Dept of Medicine

DEPARTMENT OF MEDICINE

Researcher : Ambekar CS

List of Research Outputs

Ambekar C.S., Lee J.S.K., Cheung B.M.Y., Chan L.C., Liang R.H.S. and Kumana C.R., Metabolism of Chloramphenicol Succinate, a Competitive Substrate and Inhibitor of Succinate Dehydrogenase: Possible Reason for its Toxicity, Toxicology in Vitro. 2004, 18: 441-7.

Researcher : Au WY

List of Research Outputs

Au W.Y., Lie A.K.W., Kung A.W.C., Liang R.H.S., Hawkins B.R. and Kwong Y.L., Autoimmune thyroid dysfunction after hematopoietic stem cell transplantation, Bone Marrow Transplantation. 2005, 35(4): 383-8.

Au W.Y., Ma S.Y., Chim J.C.S., Choy C., Loong F., Lie A.K.W., Lam C.C.K., Leung A.Y.H., Tse E.W.C., Yau C.C., Liang R.H.S. and Kwong Y.L., Clinicopathologic features and treatment outcome of mature T-cell and natural killer-cell lymphomas diagnosed according to the World Health Organization classification scheme: a single center experience of 10 years, Annals of Oncology. 2005, 16(2): 206-214.

Au W.Y., Hon C., Cheng V.C.C. and Ma E.S.K., Concomitant zoster myelitis and cerebral leukemia relapse after stem cell transplantation, Annals of Hematology. 2004, 84(1): 59-60.

Au W.Y., Cheung W.C. and Tung H.M., Gilbert's syndrome complicating long term parental nutrition, Journal of hepatology.. 2004, 41(1): 168-169.

Au W.Y., Ma E.S.K., Lam V.M.S., Chan L.C., Pang A.W.K. and Kwong Y.L., Glucose 6-phosphate dehydrogenase (G6PD) deficiency in elderly Chinese women heterozygous for G6PD variants, American Journal of Medical Genetics Part A. 2004, 129A(2): 208 - 211.

Au W.Y. and Liu C.L., Growth of giant hepatic hemangioma after triplet pregnancy , Hepatology. 2005, 42(5): 781.

Au W.Y. and Lo J.Y.C., HTLV-1-related lymphoma in Hong Kong Chinese, American Journal of Hematology. 2004, 78(1): 80-81.

Au W.Y., Lie A.K.W. and Cheng V.C.C., Hematopoietic progenitor cell transplantation from a donor with indeterminate human immunodeficiency virus antibody status, Transfusion. 2005, 45(5): 819-820.

Au W.Y. and Lee J.S.K., Imatinib mesylate (STI-571) and porphyria cutanea tarda in a Chinese patient, Haematologica. 2005, 90: ECR18.

Au W.Y., Gascoyne R.D., Klasa R.D., Connors J.M., Gallagher R.P., Le N.D., Loong F., Law C.K. and Liang R.H.S., Incidence and spectrum of non-Hodgkin lymphoma in Chinese migrants to British Columbia, British Journal of Haematology. 2005, 128: 792-196.

Au W.Y., Kwok J.S.Y., Chu K.M. and Ma E.S.K., Life-threatening cryoglobulinemia in HCV negative Southern Chinese and a novel association with structural aortic abnormalities, Annals of Hematology. 2005, 84: 95-98.

Au W.Y., Cheng V.C.C., Wan T.S.K. and Ma E.S.K., Myelodysplasia masquerading as parvovirus-related red cell aplasia with giant pronormoblasts, Annals of Hematology. 2004, 83(10): 670-1.

Au W.Y., Chan C., Pang A., Lie A.K.W., Liang R.H.S., Yuen P.W., Shek T.W.H., Kwong Y.L. and Pang A.W.K., Nonhematologic malignancies after allogeneic hematopoietic stem cell transplantation: incidence and molecular monitoring, Bone Marrow Transplantation. 2004, 34: 981-985.

Au W.Y., Liu C.L., Lo C.M., Fan S.T. and Ma E.S.K., Potential role for platelet apheresis for post-liver transplant thrombocytosis complicating portal vein thrombosis, Journal of Clinical Apheresis. 2004, 19(4): 192-196.

Au W.Y., Mak W., Ho S.L., Leung S.Y. and Kwong Y.L., Reversible paraneoplastic neuropathy associated with T-cell large granular lymphocyte leukemia, Neurology. 2004, 63(3): 588-589.

Au W.Y., Lie A.K.W., Liang R.H.S., Yuen P.W., Shek T.W.H. and Kwong Y.L., Secondary non-hematologic malignancies after allogeneic stem cell transplantation : incidence and molecular monitoring, 10th Congress of the International Society of hematology, Asian Pacific Division, Nagoya, Japan. Nagoya, Japan, 2004, 110.

Au W.Y., Cheung G.T.Y., Yuen W.H., Kumana C.R. and Kwong Y.L., Successful treatment of relapsed acute promyelocytic leukemia in a patient receiving continuous ambulatory peritoneal dialysis with oral arsenic trioxide, Archite Internal Medicine. 2005, 165: 1067-1068.

Au W.Y., Lie A.K.W., Kung A.W.C., Mak W. and Kwong Y.L., Thyrotoxic periodic paralysis after allogeneic haematopoietic stem cell transplantation, British Journal of Haematology. 2005, 129(1): 160.

Au W.Y., Srivastava G., Wong K.Y., Chung L.P., Ma E.S.K., Wan T.S.K. and Kwong Y.L., Transformation of diffuse large B-cell lymphoma into pre-B acute lymphoblastic leukemia: clinicopathologic features and clonal relationship, Human Pathology. 2004, 35(7): 900-903.

Au W.Y., Chim J.C.S., Lie A.K.W., Leung A.Y.H., Tse E.W.C., Ma S.Y., Liang R.H.S., Pang A.W.K., Kumana C.R. and Kwong Y.L., Treatment of relapsed acute promyelocytic leukemia by arsenic-based strategies without hematopoietic stem cell transplantation in Hong Kong: a seven-year experience, American Society of Haematology Annual Scientific Meeting. 2004.

Au W.Y., Lam P. and Shek T.W.H., Uncommon presentations of some common malignancies: Case 2. Nasopharyngeal carcinoma followed by secondary acute promyelocytic leukemia presenting with respiratory distress, Journal of Clinical Oncology. 2005, 23(6): 1314-1315.

Au W.Y., Lie A.K.W. and Cheng V.C.C., VDRL screening and haemopoietic stem cell transplantation, Bone Marrow Transplantation. 2005, 35: 1027-1028.

Au W.Y., Hon C., Chan A.C., Sano T. and Chan H.H.L., Vitiligo as a paraneoplastic syndrome preceding pituitary adenoma and subsequent acute lymphoblastic leukemia, Leukaemia & Lymphoma. 2004, 45(8): 1683-1685.

Chan G.S.W., Lam M.F., Au W.Y., Tse K.C., Chan D.T.M., Lai K.N. and Chan K.W., IgA nephropathy complicating graft-versus-host disease, another nephropathy causing nephrotic syndrome after bone marrow transplantation, Histopathology. 2004, 45(6): 648-651.

Chim J.C.S., Ooi C.G.C., Loong F., Au W.Y., Au W.Y. and Lie A.K.W., Side effects and good effects from new chemotherapeutic agents. Bortezomib in primary refractory plasmacytoma, Journal of Clinical Oncology. 2005, 23(10): 2426-8.

Chiu A., Tam S., Au W.Y., Chan S.C., Liu C.L. and Fan S.T., MARS treatment for a patient presenting with acquired hepatic glutamine synthetase deficiency after orthotopic liver transplantation (Case Report), Liver Transplantation. 2005, 11(3): 353-355.

Hon C., Law R.W., Shek T.W.H. and Au W.Y., CNS Manifestations of Malignancies CASE 1. Conjunctival Relapse of Acute Lymphoblastic Leukemia Heralding Pituitary and CNS Disease , Journal of Clinical Oncology. 2005, 23(18): 4225-4226.

Hon C., Ma E.S.K., Yau K. and Au W.Y., CNS Manifestations of Malignancies CASE 3. Leukemic Optic Neuropathy Complicating Leukemia Cutis , Journal of Clinical Oncology. 2005, 23(18): 4229-4230.

Hon C., Au W.Y. and Liang R.H.S., Conjunctival carcinoma as a novel post-stem cell transplantation malignancy, Bone Marrow Transplantation. 2004, 34(2): 181-182.

Hon C., Ho S.L., Ma E.S.K., Trendell-Smith N.J. and Au W.Y., High-grade lymphoma after azathioprine treatment for Vogt-Kaganayi-Harada syndrome, Leukemia & Lymphoma . 2005, 46: 289-292.

Hon C., Mak W., Kwok A.K.H. and Au W.Y., Immunological and electrophysiological investigations of severe ptosis after bone marrow transplantation, Bone Marrow Transplantation. 2004, 34(5): 455-458.

Hon C., Au W.Y. and Shek T.W.H., Intraocular lymphoma as a masquerade syndrome complicating cerebral lymphoma of the corpus callosum, Annals of Hematology. 2005, 84(3): 203 - 204.

Hon C., Law R.W. and Au W.Y., Scleromalacia perforans complicating graft-versus-host disease, British Journal of Haematology. 2005, 129(1): 1.

Hon C., Ma E.S.K. and Au W.Y., Unusual Sites of Metastatic Malignancy - CASE 3. Acute Leukemia Presenting As Bilateral Proptosis , Journal of Clinical Oncology. 2004, 22(24): 5015-5016.

