Researchers:
|
Wong S.S.Y.,
Wong K.H., Hui W.T., Lee S.S., Lo J.Y.C., Cao
L. and Yuen
K.Y., Differences in clinical and laboratory diagnostic
characteristics of Penicilliosis Marneffei in human
immunodeficiency virus (HIV) - and non-HIV-infected
patients, Journal of Clinical Microbiology.
2001, 39: 4535-4540.
|
|
Chan K.H.,
Maldeis N., Pope W., Yup A., Ozinskas A., Sit T., Gill
J., Seto W.H.,
Shortridge K.F.
and Peiris J.S.M.,
Evaluation of the Directigen FluA+B Test for Rapid
Diagnosis of Influenza Virus Type A and B Infections,
Journal of Clinical Microbiology. 2002, 40(5):
1675-1680.
|
|
Kumana C.R.,
Tai Y.C., Kong Y., Ma E.C.W., Kou
M., Lee R.A.,
Cheng V.C.C.,
Chiu S.S.S.
and Seto W.H.,
Curtailing unnecessary vancomycin usage in a hospital
with high rates of methicillin resistant Staphylococcus
aureus infection, British Journal Clinical Pharmacology.
2002, 52: 427-432.
|
|
Ho P.L., Cheung K.M.,
Chau P.Y. and Yuen
K.Y., Activities of newer fluoroquinolones against
Burkholderia pseudomallei, 9th Western Pacific Congress
on Chemotherapy & Infectious Diseases (in final program
& abstracts). 2001, 1.12.
|
|
Chow K.H.,
Molecular Characterization of RTX Toxin of Vibrio
cholerae Causing Epidemics (MPhil thesis).
2001.
|
|
Peiris J.S.M.,
Guan Y., Ghose P.,
Markwell D., Krauss S., Webster R.G. and Shortridge
K.F., H3N2, H9N2 and H1N1 subtype influenza viruses
cocirculate in pigs in southeastern China., Options
for the Control of Influenza IV. Eds ADME Osterhaus,
N Cox, AW Hampson. Excerpta Medica, International Congress
Series 1219, Amsterdam. 2001, 195-200.
|
| Project Title: | The molecular characterisation
of H5N1 influenza viruses isolated from geese in southern
China |
| Investigator(s): | Dr.
Guan Y., Prof. Peiris J.S.M., Prof. Shortridge K.F. |
| Department: | Microbiology |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | February 2001 |
| Completion Date: | January 2002 |
| Abstract: |
| Molecular analysis of H5N1 influenza viruses
to understand the genesis of the pathogenic H5N1 virus
associated with the 'avian flu" outbreak in Hong Kong
during 1997. |
| Project Title: | Molecular evolution
studies on H5N1/97 and related avian influenza viruses |
| Investigator(s): | Dr.
Guan Y., Prof. Peiris J.S.M., Prof. Shortridge K.F. |
| Department: | Microbiology |
| Source(s) of Funding: | Hong
Kong Research Grants Council Competitive Earmarked
Research Grants |
| Start Date: | September 2001 |
| Abstract: |
| To develop methods that can be applied to screen
large numbers of virus isolates for genetic reassortants;
to understand how the precursors of H5N1/97 virus evolved,
and continue to evolve, in their hosts in southern
China. |
| Project Title: | Vaccines for the control
of H5N1 and other avian influenza viruses |
| Investigator(s): | Dr.
Guan Y. |
| Department: | Microbiology |
| Source(s) of Funding: | HKU
Foundation Seed Grant |
| Start Date: | April 2002 |
| Project Title: | Genetic determinants
of influenza virus for inter-species transmission:
studies using a reverse genetic approach |
| Investigator(s): | Dr.
Guan Y., Prof. Peiris J.S.M., Dr. Poon L.L.M., Prof.
Shortridge K.F. |
| Department: | Microbiology |
| Source(s) of Funding: | Hong
Kong Research Grants Council Competitive Earmarked
Research Grants |
| Start Date: | August 2002 |
| Abstract: |
| Avian influenza viruses can directly impact
on human and animal health and thus cause economic
loss. The study aims to establishing a reverse genetic
system and to determine the biological significance
of the deletion of NA stalk and the NS genes, particularly
in relation to the host-restriction and pathogenesis.
Results can enhance understanding of the machanism
of inter-species transmission of influenza virus. |
|
Guan Y.,
Peiris J.S.M.,
Lipatov A.S., Ellis T.M., Dyrting K.C., Krauss S.,
Zhang L., Webster
R.G. and Shortridge
K.F., Emergence of multiple genotypes of H5N1 avian
influenza viruses in Hong Kong SAR, Proceedings
of National Academic Science (USA). 2002, 99: 8950-8955.
|
|
Guan Y.,
Peiris J.S.M.,
Kong K.F.,
Dyrthing K.C., Ellis T.M., Sit T., Zhang
L. and Shortridge
K.F., H5N1 Influenza Viruses Isolated from Geese
in Southeastern China: Evidence for Genetic Reassortment
and Interspecies Transmission to Ducks, Virology.
Elsevier Science, 2002, 292: 16-23 (2002).
|
|
Peiris J.S.M.,
Guan Y.,
Ghose P., Markwell
D., Krauss S., Webster R.G. and Shortridge
K.F., H3N2, H9N2 and H1N1 subtype influenza viruses
cocirculate in pigs in southeastern China., Options
for the Control of Influenza IV. Eds ADME Osterhaus,
N Cox, AW Hampson. Excerpta Medica, International Congress
Series 1219, Amsterdam. 2001, 195-200.
|
|
Webster R.G., Guan
Y., Peiris
J.S.M., Walker D., Krauss D., Zhou N.N., Govorkova
E.A., Ellis T.M., Dyrting K.C., Sit T., Perez D.R.
and Shortridge K.F.,
Characterization of H5N1 influenza viruses that continue
to circulate in geese in southeastern China, Journal
of Virology. 2002, 76: 118-126.
|
| Project Title: | A phenotypic and genotypic
analysis of vancomycin tolerance in Streptococcus pnemoniae |
| Investigator(s): | Dr.
Ho P.L., Dr. Que T.L., Prof. Yuen K.Y. |
| Department: | Microbiology |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | November 2000 |
| Abstract: |
| To identify the frequency of occurrence of
vancomycin tolerance in Streptococcus pneumoniae; to
identify novel mutations in the histdine kinase (vncS)
of tolerant pneumococci. |
| Project Title: | Molecular epidemiology
of fluoroquinolone-resistant streptococcus pneumoniae
in Hong kong and Canada |
| Investigator(s): | Dr.
Ho P.L., Dr. Low D.E. |
| Department: | Microbiology |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | November 2001 |
| Abstract: |
| To define the molecular epidemiology of fluoroquinolone-resistant
strains of S. pneumoniae isolated in Hong Kong and
Canada. |
|
Chiu D.C.S., Chiu
S.S.S., Chow
C.B., Ho
P.L., Lau
Y.L., Leung C.W., Tsang D.N.C., Tsang
K.W.T., Tsang T.H.F., Wong
S.S.Y., Yang Y.H. and Yuen
K.Y., Proceedings of The First Current Topic in
Infectious Diseases: Consensus Meeting on Conjugate
Vaccines of the Center of Infection, Faculty of Medicine,
The University of Hong Kong, Hong Kong Journal of
Paediatrics (new series). 2001, 6: 127-132.
|
|
Ho P.L.,
Cheung K.M.,
Chau P.Y. and Yuen
K.Y., Activities of newer fluoroquinolones against
Burkholderia pseudomallei, 9th Western Pacific Congress
on Chemotherapy & Infectious Diseases (in final program
& abstracts). 2001, 1.12.
|
|
Ho P.L.,
Yung R.W.H.,
Que T.L., Tsang D.N.C.,
Ho M., Seto W.H.,
Ng T.K., Yam W.C.
and Ng W.W.S.,
Increasing resistance of Streptococcus pneumoniae to
fluoroquinolones: results of a Hong Kong multicentre
study in 2000, Journal of Antimicrobial Chemotherapy.
