation by FISH and HLA typing., Clinical Transplantation. 2000, 14: 173-176.

Au W.Y., Kwong Y.L., Ma E.S.K., Mak Y.K., Wong K.F., Lei K.I., Ng M.H., Chan J.C.W., Lin S.Y., Lee K.K., Liang R.H.S., Hairy cell leukemia in Hong Kong Chinese: a 12-year retrospective survey, Hematological Oncology. 2000, 18: 155-159.

Au W.Y., Lie A.K.W., Lee C.K., Leung A.Y.H., Liang R.H.S., Kwong Y.L., ICE chemotherapy plus peripheral blood stem cell (PBSC) for post-BMT relapse of leukemia., International Society of Hematology. 2000.

Au W.Y., Lie A.K.W., Siu L.L., Liang R.H.S., Chim J.C.S., Leung A.Y.H., Kwong Y.L., Intensive chemotherapy with peripheral blood stem cell (PBSC) support in the treatment of leukemia relapse after allogeneic bone marrow transplantation: clinical results and chimerism findings, The Hong Kong Practitioner. 2001, 23(Suppl): 48.

Au W.Y., Shek T.W.H., Kwong Y.L., Intravascular lymphoma and Epstein Barr virus in Chinese., American Journal of Surgery Pathology. 2000, 24: 309-10.

Au W.Y., Ho W.K., Shek T.W.H., Kwong Y.L., Isolated primary granulocytic sarcoma of the nasopharynx., American Journal of Hematology. 2001, 67: 273-4.

Au W.Y., Man C., Lam C.C.K., Ma E.S.K., Wan T.S., Kwong Y.L., Late onset t-MDS after treatment for acute promyelocytic leukemia, Human Pathology. 2001, 32: 126-9.

Au W.Y., Shek T.W.H., Gascoyne R.D., Kwong Y.L., Leukaemic infiltration of an adenocarcinoma effusion., British Journal of Haematology. 2001, 112: 412.

Au W.Y., Shek T.W.H., Ma E.S.K., Leung G., Ooi C.G.C., Liang R.H.S., Kwong Y.L., Meningeal granulocytic sarcoma (chloroma) in essential thrombocythemia., Journal of Clinical Oncology. 2000, 18: 3996-7.

Au W.Y., Chan G.C.F., Chim J.C.S., Liang R.H.S., Lie A.K.W., Leung A.Y.H., Kwong Y.L., Sustained and repeated response of relapsed acute promyelocytic leukemia (APL) to arsenic therapy., The Hong Kong Practitioner. 2001, 23(Suppl): 49.

Au W.Y., Lie A.K.W., Ma E.S.K., Leung A.Y.H., Siu L.L.P., Kwong Y.L., Therapy related myelodysplastic syndrome of recipient origin after allogeneic bone marrow transplantation for acute lymphoblastic leukemia, British Journal of Haematology. 2001, 112: 424-426.

Au W.Y., Lam C.C.K., Ma E.S.K., Man C.M.S., Wan T.S.K., Kwong Y.L., Therapy-related myelodysplastic syndrome after eradication of acute promyelocytic leukemia: Cytogenetic and molecular features, Human Pathology. 2000, 32(1): 126-129.

Au W.Y., Choy C.K.W., Ng W.M., Kwong Y.L., Treatment of subcutaneous panniculitis T cell lymphoma with fludarabine., British Journal of Dermatology. 2000, 43: 408-11.

Au W.Y., Lam C.C.K., Chan E.C., Kwong Y.L., Two novel mutations in a Chinese family with Factor VII deficiency., British Journal of Haematology. 2000, 111: 143-5.

Au W.Y., Ma E.S.K., Ooi C.G.C., Liang R.H.S., Kwong Y.L., Unusual manifestations of acute leukemia: central nervous system relapse of acute promyelocytic leukemia after arsenic treatment., Journal of Clinical Oncology. 2000, 18: 3435-7.

Chim J.C.S., Choy P.T., Kwong Y.L., Negative gallium scan in Castleman's disease., Haematologica. 2001, 86: 442-3.

Chim J.C.S., Shek T.W.H., Ho J., Liang R.H.S., Kwong Y.L., Primary CD56+ gastrointestinal lymphoma., Cancer. 2001, 91: 525-533.

Chim J.C.S., Au W.Y., Shek T.W.H., Ho J., Choy C.K.W., Ma E.S.K., Tung H.M., Liang R.H.S., Kwong Y.L., Primary CD56+ lymphomas of the gastrointestinal tract., Cancer. 2001, 91: 525-533.

Chim J.C.S., Kwong Y.L., Shek W.E., Ma E.S.K., Ooi C.G.C., Splenic rupture as the presenting symptom of blastic crises in a patient with Philadelphia-negative bcr-alb-positive ET., American Journal of Hematology. 2000, 70-71.

Chim J.C.S., Shek T.W.H., Ma E.S.K., Kwong Y.L., Spontaneous Splenic rupture in Ph- +ve ET, American Journal of Hematology. 2001, 66: 70-71.

Chim J.C.S., Tam C., Liang R.H.S., Kwong Y.L., p15 and p16 gene methylation in adult acute leukemia : lack of prognostic significance., Cancer. 2001, 91: 2222-2229.

Chim J.C.S., Liang R.H.S., Tam C., Kwong Y.L., p15 and p16 promotor methylation in acute promyelocytic leukemia., Journal of Clinical Oncology. 2001, 19: 2033-2040.

Choo C.K., Ling M.T., Suen C.K.M., Chan K.W., Kwong Y.L., Retrovirus-mediated delivery of HPV16 E7 antisense RNA inhibited tumorigenicity of CaSki cells, Gynecologic Oncology. 2000, 78: 293-301.

Kwong Y.L., Au W.Y., Chim J.C.S., Pang A.W.K., Suen C., Liang R.H.S., Arsenic trioxide and idarubicin induced remissions in relapsed acute promyelocytic leukaemia : clinicopathological and molecular features of a pilot study., American Journal of Hematology. 2001, 66: 274-279.

Kwong Y.L., Lie A.K.W., Chan J.C.K., Liang R.H.S., Changes in haematopoiesis in bone marrows primed with haematopoietic growth factors before allogeneic bone marrow transplantation: an interim analysis, The Hong Kong Practitioner. 2000, 22(Suppl): 43.

Kwong Y.L., Au W.Y., Extramedullary relapses at uncommon sites after allogeneic stem cell transplantation., Bone Marrow Transplant. 2000, 26: 1134-35.

Kwong Y.L., Lam C.C.K., Chan D.T.M., Post transplantation lymphoproliferative disease of natural killer cell lineage : clinicopathological and molecular features., British Journal of Haematology. 2000, 110: 197-202.

Lau G., Lie A.K.W., Kwong Y.L., Lee C.K., Hou J., Lau Y.L., Lim W.L., Liang R.H.S., A case-controlled study on the use of HBsAg-positive donors for allogeneic hematopoietic cell transplantation, Blood. 2000, 96(2): 452-4582.

Leung A.Y.H., Suen C., Lie A.K.W., Liang R.H.S., Yuen K.Y., Kwong Y.L., A study of the role of polyoma virus in haemorrhagic cystitis in bone marrow transplantation patients., The Hong Kong Society of Haematology Annual Open Scientific Meeting & The 4th Joint Shanghai-Hong Kong Haematology Meeting 2000. 10.

Leung A.Y.H., Yuen K.Y., Cheng V.C.C., Lie A.K.W., Liang R.H.S., Kwong Y.L., Clinical characteristics and risk factors of herpes zoster after bone marrow transplantation., The Hong Kong Practitioner. 2001, 23(Suppl): 52.

Leung A.Y.H., Chow C.H., Kwong Y.L., Lie A.K.W., Fung T.K., Chow W.H., Yip A.S.B., Liang R.H.S., Genetic polymorphism at exon 4 of cytochrome P450CYP2C9 in Chinese patients might determine the warfarin dose requirement., 42nd Annual Meeting of the American Society of Hematology. San Francisco.. 2000.

Leung A.Y.H., Hawkins B.R., Chim J.C.S., Kwong Y.L., Liang R.H.S., Genetics analysis of HLA-typing in Chinese patients with idiopathic thrombocytopenic purpura, Haematologica. 2001, 86: 221-222.

Leung A.Y.H., Yuen K.Y., Lie A.K.W., Kwong Y.L., Liang R.H.S., Herpes zooster virus infection after bone marrow transplantation., 7th Hong Kong International Cancer Congress.. 2000.

Leung A.Y.H., Lie A.K.W., Lam C.C.K., Tso W.K., Lee C.K., Liang R.H.S., Kwong Y.L., Indwelling catheter-related central venous thrombosis during bone marrow transplantation, Haematologica. 2001, 86: 331-332.

Leung A.Y.H., Suen C.K.M., Lie A.K.W., Liang R.H.S., Yuen K.Y., Kwong Y.L., Polyoma BK viruria in bone marrow transplantation patients - an update after one-year., The Hong Kong Practitioner. 2001, 23(Suppl): 51.

Leung A.Y.H., Suen C.K.M., Lie A.K.W., Liang R.H.S., Yuen K.Y., Kwong Y.L., Quantification of polyoma BK viruria to predict the occurrence of hemorrhagic cystitis in bone marrow transplantation patients., Annual Meeting of American Society for Blood and Marrow Transplantation. Keystone, USA.. 2001.

Leung A.Y.H., Chim J.C.S., Kwong Y.L., Lie A.K.W., Au W.Y., Liang R.H.S., Retrospective studies of 230 Chinese adults with chronic idiopathic thrombocytopenia purpura., The Hong Kong Society of Haematology Annual Open Scientific Meeting & The 4th Joint Shanghai-Hong Kong Haematology Meeting 2000.. 2000, 19.

Leung A.Y.H., Lie A.K.W., Kwong Y.L., Yuen K.Y., Au W.Y., Wong K.K., Kwok J.S.Y., Lee T.L., Cheng V.C.C., Liang R.H.S., The 23-valent polysaccharide pneumococcal vaccination is not useful in BMT patients at risk of pneumococcal bacteremic sepsis., 7th Hong Kong International Cancer Congress.. 2000.

Leung A.Y.H., Lie A.K.W., Kwong Y.L., Yuen K.Y., Au W.Y., Wong K.K., Kwok J.S.Y., Cheng V.C.C., Liang R.H.S., The 23-valent polysaccharide pneumococcal vaccination is not useful in BMT patients at risk of pneumococcal bacteremic sepsis, The Hong Kong Practitioner. 2001, 23(Suppl): 53.

Leung A.Y.H., Lie A.K.W., Kwong Y.L., Ooi C.G.C., Yau C.C., Liang R.H.S., The use of autologous stem cell transplantation in the treatment of regionally advanced nasopharyngeal carcinoma, Haematologica. 2001, 86: E14.