Hui C.K., Bowden S., Jackson K., Au W.Y., Fong D.Y.T., Lie A.K.W., Chim J.C.S., Liang R.H.S. and Lau G., Clinical significance of intrahepatic hepatitis B virus covalently closed circular DNA in chronic hepatitis B patients who received cytotoxic chemotheraphy, Blood. 2005, 105(6): 2616-2617.

Hui C.K., Lie A.K.W., Au W.Y., Ma S.Y., Leung A.Y.H., Zhang H., Sun J.Z., Cheung W.W.W., Chim J.C.S., Kwong Y.L., Liang R.H.S. and Lau G., Effectiveness of prophylactic Anti-HBV therapy in allogeneic hematopoietic stem cell transplantation with HBsAg positive donors, American Journal of Transplantation. 2005, 5(6): 1437-45.

Hui C.K., Sun J., Au W.Y., Lie A.K.W., Yueng Y.H., Zhang H., Lee N.P., Hou J., Liang R.H.S. and Lau G., Occult hepatitis B virus infection in hematopoietic stem cell donors in a hepatitis B virus endemic area, Journal of Hepatology. 2005, 42(6): 813-9.

Lie A.K.W., Au W.Y., Ma S.Y., Leung A.Y.H., Tse E.W.C., Chan G.C.F., Ha S.Y., Lau Y.L., Kwong Y.L. and Liang R.H.S., Haemopoietic stem cell transplantation in Hong Kong – 14 years of experience at Queen Mary Hospital, 10th Congress of the International Society of hematology, Asian Pacific Division, Nagoya, Japan. Nagoya, Japan, 2004.

Pang A.W.K., Au W.Y. and Kwong Y.L., Caveolin-1 gene is coordinately regulated with the multidrug resistance 1 gene in normal and leukemic bone marrow , Leukemia Research . 2004, 28(9): 973-977.

Solal-Celigny P., Roy P., Colombat P., White J., Armitage J.O., Arranz-Saez R., Au W.Y., Bellei M., Brice P., Caballero D., Coiffier B., Conde-Garcia E., Doyen C., Federico M., Fisher R.I., Garcia-Conde J.F., Guglielmi C., Hagenbeek A., Haioun C., LeBlanc M., Lister A.T., Lopez-Guillermo A., McLaughlin P., Milpied N., Morel P., Mounier N., Proctor S.J., Rohatiner A., Smith P., Soubeyran P., Tilly H., Vitolo U., Zinzani P.L., Zucca E. and Montserrat E., Follicular Lymphoma International Prognostic Index, Blood. 2004, 104(5): 1258-1265.

Srivastava G., Shen L., Au W.Y., Kwong Y.L. and Liang R.H.S., Molecular pathogenesis of nasal NK/T-cell lymphoma, Abstract of the Proc of 63rd Annual Meeting of the Japanese Cancer Association, 29 September - 1 October 2004, Fukuoka, Japan. 2004.

Szeto C.H., Shek T.W.H., Lie A.K.W., Au W.Y., Yuen P.W. and Kwong Y.L., Squamous cell carcinoma of the tongue complicating chronic oral mucosal graft-versus-host disease after allogeneic hematopoietic stem cell transplantation, American Journal of Hematology. 2004, 77(2): 200-202.

Tsang S.K. and Au W.Y., Cough mixture abuse in pregnancy, folate deficiency, and neural tube defects?, American Journal of Hematology. 2005, 78(2): 163.

Yeung C.K., Ma S.Y., Chan H.H.L., Trendell-Smith N.J. and Au W.Y., Primary CD30+ve Cutaneous T-cell Lymphoma Associated with Chronic Burn Injury in a Patient with Longstanding Psoriasis, American Journal of Dermatopathology. 2004, 26(5): 394-396.

Researcher : Chan AKL

List of Research Outputs

Huang F., Ma L., Wu A.Y.Y., Tian L., Chan K.W., Trendell-Smith N.J., Lam A.C., Chan A.K.L., Lo C.K., Chik S.C.C., Ko K.H., To K.W., Kam S.K., Fong L.P., Li X.S., Leung S.Y., Ng M.H., Stott D.I., Liew F.Y. and MacPherson G.G., Systemic autoimmune disease induced by dendritic cells that have captured necrotic but not apoptotic dying cells, Proceedings of the 12th International Congress of Immunology and the 4th Annual Conference of FOCIS, Montreal, Canada, July 18-23, 2004. 2004.

Researcher : Chan ASW

List of Research Outputs

Li V.S.W., Wong C.W., Chan T.L., Chan A.S.W., Zhao W., Chu K.M., Chen X., Yuen S.T., Leung S.Y. and So S., Mutations of PIK3CA in gastric adenocarcinoma, BioMed Central Cancer. 2005, 5: 29.

Researcher : Chan C

List of Research Outputs

Au W.Y., Chan C., Pang A., Lie A.K.W., Liang R.H.S., Yuen P.W., Shek T.W.H., Kwong Y.L. and Pang A.W.K., Nonhematologic malignancies after allogeneic hematopoietic stem cell transplantation: incidence and molecular monitoring, Bone Marrow Transplantation. 2004, 34: 981-985.

Woo J., Lau E..., Lee P., Kwok T..., Lau W.C.S., Chan C., Chiu P.K.Y., Li E..., Sham A.S.K. and Lam D..., Impact of osteoarthritis on quality of life in a Hong Kong Chinese population, Journal of Rheumatology. 2004, 31: 2433-2438.

Researcher : Chan CK

List of Research Outputs

Hui C.K., Lai K.C., Wong R.W.M., Yuen R.M.F., Ng M.M.T., Chan C.K., Hu H.C., Cheung W.W., Lai C.L. and Wong B.C.Y., Outpatients Undergoing Therapeutic Endoscopic Retrograde Cholangiopancreatography: Six-hour Versus Overnight Observation , Journal of Gastroenterology and Hepatology. 2004, 19: 1163-1168.

Wong B.C.Y., Chan O.O., Wong K.W., Ching C.K., Wong R.W.M., Tam S., Lai K.C., Chan C.K., Yuen R.M.F. and Lam S.K., A pilot study of participation in faecal occult blood testing and screening colonoscopy after health education in Hong Kong, European Journal of Cancer Preview. 2005, 14(2): 181-184.

Wong R.W.M., Huang J., Xia H.H.X., Fung F.M.Y., Tong S.M., Cheung K.L., Ho Y.K., Lai K.C., Chan C.K., Chan O.O., Hui C.K., Lam S.K. and Wong B.C.Y., Low-dose rabeprazole, amoxicillin and metronidazole triple therapy for the treatment of Helicobacter pylori infection in Chinese patients , Journal of Gastroenterology and Hepatology. 2005, 20(6): 935-940.

Wong R.W.M., Xiao S.D., HU P.J., Wang W., Gu Q., Huang J., Xia H.H.X., WU S.M., LI C.J., CHEN M.H., CUI Y., Lai K.C., Hu H.C., Chan C.K., Lam S.K. and Wong B.C.Y., Standard treatment for Helicobacter pylori infection is suboptimal in non-ulcer dyspepsia compared to duodenal ulcer in Chinese, Alimentary Pharmacology and Therapeutics. 2005, 21: 73-81.

Wong W.M., Lai K.C., Lam K.F., Hui W.M., Huang J.Q., Xia H.H.X., Hu H.C., Lam C.L.K., Chan C.K., Lam S.K. and Wong B.C.Y., Onset and disappearance of Reflux Symptoms in a Chinese population: a one-year follow-up study, Alimentary Pharmacology and Therapeutics. 2004, 20: 803-812.

Researcher : Chan DTM

Project Title:	Internalization of human anti-DNA antibodies by mesangial cells - the role of [alpha]-actinin and actin
Investigator(s):	Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002
Completion Date:	10/2004

Abstract:

To examine the role of [alpha]-actinin and actin in the binding and internalization of anti-DNA antibodies by HMC; to investigate the synthesis of [alpha]-actinin and actin in HMC after this process; to determine the effect of anti-DNA antibody internalization on HMC morphology, proliferation, and viability, and its synthesis and secretion of IL-1[beta], IL-6 and TNF-[alpha].

Project Title:	Internalization of anti-DNA antibodies from patients with lupus nephritis by human mesangial cells
Investigator(s):	Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	11/2003

Abstract:

To characterize HMC membrane and intracellular molecules responsible for binding to anti-DNA antibodies-by trypsin, papain, or pepsin digestion, Western blotting, and protein sequencing; to examine the relationship between the properties of human anti-dsDNA antibodies (isoelectric point, binding to HMC, cellular internalization), their correlation with clinical disease activity, and their effects on cell function, morphology, proliferation, and apoptosis; to elucidate the mechanisms by which anti-dsDNA antibodies bind and penetrate plasma membrane, traverse the cytoplasm, and enter the nucleus of HMC. This will be achieved by kinetic studies using timed flow cytometry, immunohistochemistry, and confocal microscopy. The latter will also be used to investigate the binding between anti-dsDNA antibodies and cytoskeletal structures including myosin. The effects of anti-dsDNA antibodies in the presence or absence of DNA and histones on the synthesis of cytoskeletal molecules will be examined by radiolabelling and immunoprecipitation.

Project Title:	Internalization of anti-DNA antibodies from patients with lupus nephritis by human mesangial cells
Investigator(s):	Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	11/2003

Abstract:

Project Title:	Modulation of human mesangial cell F-actin and focal adhesion plaque synthesis in diabetic nephropathy
Investigator(s):	Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Abstract:

To examine the effect of physiological (5mM) and elevated (10mM and 30mM) D-glucose concentrations on cultured human mesangial cells (HMC) viability, proliferation, and activation - the latter will be determined by [alpha]-smooth muscle actin staining; to determine how physiological and elevated glucose concentrations modulate F-actin, [alpha]-actinin, vinculin and PKC expression; to determine the morphological changes of HMC cytoskeletal components by scanning and transmission electron microscopy.