The British Society for Antimicrobial Chemotharapy,
2002, 48: 659-665.
|
|
Ho P.L.,
Chan K.C.W., Chiu
S.S.S., Lam
T.H., Lau Y.L.,
Lee C.P., Lee
S.S., Li P.C.K., Lim W., Lo W.L., Morais M.M., Ng M.H.,
Thisyakorn U., Tso H.W.K. and Wang T.K.F., Universal
antenatal human immunodeficiency virus testing in Hong
Kong: consensus statement, Hong Kong Medical Journal.
2001, 7(4): 421-427.
|
|
Tang S.C.W.,
Kwok T.K., Ho
P.L., Tang W.M., Chan
D.T.M. and Lai
K.N., Necrotizing fasciitis in a renal transplant
recipient treated with FK 506: the first reported case,
Clinical Nephrology. 2001, 56(6): 481-485.
|
| Project Title: | Comparative study
of molecular and serological methods for rapid diagnosis
and monitoring therapy of tuberculosis |
| Investigator(s): | Dr.
Im S.W.K., Dr. Yam W.C. |
| Department: | Microbiology |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | November 2000 |
| Abstract: |
| To undertake a comparative study of the molecular
and the serological methods for rapid diagnosis and
monitoring of prognosis of tuberculosis post chemotherapy. |
|
Im S.W.K.,
Zhang J.Z., Zhuang H., Che X.Y., Zhu W.F., Xu G.M.,
Xia N.S. and Ng
M.H., A bacterially expressed peptide prevents
experimental infection of primates by the hepatitis
E virus, Vaccine. 2001, 19: 3726-3732.
|
|
Lam Y., Im S.W.K. and
Yam W.C., Association
of polymorphisms in the NRAMP1 gene and susceptibility
to tuberculosis in Chinese, 10th International Congress
of Human Genetics 2001 of the European Society of Human
Genetics, Vienna, Austria,. 2001.
|
|
Lu L., Ng M.H.,
Zhou B.P., Luo H.T., Nakano T., Robertson B.H. and
Im S.W.K.,
Detection and genotyping of GBV-C/HGV variants in China,
Virus Research. 2001, 73: 131-144.
|
|
Ng S.P., Tsang
R.S.W., Luk J.M.C.,
Ng M.H. and
Im S.W.K.,
Two murine monoclonal antibodies against serogroup
E salmonellae, American Society for Microbiology.
2001, 66: 419-421.
|
|
Zhang J.Z., Ng M.H.,
Xia N.S., Lau B.S.H.,
Che X.Y., Chau T.N., Lai S.T. and Im
S.W.K., Conformational antigenic determinants
generated by interactions between a bacterially expressed
recombinant peptide of the hepatitis E virus structural
protein, Journal of Medical Virology. 2001,
64: 125-132.
|
|
Zhang J.Z., Im
S.W.K., Lay S.H., Chau T.N., Lai S.T., Ng
S.P., Peiris
J.S.M., Tse C., Ng T.K. and Ng
M.H., Occurrence of hepatitis E virus IgM, low
avidity IgG serum antibodies and viremia in sporadic
cases of non-A-B, and C acute hepatitis., Journal
of Medical Virology. 2002, 66: 40-48.
|
|
Lam Y.,
Im S.W.K. and
Yam W.C., Association
of polymorphisms in the NRAMP1 gene and susceptibility
to tuberculosis in Chinese, 10th International Congress
of Human Genetics 2001 of the European Society of Human
Genetics, Vienna, Austria,. 2001.
|
| Project Title: | Molecular characterization
of group G beta-hemolytic streptococcus isolated from
bacteremic patients and analysis of prognostic factors |
| Investigator(s): | Dr.
Lau S.K.P., Dr. Woo P.C.Y., Prof. Yuen K.Y. |
| Department: | Microbiology |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | December 2001 |
| Abstract: |
| To compare the usefulness of the Vitek System
(GPI), the API system (20 STREP), and the ATB expression
system (ID32 STREP) in seciating the isolates with
gold standard; to analyze the epidemiology, clinical
diseases, and outcome of patients that developed group
G beta-hemolytic streptococcal bacteremia. |
|
Lau S.K.P.,
Woo P.C.Y.,
Leung K.W. and Yuen
K.Y., Emergence of Cotrimoxazole- and Quinolone-resistant
Campylobacter infections in bone marrow transplant
recipients, European Journal of Clinical Microbiology
and Infectious Diseases. 2002, 21: 127-129.
|
|
Lau S.K.P.,
Woo P.C.Y.,
Chan B.Y.L., Fung A.M.Y., Que T.L. and Yuen
K.Y., Haemophilus segnis polymicrobial and monomicrobial
bacteraemia identified by 16S ribosomal RNA gene sequencing,
J Med Microbiol. 2002, 51: 635-640.
|
|
Woo P.C.Y.,
Lau S.K.P.
and Yuen K.Y.,
Macrolides as immunomodulatory agents, Curr Med
Chem - Anti-inflammatory & Anti-allergy Agents.
2002, 1: 131-141.
|
|
Kumana C.R.,
Tai Y.C., Kong Y., Ma E.C.W., Kou
M., Lee
R.A., Cheng
V.C.C., Chiu
S.S.S. and Seto
W.H., Curtailing unnecessary vancomycin usage in
a hospital with high rates of methicillin resistant
Staphylococcus aureus infection, British Journal
Clinical Pharmacology. 2002, 52: 427-432.
|
|
Leung
K.L., Novel Molecular Targets of Burkholderia
pseudomallei (MPhil thesis). 2001.
|
|
Chua D.T.T.,
Huang J., Zheng
B., Lau S.Y., Luk
W., Kwong
D.L.W., Sham
J.S.T., Moss D., Yuen
K.Y. and Ng
M.H., Adoptive transfer of autologous Epstein-Barr
virus-specific cytotoxic T cells for nasopharyngeal
carcinoma, International Journal of Cancer.
2001, 94(1): 73-80.
|
|
Ma L.,
Molecular Cloning, Expression and Characterization
of Antigenic Polypeptides from the Human Blood Fluke
Schistosoma Japonicum (MPhil thesis). 2001.
|
| Project Title: | Applications research
and development |
| Investigator(s): | Prof.
Ng M.H. |
| Department: | Microbiology |
| Source(s) of Funding: | The
Hong Kong Jockey Club Charities Trust |
| Start Date: | January 1989 |
| Abstract: |
| To develop applications for research functions. |
| Project Title: | Risk behavioural sentinel
surveillance and scenario construction for prevention
and control of AIDS in Hong Kong |
| Investigator(s): | Prof.
Ng M.H., Prof. Lee S.S. |
| Department: | Microbiology |
| Source(s) of Funding: | Council
for the AIDS Trust Fund |
| Start Date: | August 1994 |
| Abstract: |
| To study the risk behaviour of AIDS. |
| Project Title: | EBV as targets of
immune intervention of NPC |
| Investigator(s): | Prof.
Ng M.H., Dr. Chua D.T.T. |
| Department: | Microbiology |
| Source(s) of Funding: | Hong
Kong Research Grants Council Competitive Earmarked
Research Grants |
| Start Date: | September 2000 |
| Abstract: |
| Nasopharyngeal carcinoma offers two types of
potential targets for immune intervention. One are
antigens specified by Epstein-Barr Virus (EBV) regularly
harbored by the tumor cells. The present study is
to advance the understanding of immune responses to
the epstein-barr virus and its relationship to the
tumor and health carriage of the virus. |
|
Chua D.T.T.,
Huang J., Zheng
B., Lau S.Y., Luk
W., Kwong D.L.W.,
Sham J.S.T.,
Moss D., Yuen K.Y.
and Ng M.H.,
Adoptive transfer of autologous Epstein-Barr virus-specific
cytotoxic T cells for nasopharyngeal carcinoma, International
Journal of Cancer. 2001, 94(1): 73-80.
|
|
Im S.W.K., Zhang
J.Z., Zhuang H., Che X.Y., Zhu W.F., Xu G.M., Xia N.S.
and Ng M.H.,
A bacterially expressed peptide prevents experimental
infection of primates by the hepatitis E virus, Vaccine.