Leung A.Y.H., Lie A.K.W., Au W.Y., Hawkins B.R., Kwong Y.L., Liang R.H.S., Unmanipulated bone marrow transplantation from one HLA locus mismatched siblings carries high transplant-related mortality in Chinese patients, Haematologica. 2001, 86: 518-22.

Liang R.H.S., Yu C.M., Au W.Y., Choy C.K.W., Kwong Y.L., Non-Hodgkins lymphoma involving the heart : metastatic lymphoma to the heart manifesting as intra-cavitary masses., Journal of Clinical Oncology. 2000, 18: 1998-1999.

Lie A.K.W., Au W.Y., Siu L.L., Liang R.H.S., Leung A.Y.H., Kwong Y.L., Intensive chemotherapy with peripheral blood stem cell support for leukaemia relapse after allogeneic bone marrow transplantation., 7th Asian Pacific BMT group meeting, Bangkok.. 2000, 130-131.

Lie A.K.W., Leung A.Y.H., Au W.Y., Hawkins B.R., Kwong Y.L., Liang R.H.S., Unmanipulated bone marrow transplantation from one-antigen mismatched sibling carries high transplant-related mortality compared with the HLA-identical counterparts, The Hong Kong Practitioner. 2001, 23(Suppl): 50.

Ma E.S.K., Au W.Y., Wan T.S.K., Kwong Y.L., Chan L.C., Translocation (15;17)(q22;q21) not associated with acute promyelocytic leukemia and negative for PML/RARa rearrangement, Haematologica. 2000, 85(7): 768-769.

Ooi C.G.C., Chim J.C.S., Khong P.L., Au W.Y., Lie A.K.W., Tsang K.W.T., Kwong Y.L., Radiologic manifestations of granulocytic sarcoma in adult leukemia, American Journal of Roentgenology. 2001, 176: 1427-1431.

Siu L.L., Chan V.N.Y., Chan J.K., Wong K.F., Liang R.H.S., Kwong Y.L., Consistent patterns of allelic loss in natural killer cell lymphoma, American Journal of Pathology. 2000, 157(6): 1803-1809.

Siu L.L.P., Chan V.N.Y., Chan J.K.C., Wong K.F., Liang R.H.S., Kwong Y.L., Consistent patterns of allelic loss in natural killer cell lymphoma, American Journal of Pathology. 2000, 157(6): 1803-1809.

So C.C., Wong K.F., Siu L.L.P., Kwong Y.L., Large cell transformation of Zezary syndrome - a conventional and molecular cytogenetic study, American Journal of Clinical Pathology. 2000, 113: 792-797.

Wong K.F., Kwong Y.L., Isochromosome 8q is a marker of secondary acute myeloid leukaemia., Cancer Genetics and Cytogenetics. 2000, 120: 171-173.

Researcher : Lai CL

List of Research Outputs

Chan A.O.O., Lam S.K., Chu K.M., Lam C.M., Kwok E.N.L., Leung S.Y., Yuen S.T., Law S.Y., Hui W.M., Lai K.C., Wong B.C.Y., Hu W.C.H., Lai C.L., Wong J., Soluble E-cadherin is a valid prognostic marker in gastric carcinoma., Gut. 2001, 48(6): 808-811.

Chan A.O.O., Lam S.K., Chu K.M., Lam C.M., Kwok E., Leung S.Y., Yuen S.T., Law S.Y.K., Hui W.M., Lai C.L., Wong C.Y., Hu H.C., Lai C.L., Wong J., Soluble E-cadherin is a valid prognostic marker in gastric carcinoma, Gut. 2001, 48: 808-811.

Chan D.T.M., Lok A.S., Lai C.L., Cheng I.K.P., Lai K.N., Hepatitis C after renal transplantation, Transplantation Proceedings. 2000, 32(7): 1799-1800.

Hui C.K., Yuen M.F., Ng I.O.L., Tsang K.W.T., Fong G.C.Y., Lai C.L., Low molecular weight Heparin-induced liver toxicity, Journal of Clinical Pharmacology. 2001, 41(6): 691-694.

Lai C.L., A new look at viral hepatitis, 7th Western Pacific Congress on Chemotherapy and Infectious Diseases held in Hong Kong. 2000.

Lai C.L., A phase 2 dose-ranging study of oral entecavir vs lamivudine in adults with chronic hepatitis B, 36th Annual Meeting of the European Association for the Study of the Liver, Prague, Czech Republic. 2001.

Lai C.L., A phase II study of entecavir vs lamivudine in adults with chronic hepatitis B (oral presentation), 36th Annual Meeting of the European Association for the Study of the Liver in Prague, Czech Republic. 2001.

Lai C.L., Acute and chronic viral hepatitis A-G, Department of Health, Hong Kong. 2001.

Lai C.L., Acute and chronic viral hepatitis A-G, Hong Kong Red Cross Blood Transfusion Services held in Hong Kong. 2001.

Lai C.L., Anti-tuberculous drugs and the liver, Hong Kong Medical Forum 2000, Department of Medicine, The University of Hong Kong. 2000.

Lai C.L., Chronic hepatitis B and acute pancreatitis, International Symposium on Hepatology 2000 (Thirteenth Annual Scientific Meeting of the Hong Kong Association for the Study of Liver Diseases). 2000.

Lai C.L., Clinical Experiences of lamivudine in the Asian Region, GlaxoSmithKline Satellite Symposium duirng the 37th Annual Meeting of the Japan Society of Hepatology, Yokohama, Japan. 2001.

Lai C.L., External reviewer on the Quality Education Fund Project "Healthy Schools" and "Healthy Society": Quality Education for Children and Teachers, Quality Education Fund Steering Committee, Education and Manpower Bureau, Hong Kong. 2000.

Lai C.L., Hepatitis B infection and treatment, Joint Scientific Meeting of the Hong Kong College of Physicians, Federation of the Royal Colleges of Physicians of the UK, Singapore Academy of Medicine and the Hong Kong College of Paediatricians held in Hong Kong. 2000.

Lai C.L., Hepatitis trials, Drug Information Association Meeting. 2000.

Lai C.L., Lamivudine 4-year clinical study data, A Major Therapeutic Advance in Chronic Hepatitis B Meeting in Vietnam. 2000.

Lai C.L., Lamivudine, Dhaka, Bangladesh. 2000.

Lai C.L., Mechanisms and treatment options for lamivudine resistance, 2nd National Single Theme Symposium on "Hepatitis B Infection in India Therapeutic Options and Prevention Strategies" at New Delhi, India. 2000.

Lai C.L., Member of the Editorial Board, Journal of the American Society of Clinical Oncology. 2001.

Lai C.L., Member of the Editorial Board, The Lancet Infectious Diseases. 2000.

Lai C.L., Member of the International Advisory Board, 19th (Golden Jubilee) Edition of Davidson's Principles and Practice of Medicine. 2001.

Lai C.L., Natural history of hepatitis B, Forum on Hepatitis B in Asia held in Hong Kong. 2001.

Lai C.L., Newer modalities for the treatment of hepatocellular carcinoma, 2nd National Single Theme Symposium on "Hepatitis B Infection in India Therapeutic Options and Prevention Strategies" at New Delhi, India. 2000.

Lai C.L., Poster presentation abstract "L-dT: An ongoing phase I/II dose-escalation trial in patients with chronic HBV infection (NV-02B-001), 37th Annual Meeting of the Japan Society of Hepatology. 2001.

Lai C.L., Poster presentation on "L-dT: An ongoing phase I/II dose escalation trial in patients with chronic HBV infection" (NV-02B-001), 36th Annual Meeting of the European Association for the Study of the Liver in Prague, Czech Republic. 2001.

Lai C.L., Yuen M.F., Profound suppression of hepatitis B virus replication with lamivudine, Journal of Medical Virology. 2000, 61(3): 367-373.

Lai C.L., Reviewer, New England Journal of Medicine. 2001.

Lai C.L., Therapy of hepatitis B infection, Liver Diseases in the New Millennium (4th Shanghai International Symposium on Liver Cancer and Hepatitis and 2nd Scientific Meeting of Cheng Si-yuan (China International) Hepatitis Research Foundation), Shanghai, China. 2000.

Lai C.L., Transcatheter intra-arterial interferon embolisation for the treatment of hepatocellular carcinoma, 2nd Annual Scientific Meeting of the Centre for the Study of Liver Disease (CSLD) held in Hong Kong. 2001.

Lai C.L., Treatment strategies for managing chronic hepatitis B, Annual Meeting of American Association for the Study of Liver Diseases, Dallas, Texas, USA. 2000.

Lai C.L., Unrestricted Biomedical Research Grant of US$500,000 for the years 2001-2005 for distinction in Infectious Diseases, Bristol-Myers Squibb. 2001.

Lai K.C., Lam S.K., Hui W.M., Wong C.Y., Chu K.M., Wong W.M., Chan O.O., Lai C.L., Lau K.K., Yuen M.F., Chan C.K., Lansoprazole reduces ulcer relapse after eradication of Helicobacter pylori in NSAIDs users, Gastroenterology. 2000, 118(Supp 2): A251.

Lau G., Cheung R.P.F., Payne S.L., Lai C.L., Lam S.K., Costs and outcomes of one-year treatment with lamivudine (Zeffix) or a single course of alpha-interferon in chronic hepatitis B, Journal of Gastroenterology and Hepatology. 2000.

Lau G.K.K., Cheung R., Payne S., Lai C.L., Lam S.K., Cost-effectiveness of one-year treatment with lamivudine (Zeffix) or a single course of A-interferon in chronic hepatitits B, Journal of Hepatology. 2000, 32(4): 1720.

Leung N.W., Lai C.L., Chang T.T., Guan R., Lee C.M., Ng K.Y., Lim S.G., Wu P.C., Dent J.C., Edmundson S., Condreay L.D., Chien R.N., Extended lamivudine treatment in patients with chronic hepatitis B enhances hepatiits B e antigen seroconversion rate: results after 3 years of therapy, Hepatology. 2001, 33(6): 1527-1532.

Liaw Y.F., Leung N.W., Chang T.T., Guan R., Tai D.I., Ng K.Y., Chien R.N., Dent J., Roman L., Edmundson S., Lai C.L., Effects of extended lamivudine therapy in Asian patients with chronic hepatitis B. Asia Hepatitis Lamivudine Study Group, Gastroenterology. 2000, 119(1): 172-80.

Lo C.M., Cheung S.T., Lai C.L., Liu C.L., Ng I.O.L., Yuen M.F., Fan S.T., Wong J., Liver transplantation in Asian patients with chronic hepatitis B using lamivudine prophylaxis., Annas ofl Surgery. 2001, 233(2): 276-281.

Lo C.M., Fan S.T., Liu C.L., Lai C.L., Lau G.K.K., Yong B.H., Ng I.O.L., Young K., Chan J.C.K., Wong J., Liver transplantation in Hong Kong - a wider application., Transplantation Proceedings. 2000, 32(7): 2141.

Lo C.M., Fan S.T., Liu C.L., Ng I.O.L., Lam B.K., Yong B.H., Lai C.L., Lau G.K.K., Wong J., More effective immunosuppression with the use of FK506 after liver transplantation., Transplantation Proceedings. 2000, 32(7): 2269-2270.