Project Title:	The effect of anti-DNA antibodies on the synthesis of pro-fibrotic cytokines, growth factors and matrix proteins in proximal tubular epithelial cells during lupus nephritis
Investigator(s):	Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

To isolate paired polyclonal anti-DNA antibodies from 12 patients with a history of clinically severe lupus nephritis during disease flare and remission; to determine the effect of human polyclonal anti-DNA antibodies on PTEC viability, proliferation and activation; to determine the effect of anti-DNA antibodies on PTEC secretion of cytokines; to investigate how anti-DNA-mediated alterations of cytokines and growth factors modulate changes in matrix synthesis and deposition.

Project Title:	Effects of mycophenolate mofetil and cyclophosphamide on mesangial cell proliferation and function in MRL/1pr mice with lupus nephritis
Investigator(s):	Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	12/2004

Abstract:

To assess the clinical effects of mycophenolate mofetil (MMF) and cyclophosphamide on disease manifestations in MRL/1pr mice with lupus nephritis; to determine the effects of MMF and cyclophosphamide on serum levels of anti-DNA antibodies, pro-inflammatory mediators, and markers of fibrosis; to examine the effects of MMF and cyclophosphamide on kidney histopathology in MRL/1pr mice with lupus nephritis, focusing on mesangial cell proliferation, synthesis of inflammatory/fibrosis mediators, and production of matrix components. The data will be analyzed in relation to corresponding changes in the parameters indicating disease activity, inflammatory cell infiltration, and immune complex deposition; to isolate mesangial cells from treated and control mice, and to assess in vitro mesangial cell activation and synthesis of inflammatory/fibrosis mediators and matrix components; to investigate whether the actions of MMF or cyclophosphamide on mesangial cells are mediated via the protein kinase C (PKC) pathway.

Project Title:	Effects of mycophenolate mofetil and cyclophosphamide on mesangial cell proliferation and function in MRL/1pr mice with lupus nephritis
Investigator(s):	Chan DTM
Department:	Medicine
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

Refer to hard copy

List of Research Outputs

Chan D.T.M., Chapman J., Lee C.J., Morad Z., Ona E.T., Park K., Pingle A., Rizvi S.A., Shaheen F.A., Sumethkull V., Tang X.D. and Watarai Y., A survey on the prevalence and management of hepatitis B after renal transplantation in Asian-Pacific countries, Transplantation Proceedings. 2004, 36(7): 2126-2127.

Chan D.T.M., Antiviral therapy for hepatitis B after kidney transplantation, Transplantation Proceedings. 2004, 36(7): 2124-2125.

Chan D.T.M., Hepatitis B and Dialysis, In: Burton D Rose, UpToDate - Physician information resource available on-line and on CD-ROM. Waltham, MA 02453, U.S.A., UpToDate, 2004.

Chan D.T.M., Hepatitis C and kidney transplantation, Asian Pacific Association for the Study of Liver Diseases Scientific Meeting, 11-15 December 2004, New Delhi, India. 2004.

Chan D.T.M., Tsang R.C.W., Tsang W.S. and Yung S.S.Y., Induction of Proximal Tubular Epithelial Cell Interleukin-6 Synthesis by Anti-DNA Antibodies Varies with the Activity of Lupus Nephritis, Journal of the American Society of Nephrology. 2004, 15: 684A.

Chan D.T.M., Kidney Transplantation in Hong Kong – Recent Developments , 9th Hong Kong Medical Forum. 2004.

Chan D.T.M. and Chan M.K., Lipid disorders in renal failure, In: Nissenson AR , Fine RN, and Gentile GE, Clinical Dialysis. Conn., USA, Appleton & Lange, 2004, 4th edition.

Chan D.T.M., Lipoprotein metabolism in dialysis patients, In: Nissenson, Allen R; Fine, Richard N. , Clinical Dialysis. New York, U.S.A., McGraw-Hill Publ, 2005, Chapter 28.

Chan D.T.M., Tse K.C., Tang C.S.O., Lai K.N. and Li F.K., Long-term outcome of patients with diffuse proliferative lupus nephritis treated with prednisolone and oral cyclophosphamide followed by azathioprine. , Lupus. 2005, 14(4): 265-272.

Chan D.T.M., Tse K.C., Tang C.S.O., Mok T.M.Y., Li F.K. and Hong Kong Nephrology Study G.R.O.U.P., Long-term study of mycophenolate mofetil as continuous induction and maintenance treatment for diffuse proliferative lupus nephritis, Journal of American Society of Nephrology. 2005, 16(4): 1076-1084.

Chan D.T.M., Lupus Nephritis, MetroDaily, 27 August. Hong Kong, 2004, 22.

Chan D.T.M., Lupus nephritis: induction therapy. , Lupus. 2005, 14 Suppl 1: S27-S32.

Chan D.T.M., Preventing renal failure in patients with severe lupus nephritis, Kidney International. 2005, 67 (Suppl 94): S116-S119.

Chan D.T.M., Prevention of renal failure in lupus nephritis, International Society of Nephrology Conference on Prevention of Renal Disease Progression, June 29 to July 1, 2004, Hong Kong. 2004.

Chan D.T.M., Tse K.C., Tang C.S.O., Lai K.N. and Ho S.K.N., Prospective study on lamivudine-resistant hepatitis B in renal allograft recipients, American Journal of Transplantation. 2004, 4(7): 1103-1109.

Chan D.T.M., Systemic Lupus Erythematosus, Sing Pao, 1 September. Hong Kong, 2004, E07.

Chan D.T.M., Treatment of Severe Lupus Nephritis, World Congress of Nephrology, 24-28 June 2005, Singapore. 2005.

Chan G.S.W., Lam M.F., Au W.Y., Tse K.C., Chan D.T.M., Lai K.N. and Chan K.W., IgA nephropathy complicating graft-versus-host disease, another nephropathy causing nephrotic syndrome after bone marrow transplantation, Histopathology. 2004, 45(6): 648-651.

Lai K.N., Leung J.C.K., Chan L.Y., Li F.K., Tang S.C.W., Lam M.F., Tse K.C., Yip T., Chan D.T.M., Wieslander A. and Vlassara H., Differential expression of receptors for advanced glycation end-products in peritoneal mesothelial cells exposed to glucose degradation products, Clinical and Experimental Immunology. 2004, 138: 466-475.

Lam M.F., Yip P.S., Leung J.C.K., Chan D.T.M., Lo W.K. and Lai K.N., Mannose binding lectin gene mutation and incidence rate of peritonitis in long-term peritoneal dialysis patients, Journal of American Society of Nephrology. 2004, 15: 598A.

Lam M.F., Lo W.K., Chu F.S., Li F.K., Yip T.P., Tse K.C., Chan D.T.M. and Lai K.N., Retroperitoneal leakage as a cause of ultrafiltration failure, Peritoneal Dialysis International. 2004, 24(5): 466-470.

Lam M.F., Yip T.P.S., Tse K.C., Li F.K., Lui S.L., Lai K.N. and Chan D.T.M., Sirolimus in kidney transplantation: a pilot study in Chinese patients, Hong Kong Journal of Nephrology. Hong Kong, 2004, 6(1): 38-42.

Leung J.C.K., Chan L.Y., Tsang W.L., Guo H., Tang S.C.W., Chan D.T.M. and Lai K.N., Differential expression of aquaporins in the kidneys of streptozotocin-induced diabetic mice , Nephrology. 2005, 10: 63-72.

Leung J.C.K., Chan Y.Y., Li F.K., Tang S.C.W., Chan K.W., Chan D.T.M., Lam M.F., Wieslander A. and Lai K.N., Glucose degradation products downregulate ZO-1 expression in human peritoneal mesothelial cells: the role of VEGF, Nephrology Dialysis Transplantation. 2005, 20(7): 1336-1349.

Li F.K., Lam M.F., Yip P.S., Chan D.T.M. and Lai K.N., Refractory fluid overload in CAPD patients: management strategies and outcomes, Journal of American Society of Nephrology. 2004, 15: 637A.

Lo W.K., Lui S.L., Chan D.T.M., Li F.K., Lam M.F., Tse K.C., Tang C.S.O., Choy C.B.Y. and Lai K.N., Minimal and optimal peritoneal Kt/V targets: results of an anuric peritoneal dialysis patient's survival analysis. , Kidney International. 2005, 67(5): 2032-2038.

Lui S.L., Chan D.T.M. and Lai K.N., Au update on immunosuppressive drugs for renal transplantation, Medical Progress. Hong Kong, 2005, 32(2): 57-63.

Lui S.L., Wong R.W.M., Ng S.Y., Chan D.T.M., Lai K.N. and Lo W.K., Seroprevalence of Helicobacter pylori in Chinese patients on continuous ambulatory peritoneal dialysis , Nephrology. 2005, 10(1): 21-24.

Lui S.L., Tang S., Li F.K., Choy C.B.Y., Chan D.T.M., Lo W.K. and Lai K.N., Tuberculous infection in southern Chinese renal transplant recipients, Clinical transplantation. 2004, 18(6): 666-671.

Mok T.M.Y., Leung P.Y., Lao T.T.H., Lo Y., Chan D.T.M., Wong R.W.S. and Lau W.C.S., Clinical predictors of fetal and maternal outcome in Chinese patients with systemic lupus erythematosus, 11th APLAR Bi-annual Congress, Jeju, Korea 11-16 September 2004.

Mok T.M.Y., Leung P.Y., Lao T.T.H., Lo Y., Chan D.T.M., Wong W.S. and Lau W.C.S., Clinical predictors of fetal and maternal outcome in Chinese patients with systemic lupus erythematosus, Annals Of The Rheumatic Diseases. 2004, 63: 1705-1706.