2001, 19: 3726-3732.
|
|
Lu L., Ng M.H.,
Zhou B.P., Luo H.T., Nakano T., Robertson B.H. and
Im S.W.K., Detection
and genotyping of GBV-C/HGV variants in China, Virus
Research. 2001, 73: 131-144.
|
|
Ng S.P., Tsang
R.S.W., Luk J.M.C.,
Ng M.H.
and Im S.W.K.,
Two murine monoclonal antibodies against serogroup
E salmonellae, American Society for Microbiology.
2001, 66: 419-421.
|
|
Nicholls J.M.,
Kremmer E., Meseda C.A., Mackett M., Hahn P., Gulley
M.L., Brink A., Swinnen L.J., Greenspan J., De
Souza Y., Grasser F., Sham
J.S.T., Ng
M.H. and Arrand J.R., Comparative analysis
of the expression of the Epstein-Barr virus (EBV) anti-apoptotic
gene BHRF1 in nasopharyngeal carcinoma and EBV-related
lymphoid diseases, Journal of Medical Virology.
2001, 65(1): 105-113.
|
|
Ong S.K., Xue S.A., Molyneux E., Broadhead R.L., Borgstein
E., Ng M.H.
and Griffin B.E., African Burkitt's Iymphoma: a new
perspective, Transactions of the Royal Society of
Tropical Medicine and Hygiene. 2001, 95: 93-96.
|
|
Zhang J.Z., Ng
M.H., Xia N.S., Lau
B.S.H., Che X.Y., Chau T.N., Lai S.T. and Im
S.W.K., Conformational antigenic determinants generated
by interactions between a bacterially expressed recombinant
peptide of the hepatitis E virus structural protein,
Journal of Medical Virology. 2001, 64: 125-132.
|
|
Zhang J.Z., Im S.W.K.,
Lay S.H., Chau T.N., Lai S.T., Ng
S.P., Peiris
J.S.M., Tse C., Ng T.K. and Ng
M.H., Occurrence of hepatitis E virus IgM,
low avidity IgG serum antibodies and viremia in sporadic
cases of non-A-B, and C acute hepatitis., Journal
of Medical Virology. 2002, 66: 40-48.
|
|
Zheng B., Ng M.H., He
L.F., Yao X., Chan K.W., Yuen
K.Y. and Wen Y.M., Therapeutic efficacy to hepatitis
B surface antigen-antibody-recombinant composite in
HBsAg transgenic mice, Vaccine. 2001, 19: 4219-4225.
|
| Project Title: | Monoclonal antibodies
against lipopolysaccharide antigens of Salmonella and
Shigella spp. |
| Investigator(s): | Dr.
Ng S.P. |
| Department: | Microbiology |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | February 2001 |
| Abstract: |
| To characteerise a panel of monoclonal antibodies
raised against the outer core region of Salamonella
lipopolysaccharides (LPS). |
| Project Title: | Collection of background
information on the alternative faecal indicators in
the environmental waters of Hong Kong and their correlation
with Escherichia coli |
| Investigator(s): | Dr.
Ng S.P., Dr. Yam W.C. |
| Department: | Microbiology |
| Source(s) of Funding: | Environment
Protection Department, Hong Kong Government |
| Start Date: | June 2001 |
| Abstract: |
| To detect and enumerate alternative faecal
microbial indicator organisms in the environmental
waters of Hong Kong and to correlate the results with
Escherichia coli in order to assess their value in
water quality monitoring. |
| Project Title: | Sero-prevalence of
viral hepatitis A in a sample Hong Kong population |
| Investigator(s): | Dr.
Ng S.P., Dr. Wong K.H. |
| Department: | Microbiology |
| Source(s) of Funding: | Health
Department of Hong Kong Government |
| Start Date: | June 2001 |
| Abstract: |
| To assess the exposure of Hong Kong population
to viral hepatitis A by surveying serum antibody against
HAV. |
|
Ng S.P.,
Ng I.S.S., Wong A.Y.H., Ching P.T.Y., Yam
W.C. and Seto
W.H., Implementation of HACCP in Queen Mary Hospital
(QMH) catering service: an initiation model for patient
catering, The 32nd IHF Congress 2001. 68.
|
|
Ng S.P.,
Tsang R.S.W., Luk
J.M.C., Ng M.H.
and Im S.W.K.,
Two murine monoclonal antibodies against serogroup
E salmonellae, American Society for Microbiology.
2001, 66: 419-421.
|
|
Zhang J.Z., Im S.W.K.,
Lay S.H., Chau T.N., Lai S.T., Ng
S.P., Peiris
J.S.M., Tse C., Ng T.K. and Ng
M.H., Occurrence of hepatitis E virus IgM, low
avidity IgG serum antibodies and viremia in sporadic
cases of non-A-B, and C acute hepatitis., Journal
of Medical Virology. 2002, 66: 40-48.
|
| Project Title: | Influenza pandemic
preparedness in Asia (Research collaboration with
national Institute of Allergy and Infectious Diseases
(NIAID), St. Jude Children's Research Hospital, Inc.
(SJCRH) and The University of Hong Kong) |
| Investigator(s): | Prof.
Peiris J.S.M., Dr. Guan Y. |
| Department: | Microbiology |
| Source(s) of Funding: | National
Institutes of Health through World Health Organization |
| Start Date: | April 1999 |
| Abstract: |
| To study influenza pandemic preparedness in
Asia. |
| Project Title: | Interactions between
avian influenza A H5N1 virus and macrophages: a basis
for immuno-pathology |
| Investigator(s): | Prof.
Peiris J.S.M., Prof. Lau Y.L., Prof. Shortridge K.F. |
| Department: | Microbiology |
| Source(s) of Funding: | Hong
Kong Research Grants Council Competitive Earmarked
Research Grants |
| Start Date: | October 1999 |
| Abstract: |
| To investigate in vitro, mechanisms that may
explain immuno-pathology caused by influenza virus
A, subtype H5N1 in humans. |
| Project Title: | Virus-macrophage interactions:
a basis for immunopathology of H5N1 influenza |
| Investigator(s): | Prof.
Peiris J.S.M., Prof. Gordan S. |
| Department: | Microbiology |
| Source(s) of Funding: | UK/HK
Joint Research Scheme (British Council / Hong Kong
Research Grants Council) |
| Start Date: | January 2000 |
| Abstract: |
| To investigate influenza virus-macrophage interactions
in vitro to better understand some unresolved issues
in the pathogenesis of the avian influenza virus H5N1
in humans - in particular, the unusual severity of
the disease in adults. |
| Project Title: | An in-vitro model
for latency and reactivation of human herpesvirus 6
and 7 |
| Investigator(s): | Prof.
Peiris J.S.M., Dr. Chiu S.S.S. |
| Department: | Microbiology |
| Source(s) of Funding: | RGC
Fundable Projects (Block Grant Funded) |
| Start Date: | November 2000 |
| Abstract: |
| To establish in-vitro models of HHV-6 and HHV-7
latency and reactivation in primary macrophage cells
and macrophage cell lines and define the transcription
patterns of viral genes in productive replication,
latency and reactivation. |
| Project Title: | Human herpesvirus
6 (HHV-6) and HHV-7 infections: reactivation, latency
and viral interactions |
| Investigator(s): | Prof.
Peiris J.S.M., Dr. Chiu S.S.S. |
| Department: | Microbiology |
| Source(s) of Funding: | Hong
Kong Research Grants Council Competitive Earmarked
Research Grants |
| Start Date: | November 2001 |
| Abstract: |
| To investigate patients with primary HHV-6
or HHV-7 inection, lateny and reactivation to: a) define
the transcription patterns of viral genes in these
different states, b) study the effect of related herpesviral
infections on the reactivation of HHV-6, HHV-7 and
CMV from latency in-vivo. To establish in-vitro models
of HHV-6 and HHV-7 latency and reactivation to a) define
the transcription patterns of viral genes in productive
replication, latency and reactivation, b) study the
effect of viral interactions on reactivation from latency,
c) study the effect of cross-reacting antibody on the
establishment of infection and latency in monocytes
and peripheral blood leukocytes. |
| Project Title: | The development and
application of DNA microarrays to study the avian influenza
virus gene pool in southern China |
| Investigator(s): | Prof.