Tong T.K., Yeung J.S.L., Fung D.M., Lai C.L., Lau W.C.S., Alterations of CD8+CD28- T cells in systemic lupus erythematosus and rheumatoid arthritis, Hong Kong Practitioner. The Hong Kong Practitioner, 2001, 23 (2) Supple: 69.

Wong B.C.Y., Chan C.K., Wong K.W., Wong W.M., Yuen M.F., Lai K.C., Hu H.C., Lau G.K.K., Lai C.L., Lam S.K., Evaluation of a new referral system for the management of dyspepsia in Hong Kong: role of open-access upper endoscopy., Journal of Gastroenterology & Hepatology. 2000, 15(11): 1251-1256.

Wong B.C.Y., Wong K.W., Chan C.K., Wong W.M., Yuen M.F., Lai K.C., Hu H.C., Lau G., Lai C.L., Lam S.K., Evaluation of new referral system for the management of dyspepsia in Hong Kong: Role of open access uper endoscopy, Journal of Gastroenterology and Hepatology. 2000, 15: 1251-1256.

Wong W.M., Wong B.C.Y., Wong K.W., Fung F.M.Y., Lai K.C., Hu H.C., Yuen S.T., Leung S.Y., Lau G.K.K., Lai C.L., Chan C.K., Go R., Lam S.K., ¹³C-urea breath test without a test meal is highly accurate for the detection of Helicobacter pylori infection in Chinese, Alimentary Pharmacology and Therapeutics. 2000, 14: 1353-1358.

Yuen M.F., Wu P.C., Lai V.C., Lau J.Y., Lai C.L., Expression of c-Myc, c-Fos, and c-Jun in hepatocellular carcinoma, Cancer. 2001, 91(1): 106-112.

Yuen M.F., Lai C.L., Prevention and management of hepatitis B: global scenario, Indian Journal of Gastroenterology. 2000, 19 Suppl 3: C3-5.

Yuen M.F., Hui C.K., Yuen J.C.H., Young J.L.P., Lai C.L., The accuracy of SM-HCV rapid test for the detection of antibody to hepatitis C virus, American Journal of Gastroenterology. 2001, 96(3): 838-841.

Researcher : Lai KC

List of Research Outputs

Chan A.O.O., Lam S.K., Chu K.M., Lam C.M., Kwok E.N.L., Leung S.Y., Yuen S.T., Law S.Y., Hui W.M., Lai K.C., Wong B.C.Y., Hu W.C.H., Lai C.L., Wong J., Soluble E-cadherin is a valid prognostic marker in gastric carcinoma., Gut. 2001, 48(6): 808-811.

Jiang X., Wong B.C.Y., Yuen S.T., Jiang S.H., Cho C.H., Lai K.C., Lin M.C., Kung H., Lam S.K., Arsenic trioxide induces apoptosis in human gastric cancer cells through up-regulation of P53 and activation of caspase-3, International Journal of Cancer. 2001, 91: 173-179.

Jiang X., Lam S.K., Lin M.C., Cho C.H., Lai K.C., Kung H., Yang D., Wong B.C.Y., P53 status determines nuclear factor-kappa B response in Triptolide-induced apoptosis in gastric cancer [Poster presentation, 92nd Annual meeting of the American Association of Cancer Research], Proceedings of American Association of Cancer Research Annual Meeting. 2001, 42: 659.

Lai K.C., Lam S.K., Hui W.M., Wong C.Y., Chu K.M., Wong W.M., Chan O.O., Lai C.L., Lau K.K., Yuen M.F., Chan C.K., Lansoprazole reduces ulcer relapse after eradication of Helicobacter pylori in NSAIDs users, Gastroenterology. 2000, 118(Supp 2): A251.

Wang W.H., Wong B.C.Y., Berg D.E., Fung F.M.Y., Lai K.C., Wong W.M., Wong K.W., Cho C.H., Lam S.K., Mixed genotype and metronidazole susceptibility patterns of Helicobacter pylori in Hong Kong, Gastroenterology. 2000, 118:4 (suppl 2): A503.

Wong B.C.Y., Wong W.M., Wang W.H., Tang V.S.Y., Young J., Lai K.C., Yuen S.T., Leung S.Y., Hu H.C., Chan C.K., Hui W.M., Lam S.K., An evaluation of invasive and non-invasive tests for the diagnosis of Helicobacter pylori infection in Chinese, Alimentary Pharmacology and Therapeutics. 2000, 15(4): 505-511.

Wong B.C.Y., Chan C.K., Wong K.W., Wong W.M., Yuen M.F., Lai K.C., Hu H.C., Lau G.K.K., Lai C.L., Lam S.K., Evaluation of a new referral system for the management of dyspepsia in Hong Kong: role of open-access upper endoscopy., Journal of Gastroenterology & Hepatology. 2000, 15(11): 1251-1256.

Wong B.C.Y., Wong K.W., Chan C.K., Wong W.M., Yuen M.F., Lai K.C., Hu H.C., Lau G., Lai C.L., Lam S.K., Evaluation of new referral system for the management of dyspepsia in Hong Kong: Role of open access uper endoscopy, Journal of Gastroenterology and Hepatology. 2000, 15: 1251-1256.

Wong B.C.Y., Wang W., Berg D.E., Fung F.M.Y., Wong K.W., Wong W.M., Lai K.C., Cho C.H., Hui W.M., Lam S.K., High prevalence of mixed infections by Helicobacter pylori in Hong Kong: metronidazole sensitivity and overall genotype, Alimentary Pharmacology and Therapeutics. 2000, 15: 493-503.

Wong B.C.Y., Wong W.M., Wang W.H., Fung F.M.Y., Lai K.C., Chu K.M., Yuen S.T., Leung S.Y., Hu H.C., Yuen M.F., Lau G., Chan C.K., Lam S.K., One-week Ranitidine Bismuth Citrate-based triple therapy for the eradication of Helicobacter pylori in Hong Kong with high prevalence of metronidazole resistance, Alimentary Pharmoacology and Therapeutics. 2001, 15: 403-409.

Wong B.C.Y., Wang W.H., Lau G., Wong W.M., Fung F.M.Y., Kung N.N.S., Chu K.M., Lai K.C., Hu H.C., Hu F.L., Liu X.G., Chan C.K., Yuen M.F., Hui W.M., Lam S.K., Three-day lansoprazole quadruple therapy for Helicobacter pylori-positive duodenal ulcers: a randomized contolled study [Oral presentation, 6th Medical Research Conference, Department of Medicine, 13-14 January], The Hong Kong Practitioner. 2001, 23 (2-suppl): 18.

Wong W.M., Wong B.C.Y., Wong K.W., Fung F.M.Y., Lai K.C., Hu H.C., Yuen S.T., Leung S.Y., Lau G.K.K., Lai C.L., Chan C.K., Go R., Lam S.K., ¹³C-urea breath test without a test meal is highly accurate for the detection of Helicobacter pylori infection in Chinese, Alimentary Pharmacology and Therapeutics. 2000, 14: 1353-1358.

Zhou X.M., Lai K.C., Lam S.K., Zhang H.B., Lan X.R., Fan X.M., Hui W.M., Fan D.M., Wong B.C.Y., Induced gastric mucosal apoptosis in Helicobacter pylori positive patients taking low lose aspirin: a 6-month case-control study, Proceedings, Second Joint Scientific Meeting, Hong Kong Society of Gastroenterology, Hong Kong Society of Digestive Endoscopy, Hong Kong Society for Coloproctology, 2 September. 2000.

Researcher : Lai KN

Project Title:	What is the acceptable dialysis adequacy for Asian patients undergoing continuous ambulatory peritoneal dialysis treatment?
Investigator(s):	Prof. Lai K.N. , Dr. Yu A.W.Y.
Department:	Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	January 1998

Abstract:

To assess prospectively whether Kt/V < 1.7 is associated with increased morbidity and mortality in patients from Hong Kong receiving CAPD treatment; to assess prospectively the cost-effectiveness of three x 2 liters daily CAPD exchanges in Asian patients with smalller body size and to determine an optimal dialysis therapeutic target for this regime.

Project Title:	The mechanism of binding of IgA to mesangial cells - the pivotal issue of the pathogenesis of IgA nephropathy
Investigator(s):	Prof. Lai K.N.
Department:	Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	November 1998

Abstract:

To investigate the mechanisms by which the "pathogenetic" polymeric IgA (pIgA) from patients with IgA nephropathy (IgAN) is taken up by the mesangial cells of the kidney - the first and the essential step in the development of the nephritis. Emphasis will be focussed in the binding of pIgA either by specific immunoglobulin or lectin receptors, or by interaction through electrostatic charge. Interruption of the binding will prevent the inflammatory process in the mesangial cells and, hence, reducing the progression of glomerular sclerosis and renal failure.

Project Title:	The mechanism of binding of IgA to mesangial cells - the pivotal issue of the pathogenesis of IgA nephropathy
Investigator(s):	Prof. Lai K.N.
Department:	Medicine
Source(s) of Funding:	RGC Fundable Projects (Block Grant Funded)
Start Date:	November 1998

Abstract:

Project Title:	Role of angiotensin II in renal fibrosis
Investigator(s):	Prof. Lai K.N. , Dr. Lan H.Y.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	July 1999
Completion Date:	June 2001

Abstract:

To determien whether Ang II plays a role in renal fibrosis through the TEMT mechanism.

Project Title:	The expression of water channels in human peritoneal and pleural mesothelial cell in specific disease status
Investigator(s):	Prof. Lai K.N.
Department:	Medicine
Source(s) of Funding:	RGC Fundable Projects (Block Grant Funded)
Start Date:	November 2000

Abstract:

To study two area of mesothelial cell biology, namely (a) peritoneal mesothelial cells in peritoneal dialysis and (b) pleural mesothelial cells in serositis.

List of Research Outputs

Chan D.T.M., Lok A.S., Lai C.L., Cheng I.K.P., Lai K.N., Hepatitis C after renal transplantation, Transplantation Proceedings. 2000, 32(7): 1799-1800.

Chan D.T.M., Li F.K., Chan Y.Y., Lai K.N., Long-term effects of 1.1% amino acid dialysate in Chinese CAPD patients, Abstracts of the 10th International Congress on Nutrition and Metabolism in Renal Disease. July 4-6, Lyon, France, 2000, 38.

Chan D.T.M., Ho S.K.N., Fang G.X., Cheng I.K.P., Lai K.N., Longitudinal profile of HBV DNA in renal allograft recipients, Abstracts of the Congress of the International Society of Transplantation. August 27-31,Rome, Italy, 2000.

Chan D.T.M., Li F.K., Tang C.S.O., Wong R.W.S., Fang G.X., Ji Y.L., Lau W.C.S., Wong A.K.M., Tong M.K.L., Chan K.W., Lai K.N., for the Hong Kong-Guangzhou Nephrology Study Group. Efficacy of Mycophenolate Mofetil in patients with diffuse proliferative lupus nephritis, The New England Journal of Medicine. 2000, 343 (16): 1156-1162.