Mok T.M.Y., Lo Y., Chan D.T.M., Wong R.W.S. and Lau W.C.S., Tuberculosis in systemic lupus erythematosus in an endemic area and the role of isoniazid prophylaxis during corticosteroid therapy. , Journal of rheumatology. 2005, 32(4): 609-615.

Tang S.C.W., Ho Y.W., Leung V.K., Leung C.Y., Chan D.T.M. and Lai K.N., Lamivudine improves renal outcome in hepatitis-B related membranous nephropathy, Journal of American Society of Nephrology. 2004, 15: 341A.

Tang S.C.W., Leung W.S., Chan V., Chu C.M., Lam B., Leung H., Lam W.O., Ho Y.W., Chan D.T.M. and Lai K.N., Sleep apnea in patients undergoing nocturnal peritoneal dialysis., Peritoneal Dialysis International. 2004, 24 (S2): S49.

Yung S.S.Y., Tsang R.C.W., Leung J.K.H. and Chan D.T.M., Anti-DNA antibodies from patients with lupus nephritis induce IL-6 expression in renal tubular epithelial cells, Nephrology. 2005, 10: A277.

Yung S.S.Y., Liu Z.H., Li L.S. and Chan D.T.M., Emodin abrogates mediators of inflammation and fibrosis and morphological changes in human peritoneal mesothelial cells induced by peritoneal dialysis fluid, Nephrology. 2005, 2005: A64.

Yung S.S.Y., Tsang R.C.W., Leung J.K.H. and Chan D.T.M., Induction of IL-6 by anti-DNA antibodies in proximal tubular epithelial cells varies with the activity of lupus nephritis, Lupus. 2005, 14: 237.

Yung S.S.Y., Tsang R.C.W., Leung J.K.H. and Chan D.T.M., Induction of IL-6 synthesis in proximal tubular epithelial cells by anti-DNA antibodies varies with lupus nephritis activity, 10th Medical Research Conference. 19-20 February 2005. Nephrology 45.

Zhang Q., Yung S.S.Y., Leung J.K.H. and Chan D.T.M., High Glucose Concentration Reduces Human Mesangial Cell alpha-actinin-1 and F-actin Expression through the induction of TGF-beta1 and PKC-alpha, Journal of the American Society of Nephrology. 2004, 15: 726A.

Zhang Q., Yung S.S.Y., Leung J.K.H. and Chan D.T.M., The effect of elevated glucose concentration on the expression of alpha-actinin-1 and F-actin in human mesangial cells, 10th Medical Research Conference. 19-20 February 2005. Nephrology 47.

Researcher : Chan HHL

Project Title:	The role of epidermal cooling in improving the outcome of laser therapy in the treatment of Nevus of Ota
Investigator(s):	Chan HHL, Lam LK
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	12/2000

Abstract:

To assess whether epidermal cooling would reduce pain, swelling, complications but improve clinical response and reduce the number of session required for laser treatment for Nevus of Ota.

Project Title:	The use of vascular lasers in the treatment of port wine stain in chinese
Investigator(s):	Chan HHL, Wei WI
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	11/2001

Abstract:

To establish the importance of epidermal cooling when 585nm pulse dye laser is used for the treatment of port wine stain in Chinese; to compare the clinical efficacy, patients' tolerability and complications of two commerical available vascular lasers that are equipped with different cooling devices in the treatment of port wine stain in Chinese.

List of Research Outputs

Au W.Y., Hon C., Chan A.C., Sano T. and Chan H.H.L., Vitiligo as a paraneoplastic syndrome preceding pituitary adenoma and subsequent acute lymphoblastic leukemia, Leukaemia & Lymphoma. 2004, 45(8): 1683-1685.

Chan H.H.L. and Kono T., The Use Of Lasers And Intense Pulsed Light Sources For The Treatment Of Pigmentary Lesions, Skin Therapy Letter. 2004, 9(8): 5-7.

Chan H.H.L., Wong S.Y., Ho W.S., Lam L.K. and Wei W.I., The use of pulsed dye laser for the prevention and treatment of hypertrophic scars in Chinese persons, Dermatologic Surgery. 2004, 30: 987-994.

Chuh A.A.T. and Chan H.H.L., Effect On Quality Of Life In Patients With Pityriasis Rosea: Is It Associated With Rash Severity?, International Journal Of Dermatology. 2005, 44(5): 372-7.

Chuh A.A.T., Chan H.H.L. and Zawar V., Is Human Herpesvirus 7 The Causative Agent Of Pityriasis Rosea?--a Critical Review, International Journal Of Dermatology. 2004, 43(12): 870-5.

Yeung C.K., Ma S.Y., Chan H.H.L., Trendell-Smith N.J. and Au W.Y., Primary CD30+ve Cutaneous T-cell Lymphoma Associated with Chronic Burn Injury in a Patient with Longstanding Psoriasis, American Journal of Dermatopathology. 2004, 26(5): 394-396.

Researcher : Chan JCK

Project Title:	Application of the APACHE II and III prognostic scoring methods in the 14-bed Intensive Care Unit at Queen Mary Hospital
Investigator(s):	Chan JCK, Lam WK
Department:	Medicine
Source(s) of Funding:	Health Services Research Fund - Full Grants
Start Date:	07/1995

Abstract:

To evaluate the usefulness of the APACHE II and III prognostic scoring methods in the 14-bed ICU at Queen Mary Hospital; to compare our ICU performance in terms of actual mortality with the predicted mortality based on the APACHE II predictive equation; to correlate the APACHE II and III severity scores. As the mortality prediction equation for APACHE III is only commercially available, a close correlation between APACHE II and III scores would support using the APACHE II scoring and prediction method as the standard method rather than financially investing in the APACHE III system.

List of Research Outputs

Researcher : Chan K

List of Research Outputs

Chan K. and Chan V.N.Y., Microarray and diagnosis of thalassemia and haemophilia B, Xth Congress of the International Society of Hematology, Asian Pacific Division, Nagoya, Japan. 2004.

Researcher : Chan KW

List of Research Outputs

Chan K.W., Xu A., Hoo R.L.C., Tan K.C.B., Zhang J., Lam C.W. and Lam K.S.L., Selective Reduction of the High Molecular Weight Form of Adiponectin by Testosterone: A Potential Mechanism That Underlies the Sexual Dimorphism of Adiponectin Oligomeric Distribution, The Endocrine Society’s 87th Annual Meeting, June 4-7, 2005, San Diego, USA. 2005.

Chan K.W., Xu A., Hoo R.L.C., Lam C.W. and Lam K.S.L., Sexual dimorphism of adiponectin: Why do men have higher risk to diabetes and atherosclerosis than women?, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005. Endocrinology 24.

Xu A., Chan K.W., Wang Y., Zhang J., Hoo R.L.C., Xu J., Chow W.S. and Lam K.S.L., Angiopoietin-like Protein 4 Decreases Blood Glucose and Improves Glucose Tolerance but Induces Hyperlipidemia and Hepatic Steatosis in Mice, Proceedings of the National Academy of Sciences of the United States of America. 2005, 102: 6086-6091.

Xu A., Lam M.C., Chan K.W., Wang Y., Zhang J.C.L., Xu J., Chen B., Chow W.S., Tso A.W. and Lam K.S.L., Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice, Proc Natl Academic Science USA. 2005, 102(17): 6086-91.

Xu A., Lam C.W., Chan K.W., Zhang J., Hoo R.L.C., Xu J., Chen B. and Lam K.S.L., Angiopoietin-like protein 4 is a novel metabolic hormone with therapeutic potentials for hyperglycemia and insulin resistance, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005. Endocrinology 22.

Xu A., Chan K.W., Hoo R.L.C., Wang Y., Zhang J., Chen B., Cynthia T., Cooper G.J.S. and Lam K.S.L., Testosterone Selectively Reduces the High Molecular Weight Form of Adiponectin by Inhibiting Its Secretion from Adipocytes, The Journal of Biological Chemistry. 2005, 280: 18073-18080.

Xu A., Chan K.W., Hoo R.L.C., Wang Y., Tan K.C.B., Zhang J.C.L., Chen B., Lam M.C., Tse C., Cooper G.J. and Lam K.S.L., Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes, J Biol Chem. 2005, 280(18): 18073-80.

Researcher : Chan KW

List of Research Outputs

Researcher : Chan LY

List of Research Outputs

Chan L.Y., Leung J.C.K., Tsang W.L., Tang S.C.W. and Lai K.N., Activation of tubular epithelial cells by mesangial-derived TNF-alpha: glomerulotubular communication in IgA nephropathy , Kidney International. 2005, 67: 602-612.

Chan L.Y., Leung J.C.K. and Lai K.N., Novel mechanisms of tubulointerstitial injury in IgA nephropathy: a new therapeutic paradigm in the prevention of progressive renal failure, Clinical and Experimental Nephrology . 2004, 8: 297-303.

Lai K.N., Leung J.C.K., Chan L.Y., Li F.K., Tang S.C.W., Lam M.F., Tse K.C., Yip T., Chan D.T.M., Wieslander A. and Vlassara H., Differential expression of receptors for advanced glycation end-products in peritoneal mesothelial cells exposed to glucose degradation products, Clinical and Experimental Immunology. 2004, 138: 466-475.

Lai K.N., Chan L.Y., Tsang W.L., Tang S.C.W. and Leung J.C.K., Differential regulation of AT1 and AT2 receptors by angiotensin II in human mesangial and renal proximal tubular epithelial cells, Journal of American Society of Nephrology. 2004, 15: 841A.

Lai K.N., Chan L.Y. and Leung J.C.K., Mechanisms of tubulointerstitial injury in IgA nephropathy, Kidney International. 2005, 67(suppl 94): S110-S115.