Peiris J.S.M., Dr. Guan Y., Dr. Yang M.M.S. |
| Department: | Microbiology |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | November 2001 |
| Abstract: |
| To develop a DNA microarray to genotype H9N2,
H6N1 and H5N1 subtype viruses of diverse lineages.
The longer term aim (through other research funding)
would be to develop a comprehensive DNA array that
can characterise all (or most) avian influenza viruses
in this region. Such high throughput methods will
allow a detailed understanding of the evolution of
these viruses and the genetic basic for interspecies
transmission. |
| Project Title: | The Zoonotic potential
of influenze viruses in Southeastern China |
| Investigator(s): | Prof.
Peiris J.S.M., Dr. Guan Y., Prof. Shortridge K.F.,
Dr. Webster R.G. |
| Department: | Microbiology |
| Source(s) of Funding: | The
Wellcome Trust, U.K. |
| Start Date: | May 2002 |
| Abstract: |
| To establish the epidemiological dynamics and
a spatially structured ecological / epidemiological
model of influenza in poultry and pigs in Hong Kong
and mainland China that provide conditions for interspecies
transmission of influenza viruses; to determine if
certain genotypes of influenza viruses have pandemic
potential. |
|
Chan K.H., Maldeis
N., Pope W., Yup A., Ozinskas A., Sit T., Gill J.,
Seto W.H., Shortridge K.F.
and Peiris J.S.M.,
Evaluation of the Directigen FluA+B Test for Rapid
Diagnosis of Influenza Virus Type A and B Infections,
Journal of Clinical Microbiology. 2002, 40(5):
1675-1680.
|
|
Chiu S.S.S.,
Lau Y.L. and
Peiris J.S.M.,
Influenza in Hong Kong Children, Jount Scientific
Meeting, Hong Kong College of Physicians, Hong Kong
College of Pediatricians, Hong Kong College of Family
Physicians and Hong Kong College of Pathologists, Hong
Kong, 27-28 October 2001.
|
|
Chiu S.S.S.,
Lau Y.L. and
Peiris J.S.M.,
Rates of Hospitalization for Respiratory Disease Among
Children With No Underlying Conditions During Influenza
Seasons, The 23rd International Congress of Pediatrics,
Beijing, China, 9-14 September 2001. 188.
|
|
Chuh A.A.T.,
Chiu S.S.S.
and Peiris J.S.M.,
Human Herpesvirus 6 and 7 DNA in Peripheral Blood Leucocytes
and Plasma in Patients with Pityriasis Rosea by Polymerase
Chain Reaction: A Prospective Case Control Study, Acta
Dermatology and Venereology. 2001, 81: 289-290.
|
|
Guan Y., Peiris J.S.M.,
Lipatov A.S., Ellis T.M., Dyrting K.C., Krauss S.,
Zhang L., Webster
R.G. and Shortridge
K.F., Emergence of multiple genotypes of H5N1 avian
influenza viruses in Hong Kong SAR, Proceedings
of National Academic Science (USA). 2002, 99: 8950-8955.
|
|
Guan Y., Peiris J.S.M.,
Kong K.F.,
Dyrthing K.C., Ellis T.M., Sit T., Zhang
L. and Shortridge
K.F., H5N1 Influenza Viruses Isolated from Geese
in Southeastern China: Evidence for Genetic Reassortment
and Interspecies Transmission to Ducks, Virology.
Elsevier Science, 2002, 292: 16-23 (2002).
|
|
Peiris J.S.M.,
Guan Y., Ghose P., Markwell
D., Krauss S., Webster R.G. and Shortridge
K.F., H3N2, H9N2 and H1N1 subtype influenza viruses
cocirculate in pigs in southeastern China., Options
for the Control of Influenza IV. Eds ADME Osterhaus,
N Cox, AW Hampson. Excerpta Medica, International Congress
Series 1219, Amsterdam. 2001, 195-200.
|
|
Peiris J.S.M.,
Invited Symposium lecture: Molecular Methods in Clinical
Microbiology. Challenges and Opportunities in Pathology.,
Joint Meeting of the Royal College of Pathologists
of Australasia and the Hong Kong Division of the International
Academy of Pathology.. 2001.
|
|
Peiris J.S.M.,
Nairobi sheep disease, In: Service MW (eds.), Encyclopedia
of Arthropod-transmitted Infections of Man and Domesticated
Animals. CABI Publishing, 2001.
|
|
Peiris J.S.M.,
Nairobi sheep disease, In: Ed. Service MW. Encyclopedia
of Arthropod-transmitted Infections of Man and Domesticated
animals. New York, CABI International, 2001, 364-368.
|
|
Peiris J.S.M.,
R-Mix cells are faster, at least as sensitive and marginally
more costly than conventional cell lines for the detection
of respiratory viruses., Virus International. 2002
http://www.virusint.com/virusint/. 2001.
|
|
Peiris J.S.M.,
Report of the Investigation team for the 2002 avian
influenza incident, Government of the Hong Kong
SAR. May 2002. 2002.
|
|
Peiris J.S.M.,
Respiratory Tract Viruses, In: Warrell, Cox, Firth,
Benz (eds.), Oxford Textbook of Medicine. 2001,
4th Edition.
|
|
Seo S.H., Peiris
J.S.M. and Webster R.G., Protective cross-reactive
cellular immunity to lethal A/Goose/Guangdong/1/96-like
H5N1 influenza virus is correlated with the proportion
of pulmonary CD8(+)T cells expressing gamma interferon.,
Journal of Virology. 2002, 76: 4886-90.
|
|
Tong C.Y.W., Bakran A., Williams H., Cuevas L.E., Peiris J.S.M.
and Hart C.A., Association of tumour necrosis factor
alpha and interleukin 6 levels with cytomegalovirus
DNA detection and disease after renal transplantation,
Journal of Medical Virology. 2001, 64: 29-34.
|
|
Tong C.Y.W., Bakran A., Williams H., Cuevas L.E., Peiris J.S.M.
and Hart C.A., Association of tumour necrosis factor
aplha and interleukin 6 levels with cytomegalovirus
DNA detection and disease after renal transplantation.,
Journal of Medical Virology. 2001, 64: 29-34.
|
|
Webster R.G., Guan
Y., Peiris
J.S.M., Walker D., Krauss D., Zhou N.N., Govorkova
E.A., Ellis T.M., Dyrting K.C., Sit T., Perez D.R.
and Shortridge K.F.,
Characterization of H5N1 influenza viruses that continue
to circulate in geese in southeastern China, Journal
of Virology. 2002, 76: 118-126.
|
|
Yuen K.Y. and
Peiris J.S.M.,
Influenza, In: M Ip, M Chan-Yeung, WK Lam, NS Zhong
(eds.), Respiratory Diseases - the Asian Perspective.
2001.
|
|
Zhang J.Z., Im S.W.K.,
Lay S.H., Chau T.N., Lai S.T., Ng
S.P., Peiris
J.S.M., Tse C., Ng T.K. and Ng
M.H., Occurrence of hepatitis E virus IgM, low
avidity IgG serum antibodies and viremia in sporadic
cases of non-A-B, and C acute hepatitis., Journal
of Medical Virology. 2002, 66: 40-48.
|
|
Ho P.L., Yung R.W.H., Que T.L.,
Tsang D.N.C.,
Ho M., Seto W.H.,
Ng T.K., Yam W.C.
and Ng W.W.S.,
Increasing resistance of Streptococcus pneumoniae to
fluoroquinolones: results of a Hong Kong multicentre
study in 2000, Journal of Antimicrobial Chemotherapy.
The British Society for Antimicrobial Chemotharapy,
2002, 48: 659-665.
|
|
Chan K.H., Maldeis
N., Pope W., Yup A., Ozinskas A., Sit T., Gill J.,
Seto W.H.,
Shortridge K.F.
and Peiris J.S.M.,
Evaluation of the Directigen FluA+B Test for Rapid
Diagnosis of Influenza Virus Type A and B Infections,
Journal of Clinical Microbiology. 2002, 40(5):
1675-1680.
|
|
Ho P.L., Yung R.W.H., Que T.L., Tsang
D.N.C., Ho M., Seto
W.H., Ng T.K., Yam
W.C. and Ng
W.W.S., Increasing resistance of Streptococcus
pneumoniae to fluoroquinolones: results of a Hong Kong
multicentre study in 2000, Journal of Antimicrobial
Chemotherapy. The British Society for Antimicrobial
Chemotharapy, 2002, 48: 659-665.
|
|
Kumana C.R.,
Tai Y.C., Kong Y., Ma E.C.W., Kou
M., Lee R.A.,
Cheng V.C.C.,
Chiu S.S.S.
and Seto W.H.,
Curtailing unnecessary vancomycin usage in a hospital
with high rates of methicillin resistant Staphylococcus
aureus infection, British Journal Clinical Pharmacology.