Ho S.K., Li F.K., Lai K.N., Chan D.T.M., Comparison of the CMV brite turbo assay and the digene hybrid capture CMV DNA (Version 2.0) assay for quantitation of cytomegalovirus in renal transplant recipients, Journal of Clinical Microbiology. 2000, 38(10): 3743-3745.

Lai K.N., Li F.K., Lan H.Y., Tang S.C.W., Tsang A.W., Chan D.T.M., Leung J.C.K., Expression of aquaporin-1 in human peritoneal mesothelial cells and its upregulation by glucose in vitro, Journal of American Society of Nephrology. 2001, 12(5): 1036-1045.

Lai K.N., Hepatitis B associated renal disease, In: D Adu, P Emery and M Madiao, In: Rheumatology and the Kidney [Oxford Clinical Nephrology Series], Oxford University Press, Oxford. 2001, 377-393.

Lai K.N., Hepatitis C virus screening in hemodialysis unit, American Journal of Kidney Diseases. 2001, 38: 186-188.

Lai K.N., Ho S.K., Leung J.C.K., Tang S.C.W., Chan D.T.M., Li F.K., Increased survival of mesothelial cells from the peritoneum in peritoneal dialysis fluid, Cell Biology International. 2001, 25(5): 445-450.

Lam M.F., Li F.K., Choy C.B.Y., Tang S.C.W., Lo W.K., Lui S.L., Chu S.M., Tam P.C., Chan D.T.M., Lai K.N., The impact of the establishment of a multiorgan transplantation program on cold ischemia time and delayed graft function in renal transplantation, Transplantation Proceedings. 2000, 32(7): 1611-1612.

Leung J.C.K., Tang S.C.W., Lam M.F., Chan D.T.M., Lai K.N., Charge-dependent binding of polymeric IgA1 to human mesangial cells in IgA nephropathy, Kidney International. 2001, 59(1): 277-285.

Li F.K., Chan D.T.M., Lai K.N., Alloimmune hemolysis after renal transplantation, American Journal of Nephrology. 2000, 20(6): 473-475.

Li F.K., Lui S.L., Lai K.N., Chan D.T.M., Current issues in renal transplantation: immunology and immunosuppression, Medical Progress. 2000, 27: 19-26.

Li F.K., Lui S.L., Lai K.N., Chan D.T.M., Current issues in renal transplantation, Medical Progress. 2000, 27(9): 13-18.

Li F.K., Lai K.N., Current issues in the therapy of chronic renal failure: Dialysis, Medical Progress. 2000, 27(8): 9-14.

Li F.K., Lai K.N., Current issues in the therapy of chronic renal failure: dialysis, In: , Medical Progress. 2000, 27: 9-14.

Li F.K., To C.H., Leung J.C.K., Chan D.T.M., Lai K.N., Electrophysiology and glucose transport of human peritoneal mesothelial cells: implications for peritoneal dialysis, Peritoneal Dialysis International. 2001, 21(2): 115-121.

Li F.K., Ho S.K.N., Chan D.T.M., Lai K.N., Significance of monocytic cytokines on the immune responsiveness of renal transplant recipients. [33rd Annual Meeting and 2000 Renal Week, American Society of Nephrology, October 10-16, 2000, Toronto, Ontario, Canada], Journal of American Society of Nephrology. 2000, 11: 476A-477A.

Li F.K., Chan D.T.M., Lai K.N., Significance of transmesothelial ionic and molecular transport in pertioneal dialysis, International Society of Nephrology: 2nd Conference on Forefront in Nephrology. 2000.

Lui S.L., Loretta Chan Y.Y., Zhang X.H., Zhu W., Chan D.T.M., Fung P.C.W., Lai K.N., Effect of mycophenolate mofetil on nitric oxide production and inducible nitric oxide synthase gene expression during renal ischaemia-reperfusion injury, Nephrology Dialysis Transplantation. 2001, 16: 1-6.

Lui S.L., Luk W.K., Cheung C.Y., Chan D.T.M., Lai K.N., Peiris J.S.M., Nosocomial outbreak of parvovirus B19 infection in a renal transplant unit, Transplantation. 2001, 71(1): 59-64.

Siu C.W., Chan D.T.M., Li F.K., Choy C.B.Y., Lui S.L., Lo C.Y., Tang S.C.W., Lo W.K., Lai K.N., Association between anti-thymocyte globulin administration and cytomegalic virus infection and/or CMV disease in cadaveric renal allograft recipients, Transplantation Proceedings. 2000, 32(7): 1932-1934.

Szeto C.C., Wong T.Y., Lai K.B., Lam C.W., Lai K.N., Li P.K., Dialysate hyaluronan concentration predicts survival but not peritoneal sclerosis in continuous ambulatory peritoneal dialysis, American Journal of Kidney Diseases. 2000, 36(3): 609-614.

Tang S.C.W., Tso W.K., Li J.H., Li C.L., Chan D.T.M., Lai K.N., Clinical outcome following percutaneous transluminal angioplasty for transplant renal artery stenoses, Transplantation Proceedings. 2000, 32(7): 1889-1891.

Tang S.C.W., Lai K.N., Gene polymorphism in IgA nephropathy, Nephrology. 2001, 6: 63-70.

Tang S.C.W., Chan D.T.M., Lui S.L., Li F.K., Lo W.K., Lai K.N., Risk factors for avascular bone necrosis after renal transplantation, Transplantation Proceedings. 2000, 32(7): 1873-1875.

Tang S.C.W., Lai K.N., Chan D.T.M., Lan H.Y., Ho S.K., Sacks S.H., Transferrin but not albumin mediates stimulation of complement C3 biosynthesis in human proximal tubular epithelial cells, American Journal of Kidney Diseases. 2001, 37(1): 94-103.

Wang A.Y., Yu A.W., Li P.K., Lam P.K., Leung C.B., Lai K.N., Lui S.F., Factors predicting outcome of fungal peritonitis in peritoneal dialysis: analysis a 9-year experience of fungal peritonitis in a single center, American Journal of Kidney Diseases. 2000, 36(6): 1183-1192.

Wong T.Y., Szeto C.C., Lai K.B., Lam C.W., Lai K.N., Li P.K., Longitudinal study of peritoneal membrane function in continuous ambulatory peritoneal dialysis: relationship with peritonitis and fibrosing factors, Peritoneal Dialysis International. 2000, 20(6): 679-685.

Yu X.Q., Wu L.L., Huang X.R., Yang N., Gilbert R.E., Cooper M.E., Johnson R.J., Lai K.N., Lan H.Y., Osteopontin expression in progressive renal injury in remnant kidney: role of angiotensin II, Kidney International. 2000, 58(4): 1469-1480.

Researcher : Lam CLK

Project Title:	Translation and testing version 2 of the 36-item short-form health survey (SF-36) on the Chinese
Investigator(s):	Dr. Lam C.L.K. , Ms Gandek B.
Department:	Family Medicine Unit of the Department of Medicine
Source(s) of Funding:	Centre for Education and Research in Family Medicine Fund
Start Date:	February 1998
Completion Date:	December 2000

Abstract:

To test if version 2 of the SF-36 is reliable and acceptable when applied to the Chinese, and to compare if there is any difference between the results of version 1 and version 2 of the SF-36 on the general population of Hong Kong.

Project Title:	Development of the Chinese (HK) SF-8 health survey
Investigator(s):	Dr. Lam C.L.K. , Ms Gandek B.
Department:	Family Medicine Unit of the Department of Medicine
Source(s) of Funding:	Health Assessment Laboratory, U.S.A.
Start Date:	June 2001

Abstract:

To translate the SF-8 health survey to Chinese; to evaluate the equivalence of the meaning of the Chinese SF-8 to those of the original SF-8.

List of Research Outputs

Chan L.Y., Fong D.Y.T., Lam C.L.K., Chan-Yeung M., Say J., Yan C.P.K., Leung R., Ooi C.G.C., Ip M.S.M., Lam W.K., Tsang K.W.T., Validation of the Hong Kong Chinese Version of St. George's Respiratory Questionnaire (SGRQ), Medical Research Conference 13-14 January 2001. Hong Kong.

Researcher : Lam KSL

Project Title:	Losartan renal protection study
Investigator(s):	Prof. Lam K.S.L. , Dr. Wat N.M.S.
Department:	Medicine
Source(s) of Funding:	Merck Research Laboratories, U.S.A.
Start Date:	January 1997

Abstract:

To study the beneficial effect of angiotensin II receptor blockade on renal function of NIDDM patients with moderately severe, diabetic nephropathy.

Project Title:	Interaction between the polyol pathway and non-enzymatic glycation in the pathogenesis of diabetic nephoropathy
Investigator(s):	Prof. Lam K.S.L. , Dr. Chung S.S.M., Dr. Chung S.K.
Department:	Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	October 1998

Abstract:

To introduce the AR gene into transgenic mice to increase the level of this enzyme in the kidney glomerular cells, to study the effect on the development of diabetic kidney disease in these animals. The effect of agents which block the binding of AGEs to its receptor will also be studied to investigate the interaction between these two pathways. The genetic manipulations to change the enzyme activity circumvent the use of chemical inhibitors which may interact with unintended target enzymes, and should contribute to the understanding and management of diabetic kidney disease.

Project Title:	Molecular genetics of early onset type 2 diabetes in Chinese
Investigator(s):	Prof. Lam K.S.L. , Prof. Chan V.N.Y., Dr. Wat N.M.S.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	July 1999
Completion Date:	June 2001

Abstract:

To determine the contribution of mutations in the glucokinase and HNF-1a genes to the development of early onset type 2 diabetes in Hong Kong Chinese; to investigate the genotype-phenotype relationship in patients with mutations in these genes; to build up a DNA bank of families with early onset diabetes for the search of new susceptibility genes using polymorphic chromosome markers and likage analysis, and emerging information from the Human genome Project.

Project Title:	Impaired glucose tolerance as a marker for cardiovascular risk
Investigator(s):	Prof. Lam K.S.L. , Prof. Lam T.H., Dr. Wat N.M.S.
Department:	Medicine
Source(s) of Funding:	Health Care and Promotion Fund
Start Date:	April 2000

Abstract:

To determine the conversion rate of IGT to type 2 diabetes (NIDDM), as compared to normal subjects, at 5 years using the WHO (1985 and 1998) and the ADA (1997) diagnostic criteria; to ascertain the prevalence and incidence of increased blood pressure as well as its associations with other cardiovascular risk factors at 5 years among IGT subjects as compared to normal subjects.