Lai K.N., Chan L.Y., Tang S.C.W., Tsang W.L., Li F.K., Lam M.F., Lui S.L. and Leung J.C.K., Mesangial expression of angiotensin II receptor in IgA nephropathy and its regulation by polymeric IgA1 , Kidney International. 2004, 66: 1403-1416.

Lai K.N., Tang S.C.W., Tsang W.L., Chan L.Y. and Leung J.C.K., Ganaderma extract prevents albumin-induced oxidative damage and chemokine synthesis in cultured human proximal tubular epithelial cells, Journal of American Society of Nephrology. 2004, 15: 107A.

Leung J.C.K., Chan L.Y., Tsang W.L., Tang S.C.W. and Lai K.N., Anti-macrophage migration inhibitory factor reduces transforming growth factor-beta 1 expression in experimental IgA nephropathy, Nephrology Dialysis Transplantation. 2004, 19: 1976-1985.

Leung J.C.K., Chan L.Y., Tsang W.L., Guo H., Tang S.C.W., Chan D.T.M. and Lai K.N., Differential expression of aquaporins in the kidneys of streptozotocin-induced diabetic mice , Nephrology. 2005, 10: 63-72.

Leung J.C.K., Chan L.Y., Tsang W.L., Tang S.C.W. and Lai K.N., Increased synthesis of TNF-a and IL-6 by mesangial cells cultured with polymeric anionic IgA from patients with IgA nephropathy, Journal of American Society of Nephrology. 2004, 15: 224A.

Tang S.C.W., Leung J.C.K., Chan L.Y., Tsang W.L. and Lai K.N., Albumin-induced interleukin-8 expression in renal tubular cells is abrogated by angiotensin type 2 but not type 1 receptor blockade, Journal of American Society of Nephrology. 2004, 15: 847A.

Researcher : Chan MMW

Project Title:	Candidate gene polymorphisms associated with asthma and allergy in Hong Kong
Investigator(s):	Chan MMW, Ip MSM, Tan-Un KC
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2001
Completion Date:	08/2004

Abstract:

To recruit 150 Chinese patients with asthmas from the Asthma Clinic at the Queen Mary Hospital in Hong Kong; to phenotype these patients according to their asthma severity and atopic status; to determine the prevalence of some of the specific polymorphisms of genes associated with allergy and asthma; to recruit an equal number of controls without asthma and to determine the prevalence of specific polymorphisms of genes associated with allergy and asthma.

Project Title:	A surveillance program of tuberculosis in old age homes in Hong Kong
Investigator(s):	Chan MMW, Chu LW, Lam WK, Wong C.P., Kam K.M., Dai D.L.K.
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	11/2001

Abstract:

To conduct a cross-sectional screening examination for tuberculosis in old age homes in several districts in Hong Kong, SAR; to ensure that directly observed therapy (DOT) is given to those with active disease diagnosed through the screening program in collaboration with the Hong Kong Government Tuberculosis and Chest Service (Chest Service); to provide a screening examination for tuberculosis for new residents on entry to the old age homes participating in the program; to participate, in collaboration with the Chest Service, in contact examination on residents in the same home from which an active case of tuberculosis is being diagnosed; to provide education to the staff of old age homes on early recognition of tuberculosis, its treatment and possible side effects to evaluate the effectiveness of the program.

Project Title:	A surveillance program of tuberculosis in old age homes in Hong Kong
Investigator(s):	Chan MMW, Chu LW, Lam WK, Dai D.L.K., Wong C.P., Kam K.M.
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2004

Abstract:

To conduct a cross-sectional screening examination for tuberculosis in old age homes in several districts in Hong Kong, SAR; to ensure that directly observed therapy (DOT) is given to those with active disease diagnosed through the screening program in collaboration with the Hong Kong Tuberculosis and Chest Service, Department of Health (Chest Service); to provide a screening examination for tuberculosis for new residents on entry to the old age homes participating in the program; to participate, in collaboration with the Chest Service, in contact examination on residents in the same home from which an active case of tuberculosis is being diagnosed; to provide education to the staff of old age homes on early recognition of tuberculosis, its treatment and possible side effects; to evaluate the effectiveness of the program.

List of Research Outputs

Bovornkitti S., Lam W.K. and Chan M.M.W., Smoking and lung health. In Ed. Ip MSM, Chan MMW, Lam WK, Zhong NS, Respiratory Medicine : An Asian Perspective. Hong Kong University Press, Hong Kong, 2005, Chapter 20: 347-363.

Brauer M. and Chan M.M.W., Air pollution and Health, In: Ip SM, Chan MMW, Zhong NS, Lam WK, Respiratory Disease - The Asian Perspective. The University of Hong Kong Press, 2005, 327-346.

Chan M.M.W. and Wong G.K., Asthma Epidemiology, In: Ip SM, ChanMMW, Zhong NS, Lam WK, Respiratory Disease- The Asian Perspective. The University of Hong Kong Press, 2005, 3-24.

Chan M.M.W. and Ip M.S.M., Asthma Management, In: Ip SM, Chan MMW, Zhong NS, Lam WK, In: Respiratory Disease- The Asian Perspective. The University Hong Kong Press, 2005, 25-42.

Chan M.M.W. and Ip M.S.M., Asthma management. In: Ed. Ip MSM, Chan MMW, Lam WK, Zhong NS, Respiratory Medicine - An Asian Perspective. Hong Kong University Press, 2005, pp. 25-42.

Chan M.M.W., Diet, Lifestyle and Health, Impact of demographic change 2005. www.civic-exchange.org. 2005.

Chan M.M.W., Tan-Un K.C., Ip M.S.M., Tsang K.W.T., Ho S.P., Ho J.C.M., Chan H. and Lam W.K., Lung Cancer Susceptibility and Polymorphism of Glutathione-S-transferase Genes in Hong Kong, Lung Cancer. 2004, 45(2): 155-160.

Chan M.M.W. and Ng T.P., Occupational airway disease, In: Ip SM, Chan MMW, Zhong NS, Lam WK, Respiratory Disease - The Asian Perspective . The University of Hong Kong Press, 2005, 365-378.

Chan M.M.W. and Ng T.P., Occupational parenchymal disease, In: Ip SM, Chan MMW, Zhong NS, Lam WK, Respiratory Disease - The Asian Perspective. The University of Hong Kong Press, 2005, 379-400.

Chan M.M.W., Lam W.K., Mak J.C.W., Ho S.P., Chan H.W., Tsang K.W.T., Ip M.S.M., Ho J.C.M., Wong M.P. and Tan-Un K., Polymorphisms of CYP and GST genes, passive smoke and lung cancer risk in Hong Kong Chinese, European Respiratory Journal. 2004, 24: Suppl 48: 457s.

Chan M.M.W., Severe acute respiratory syndrome (SARS) and healthcare workers , Int J Occup Environ Health. 2004, 10(4): 421-7.

Chan M.M.W., Ferguson A., Dimich-Ward H., Watson W., Rousseau R., Lilley M., DyBuncio A. and Becker A., The Canadian Primary Prevention of Asthma in Childhood- outcomes at 7 years, Journal of Allergy and Clinical Immunology. 2005, 116: 49-55.

Chan M.M.W., The Medical Challenge, In: Edited by Loh C, The epi-centre- Severe Acute Respiratory Syndrome . The University of Hong Kong Press, 2004, 17-32.

Chan M.M.W. and Loh C., The coronavirus, In: Edited by Loh C, The epicentre: Severe acute respiratory syndrome. The University of Hong Kong Press, 2004, 43-54.

Dimich-Ward H., Lawson J., Hingston A. and Chan M.M.W., Impact of smoking policy on the respiratory health of food and beverage servers, Scan J Work Environ Health. 2005, 31(1): 75-81.

Dimich-Ward H., Hingstons A., Lawson J. and Chan M.M.W., Impact of workplace policy on the respiratory health of hospitality workers., Chest. 2004, 126: 1048-53.

Dimich-Ward H., Wymer M.L. and Chan M.M.W., Respiratory health survey of respiratory therapists, Chest. 2004, 126(4): 1048-53.

Ho J.C.M., Lam W.K., Wong M.P., Wong M.K., Ooi C.G.C., Ip M.S.M., Chan M.M.W. and Tsang K.W.T., Lymphoepithelioma-like carcinoma of the lung : experience with ten cases, International Journal of Tuberculosis and Lung Disease. 2004, 8(7): 890-895.

Ho J.C.M., Mak J.C.W., Ho S.P., Ip M.S.M., Tsang K.W.T., Lam W.K. and Chan M.M.W., Manganese superoxide dismutase and catalase genetic polymorphisms activity levels and lung cancer risk in Chinese in Hong Kong, 10th Medical Research Conference, Department of Medicine, The University of Hong Kong, February 2005. Abstract Book: RM 66.

Ho J.C.M., Ho S.P., Chan M.M.W., Mak J.C.W., Ip M.S.M., Ko K.W., Yan C.P.K., Wong M.P., Tsang K.W.T. and Lam W.K., Non-small cell lung cancer in Chinese is associated with disturbance in systemic antioxidant profiles, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December, 2004. Respirology. 2004, 9 (Supp): A114.

Ho J.C.M., Wu A.Y.Y., Lam B., Ooi C.G.C., Khong P.L., Ho P.L., Chan M.M.W., Zhong N.S., Ko K.W., Lam W.K. and Tsang K.W.T., Pentaglobin in steroid-resistant severe acute respiratory syndrome, International Journal of Tuberculosis and Lung Disease. 2004, 8(10): 1173-1179.

Ho S.P., Chan M.M.W., Chow K.M., Ip M.S.M. and Mak J.C.W., Antioxidant enzyme activities in healthy Chinese adults: influence of age, gender, and smoking, Respirology. 2005, 10: 305-309.