2002, 52: 427-432.
|
|
Ng S.P., Ng
I.S.S., Wong A.Y.H., Ching P.T.Y., Yam
W.C. and Seto
W.H., Implementation of HACCP in Queen Mary
Hospital (QMH) catering service: an initiation model
for patient catering, The 32nd IHF Congress 2001.
68.
|
| Project Title: | Melatonin signalling
in the regulation of human choriocarcinoma cell growth |
| Investigator(s): | Dr.
Shiu S.Y.W., Dr. Wong J.T.Y. |
| Department: | Physiology |
| Source(s) of Funding: | Hong
Kong Research Grants Council Competitive Earmarked
Research Grants |
| Start Date: | October 1999 |
| Abstract: |
| To define the molecular and cellular mechanisms
of melatonin signalling involved in the growth regulation
of this human placetal cancer, which is prevalent in
Oriental females. |
| Project Title: | Cross-talks between
melatonin and growth factors in the regulation of human
prostate cancer cell proliferation |
| Investigator(s): | Dr.
Shiu S.Y.W. |
| Department: | Physiology |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | November 2000 |
| Abstract: |
| To study the mechanisms of possible cross-talks
between melatonin and growth factors in the modulation
of human prostate cancer cell growth. |
| Project Title: | A 'proteomics' approach
to understanding melatonin signaling in prostate cancer |
| Investigator(s): | Dr.
Shiu S.Y.W., Dr. Chan K.F.J. |
| Department: | Physiology |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | November 2001 |
| Abstract: |
| To study melatonin signaling in prostate cancer
LNCaP cells |
| Project Title: | Combating prostate
diseases: development of prostate proteomics detection
database and unraveling novel ethnobotanical drug treatment
methods |
| Investigator(s): | Dr.
Shiu S.Y.W. |
| Department: | Physiology |
| Source(s) of Funding: | HKU
Foundation Seed Grant |
| Start Date: | April 2002 |
| Abstract: |
| To study combating prostate diseases: development
of prostate proteomics detection database and unraveling
novel ethnobotanical drug treatment methods. |
| Project Title: | Influenza A virus
surveillance of domestic pigs of Southern China |
| Investigator(s): | Prof.
Shortridge K.F. |
| Department: | Microbiology |
| Source(s) of Funding: | Block
Grant Earmarked for Research
Wing
Lung Bank Medical Research Fund |
| Start Date: | July 1992 |
| Abstract: |
| The domestic pig of Southern China will be
submitted to influenza virus surveillance studies.
This is because (A) Southern China is now recognized
as a hypothetical influenza epicentre, the pig a "mixing
vessel" for the two-way transmission of influenza viruses
between the domestic duck, the prime influenza virus
reservoir, and man and that it is now 28 years since
the Hong Kong virus first appeared in man and (B) recent
surveillance studies of pigs have detected purely avian
influenza virus. It is now of even greater importance
to know whether natural reassortants of pandemic potenital
still exist with the potential of crossing the species
barrier to humans. |
| Project Title: | Surveillance of chicken
in selected, repopulated Hong Kong poultry markets
for H5N1 and other influenza viruses |
| Investigator(s): | Prof.
Shortridge K.F. |
| Department: | Microbiology |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | July 1998 |
| Abstract: |
| To carry out regular surveillance of selected
markets to see if they have the potential to become
breeding grounds for influenza viruses. |
|
Chan K.H., Maldeis
N., Pope W., Yup A., Ozinskas A., Sit T., Gill J.,
Seto W.H., Shortridge K.F.
and Peiris J.S.M.,
Evaluation of the Directigen FluA+B Test for Rapid
Diagnosis of Influenza Virus Type A and B Infections,
Journal of Clinical Microbiology. 2002, 40(5):
1675-1680.
|
|
Guan Y., Peiris J.S.M.,
Lipatov A.S., Ellis T.M., Dyrting K.C., Krauss S.,
Zhang L., Webster
R.G. and Shortridge
K.F., Emergence of multiple genotypes of H5N1
avian influenza viruses in Hong Kong SAR, Proceedings
of National Academic Science (USA). 2002, 99: 8950-8955.
|
|
Guan Y., Peiris J.S.M.,
Kong K.F.,
Dyrthing K.C., Ellis T.M., Sit T., Zhang
L. and Shortridge
K.F., H5N1 Influenza Viruses Isolated from
Geese in Southeastern China: Evidence for Genetic Reassortment
and Interspecies Transmission to Ducks, Virology.
Elsevier Science, 2002, 292: 16-23 (2002).
|
|
Peiris J.S.M.,
Guan Y., Ghose P., Markwell
D., Krauss S., Webster R.G. and Shortridge
K.F., H3N2, H9N2 and H1N1 subtype influenza
viruses cocirculate in pigs in southeastern China.,
Options for the Control of Influenza IV. Eds ADME
Osterhaus, N Cox, AW Hampson. Excerpta Medica, International
Congress Series 1219, Amsterdam. 2001, 195-200.
|
|
Shortridge K.F.,
Influenza activity in non-human hosts in southern China,
Japanese Society for the Control of Influenza (speaker
by invitation). Okinawa, Japan, 2001.
|
|
Webster R.G., Guan
Y., Peiris
J.S.M., Walker D., Krauss D., Zhou N.N., Govorkova
E.A., Ellis T.M., Dyrting K.C., Sit T., Perez D.R.
and Shortridge
K.F., Characterization of H5N1 influenza viruses
that continue to circulate in geese in southeastern
China, Journal of Virology. 2002, 76: 118-126.
|
|
Ho P.L., Yung R.W.H., Que T.L., Tsang D.N.C.,
Ho M., Seto W.H.,
Ng T.K., Yam W.C.
and Ng W.W.S.,
Increasing resistance of Streptococcus pneumoniae to
fluoroquinolones: results of a Hong Kong multicentre
study in 2000, Journal of Antimicrobial Chemotherapy.
The British Society for Antimicrobial Chemotharapy,
2002, 48: 659-665.
|
|
Woo P.C.Y.,
Leung P.K.L., Tsoi
H.W., Chan B.Y.L., Que T.L. and Yuen
K.Y., Characterization of a novel insertion sequence,
ISBp1, in Burkholderia pseudomallei, Archives of
Microbiology. 2002, 177: 267-273.
|
|
Woo P.C.Y.,
Leung P.K.L., Tsoi
H.W. and Yuen
K.Y., Cloning and characterisation of maIE in Burkholderia
pseudomallei, Journal of Med Microbiol. 2001,
50: 330-338.
|
|
Woo P.C.Y.,
Leung K.W., Tsoi
H.W., Wong
S.S.Y., Teng
L.L. and Yuen
K.Y., Thermo-tolerant campylobacter fetus bacteraemia
identified by 16S ribosomal RNA gene sequencing: an
emerging pathogen in immunocompromised patients, Journal
of Medical Microbiology. 2002, 51: 740-746.
|
|
Wang T.K.F.,
Fung A.M.Y., Woo
P.C.Y., Yuen
K.Y. and Wong
S.S.Y., Streptococcus agalactiae (Lancefield Group
B) bacteraemia in Nonpregnant adults, European Journal
of Clinical Microbiology and Infectious Diseases.
2002, 21: 140-142.
|
| Project Title: | Effect of ampicillin
on the immunogenicity of live-attenuated Salmonella
typhi and protein antigen and DNA vaccine carried in
it |
| Investigator(s): | Dr.