Project Title:	Mutational analysis and genotype-phenotype correlation in Chinese patients with multiple endocrine neoplasia type 1
Investigator(s):	Prof. Lam K.S.L. , Dr. Lam K.Y., Dr. Lo C.Y.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	November 2000

Abstract:

To conduct germ line mutation analysis of the MEN1 gene in 11 Chinese families with multiple endocrine neoplasia type 1 (MEN1); to investigate the pathogenesis of the MEN1 tumours by means of somatic mutation analysis of the MEN1 gnee and loss of heterozygosity (LOH) studies; to determine whether there is any genotype- phenotype correlation in these MEN1 families.

List of Research Outputs

Au W.Y., Chow W.S., Lam K.S.L., Cockram C.S., Ko T.C., Kwong Y.L., Acute leukemia in acromegalic patients, British Journal of Haematology. 2000, 110: 871-3.

Chu L.W., Lam K.S.L., Tam S.C.F., Hu W., Hui S.L., Chin A., Chiu K.C., Ng P., A randomised controlled trial of low dose recombinant human growth hormone in the treatment of malnourished elderly patients., Journal of Clinical Endocrinology & Metabolism. 2001, 86: 1913-1920.

Ho E.C.M., Lam K.S.L., Chung S.S.M., Chung S.K., Aldose reductase-deficient mice are alleviated from the depletion of GSH in the peripheral nerve and MNCV deficit associated with diabetes, 61st American Diabetes Association meeting, Philadelphia, USA. 2001, 238OR.

Ho E.C.M., Lam K.S.L., Chung S.S.M., Chung S.K., Aldose reductase-deficient mice are protected from motor nerve conduction deficit associated with diabetes, 13^th Annual Scientific Meeting of the Hong Kong Society of Endocrinology, Metabolism and Reproduction, December 3. 2000.

Ho E.C.M., Lam K.S.L., Chung S.S.M., Chung S.K., Aldose reductase-deficient mice are protected from reduction of nerve conduction associated with diabetes, Fifth Diabetic Neuropathy Satellite to the International Diabetes Federation Congress 2000, San Jose, Costa Rica, October 31 - November 4. 2000.

Ip M.S.M., Wat N.M.S., Tan K.C.B., Peh W.C.G., Ho J.C.M., Lam K.S.L., Effect of a somatostatin analogue on sleep apnea in acromegaly - correlation with CT cephalometry and hormonal activity, ENDO 2000, Toronto, Canada. June 2000.

Ip M.S.M., Lam K.S.L., Ho C.M., Tsang K.W.T., Lam W.K., Serum leptin and vascular risk factors in obstructive sleep apnoea, Chest. 2000, 118: 582-586.

Janus E.D., Wat N.M.S., Lam K.S.L., Cockram C.S., Siu S.T.S., Liu L.J., Lam T.H., The prevalence of diabetes, association with cardiovascular risk factors and implications of diagnostic criteria (ADA 1997 and WHO 1998) in a 1996 community based population study in Hong Kong Chinese., Diabetic Medicine. 2000, 17: 714-715.

Lam A.K.Y., Lo C.Y., Wat N.M.S., Luk J.M.C., Lam K.S.L., The clinicopathological features and importance of p53, Rb, and mdm2 expression in phaeochromocytomas and paragangliomas, Journal of Clinical Pathology. 2001, 54(6): 443-448.

Lam K.S.L., Endocrine Disorders, In: WS Pang, MK Teoh, SK Ming, Medicine & Surgery in the Older Person. Armour Publishing, 2000, 1st edition: 431-454.

Lam T.H., Liu L.J., Janus E.D., Lam K.S.L., Hedley A.J., Fibrinogen, other cardiovascular risk factors and diabetes mellitus in Hong Kong: a community with high prevalence of Type 2 diabetes mellitus and impaired glucose tolerance, Diabetic Medicine. UK, 2001, 17: 798-806.

Liu Y.F., Wat N.M.S., Chung S.S.M., Lam K.S.L., Diabetic nephropathy is associated with the Z-2 microstatellite allele of the aldose reductase gene in Chinese subjects with Type 2 diabetes., 17th International Diabetes Federation Congress, Mexico City, USA.. 2000.

Lo C.Y., Chan F.L., Tam S.C.F., Cheng P.W., Fan S.T., Lam K.S.L., Value of intra-arterial calcium injection with hepatic venous sampling for regionalisation of pancreatic insulinomas., Surgery. 2000, 128: 903-9.

Tan K.C.B., Tso A.W.K., Tam S.C.F., Pang W.C., Lam K.S.L., Acute effect of orlistat on postprandial lipaemia in overweight patients with type 2 diabetes., 72nd EAS Congress, Glasgow, UK. 2001.

Tan K.C.B., Tso A.W.K., Lam K.S.L., Effect of Sandostatin LAR on serum leptin levels in patients with accomegaly., Clinical Endocrinology. 2000, 53: 1-6.

Tan K.C.B., Lam K.S.L., Effects of Sandostatin LAR treatment on the metabolic changes in acromegaly., Symposium on Acromegaly, Taipei, Taiwan. 2000.

Tan K.C.B., Tso A.W.K., Pang W.C., Lam K.S.L., Effects of Sandostatin(R) LAR(R) on lipoprotein metabolism in patients with acromegaly - a six-month prospective study, 83rd Annual Meeting of the Endocrine Society, Denver, USA. 2001.

Tan K.C.B., Chow W.S., O K., Ai V., Lam K.S.L., Hyperhomocysteinaemia on endothelial dysfunction in type 2 diabetes mellitus., 5th European Congress of Endocrinology, Turin, Italy. 2001.

Tan K.C.B., Chow W.S., Ai V.H.G., Metz C., Bucala R., Lam K.S.L., Serum advanced glycation end products and carotid intima-media thickness in Type 2 diabetes mellitus., 11th International Congress of Endocrinology, Sydney, Australia. 2000.

Tan K.C.B., Pang W.C., Lam K.S.L., Treatment of a acromegaly with Sandostatin (R) LAR associated with increase in lipoprotein lipase activity and HDL levels., 11th International Congress of Endocrinology, Sydney, Australia. 2000.

Wat N.M.S., Lam T.H., Janus E.D., Lam K.S.L., Central, but not overall overall, obesity predicts the worsening of glycaemia in South Chinese, Diabetologia. 2001, 43(Suppl 1): A116.

Wat N.M.S., Lam T.H., Janus E.D., Lam K.S.L., Central, but not overall, obesity predicts the worsening of glycaemia in southern Chinese., 36th Annual Meeting of the EASD, Jerusalem, Israel. 2000.

Wat N.M.S., Lee K.K., Lam T.H., Janus E.D., Lam K.S.L., Contribution of obesity on cardiovascular risk factors in southern Chinese - relevance of the new Asian criteria for obesity., 11th International Congress of Endocrinology, Sydney, Australia. 2000.

Wat N.M.S., Lo C.Y., Lam Y.K., Chan J.C.W., Lam K.S.L., Germline mutation analysis in Hong Kong Chinese families with multiple endocrine neoplasia type 2., 11th International Congress of Endocrinology, Sydney, Australia. 2000.

Wat N.M.S., Janus E.D., Lam T.H., Lam K.S.L., Obesity in relation to the prevalence and incidence of hypertension in southern Chinese, 5th European Congress of Endocrinology, Turin,Italy. 2001.

Wat N.M.S., Janus E.D., Lam T.H., Tso A.W.K., Lam K.S.L., Obesity in relation to the prevalence and incidence of type 2 diabetes in southern Chinese: implications of the proposed asian criteria, 61st American Diabetes Association meeting, Philadelphia, USA. 2001, 868-P.

Xu J., Chan V.N.Y., Zhang W., Lam K.S.L., High Frequency of Mutations in the Hepatocyte Nuclear Factor-1 alpha in Chinese Subjects with Familial Early-Onset Type 2 Diabetes: Identificatioin and Functional Analysis, 61st Scientific Sessions, American Diabetes Association, June 22-26, 2001, Philadelphia, Pennsylvania, USA. 2001.

Xu J., Chan V.N.Y., Zhang W., Lam K.S.L., High frequency of mutations in the hepatocyte nuclear factor-1aGene identification and functional analysis, 61st American Diabetes Association meeting, Philadelphia, USA. 2001, 1019-P.

Xu J., Chan V.N.Y., Lam K.S.L., Mutations in the Hepatocyte Nuclear Factor-1 Alpha Gene in Southern Chinese Subjects with Early-Onset Type 2 Diabetes, 3rd HUGO-Pacific Meeting, Shanghai, China, October 18-21, 2000.

Xu J., Zhang W., Chan V.N.Y., Lam K.S.L., Mutations in the Hepatocyte Nuclear Factor-1 alpha Gene in Chinese Subjects with Familial Early-Onset Type 2 Diabetes: Identification and Functional Analysis, Semi-final of the 7th Challenge Cup Competition, April 27, 2001, The University of Hong Kong. 2001.

Xu J., Chan V.N.Y., Lam K.S.L., Mutations in the Hepatocyte Nuclear Factor-1 alpha Gene in Southern Chinese Subjects with Early-Onset Type 2 Diabetes, 6th Medical Research Conference, Department of Medicine, The University of Hong Kong, Jan 13-14, 2001.

Xu J., Chan V.N.Y., Lam K.S.L., The Hepatocyte Nuclear Factor-1 alpha Gene Plays a Significant Role in Southern Chinese Subjects With Early-Onset Type 2 Diabetes, 5th Research Postgraduate Symposium, The University of Hong Kong, December 7-9, 2000.

Zhang M., Wat N.M.S., Tso A.W.K., Chung S.S.M., Lam K.S.L., Are promotor variants of the glucokinase gene predictive of the development of diabetes in subjects with impaired glucose tolerance?, 17th International Diabetes Federation Congress, Mexico City, USA. 2000.

Researcher : Lam RWF

List of Research Outputs

Yu C.M., Lau C.P., Yang H., Wang Q., Lee S.W.L., Chan R.H.W., Lam L., Lam Y.M., Lee P.Y., Jim M.H., Ng W., Tse H.F., Lee K.L.F., Ho P.C., Lam R.W.F., "Isolated" left ventricular diastolic dysfunction - The condition need to be redefined, The Hong Kong Practitioner. 2001, 23 no. 2: 1.

Researcher : Lam SK

Project Title:	To measure the gastroduodenal mucosal blood flow, nitric oxide and prostaglandin content of the gastric mucosa at different phases of healing of duodenal ulcer, before and after eradication of Helicobacter pylori (HP)
Investigator(s):	Prof. Lam S.K. , Dr. Cho C.H., Dr. Hui W.M., Dr. Lau K.K.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	July 1996

Abstract:

To measure the gastroduodenal mucosal blood flow, nitrous oxide and prostaglandin content of the gastric mucosa at different phases of healing of duodenal ulcer, before and after eradication of Helicobacter pylori (HP).

Project Title:	A study on the proliferative activity and apoptosis in gastric epithelial cells of helicobacter pylori (HP) infected patients on non-steroidal anti-inflammatory drugs (NSAIDs) before and after treatment with antibiotics and misoprostol
Investigator(s):	Prof. Lam S.K. , Dr. Hui W.M., Dr. Lam K.C., Dr. Yuen S.T.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	July 1997

Abstract:

To study the mechanism of gastric epithelial injury by HP infection and NSAIDs; to study the interaction between HP infection and NSAIDs in gastric epithelial injury; to study the changes in gastric epithelial injury after HP eradication and administration of cytoprotective agents.