Ho S.P., Chan M.M.W., Wong M.P., Tsang K.W.T., Ip M.S.M., Lam W.K. and Mak J.C.W., Transforming growth factor (TGF)-beta 1 gene common polymorphisms and plasma TGF-beta 1 levels in patients with lung cancer, 10th Medical Research Conference, Department of Medicine, The University of Hong Kong, February 2005. Abstract Book: RM 60.

Ho S.P., Chan M.M.W., Tsang K.W.T., Ip M.S.M., Lam W.K. and Mak J.C.W., Transforming growth factor (TGF)-beta 1 gene common polymorphisms and plasma TGF-beta 1 levels in patients with lung cancer, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A120.

Ip M.S.M., Ko K.W., Lau A.C.W., Yu W.C., Tang K.S., Choo K., Ling S.O., Chan J.W. and Chan M.M.W., Reference values of spirometry for adult Chinese in Hong Kong, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A162.

Ip M.S.M., Chan M.M.W., Lam W.K. and Zhong N.S., Respiratory Medicine - An Asian Perspective. Hong Kong University Press, 2005.

Lam W.K., Tsang K.W.T., Ooi C.G.C., Ip M.S.M. and Chan M.M.W., Infections: Severe Acute Respiratory Syndrome., In: Ip M, Chan-Yeung M, Lam WK, Zhong NS, Respiratory Medicine, An Asian Perspective. Hong Kong, Hong Kong University Press, 2004, 307-323.

Lam W.K., White N.W. and Chan M.M.W., Lung cancer epidemiology and risk factors in Asia and Africa, International Journal of Tuberculosis and Lung Disease . 2004, 8: 1045-1057.

Lam W.K., Tsang K.W.T., Ooi C.G.C., Ip M.S.M. and Chan M.M.W., Severe Acute Respiratory Syndrome. In: Ed. Ip MSM, Chan MMW, Lam WK, Zhong NS, Respiratory Medicine - An Asian Perspective. Hong Kong University Press, 2005, Chapter 18: pp. 307-323.

Mak J.C.W., Leung C.M., Ho S.P., Law K.W., Tsang K.W.T., Lam W.K., Ip M.S.M. and Chan M.M.W., Genetic susceptibility of transforming growth factor beta-1 common polymorphisms to Chinese patients with asthma, American Thoracic Society International Conference, San Diego, USA. May 2005. Proceedings of the American Thoracic Society. 2005, p.A78.

Mak J.C.W., Ho J.C.M., Ho S.P., Yu W.C., Yew W.W., Tsang K.W.T., Lam W.K., Ip M.S.M. and Chan M.M.W., Increased oxidative stress and altered antioxidant status in Chinese patients with COPD, European Respiratory Journal. 2004, 24: Suppl 48: 62s.

Mak J.C.W., Ho J.C.M., Ho S.P., Leung C.M., Law K.W., Ip M.S.M. and Chan M.M.W., Polymorphisms of superoxide dismutase and catalase genes and their functional activity levels in Chinese patients with asthma, American Thoracic Society International Conference, San Diego, USA. May 2005. Proceedings of the American Thoracic Society . 2005, p.A78.

Mak J.C.W., Leung H.C., Ho S.P., Lam W.K., Tsang K.W.T., Ip M.S.M. and Chan M.M.W., Systemic antioxidant status in Chinese patients with asthma, European Respiratory Journal. 2004, 24: Suppl 48: 509s.

Mak J.C.W., Leung C.M., Ho S.P., Lam W.K., Tsang K.W.T., Ip M.S.M. and Chan M.M.W., Systemic oxidative and antioxidative status in Chinese patients with asthma, Journal of Allergy and Clinical Immunology. 2004, 114(2): 260-264.

Mo H.Y., Xu J., Ren X.L., Zeng G.Q., Tan Y.X., Chen R.C., Chan M.M.W. and Zhong N.S., Evaluation by indirect immunofluorescent assay and enzyme linked immunosorbent assay of the dynamic changes of serum antibody responses against severe acute respiratory syndrome coronavirus , Chin Med J (Engl). 2005, 118(6): 446-50.

Tarlo S. and Chan M.M.W., Occupational Asthma, In: 2nd Edition, Occupational and Environmental Medicine. Rosenstock and Cullen, 2004.

Wang J., Law K.W., Ip M.S.M., Wu A.Y.Y., Wong M.K., Lam B., Chow K.M. and Chan M.M.W., Effect of asthma self management programme on asthma morbidity and health care utilization in adult patients admitted to hospital with acute asthma in Hong Kong: A randomized controlled trial, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A91.

Yu W.C., Hui D.S. and Chan M.M.W., Antiviral agents and corticosteroids in the treatment of severe acute respiratory syndrome (SARS) , Thorax. 2004, 59(8): 643-5.

Yu W.C., Hui D.S., Chan M.M.W. and Lai C.K.W., Editorial. Antivirals and Corticosteroids in the Treatment of Severe Acute Respiratory Syndrome (SARS)., Thorax. 2004, 59: 643-5.

Researcher : Chan MTL

List of Research Outputs

Leung A.Y.H., Chan M.T.L., Yuen K.Y., Cheng V.C.C., Chan K.H., Wong L.P., Liang R.H.S., Lie A.K.W. and Kwong Y.L., Ciprofloxacin Decreased Polyoma BK Virus Load in Patients Who Underwent Allogeneic Hematopoietic Stem Cell Transplantation, Clinical Infectious Disease. 2005, 40: 528-537.

Leung A.Y.H., Chan M.T.L. and Kwong Y.L., Genotyping of the noncoding control region of BK virus in patients with haemorrhagic cystitis after allogeneic haematopoietic stem cell transplantation, Bone Marrow Transplantation. 2005, 35: 531?532.

Leung A.Y.H., Chan M.T.L., Cheng V.C.C., Lie A.K.W., Yuen K.Y. and Kwong Y.L., Polyoma BK viruria in patients undergoing autologous hematopoietic stem cell transplantation, Bone Marrow Transplantation. 2005, 35: 1029?1030.

Leung A.Y.H., Chan M.T.L., Cheng V.C.C., Yuen K.Y. and Kwong Y.L., Quantification of Adenovirus in the Lower Respiratory Tract of Patients without Clinical Adenovirus-Related Respiratory Disease, Clinical Infectious Disease. 2005, 40: 1541-1544(online).

Researcher : Chan OO

Project Title:	Association of CpG island methylation of E-cadherin gene and Helicobacter pylori in gastric carcinogenesis
Investigator(s):	Chan OO
Department:	Medicine
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2004

Abstract:

Refer to hard copy

List of Research Outputs

Chan O.O., Chu K.M., Sun Y., Cheung K.L., Lam S.K., Yuen R.M.F., Hui W.M. and Wong B.C.Y., The association between Interleukin 1 beta polymorphism and hypermethylation at tumor suppressor genes in gastric cancer. Conference paper at the Annual Meeting of the American Gastroenterology Associatoin, Digestive Diseases Week (DDW) Chicago, Illinois, USA. May 14-19, Gastroenterology. 2005, 128(4 Suppl 2): A399.

Gu Q., Wang J., Xia H.H.X., Lin M.C., He H., Zou B., Tu S., Yang Y., Liu X.G., Lam S.K., Wong R.W.M., Chan O.O., Yuen R.M.F., Kung H. and Wong B.C.Y., Activation of the Caspase-8/Bid and Bax Pathways in Aspirin-Induced Apoptosis in Gastric Cancer, Carcinogenesis. 2005, 26(3): 541-546.

Gu Q., Xia H.H.X., Wang W., Wang J., Wong R.W.M., Chan O.O., Yuen M.F., Lam S.K., Cheung K.L., Liu X.G. and Wong B.C.Y., Effect of Cyclo-Oxygenase Inhibitors on Helicobacter pylori Susceptibility to Metronidazole and Clarithromycin, Alimentary Pharmacology and Therapeutics. 2004, 20: 675-681.

Jiang X., Tu S., Cui J., Lin M.C., Xia H.H.X., Wong R.W.M., Chan O.O., Yuen M.F., Jiang S.H., Lam S.K., Kung H., Soh J.W., Weinstein I.B. and Wong B.C.Y., Antisense Targeting Protein Kinase C Alpha and Beta1 Inhibits Gastric Carcinogenesis, Cancer Research. 2004, 64: 5787-5794.

Lai K.C., Hui W.M., Wong B.C.Y., Hu H.C., Chan O.O. and Lam S.K., Lansorprazole but not Rofecoxib reduced dyspeptic symptoms of patients on NSAIDS, Gastroenterology. 2005, 128(4 Suppl 2): A24.

Li G., Xia H.H.X., Chen M.H., Chan O.O., Cho C.H., Lam S.K., Berg D., Feng Z., Langenbach R. and Wong B.C.Y., Effects of Cyclooxygenase-1 and -2 Gene Disruption on Helicobacter pylori-Induced Inflammation, Apoptosis and Proliferation, Journal of Gastroenterology and Hepatology. 2004, 19(Suppl.): A299.

Tu S., Cui J., Liston P., Jiang X., Xu R., Lin M.C., Zhu Y.B., Zou B., Ng S.M., Jiang S.H., Xia H.H.X., Wong R.W.M., Chan O.O., Yuen R.M.F., Lam S.K., Kung H. and Wong B.C.Y., Gene Therapy for Colon Cancer by Adeno-Associated Viral Vector-Mediated Transfer of Survivin Cys84Ala Mutant, Gastroenterology. 2005, 128: 361-375.

Wong B.C.Y., Chan O.O., Wong K.W., Ching C.K., Wong R.W.M., Tam S., Lai K.C., Chan C.K., Yuen R.M.F. and Lam S.K., A pilot study of participation in faecal occult blood testing and screening colonoscopy after health education in Hong Kong, European Journal of Cancer Preview. 2005, 14(2): 181-184.