Wong S.S.Y., Dr. Woo P.C.Y., Prof. Yuen K.Y. |
| Department: | Microbiology |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | November 2000 |
| Abstract: |
| To study the effects of ampicillin on the immunogenicity
of oral Ty21a and the protein antigen and DNA vaccine
carried in it; to examine the effects of ampicillin
on the serum antibody response against LPS of S. typhi,
heat-killed Ty21a-stimulated lymphocyte proliferation
index, and survival of mice upon wild type S. typhi
challenge after oral Ty21a immunization; to study the
effect of ampicillin on the serum antibody response
againset tetanus toxoid and hepatitis B surface antigen
in mice administered with the fragment c of tetanus
toxoid and DNA encoding HBsAg carried in Ty21a respectively. |
| Project Title: | Random exploration
of the genome of the dimorphic fungus penicillium marneffei |
| Investigator(s): | Dr.
Wong S.S.Y., Dr. Woo P.C.Y., Prof. Yuen K.Y. |
| Department: | Microbiology |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | November 2001 |
| Abstract: |
| To answer the following questions: (1) the
number and sizes of the chromosomes (karyotyping) of
P. marneffei; (2) the phylogenetic relationship between
P. marneffei and other fungi; specially, whether a
sexual stage of it exists in nature which explains
why it is difficult to isolate the fungus from environmental
samples; (3) to perform a random exploration of the
P. marneffei genome and analyze 2000 random sequence
tags of the genome of the fungus. This would enable
us to better understand the basic mechanisms of dimorphism,
biochemical properties, disease pathogenesis, virulence,
and immune defence and thus pave the way to treat or
prevent the disease. |
|
Chiu D.C.S., Chiu
S.S.S., Chow
C.B., Ho P.L.,
Lau Y.L., Leung
C.W., Tsang D.N.C., Tsang
K.W.T., Tsang T.H.F., Wong
S.S.Y., Yang Y.H. and Yuen
K.Y., Proceedings of The First Current Topic in
Infectious Diseases: Consensus Meeting on Conjugate
Vaccines of the Center of Infection, Faculty of Medicine,
The University of Hong Kong, Hong Kong Journal of
Paediatrics (new series). 2001, 6: 127-132.
|
|
Wang T.K.F.,
Fung A.M.Y., Woo
P.C.Y., Yuen
K.Y. and Wong
S.S.Y., Streptococcus agalactiae (Lancefield
Group B) bacteraemia in Nonpregnant adults, European
Journal of Clinical Microbiology and Infectious Diseases.
2002, 21: 140-142.
|
|
Wang T.K.F., Wong
S.S.Y. and Woo
P.C.Y., Two cases of pyomyositis caused by Klebsiella
pneumoniae and review of the literature, European
Journal of Clinical Microbiology and Infectious Diseases.
2001, 20: 576-580.
|
|
Wong S.S.Y.,
Woo P.C.Y.
and Yuen K.Y.,
Candida tropicalis and Penicillium marneffei mixed
fungaemia in a patient with Waldenstrom's Macroglobulinaemia,
European Journal of Clinical Microbiology and Infectious
Diseases. 2001, 20: 132-135.
|
|
Wong S.S.Y.,
Wong K.H., Hui W.T., Lee S.S., Lo J.Y.C., Cao
L. and Yuen
K.Y., Differences in clinical and laboratory diagnostic
characteristics of Penicilliosis Marneffei in human
immunodeficiency virus (HIV) - and non-HIV-infected
patients, Journal of Clinical Microbiology.
2001, 39: 4535-4540.
|
|
Woo P.C.Y.,
Leung K.W., Tsoi
H.W., Wong
S.S.Y., Teng
L.L. and Yuen
K.Y., Thermo-tolerant campylobacter fetus bacteraemia
identified by 16S ribosomal RNA gene sequencing: an
emerging pathogen in immunocompromised patients, Journal
of Medical Microbiology. 2002, 51: 740-746.
|
| Project Title: | Use of 16S ribosomal
RNA sequencing for bacterial identification |
| Investigator(s): | Dr.
Woo P.C.Y., Dr. Wong S.S.Y., Prof. Yuen K.Y. |
| Department: | Microbiology |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | November 2000 |
| Abstract: |
| To apply a novel molecular technique for the
identification of pathogenic bacteria that are not
identifiable using conventional microbiological techniques. |
| Project Title: | Penicilliosis marneffei
in AIDS patients |
| Investigator(s): | Dr.
Woo P.C.Y., Dr. Chan K., Prof. Yuen K.Y. |
| Department: | Microbiology |
| Source(s) of Funding: | Council
for the AIDS Trust Fund |
| Start Date: | July 2001 |
| Abstract: |
| To search for a novel antigen of which the
immune response against it is life long, such antigen
would be crucial in the understanding of the seroepidemiology
of the infection, as well as how the pathogen is transmitted
exactly. Furthermore, such an antigen may be important
in the development of vaccine in penicilliosis marneffei.
This could be important to reduce the need for secondary
prophylaxis as these patients may have to take antifungal
for life. |
| Project Title: | Molecular characterization
of thermotolerant Campylobacter species isolated from
bacteremic patients |
| Investigator(s): | Dr.
Woo P.C.Y., Dr. Wong S.S.Y., Prof. Yuen K.Y. |
| Department: | Microbiology |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | November 2001 |
| Abstract: |
| To study clinical characteristics of the corresponding
patients |
|
Chan C.M., Woo
P.C.Y., Leung
A.S.P., Lau
S.K.P., Che X.Y., Cao
L. and Yuen
K.Y., Detection of antibodies specific to an antigenic
cell wall Galactomannoprotein for serodiagnosis of
Aspergillus fumigatus Aspergillosis, Journal of
Clinical Microbiology. 2002, 40: 2041-2045.
|
|
Hui J.Y.H., Woo
P.C.Y., Lo S.S. and Chan J.C.S., Over-the-counter
medication and its effects, The Lancet. 2002,
359: 1120.
|
|
Lau S.K.P.,
Woo P.C.Y.,
Leung K.W. and Yuen
K.Y., Emergence of Cotrimoxazole- and Quinolone-resistant
Campylobacter infections in bone marrow transplant
recipients, European Journal of Clinical Microbiology
and Infectious Diseases. 2002, 21: 127-129.
|
|
Lau S.K.P.,
Woo P.C.Y.,
Chan B.Y.L., Fung A.M.Y., Que T.L. and Yuen
K.Y., Haemophilus segnis polymicrobial and monomicrobial
bacteraemia identified by 16S ribosomal RNA gene sequencing,
J Med Microbiol. 2002, 51: 635-640.
|
|
Wang T.K.F.,
Fung A.M.Y., Woo
P.C.Y., Yuen
K.Y. and Wong
S.S.Y., Streptococcus agalactiae (Lancefield Group
B) bacteraemia in Nonpregnant adults, European Journal
of Clinical Microbiology and Infectious Diseases.
2002, 21: 140-142.
|
|
Wang T.K.F., Wong
S.S.Y. and Woo
P.C.Y., Two cases of pyomyositis caused by
Klebsiella pneumoniae and review of the literature,
European Journal of Clinical Microbiology and Infectious
Diseases. 2001, 20: 576-580.
|
|
Wong L.P., Woo
P.C.Y., Wu
A.Y.Y. and Yuen
K.Y., DNA immunization using a secreted cell wall
antigen Mp1p is protective against penicillium marneffei
infection, Vaccine. 2002, 3262: 1-9.
|
|
Wong S.S.Y.,
Woo P.C.Y.
and Yuen K.Y.,
Candida tropicalis and Penicillium marneffei mixed
fungaemia in a patient with Waldenstrom's Macroglobulinaemia,
European Journal of Clinical Microbiology and Infectious
Diseases. 2001, 20: 132-135.
|
|
Woo P.C.Y.,
Leung P.K.L., Tsoi
H.W., Chan B.Y.L., Que T.L. and Yuen
K.Y., Characterization of a novel insertion sequence,
ISBp1, in Burkholderia pseudomallei, Archives of
Microbiology. 2002, 177: 267-273.
|
|
Woo P.C.Y.,
Leung P.K.L., Tsoi
H.W. and Yuen
K.Y., Cloning and characterisation of maIE in Burkholderia
pseudomallei, Journal of Med Microbiol. 2001,
50: 330-338.
|
|
Woo P.C.Y.,
Lau S.K.P.
and Yuen K.Y.,
Macrolides as immunomodulatory agents, Curr Med
Chem - Anti-inflammatory & Anti-allergy Agents.