Project Title:	Macrophage migration inhibitory factor expression in chronic gastritis and peptic ulcer in patients with helicobacter pylori infection
Investigator(s):	Prof. Lam S.K. , Dr. Lan H.Y., Dr. Wong B.C.Y.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	July 1999

Abstract:

To identify the cell type(s) responsible for constitutive MIF expression within the human stomach; to examine the potential role of MIF expression in the development of human gastritis and gastric ulcer.

Project Title:	Chemoprevention of gastric cancer by treatment of Helicobacter pylori infection
Investigator(s):	Prof. Lam S.K. , Dr. Ho J.C.Y., Dr. Lam K.C., Dr. Wong B.C.Y., Dr. Yuen S.T.
Department:	Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	July 1999

Abstract:

To assess if the treatment of Helicobactor pylori infection in asymtomatic individuals can reduce the incidence of gastric cancer in a high risk area over a five year period; to assess if the treatment of Helicobactor pylori infection will lead to progression or regression of various precancerous gastric conditions including gastric atrophy, intestinal metaplasia and dysplasia over a five year period; to assess the long term sequelae of Helicobacter pylori eradication both clinically, including development of gastroesophageal reflux, and histologically, including changes in cell proliferation and apoptosis.

List of Research Outputs

Chan A.O.O., Lam S.K., Chu K.M., Lam C.M., Kwok E.N.L., Leung S.Y., Yuen S.T., Law S.Y., Hui W.M., Lai K.C., Wong B.C.Y., Hu W.C.H., Lai C.L., Wong J., Soluble E-cadherin is a valid prognostic marker in gastric carcinoma., Gut. 2001, 48(6): 808-811.

Chan A.O.O., Lam S.K., Chu K.M., Lam C.M., Kwok E., Leung S.Y., Yuen S.T., Law S.Y.K., Hui W.M., Lai C.L., Wong C.Y., Hu H.C., Lai C.L., Wong J., Soluble E-cadherin is a valid prognostic marker in gastric carcinoma, Gut. 2001, 48: 808-811.

Ding S.Z., Cho C.H., Lam S.K., Regulation of interleukin 6 production in a human gastric epithelial cell line MKN-28, Cytokine. 2000, 12, No. 7: 1129-1135.

Fan X.M., Lin M.C., Lam S.K., Kung H., Masferrer J.L., Koko A.T., Cho C.H., Wong B.C.Y., Sepcific imhibition of cyclooxygenase-2 down-regulates NF-kappaB activation in gastric cancer cells by blocking its nuclear translocation [6th Medical Research Conference, Department of Medicine, University of Hong Kong, 13-14 January], The Hong Kong Practitioner. 2001, 23 (2-suppl): 45.

Fan X.M., Lam S.K., Zhou X.M., Wang W.P., Cho C.H., Leung S.Y., Yuen S.T., Lin M.C., Kung H., Specific cyclooxygenase-2 (COX-2) inhibitor induce apoptosis in gastric cancer cells, Proceedings, Second Joint Scientific Meeting, Hong Kong Society of Gastroenterology, Hong Kong Society of Digestive Endoscopy, Hong Kong Society for Coloproctology, 2 September. 2000.

Fung P.C.W., Lam S.K., Diseases, Nitric Oxide and Related Potent Therapy, Medical Progress. 2001, 19-22.

Guo X., Liu S.L.E., Ko J.K.S., Wong B.C.Y., Ye Y., Lam S.K., Cho C.H., Protective role of cyclooxygenase inhibitors in the adverse action of passive cigarette smoking on the initiation of experimental colitis in rats, European Journal of Pharmacology. 2000, 411: 193-203.

Jeong J.Y., Mukhopadhyay A.K., Dailidiene D., Wang W.P., Velapatino B., Gilman R.H., Parkinson A.J., Nair G.B., Wong B.C.Y., Lam S.K., Mistry R., Segal I., Yuan Y., Gao H., Alarcon T., Lopez Brea N.M., Gong Y., Goodwin A., Hoffman P.S., Berg D.E., Sequential inactivation of rdxA (HP0954) and frxA (HP0642) nitroreductase genes causes moderate and high-level metronidazole resistance in Helicobacter pylori, Journal of Bateriology. 2000, 182: 5082-5090.

Jiang X., Wong B.C.Y., Yuen S.T., Jiang S.H., Cho C.H., Lai K.C., Lin M.C., Kung H., Lam S.K., Arsenic trioxide induces apoptosis in human gastric cancer cells through up-regulation of P53 and activation of caspase-3, International Journal of Cancer. 2001, 91: 173-179.

Jiang X., Lam S.K., Lin M.C., Cho C.H., Lai K.C., Kung H., Yang D., Wong B.C.Y., P53 status determines nuclear factor-kappa B response in Triptolide-induced apoptosis in gastric cancer [Poster presentation, 92nd Annual meeting of the American Association of Cancer Research], Proceedings of American Association of Cancer Research Annual Meeting. 2001, 42: 659.

Jiang X., Lam S.K., Lin M.C., Cho C.H., Lai K.C., Kung H., Yang D., Wong B.C.Y., p53 status determines nuclear factor-kappa B response in Triptolide-induced apoptosis in gastric cancer (poster presentation), 92nd Annual meeting of the American Association of Cancer Research (March 24-28, 2001) Proceedings of American Association of Cancer Research Annual Meeting. 2001, 42: 659.

Jiang X., Lam S.K., Lin M.C., Cho C.H., Lai K.C., Kung H., Yang D., Wong B.C.Y., p53 status determines nuclear factor-kb response in triptolide-induced apoptosis in gastric cancer, The 92nd Annual meeting of the American Association for Cancer Research, New Orleans, USA, March 24-28. 2001.

Lai K.C., Lam S.K., Hui W.M., Wong C.Y., Chu K.M., Wong W.M., Chan O.O., Lai C.L., Lau K.K., Yuen M.F., Chan C.K., Lansoprazole reduces ulcer relapse after eradication of Helicobacter pylori in NSAIDs users, Gastroenterology. 2000, 118(Supp 2): A251.

Lam S.K., Differences in peptic ulcer between East and West., Bailliere's Clinical Gastroenterology. 2000, 14: 41-52.

Lan X.R., Hui W.C., Chen Y.X., Wong B.C.Y., Metz C., Bucala R., Fung P.C.W., Lam S.K., Lan H.Y., Macrophage migration inhibitory factor is an important medicator in gastric inflammatory disease [Oral presentation, 6th Medical Research Conference, Department of Medicine, University of Hong Kong, 13-14 January], The Hong Kong Practitioner. 2001, 23 (2-suppl): 45.

Lau G., Cheung R.P.F., Payne S.L., Lai C.L., Lam S.K., Costs and outcomes of one-year treatment with lamivudine (Zeffix) or a single course of alpha-interferon in chronic hepatitis B, Journal of Gastroenterology and Hepatology. 2000.

Lau G.K.K., Tsiang M., Hou J., Yuen S.T., Carman W.F., Zhang L., Gibbs C.S., Lam S.K., Combination therapy with lamivudine and famciclovir for chronic hepatitis B infected Chinese: a viral dynamics study, Hepatology. 2000, 32: 394-399.

Lau G.K.K., Cheung R., Payne S., Lai C.L., Lam S.K., Cost-effectiveness of one-year treatment with lamivudine (Zeffix) or a single course of A-interferon in chronic hepatitits B, Journal of Hepatology. 2000, 32(4): 1720.

Tsang K.W.T., Lam W.K., Chan N.K., Wu W., Kwok E., Zheng L., Wong B.C.Y., Lam S.K., Helicobacter pylori sero-prevalence in asthma, Respiratory Medicine. 2000, 94: 756-760.

Tsang K.W.T., Lam W.K., Chan K.N., Hu H.C., Wu A.Y.Y., Kwok E.N.L., Zheng L., Wong B.C.Y., Lam S.K., Helicobacter pylori sero-prevalence in asthma, Respiratory Medicine. 2000, 94: 756-60.

Wang W.H., Wong B.C.Y., Berg D.E., Fung F.M.Y., Lai K.C., Wong W.M., Wong K.W., Cho C.H., Lam S.K., Mixed genotype and metronidazole susceptibility patterns of Helicobacter pylori in Hong Kong, Gastroenterology. 2000, 118:4 (suppl 2): A503.

Wang W.H., Wong B.C.Y., Lam S.K., Pooled analysis of Helicobacter pylori eradication regimes in Asia, Journal of Gastroenterology and Hepatology. 2000, 15: 1007-1016.

Wang W.P., Fan X.M., Lam S.K., Cho C.H., Lin M.C., Kung H., Hui W.M., Wong B.C.Y., Inhibition of 12-lipoxygenase induced apoptosis in human gastric cancer cells, Proceedings, Second Joint Scientific Meeing, Hong Kong Society of Gastroenterology, Hong Kong Society of Digestive Endosocpy, Hong Kong Society for Colopractology,2 September. 2000.

Wong B.C.Y., Wong W.M., Wang W.H., Tang V.S.Y., Young J., Lai K.C., Yuen S.T., Leung S.Y., Hu H.C., Chan C.K., Hui W.M., Lam S.K., An evaluation of invasive and non-invasive tests for the diagnosis of Helicobacter pylori infection in Chinese, Alimentary Pharmacology and Therapeutics. 2000, 15(4): 505-511.

Wong B.C.Y., Jiang X., Zhu G.H., Lin M.C., Kung H., Lam S.K., Chemoprevention of gastric cancer through modulation of Protein Kinase C by non-steroidal anti-inflammatory drugs, 5th International Symposium on Predictive Oncology and Therapy. Impact of Biotechnology on Cancer Diagnostic & Prognostic Indicators, organised by the International Society for Preventive Oncology, Geneva, Switzerland, October 28-31. 2000.

Wong B.C.Y., Fan X.M., Lin M.C., Kung H., Lam S.K., Cyclooxygenase-2 and protein kinase C signalling in gastric cancer, Molecular Genetic Basis of Cancer. 2001, 224-229.

Wong B.C.Y., Lam S.K., Dyspepsia, Hong Kong Practitioner. 2000, 22: 417-425.

Wong B.C.Y., Chan C.K., Wong K.W., Wong W.M., Yuen M.F., Lai K.C., Hu H.C., Lau G.K.K., Lai C.L., Lam S.K., Evaluation of a new referral system for the management of dyspepsia in Hong Kong: role of open-access upper endoscopy., Journal of Gastroenterology & Hepatology. 2000, 15(11): 1251-1256.