Wong R.W.M., Huang J., Xia H.H.X., Fung F.M.Y., Tong S.M., Cheung K.L., Ho Y.K., Lai K.C., Chan C.K., Chan O.O., Hui C.K., Lam S.K. and Wong B.C.Y., Low-dose rabeprazole, amoxicillin and metronidazole triple therapy for the treatment of Helicobacter pylori infection in Chinese patients , Journal of Gastroenterology and Hepatology. 2005, 20(6): 935-940.

Wong R.W.M., Lai K.C., Hui W.M., Hu H.C., Huang J., Wong Y.H., Xia H.H.X., Chan O.O., Lam S.K. and Wong B.C.Y., Pathophysiology of Gastroesophageal Reflux Diseases in ChineseRole of Transient Lower Esophageal Sphincter Relaxation and Esophageal Motor Dysfunction, American Journal of Gastroenterology. 2004, 99: 2088-2093.

Xia B., Xia H.H.X., Lam S.K., Chan O.O., Lai K.C., Hu H.C. and Wong B.C.Y., Trends in prevalence of peptic ulcer disease and Helicobacter pylori infection and frequency of NSAID intake in general practitioner-referred dyspeptic patients over 6 years in Hong Kong, Gastroenterology. 2005, 128(4 Suppl 2): A230.

Xia H.H.X., Li G., Chen M.H., Chan O.O., Cho C.H., Lam S.K., Berg D., Feng Z., Langenbach R. and Wong B.C.Y., Cyclooxygenase-1 and -2 Gene Disruption Potentiate TH1 Polarization in Response to Helicobacter pylori, Journal of Gastroenterology and Hepatology. 2004, 19(Suppl.): A366.

Xia H.H.X., Lam S.K., Chan O.O., Lin M.C., Kung H., Ogura K., Berg D.E. and Wong B.C.Y., Macrophage Migration Inhibitory Factor Stimulated by Helicobacter pylori Increases Proliferation of Gastric Epithelial Cells, World Journal of Gastroenterology. 2005, 11(13): 1946-1950.

Yong J.L., Lam C.M., Chan O.O., Poon R.T.P., Liu C.L., Lo C.M. and Fan S.T., Better survival in female patients with hepatocellular carcinoma (Abstract), Asian Journal of Surgery. 2005, 28(Suppl 2): S94.

Yong J.L., Lam C.M., Chan O.O., Poon R.T.P., Liu C.L., Lo C.M. and Fan S.T., Better survival in female patients with hepatocellular carcinoma (Abstract), The 4th International Meeting on Hepatocellular Carcinoma: Eastern and Western Experiences, Hong Kong, 14-16 December 2004.

Yuen M.F., Ng I.O.L., Fan S.T., Yuan H., Wong D.K.H., Yuen J.C.H., Sum S.M., Chan O.O. and Lai C.L., Significance of HBV DNA levels in liver histology of HBeAg and anti-HBe positive patients with chronic hepatitis B, American Journal of Gastroenterology. 2004, 99(10): 2032-2037.

Yuen R.M.F., Lim W.L., Chan O.O., Wong D.K.H., Sum S.M. and Lai C.L., 18-year follow-up study of a prospective randomized trial of hepatitis B vaccinations without booster doses in children, Clinical Gastroenterology and Hepatology. 2004, 2(10): 941-5.

Yuen R.M.F., Wong D.K.H., Sum S.M., Yuan H., Yuen J.C.H., Chan O.O., Wong B.C.Y. and Lai C.L., Effect of lamivudine therapy on the serum covalently closed circular DNA of chronic hepatitis B infection., 55th Annual Meeting of the American Association for the Study of Liver Diseases, Boston, USA 29 Oct-2 Nov 2004 (Published in Hepatology). 2004, 40(4): 671A.

Yuen R.M.F., Wong D.K.H., Sum S.M., Yuan H., Yuen J.C.H., Chan O.O., Wong B.C.Y. and Lai C.L., Effect of lamivudine therapy on the serum covalently closed-circular (ccc) DNA of chronic hepatitis B infection., American Journal of Gastroenterology. 2005, 100(5): 1099-103.

Yuen R.M.F., Yuan H., Sablon E., Wong D.K.H., Chan O.O., Wong B.C.Y. and Lai C.L., Long-term follow-up study of Chinese patients with YMDD mutations: significance of hepatitis B virus genotypes and characteristics of biochemical flares, Journal of Clinical Microbiology. 2004, 42(9): 3932-6.

Yuen R.M.F., Fung S.K., Tanaka Y., Kato T., Mizokami M., Yuen J.C.H., Wong D.K.H., Yuan H., Sum S.M., Chan O.O., Wong B.C.Y. and Lai C.L., Longitudinal study of hepatitis activity and viral replication before and after HBeAg seroconversion in chronic hepatitis B patients infected with genotypes B and C., Journal of Clinical Microbiology. 2004, 42(11): 5036-40.

Yuen R.M.F., Yuan H., Wong D.K.H., Yuen J.C.H., Wong R.W.M., Chan O.O., Wong B.C.Y., Lai K.C. and Lai C.L., Prognostic determinants for chronic hepatitis B in Asians: therapeutic implications., Gut. 2005, online.

Yuen R.M.F., Tanaka K., Mizokami M., Yuen J.C.H., Hui C.K., Wong D.K.H., Yuan H., Sum S.M., Chan O.O., Wong B.C.Y., Fan S.T. and Lai C.L., Role of hepatitis B virus genotypes Ba and C, core promoter and precore mutations on hepatocellular carcinoma: a case control study, Carcinogenesis. 2004, 25(9): 1593-1598.

Zhu S., Xia H.H.X., Lam S.K., Yu L., Yang Y., Sun Y., Wang J., Chan O.O. and Wong B.C.Y., Alterations of gastric homeoprotein expression in H. Pylori infection and/or intestinal metaplasia, Gastroenterology. 2005, 128(4 Suppl 2): A598.

Zhuang Z., Tsao G.S.W., Xia H.H.X., He H., Chan O.O., Lam S.K. and Wong B.C.Y., COX-2 inhibition induces apoptosis in human esophageal epithelial cells: implication for chemoprevention, Gastroenterology. 2005, 128(4 Suppl 2): A299.

Researcher : Chan RHW

List of Research Outputs

Siu C.W., Chan R.H.W., Tse H.F., Lau C.P., Jim M.H., Ho H.H. and Chu F., Recurrent acute heart failure caused by sliding hiatus hernia. , Postgrad Med Journal. 2005, 81(954): 268-9.

Researcher : Chan SM

List of Research Outputs

Kwok C.F., Chan S.M., Lee K.K., Ho A.Y.Y., Chan Y.Y., Li P.F., Wong Y.W., Leung F., Luk K.D.K. and Kung A.W.C., An evaluation of a secondary prevention programme against osteoporosis fractures, 6th Regional Osteoporosis Conference, 21-22 May 2005, Hong Kong. 2005.

Researcher : Chan TK

List of Research Outputs

Chan V.N.Y., Yip B., Yam I.Y.L., Au P., Lin C.K., Wong V.C.N. and Chan T.K., Carrier incidence for spinal muscular atrophy in southern Chinese, Journal of Neurology. 2004, 251: 1089-1093.

Chan V.N.Y., Yam I.Y.L., Yeung W.S.B., Ng E.H.Y., Ho P.C. and Chan T.K., Preimplantation diagnosis of homozygous alpha° thalassemia, Xth Congress of the International Society of Hematology, Asian Pacific Division, Nagoya, Japan, September. 2004.

Researcher : Chan VNY

Project Title:	Development of a microarray based assay to study epigenomic alternation in breast cancer using comparative methylation hybridization
Investigator(s):	Chan VNY, Chow LWC, Lee SMY
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002

Abstract:

To make use of the microarray techology to develop an assay that will generate the methylation profile of breast tumours that can be used for either diagnostic or prognostic evaluation in clinics.

Project Title:	Localisation of the disease or disease-susceptibility gene for adolescent idiopathic scoliosis
Investigator(s):	Chan VNY, Chan K, Lee SMY, Luk KDK
Department:	Medicine
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	11/2003

Abstract:

To identify genes along the mouse chromosome 17 (which is in synteny to human chromosome 19p), that are expressed in tissues associated with AIS phenotype, such as muscle, bone, cartilage, tendon, etc; to identify by differential gene expression analysis those genes along human chromosome 19p13, expressed (differently- decreased or increased) in AIS patients compared to human control subjects; to sequence those genes of interest in genomic DNA of the indexed patients in the relevant AIS families, in order to identify the causative mutations.

Project Title:	Localisation of the disease or disease-susceptibility gene for adolescent idiopathic scoliosis
Investigator(s):	Chan VNY, Chan K, Luk KDK, Cheng CK
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	11/2003

Abstract:

List of Research Outputs

Chan K. and Chan V.N.Y., Microarray and diagnosis of thalassemia and haemophilia B, Xth Congress of the International Society of Hematology, Asian Pacific Division, Nagoya, Japan. 2004.

Chan V.N.Y., Yip B., Yam I.Y.L., Au P., Lin C.K., Wong V.C.N. and Chan T.K., Carrier incidence for spinal muscular atrophy in southern Chinese, Journal of Neurology. 2004, 251: 1089-1093.

Chan V.N.Y., Chairman of oral session, Xth Congress of the International Society of Hematology, Asian Pacific Division, Nagoya, Japan, September. 2004.

Chan V.N.Y., Member of International Advisory Committee, Xth Congress of the International Society of Hematology, Asian Pacific Division, Nagoya, Japan. 2004.

Chan V.N.Y., Member, Asian Network Thalassemia Control. 2005.