2002, 1: 131-141.
|
|
Woo P.C.Y.,
Leung K.W., Tsoi
H.W., Wong
S.S.Y., Teng
L.L. and Yuen
K.Y., Thermo-tolerant campylobacter fetus bacteraemia
identified by 16S ribosomal RNA gene sequencing: an
emerging pathogen in immunocompromised patients, Journal
of Medical Microbiology. 2002, 51: 740-746.
|
|
Woo P.C.Y.,
Wong L.P., Zheng
B. and Yuen
K.Y., Unique immunogenicity of hepatitis B virus
DNA vaccine presented by live-attenuated Salmonella
typhimurium, Vaccine. 2001, 19: 2945-2954.
|
|
Xin B.,
Study on the Signalling Mechanisms of Epstein-Barr
Virus Transforming Protein LMP1 in Cell Proliferation,
Transformation and Tumorigenesis (PhD thesis).
2001.
|
| Project Title: | A pilot project to
study HIV drug resistance pattern and applicability
of incorporating resistance testing in treatment of
HIV infection in Hong Kong |
| Investigator(s): | Dr.
Yam W.C. |
| Department: | Microbiology
(Hospital Pathology Services) |
| Source(s) of Funding: | Council
for the AIDS Trust Fund |
| Start Date: | June 2001 |
| Abstract: |
| To develop laboratory expertise in doing molecular
biology study on HIV/AIDS; to study the HIV genotypic
resistance patterns in patients failing HAART locally;
to study the local relevance and applicability of genotypic
resistance in optimising treatment decisions; to develop
a protocol on the incorporation of genotypic resistance
testing for managing treatment failures. |
|
Ho P.L., Yung R.W.H., Que T.L., Tsang
D.N.C., Ho M., Seto
W.H., Ng T.K., Yam
W.C. and Ng
W.W.S., Increasing resistance of Streptococcus
pneumoniae to fluoroquinolones: results of a Hong Kong
multicentre study in 2000, Journal of Antimicrobial
Chemotherapy. The British Society for Antimicrobial
Chemotharapy, 2002, 48: 659-665.
|
|
Lam Y., Im S.W.K. and Yam W.C., Association
of polymorphisms in the NRAMP1 gene and susceptibility
to tuberculosis in Chinese, 10th International Congress
of Human Genetics 2001 of the European Society of Human
Genetics, Vienna, Austria,. 2001.
|
|
Ng S.P., Ng
I.S.S., Wong A.Y.H., Ching P.T.Y., Yam
W.C. and Seto
W.H., Implementation of HACCP in Queen Mary Hospital
(QMH) catering service: an initiation model for patient
catering, The 32nd IHF Congress 2001. 68.
|
| Project Title: | The identification
and characterization of Aspergillus fumigatus antigen(s)
for the rapid diagnosis of invasive aspergillosis |
| Investigator(s): | Prof.
Yuen K.Y., Dr. Cao L., Dr. Wong S.S.Y. |
| Department: | Microbiology |
| Source(s) of Funding: | Hong
Kong Research Grants Council Competitive Earmarked
Research Grants |
| Start Date: | September 2000 |
| Abstract: |
| To understand the differential expression and
function of the proteins to aid in formulating the
most appropriate strategy for the diagnosis of invasive
aspergillosis. |
| Project Title: | Effect of clarithromycin
on oral mucositis in bone marrow transplant recipients |
| Investigator(s): | Prof.
Yuen K.Y., Dr. Wong S.S.Y., Dr. Woo P.C.Y. |
| Department: | Microbiology |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | November 2000 |
| Abstract: |
| To investigate the potential beneficial effects
of clarithromycin on oral mucositis in BMT recipients
with or without total body irradiation as part of the
conditioning regimen. |
| Project Title: | Characterization of
a novel insertion sequence, ISBp1, in Burkholderia
pseudomallei |
| Investigator(s): | Prof.
Yuen K.Y., Dr. Wong S.S.Y., Dr. Woo P.C.Y. |
| Department: | Microbiology |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | November 2001 |
| Abstract: |
| To clone and characterize a novel insertion
sequence in B. pseudomallei. The potential usefulness
of such a sequence for molecular typing will also be
investigated. |
| Project Title: | Establishment of core
facilities for the HKU HIV/AIDS research laboratories |
| Investigator(s): | Prof.
Yuen K.Y. |
| Department: | Microbiology |
| Source(s) of Funding: | Council
for the AIDS Trust Fund |
| Start Date: | November 2001 |
| Abstract: |
| To support the development of state-of-art
clinical management of HIV/AIDS founded on scientific
research and clinical trials; to undertake research
for expanding the knowledge base on HIV molecular epidemiology
in Hong Kong and the reigon; to examine the immunological
mechanisms underlying HIV pathogenesis; to study AIDS
associated infectious diseases; to build expertise
in HIV molecular biology and immunology. |
|
Chiu D.C.S., Chiu
S.S.S., Chow
C.B., Ho P.L.,
Lau Y.L., Leung
C.W., Tsang D.N.C., Tsang
K.W.T., Tsang T.H.F., Wong
S.S.Y., Yang Y.H. and Yuen
K.Y., Proceedings of The First Current Topic
in Infectious Diseases: Consensus Meeting on Conjugate
Vaccines of the Center of Infection, Faculty of Medicine,
The University of Hong Kong, Hong Kong Journal of
Paediatrics (new series). 2001, 6: 127-132.
|
|
Chua D.T.T.,
Huang J., Zheng
B., Lau S.Y., Luk
W., Kwong D.L.W.,
Sham J.S.T.,
Moss D., Yuen
K.Y. and Ng
M.H., Adoptive transfer of autologous Epstein-Barr
virus-specific cytotoxic T cells for nasopharyngeal
carcinoma, International Journal of Cancer.
2001, 94(1): 73-80.
|
|
Ho P.L., Cheung K.M., Chau
P.Y. and Yuen
K.Y., Activities of newer fluoroquinolones
against Burkholderia pseudomallei, 9th Western Pacific
Congress on Chemotherapy & Infectious Diseases (in
final program & abstracts). 2001, 1.12.
|
|
Lau S.K.P.,
Woo P.C.Y.,
Leung K.W. and Yuen
K.Y., Emergence of Cotrimoxazole- and Quinolone-resistant
Campylobacter infections in bone marrow transplant
recipients, European Journal of Clinical Microbiology
and Infectious Diseases. 2002, 21: 127-129.
|
|
Lau S.K.P.,
Woo P.C.Y.,
Chan B.Y.L., Fung A.M.Y., Que T.L. and Yuen
K.Y., Haemophilus segnis polymicrobial and
monomicrobial bacteraemia identified by 16S ribosomal
RNA gene sequencing, J Med Microbiol. 2002,
51: 635-640.
|
|
Saing H., Fan S.T., Lo
C.M., Wei W.I.,
Chan K.L.,
Tam P.K.H.,
Tsoi N.S.,
Yuen K.Y.,
Ng I.O.L., Tsoi
W.K. and Wong J.,
Paediatric liver transplantation: experience at Queen
Mary Hospital, Hong Kong (1993-2001) (Abstract), 3rd
Annual Scientific Meeting, Centre for the Study of
Liver Disease, The University of Hong Kong, Hong Kong,
23-24 February, 2002.
|
|
Wang T.K.F.,
Fung A.M.Y., Woo
P.C.Y., Yuen
K.Y. and Wong
S.S.Y., Streptococcus agalactiae (Lancefield Group
B) bacteraemia in Nonpregnant adults, European Journal
of Clinical Microbiology and Infectious Diseases.