Wong B.C.Y., Wong K.W., Chan C.K., Wong W.M., Yuen M.F., Lai K.C., Hu H.C., Lau G., Lai C.L., Lam S.K., Evaluation of new referral system for the management of dyspepsia in Hong Kong: Role of open access uper endoscopy, Journal of Gastroenterology and Hepatology. 2000, 15: 1251-1256.

Wong B.C.Y., Wang W., Berg D.E., Fung F.M.Y., Wong K.W., Wong W.M., Lai K.C., Cho C.H., Hui W.M., Lam S.K., High prevalence of mixed infections by Helicobacter pylori in Hong Kong: metronidazole sensitivity and overall genotype, Alimentary Pharmacology and Therapeutics. 2000, 15: 493-503.

Wong B.C.Y., Wong W.M., Wang W.H., Fung F.M.Y., Lai K.C., Chu K.M., Yuen S.T., Leung S.Y., Hu H.C., Yuen M.F., Lau G., Chan C.K., Lam S.K., One-week Ranitidine Bismuth Citrate-based triple therapy for the eradication of Helicobacter pylori in Hong Kong with high prevalence of metronidazole resistance, Alimentary Pharmoacology and Therapeutics. 2001, 15: 403-409.

Wong B.C.Y., Wang W.H., Lau G., Wong W.M., Fung F.M.Y., Kung N.N.S., Chu K.M., Lai K.C., Hu H.C., Hu F.L., Liu X.G., Chan C.K., Yuen M.F., Hui W.M., Lam S.K., Three-day lansoprazole quadruple therapy for Helicobacter pylori-positive duodenal ulcers: a randomized contolled study [Oral presentation, 6th Medical Research Conference, Department of Medicine, 13-14 January], The Hong Kong Practitioner. 2001, 23 (2-suppl): 18.

Wong B.C.Y., Lam S.K., Treatment regimes for Helicobacter pylori infection in Asia Pacific region, Journal of Modern Digestion and Intervention. 2000, 5 Suppl: 46-48.

Wong B.C.Y., Chang F.Y., Abid S., Abbas Z., Lin B.R., Van Rensburg C., Chen P.C., Schneider H., Simjee A.E., Hamid S.S., Seebaran A., Zhang J., Destefano M., Lam S.K., Triple therapy with clarithromycin, omeprazole, and amoxicillin for eradication of Helicobacter pylori in duodenal ulcer patients in Asia and Africa, Alimentary Pharmoacology and Therapeutics. 2000, 14: 1529-1536.

Wong W.M., Wong B.C.Y., Wong K.W., Li T.M., Cheung K.L., Fung F.M.Y., Xia H.H.X., Lam S.K., Low dose 13C-Urea breath test with citrate is equally reliable for the detection of Helicobacter pylori infection in Chinese [6th Medical Research Conference, Department of Medicine, University of Hong Kong, 13-14 January], The Hong Kong Practitioner. 2001, 23 (2-suppl): 19.

Wong W.M., Wong B.C.Y., Wong K.W., Fung F.M.Y., Lai K.C., Hu H.C., Yuen S.T., Leung S.Y., Lau G.K.K., Lai C.L., Chan C.K., Go R., Lam S.K., ¹³C-urea breath test without a test meal is highly accurate for the detection of Helicobacter pylori infection in Chinese, Alimentary Pharmacology and Therapeutics. 2000, 14: 1353-1358.

Wu A.Y.Y., Lam S.K., An update on food allergy, Medical Progress. 2001, 28: 23-28.

Xia H.H.X., Zhang G.S., Talley N.J., Henwood C., Wyatt J.M., Adams S., Wong B.C.Y., Lam S.K., Expression of Ki-67 and bcl-2 in gastric epithelial cells: role of antralization in gastric carcinogenesis [6th Medical Research Conference, Department of Medicine, University of Hong Kong 13-14 January], The Hong Kong Practitioner. 2001, 23 (2-suppl): 46.

Xia H.H.X., Wong B.C.Y., Talley N.J., Lam S.K., Helicobacter pylori infection - current treatment practice, Experts Opinion on Pharmacotherapy. 2001, 2: 253-266.

Zhou X.M., Lai K.C., Lam S.K., Zhang H.B., Lan X.R., Fan X.M., Hui W.M., Fan D.M., Wong B.C.Y., Induced gastric mucosal apoptosis in Helicobacter pylori positive patients taking low lose aspirin: a 6-month case-control study, Proceedings, Second Joint Scientific Meeting, Hong Kong Society of Gastroenterology, Hong Kong Society of Digestive Endoscopy, Hong Kong Society for Coloproctology, 2 September. 2000.

Researcher : Lam TP

Project Title:	A study of the health ecology of a fishing community in Hong Kong
Investigator(s):	Dr. Lam T.P. , Prof. Dixon A.S., Prof. Underwood P., Dr. d'Abbs P.
Department:	Family Medicine Unit of the Department of Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	July 1996
Completion Date:	September 2000

Abstract:

To investigate the health ecology of a fishing community in Hong Kong. In particular it will examine the history and social organisation of the community, describing the community's pattern of public and domestic health and health services, and outlines in detail how and why this community uses the available facilities.

Project Title:	What are the learning outcomes and effects on students' attitudes to the learning process of introducing a clinical skills component in the early years of a PBL medical course?
Investigator(s):	Dr. Lam T.P. , Dr. Chow L.W.C., Dr. Irwin M.G.
Department:	Family Medicine Unit of the Department of Medicine
Source(s) of Funding:	Teaching Development Grants issued by The University Grants Committee of Hong Kong
Start Date:	April 1998
Completion Date:	December 2000

Abstract:

To investigate the learning outcomes and effects on students' attitudes to the learning process of the clinical skills component of a PBL medical course, and to develop a mechanism to enhance these outcomes and to improve students' attitudes to learning.

Project Title:	What are the health care experiences of patients with low literacy in Hong Kong?
Investigator(s):	Dr. Lam T.P. , Dr. Cheng Y.H.
Department:	Family Medicine Unit of the Department of Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	July 1999

Abstract:

To investigate the health care experiences of patients with low literacy in Hong Kong and what are the coping mechanisms they use to deal with these problems.

Project Title:	Why do family doctors prescribe antibiotics for upper respiratory tract infection?
Investigator(s):	Dr. Lam T.P. , Dr. Lam K.F.
Department:	Family Medicine Unit of the Department of Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	November 2000

Abstract:

To investigate the clinical factors which may influence family physicians' decision to prescribe antibiotics for upper respiratory tract infections (URTI).

List of Research Outputs

Researcher : Lam WK

List of Research Outputs

Au W.Y., Ho C.M., Lie A.K.W., Sun J., Zheng L., Liang R.H.S., Lam W.K., Tsang K.W.T., Ciliary assessment in bone marrow transplantation patients., Bone Marrow Transplantation. 2001, 27: 1147-51.

Chan K.N., Ip M.S.M., Law B., Wu A.Y.Y., Chan M.M.W., Tsang K.W.T., Lee S.L., Chan E., Siu E., Lam W.K., Effectiveness of an asthma education program, American Journal of Respiratory and Critical Care Medicine. 2000, 161: A320.

Chan L.Y., Fong D.Y.T., Lam C.L.K., Chan-Yeung M., Say J., Yan C.P.K., Leung R., Ooi C.G.C., Ip M.S.M., Lam W.K., Tsang K.W.T., Validation of the Hong Kong Chinese Version of St. George's Respiratory Questionnaire (SGRQ), Medical Research Conference 13-14 January 2001. Hong Kong.

Choi K., Lam W.K., Management of community acquired pneumonia in the immunocompetent adult, Hong Kong Medical Association Continuing Medical Education Bulletin. 2001, Jan: 1-6.

Ho J.C., Chan K.N., Hu W.H., Lam W.K., Zheng L., Tipoe G.L., Sun J., Leung Y.H., Tsang K.W.T., The effect of aging on nasal mucocilliary clearance, beat frequency, and ultrastructure of respiratory cilia, American Journal of Respiratory and Critical Care Medicine. 2001, 163 (3): 983-988.

Ho J.C.M., Tsang K.W.T., Lam B., Lam C.L., Wang J., Ip S., Yan C.P.K., Ip M.S.M., Chan M.M.W., Lam W.K., A multicentre Asian trial of docetaxel and cisplatinin advanced non-small cell lung cancer, Hong Kong Practitioner. 2001, 23 Suppl 2: 29.

Ho J.C.M., Lam W.K., Ooi C.G.C., Tsang K.W.T., Wong M.P., Chemotherapy in advanced lymphoepithelioma-like carcinoma (LELC) of lung, Lung Cancer. 2000, 29(Suppl 1): 76 (abst 249).

Ho J.C.M., Lam W.K., Ip M.S.M., Nguyer T., Tsang K.W.T., Phase II trial of taxotere and cisplatin in advanced non-small cell lung cancer, Lung Cancer. 2000, 29(Suppl 1): 44 (abst 141).

Ho J.C.M., Lam W.K., Hu W., Leung R., Sun J.Z., Tipoe G.L., Zheng I., Chu L.W., Tsang K.W.T., The effects of aging on respiratory ciliary function and electron microscopic abnormalities, American Journal of Respiratory and Critical Care Medicine. 2000, 161: A123.

Ho J.C.M., Lam W.K., What is ras gene and its role in lung cancer?, Hong Kong Thoracic Society/American College of Chest Physicians Newsletter. 2000, 10(2): 30.

Ho J.C.S., Lam W.K., Ooi C.G.C., Lam B., Tsang K.W.T., Lymphoepithelioma-like carcinoma of the lung., Respiratory Medicine. 2000, 94(10): 943-947.

Ip M.S.M., Lam B., Lauder I.J., Tsang K.W.T., Chung K.F., Mok W.Y.W., Lam W.K., A community study of sleep disordered breathing in middle-aged Chinese men in Hong Kong, Chest. 2001, 119: 62-69.

Ip M.S.M., Lam B., Cheng S., Zheng L., Tsang K.W.T., Fung P.C.W., Lam W.K., Circulating nitic oxide is suppressed in obstruvtive sleep apnea and is reversed by nCPAP, American Journal of Respiratory and Critical Care Medicine. 2000, 162: 2166-2171.

Ip M.S.M., Lam K.S.L., Ho C.M., Tsang K.W.T., Lam W.K., Serum leptin and vascular risk factors in obstructive sleep apnoea, Chest. 2000, 118: 582-586.

Ip M.S.M., Lam B., Ip T.Y., Mok W.Y.W., Tsang K.W.T., Chan M.M.W., Lam W.K., Vascular risk profile in obstructive sleep apnoea, 10th European Respiratory Society Annual Congress, Florence, Italy. Aug - Sep 2000. 161: 274s(P1959).

Ip S., Lam W.K., Wang J., Ho J.C.M., Tsang K.W.T., Exhaled nitric oxide (NO) in volunteers: the effect of age and gender, European Respiratory Journal. 2000, 16 (Suppl 31): 258S.

Kumana C.R., Kou M., Lauder I.J., Ip M.S.M., Lam W.K., Increasing use of inhaled steroids associated with declining asthma mortality, Journal of Asthma. NY, USA, Marcel Dekker, 2001, 38: 161-167.