2002, 21: 140-142.
|
|
Wong L.P., Woo
P.C.Y., Wu
A.Y.Y. and Yuen
K.Y., DNA immunization using a secreted cell
wall antigen Mp1p is protective against penicillium
marneffei infection, Vaccine. 2002, 3262: 1-9.
|
|
Wong S.S.Y.,
Woo P.C.Y.
and Yuen K.Y.,
Candida tropicalis and Penicillium marneffei mixed
fungaemia in a patient with Waldenstrom's Macroglobulinaemia,
European Journal of Clinical Microbiology and Infectious
Diseases. 2001, 20: 132-135.
|
|
Wong S.S.Y.,
Wong K.H., Hui W.T., Lee S.S., Lo J.Y.C., Cao
L. and Yuen
K.Y., Differences in clinical and laboratory
diagnostic characteristics of Penicilliosis Marneffei
in human immunodeficiency virus (HIV) - and non-HIV-infected
patients, Journal of Clinical Microbiology.
2001, 39: 4535-4540.
|
|
Woo P.C.Y.,
Li J.H.C., Tang W.M. and Yuen
K.Y., Acupuncture mycobacteriosis, The New
England Journal of Medicine. 2001, 345: 842-843.
|
|
Woo P.C.Y.,
Leung P.K.L., Tsoi
H.W., Chan B.Y.L., Que T.L. and Yuen
K.Y., Characterization of a novel insertion
sequence, ISBp1, in Burkholderia pseudomallei, Archives
of Microbiology. 2002, 177: 267-273.
|
|
Woo P.C.Y.,
Leung P.K.L., Tsoi
H.W. and Yuen
K.Y., Cloning and characterisation of maIE
in Burkholderia pseudomallei, Journal of Med Microbiol.
2001, 50: 330-338.
|
|
Woo P.C.Y.,
Lau S.K.P.
and Yuen K.Y.,
Macrolides as immunomodulatory agents, Curr Med
Chem - Anti-inflammatory & Anti-allergy Agents.
2002, 1: 131-141.
|
|
Woo P.C.Y.,
Leung K.W., Tsoi
H.W., Wong
S.S.Y., Teng
L.L. and Yuen
K.Y., Thermo-tolerant campylobacter fetus bacteraemia
identified by 16S ribosomal RNA gene sequencing: an
emerging pathogen in immunocompromised patients, Journal
of Medical Microbiology. 2002, 51: 740-746.
|
|
Woo P.C.Y.,
Wong L.P., Zheng
B. and Yuen
K.Y., Unique immunogenicity of hepatitis B
virus DNA vaccine presented by live-attenuated Salmonella
typhimurium, Vaccine. 2001, 19: 2945-2954.
|
|
Yuen K.Y.,
Emerging infectious diseases in Hong Kong, Hong
Kong Medical Journal. 2001, 7: 224-226.
|
|
Yuen K.Y.
and Peiris J.S.M.,
Influenza, In: M Ip, M Chan-Yeung, WK Lam, NS Zhong
(eds.), Respiratory Diseases - the Asian Perspective.
2001.
|
|
Zheng B., Ng M.H., He L.F.,
Yao X., Chan K.W., Yuen
K.Y. and Wen Y.M., Therapeutic efficacy to
hepatitis B surface antigen-antibody-recombinant composite
in HBsAg transgenic mice, Vaccine. 2001, 19:
4219-4225.
|
|
Ho P.L., Yung R.W.H.,
Que T.L., Tsang D.N.C.,
Ho M., Seto W.H.,
Ng T.K., Yam W.C.
and Ng W.W.S.,
Increasing resistance of Streptococcus pneumoniae to
fluoroquinolones: results of a Hong Kong multicentre
study in 2000, Journal of Antimicrobial Chemotherapy.
The British Society for Antimicrobial Chemotharapy,
2002, 48: 659-665.
|
|
Guan Y., Peiris J.S.M.,
Lipatov A.S., Ellis T.M., Dyrting K.C., Krauss S.,
Zhang L.,
Webster R.G. and Shortridge
K.F., Emergence of multiple genotypes of H5N1 avian
influenza viruses in Hong Kong SAR, Proceedings
of National Academic Science (USA). 2002, 99: 8950-8955.
|
|
Guan Y., Peiris J.S.M.,
Kong K.F.,
Dyrthing K.C., Ellis T.M., Sit T., Zhang
L. and Shortridge
K.F., H5N1 Influenza Viruses Isolated from Geese
in Southeastern China: Evidence for Genetic Reassortment
and Interspecies Transmission to Ducks, Virology.
Elsevier Science, 2002, 292: 16-23 (2002).
|
| Project Title: | A study of novel approach
of therapeutic vaccine for HBV chronic infection in
transgenic mouse model |
| Investigator(s): | Dr.
Zheng B. |
| Department: | Microbiology |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | November 2000 |
| Completion Date: | October 2002 |
| Abstract: |
| To evaluate therapeutic efficacy of different
approaches using HBsAg positive transgenic mice as
HBV chronic infection model. |
| Project Title: | CCR5 expression on
antigen-presenting cens in HIV infection |
| Investigator(s): | Dr.
Zheng B., Prof. Lee S.S. |
| Department: | Microbiology |
| Source(s) of Funding: | Council
for the AIDS Trust Fund |
| Start Date: | January 2001 |
| Abstract: |
| To describe the pattern of CCR5 expression
on APC in HIV infection; to correlate this pattern
to HIV infected APC; to determine the functional and/or
quantitative deficiency in CCR5 expressing APC. |
| Project Title: | The pattern of chemokine
receptor polymorphism in healthy and HIV positive Chinese
adults |
| Investigator(s): | Dr.
Zheng B., Prof. Lee S.S. |
| Department: | Microbiology |
| Source(s) of Funding: | Council
for the AIDS Trust Fund |
| Start Date: | January 2001 |
| Abstract: |
| To determine the prevalence of the major forms
of CCR5 promoter and CCR2 polymorphism in healthy Chinese
adults; to compare the pattern between healthy adults
and HIV infected individuals in Hong Kong. |
| Project Title: | A study of gamma-delta
T cell response to nasopharyngeal carcinoma |
| Investigator(s): | Dr.
Zheng B. |
| Department: | Microbiology |
| Source(s) of Funding: | Hong
Kong Research Grants Council Competitive Earmarked
Research Grants |
| Start Date: | July 2001 |
| Abstract: |
| To carry out a detailed study of gamma-delta
T cell response of NPC patients with active disease,
those who were treated and had been in disease free
remission for over 5 years and healthy control subjects;
to study the anti-tumor effect of ex vivo expanded
gamma-delta T cells in the mouse model that we have
developed. |
| Project Title: | Functional studies
of dendritic cells in chronic Chinese Hepatitis B patients |
| Investigator(s): | Dr.
Zheng B., Prof. Qu D., Prof. Wen Y.M., Prof. Yuen K.Y.,
Dr. Zhang J.M., Dr. Zhu N.S. |
| Department: | Microbiology |
| Source(s) of Funding: | National
Natural Science Foundation of China |
| Start Date: | December 2001 |
| Abstract: |
| To ascertain if defective DC indeed contribute
to CHBVI and if the defect may account for the immune
tolerance; to investigate the mechanism of the DC functional
deficit; to determine the extent to which it contributes
to the infection; to investitate whether the defect
may affectimmune response to other viruses or the general
immune status of the individuals; to determine whether
the defect may be overcome by ex vivo cytokine treatment
to restore the function of DC and/or by improving antigen
uptake by DC. |
|
Chua D.T.T.,
Huang J., Zheng
B., Lau S.Y., Luk
W., Kwong D.L.W.,
Sham J.S.T.,
Moss D., Yuen K.Y.
and Ng M.H.,
Adoptive transfer of autologous Epstein-Barr virus-specific
cytotoxic T cells for nasopharyngeal carcinoma, International
Journal of Cancer. 2001, 94(1): 73-80.
|
|
Woo P.C.Y.,
Wong L.P., Zheng
B. and Yuen
K.Y., Unique immunogenicity of hepatitis B virus
DNA vaccine presented by live-attenuated Salmonella
typhimurium, Vaccine. 2001, 19: 2945-2954.
|
|
Zheng B.,
Ng M.H., He
L.F., Yao X., Chan K.W., Yuen
K.Y. and Wen Y.M., Therapeutic efficacy to hepatitis
B surface antigen-antibody-recombinant composite in
HBsAg transgenic mice, Vaccine. 2001, 19: 4219-4225.
|
-- End of Listing --
|