Lam B., Lam C.L., Lam W.K., Ho J.C.M., Tsang K.W.T., Adenocarcinoma is not uncommon in non-smoking female, Lung Cancer. 2000, 29 (Suppl 1): 238 (abst 817).

Lam B., Lam W.K., Ooi C.G.C., Ho J.C.M., Tsang K.W.T., Bronchial brushing does not improve the diagnostic yield by biopsy and washing in patients with bronchoscopically visible tumour, 11th World Congress for Bronchoscopy, Yokohama, Japan. 2000, Abst No. 200.

Lam B., Tsang K.W.T., Lam W.K., Ip M.S.M., Nasal pressure sensor has no better correlation with arousal index than thermistor, Abstract Book of World Congress on Sleep Apnoea. 2000, 13.

Lam B., Ip M.S.M., Sam K., Au C.L., Tsang K.W.T., Lam W.K., Cooke M.S., One year efficacy of oral appliance in treating sleep apnoea has no correlation with the change in cross section of the upper airway, 6th World Congress on Sleep Apnoea, Sydney, Australia. 2000, 93: 119.

Lam C.L., Lam W.K., Tsang K.W.T., Ip M.S.M., Characteristics of young Chinese patients (less than 40 years of age) having carcinoma of lung compared to patients of older age group, Lung Cancer. 2000, 29(Suppl 1): 237 (abst 815).

Lam C.L., Lam W.K., Ip M.S.M., Tsang K.W.T., Lam B., Ho J.C.M., Ip S., Wang J., The use of gemcitabine and cisplatin Chinese patients with advanced non-small cell lung carcinoma (NSCLC), Medical Research Conference, University Department of Medicine, Hong Kong. 2001, 23(Suppl 2): 24 (G-RM-1).

Lam O.B., Ooi C.G.C., Sam K., Lam W.K., Ip M.S.M., Upper airway change after oral appliance in obstructive sleep apnoea patients - difference exist in good and poor responders., Journal of the Japanese Respiratory Society. 2001, 39(S-2): 80.

Lam W.K., Archives in respiratory medicine : history of Hong Kong Lung Foundation, Hong Kong Thoracic Society/American College of Chest Physicians Newsletter. 2001, 11(1): 3-4.

Lam W.K., Tsang K.W.T., Ip M.S.M., Bronchiectasis : conventional and new, innovative medical treatments, 2nd International Meeting on Respiratory Care (RESPINA 2000), Jakarta, Indonesia. 2000, P.77: T11-1.

Lam W.K., Tsang K.W.T., Ip M.S.M., Chemotherapy for advanced non-small cell lung cancer : role of paclitaxel and gemcitabine, Hong Kong Medical Journal. 2000, 5: 180-186.

Lam W.K., Ho J.C.M., Lam B., Ip M.S.M., Tsang K.W.T., Chemotherapy for stage IIIB and stage IV non-small cell lung cancer (NSCLC) - Hong Kong experience, 9th World Conference on Lung Cancer (Tokyo, Japan 2000) Satellite Symposium - Recent Trends in the Management of Lung Cancer. 2000, abstract: p, 5.

Lam W.K., Chan L.Y., Leung R., Fung P.C.W., Zheng L., Lam C.L., Shum I.H.Y., Ho J.C.M., Ip S., Ip M.S.M., Tsang K.W.T., Exhaled nitric oxide levels in steady state bronchiectasis : a prospective study, European Respiratory Journal. 2000, 16 (Suppl 1): 399S.

Lam W.K., Wong M.P., Lung M.L., Tsang K.W.T., Ip M.S.M., Fu K.H., Chiu S.W., Yew W.W., Genetic changes in non-smoking Chinese women with lung cancer, Lung Cancer. 2000, 29(Suppl 2): 65.

Lam W.K., Chan L.Y., Fung P.C.W., Zheng L., Shum I.H.Y., Leung R., Ho J.C.M., Ip S., Wang J., Ip M.S.M., Tsang K.W.T., Is there a correlation between nitric oxide (NO) in exhaled air, sputum, serum, saliva and urine of bronchiectatic patients?, European Respiratory Journal. 2000, 16(Suppl 31): 399S.

Lam W.K., Message from the President-elect, Asia Pacific Society of Respirology Newsletter. 2000, 9(2): 2-3.

Lam W.K., Milestones in asthma management, Excerpta Medica Monograph. 2000, 1-2.

Lam W.K., Lam C.L., Tsang K.W.T., Pulmonary cryptococcosis, 2nd International Meeting on Respiratory Care (RESPINA 2000), Jakarta, Indonesia. 2000, P.46: T4-4.

Lam W.K., The molecular epidemiology of lung cancer in Chinese, Hong Kong experience, International Symposium on Lung Cancer, National Taiwan University College of Medicine, Taipei, Taiwan. 2001, Programme & Abstract Book: p.5-6.

Ooi C.G.C., Chan P.K., Lee J.C., Fok C.Y., Lam W.K., Tsang K.W.T., High resolution computed tomography quantification of bronchiectasis with functional-morphologic correlation., 97th International Conference of the American Thoracic Society, 2001, San Francisco, California.. USA, 2001.

Ooi C.G.C., Tsang K.W.T., Cheung R.T.F., Lam W.K., Fok C.Y.M., Ng F.M.L., Chan F.L., Ngan H., Lung volume measurement in chronic obstructive pulmonary disease: Application of helical computed tomography., Journal of the Hong Kong College of Radiologists. 2000, 4: 53-58.

Ooi C.G.C., Cheng R.S., Lam V.S., Fok C.Y.M., Ngan H., Lam W.K., Tsang K.W.T., Mediastinal nodal calcification pattern on computed tomography in silicosis., 97th International Conference of the American Thoracic Society, 2001, San Francisco, California.. USA, 2001.

Ooi C.G.C., Kwong D.L.W., Chan K.N., Ngan H., Lock D.T.W., Lam W.K., Chan F.L., Au G.K.H., Tsang K.W.T., Serial HRCT changes after 3-field radiation treatment of breast cancer., Clinical Radiology. 2000, 55: 817-824.

Ooi C.G.C., Tsang K.W.T., Chan K.N., Lock D.T.W., Ng F.M.L., Lam W.K., Chan F.L., Ngan H., Three-dimensional (3D) CT-volumetric assessment of lung volume and emphysema in silicosis., Imaging, Oncology, Science. Birmingham, UK, 2000.

Tsang K.W.T., Shum H.Y.I., Ho J.C.M., Leung Y.H., Taylor G., Zheng L., Tipoe G.L., Chan L.Y., Fung P.C.W., Lam W.K., Downregulation of endothelin (ET)-1 and interleukin (IL)-8 expression in human respiratory mucosa by Pseudomonas aeruginosa pyocyanin and 1-hydroxy-phenazine, Hong Kong Practitioner. 2001, 23 Suppl 2: 67.

Tsang K.W.T., Ip S.K., Leung Y.H., Tipoe G.L., Chan L.Y., Shum H.Y.I., Zheng L., Yan C.P.K., Fung P.C.W., Lam W.K., Exhaled NO: effects of age, gender and body size, American Journal of Respiratory and Critical Care Medicine. 2001, 163 (5): A50.

Tsang K.W.T., Lam W.K., Chan N.K., Wu W., Kwok E., Zheng L., Wong B.C.Y., Lam S.K., Helicobacter pylori sero-prevalence in asthma, Respiratory Medicine. 2000, 94: 756-760.

Tsang K.W.T., Lam W.K., Chan K.N., Hu H.C., Wu A.Y.Y., Kwok E.N.L., Zheng L., Wong B.C.Y., Lam S.K., Helicobacter pylori sero-prevalence in asthma, Respiratory Medicine. 2000, 94: 756-60.

Tsang K.W.T., Ip M.S.M., Fung P.C.W., Zheng L., Shum H.Y.I., Leung Y.H., Chan L.Y., Tipoe G.L., Ooi C.G.C., Ho J.C.M., Lam W.K., Pseudomonas aeruginosa infection is associated with reduced exhaled NO in bronchiectasis, American Journal of Respiratory and Critical Care Medicine. 2001, 163 (5): A671.

Tsang K.W.T., Ip S.K., Fung P.C.W., Ooi C.G.C., Shum H.Y.I., Leung Y.H., Chan L.Y., Tipoe G.L., Zheng L., Ip M.S.M., Ho J.C.M., Chan M.M.W., Lam W.K., Pseudomonas aeruginosa infection is associated with reduced exhaled NO in bronchiectasis, Hong Kong Practitioner. 2001, 23 Suppl 2: 30.

Tsang K.W.T., Leung Y.H., Taylor G., Tipoe G.L., Chan L.Y., Shum H.Y.I., Fung P.C.W., Lam W.K., Pseudomonas aeruginosa pyocyanin and 1-hydroxyphenazine downregulate endothelin-1 and interleukin-8 expression in human respiratory mucosa, American Journal of Respiratory and Critical Care Medicine. 2001, 163 (5): A671.

Tsang K.W.T., Ip S.K., Leung Y.H., Tipoe G.L., Chan L.Y., Shum H.Y.I., Zheng L., Yan C.P.K., Fung P.C.W., Lam W.K., The effects of gender on exhaled NO production among volunteers, Hong Kong Practitioner. 2001, 23 Suppl 2: 28.

Wang J., Lam W.K., Ho J.C.M., Ip S., Tsang K.W.T., Combination of paclitaxel and carboplatin in advanced non-small cell lung cancer (NSCLC), European Respiratory Journal. 2000, 16(Suppl 31): 529S.

Wang J., Lam W.K., Ho J.C.M., Ip M.S.M., Tsang K.W.T., Paclitaxel and carboplatin in advanced non-small cell lung carcer (NSCLC), Hong Kong experience, Medical Research Conference, University Department of Medicine, Hong Kong. 2001, 23(Suppl 2): 25 (G-RM-3).

Zheng L., Tipoe G.L., Lam W.K., Ho J.C.M., Shum H.Y.I., Ooi G.C., Leung Y.H., Tsang K.W.T., Endothelin-1 in stable bronchiectasis, European Respiratory Journal. 2000, 16: 146-149.

Zheng L., Lam W.K., Shum H.Y.I., Tipoe G.L., Yan C., Ip M.S.M., Tsang K.W.T., Overexpression of metalloproteinase-8 and -9 in bronchiectatic airways in vivo, The Hong Kong Practitioner. 2001, 2: 64.

Zheng L., Tipoe G.L., Lam W.K., Leung Y.H., Ho J.C., Ooi G.C., Shum H.Y.I., Tsang K.W.T., Up-regulation of circulating adhesion molecules in bronchiectasis, European Respiratory Journal. 2000, 16: 691-696.

Researcher : Lam WK

List of Research Outputs

Chan K.N., Ip M.S.M., Law B., Wu A.Y.Y., Chan M.M.W., Tsang K.W.T., Lee S.L., Chan E.,