Chan V.N.Y., Member, Faculty Health and Safety Committee, Faculty of Medicine, HKU. 2005.

Chan V.N.Y., Member, Promotion & Tenure Panel, Faculty of Science, HKU. 2005.

Chan V.N.Y., Yam I.Y.L., Yeung W.S.B., Ng E.H.Y., Ho P.C. and Chan T.K., Preimplantation diagnosis of homozygous alpha° thalassemia, Xth Congress of the International Society of Hematology, Asian Pacific Division, Nagoya, Japan, September. 2004.

Chan V.N.Y., Reviewer, Archives of Medical Research, 2002 - to date. 2005.

Chan V.N.Y., Reviewer, International Journal of Hematology, 2003 - to date. 2005.

Gu J., Chan V.N.Y. and Kung A.W.C., Determinants of bone mineral density in early postmenopausal Asian women: The significance of family history of fracture, 6th Regional Osteoporosis Conference, 21-22 May 2005, Hong Kong. 2005.

Jin L., Lau H.L., Smith D.K., Lau K.S., Cheung P.T., Kwan E.Y.W., Low L.C.K., Chan V.N.Y. and Kung A.W.C., A family with osteoporosis-pseudoglioma syndrome (OPG) due to compound heterozygous mutation of the LRP5 gene, HKU 10th Medical Research Conference. 2005.

Jin L., Lau H.L., Smith D.K., Lau K.S., Cheung P.T., Kwan E.Y.W., Low L.C.K., Chan V.N.Y. and Kung A.W.C., Family with osteoporosis Pseudolioma Syndrome due to compound heterozygosity of two novel mutations of the LRP5 gene, 6th Regional Osteoporosis Conference, 21-22 May 2005, Hong Kong. 2005.

Kung A.W.C., Lai M.H., Lau H.L. and Chan V.N.Y., Polymorphisms in the promoter region of the estrogen receptor beta gene are associated with higher risks of osteoporosis in both men and women, Osteoporosis Global Conference, 2nd Joint Meeting of European Calcified Tissue and International Bone & Mineral Society, 25-29 June 2005, Geneva, Switzerland. 2005.

Kung A.W.C., Lau H.L., Paterson A.D., Cheung W.M.W., Luk K.D.K. and Chan V.N.Y., Test of linkage and/or association of genes and bone mineral density in Chinese, 26th Annual Meeting of the American Society for Bone & Mineral Research, October 1-5, 2004, Seattle, USA. Journal of Bone and Mineral Research. 2004, 19(Supl 1): SU159.

Lai M.H., Lau H.L., Chan V.N.Y. and Kung A.W.C., Estrogen receptor beta gene polymorphisms in the promoter region are associated with higher risks of osteoporosis in both men and women, The Endocrine Society’s 87th Annual Meeting, June 4-7, 2005, San Diego, USA. 2005.

Lai M.H., Lau H.L., Chan V.N.Y. and Kung A.W.C., Polymorphisms in the promoter region of the estrogen receptor beta gene are associated with higher risks of osteoporosis in both men and women, HKU 10th Medical Research Conference. 2005.

Lai M.H., Lau H.L., Chan V.N.Y. and Kung A.W.C., Promoter polymorphisms of the estrogen receptor beta gene are associated with higher risks of osteoporosis in both men and women, 6th Regional Osteoporosis Conference, 21-22 May 2005, Hong Kong. 2005.

Leung K.Y., Lee C.P., Tang M.H.Y., Lau E.T., Ng L.K.L., Lee Y.P., Chan H.Y., Ma E.S.K. and Chan V.N.Y., Cost-effectiveness of prenatal screening for thalassaemia in Hong Kong, Prenatal Diagnosis. 2004, 24: 899-907.

Leung K.Y., Lee C.P., Tang M.H.Y., Chan H.Y. and Chan V.N.Y., Prenatal Diagnosis of Alpha-thalassemia in a Twin Pregnancy, Ultrasound in Obstetrics & Gynecology. 2005, 25: 201-202.

Xu J., Dan Q., Chan V.N.Y., Wat N.M.S., Tam S., Tiu S.C., Lee K.F., Siu S.C., Tsang M.W., Fung L.M., Chan K.W. and Lam K.S.L., Genetic and Clinical Characteristics of Maturity-onset Diabetes of the Young in Chinese Patients, European Journal of Human Genetics. 2005, 13: 422-427.

Researcher : Chan WK

List of Research Outputs

Jin O., Chan W.K., Mok T.M.Y., Sun L.Y. and Lau W.C.S., Osteopontin (OPN), matrix metalloproteinase (MMP)-3 and lupus nephritis (LN), 11th APLAR Bi-annual Congress, Jeju, Korea 11-16 September 2004.

Lau W.C.S., Yeung J.S.L., Chan W.K. and Ren Y., Diminished macrophage (Mac) clearance of apoptotic polymorphonuclear cells (PMN) in patients with rheumatoid arthritis (RA), 11th APLAR Bi-annual Congress, Jeju, Korea 11-16 Septemer 2004.

Researcher : Chan YL

List of Research Outputs

Ho W.L., Chan Y.L., Kwok H.H., Mak W., Chu A.C.Y., Kung M.H.W., Ramsden D.B. and Ho S.L., mpp+ Modulates Mitochondrial Uncoupling Protein Ucp2, Ucp4 And Ucp5 Expression In Catecholaminergic (sk-n-sh) Cells , J Neurosci Res. 2005, 81(2): 261-8.

Ho W.L., Chan Y.L., Leung K.C., Kung M.H.W., Ramsden D.B. and Ho S.L., Potential Role Of Uncoupling Proteins, Ucp2, -4, And -5, In The Neuroprotective Effects Of Estrogen On Mpp+-induced Neurotoxicity. , 8th International Congress of Parkinson's disease & Movement Disorders, Rome, Italy. 2004.

Researcher : Chan YY

List of Research Outputs

Leung J.C.K., Chan Y.Y., Li F.K., Tang S.C.W., Chan K.W., Chan D.T.M., Lam M.F., Wieslander A. and Lai K.N., Glucose degradation products downregulate ZO-1 expression in human peritoneal mesothelial cells: the role of VEGF, Nephrology Dialysis Transplantation. 2005, 20(7): 1336-1349.

Researcher : Chau FY

List of Research Outputs

Cheung B.M.Y., Lam T.H., Lam K.S.L., Tam S., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., Follow Up of the Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., High Blood Pressure is Related to Obesity in Hong Kong, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Lipid Profile of the Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Obesity in the Hong Kong Cardiovascular Risk Factor Prevalence Survey-2 (CRISPS2) Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of Diabetes Mellitus (DM) in the Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Wat N.M.S., Lo L.F., Chau F.Y., Lam T.H., Leung G.M., Tam S., Cheng C.H., Kumana C.R., Lau C.P. and Lam K.S.L., Prevalence of Hypertension in Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort, J Hong Kong Coll Cardiol. 2004, 12: 33.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Relationship Between Hypertension and Obesity in Hong Kong, 3rd Asian-Pacific Congress on Hypertension, Singapore 2004.

Man Y.B., Cheung B.M.Y., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of Hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004.

Researcher : Chau J

List of Research Outputs

Yu C.M., Lau C.P., Chau J., McGhee S.M., Kong S.L., Cheung B.M.Y. and Li L.S.W., A short course of cardiac rehabilitation program is highly cost effective in improving long-term quality of life in patients with recent myocardial infarction or percutaneous coronary intervention, Archives of Physical Medicine and Rehabilitation. 2004, 85(12): 1915-22.

Researcher : Chen B

List of Research Outputs

Chen B., Xu A., Lam C.W., Hoo R.L.C. and Lam K.S.L., Adenovirus-mediated expression of adiponectin alleviates liver fibrosis and induces apoptosis of activated hepatic stellate cells, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005. Endocrinology 23.

Hoo R.L.C., Xu A., Lam C.W., Chen B., Carling D. and Lam K.S.L., Adenovirus-mediated expression of constitutively active AMP-activated protein kinase alleviates diabetes in db/db diabetic mice, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005. Endocrinology 25.

Xu A., Hoo R.L.C., Hoo R.L.C., Lam C.W., Chen B. and Lam K.S.L., Adenovirus-Mediated Expression of Adiponectin Alleviates Endothelial Dysfunction and Oxidative Stress Associated with db/db Diabetic Mice, The Endocrine Society’s 87th Annual Meeting, June 4-7, 2005, San Diego, USA. 2005.

Xu A., Lam M.C., Chan K.W., Wang Y., Zhang J.C.L., Xu J., Chen B., Chow W.S., Tso A.W. and Lam K.S.L., Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice, Proc Natl Academic Science USA. 2005, 102(17): 6086-91.

Xu A., Lam C.W., Chan K.W., Zhang J., Hoo R.L.C., Xu J., Chen B. and Lam K.S.L., Angiopoietin-like protein 4 is a novel metabolic hormone with therapeutic potentials for hyperglycemia and insulin resistance, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005. Endocrinology 22.

Xu A., Chan K.W., Hoo R.L.C., Wang Y., Zhang J., Chen B., Cynthia T., Cooper G.J.S. and Lam K.S.L., Testosterone Selectively Reduces the High Molecular Weight Form of Adiponectin by Inhibiting Its Secretion from Adipocytes, The Journal of Biological Chemistry. 2005, 280: 18073-18080.

Researcher : Chen S

List of Research Outputs

Chen S. and Cheung R.T.F., Neuropeptide Y-Y1 receptor agonist worsens while antagonist improves survival of cultured Y1-expressing neuronal cells following oxygen and glucose deprivation, Journal of Biomedical Science. 2004, 11: 781-788.

Cheung R.T.F. and Chen S., Neuropeptide Y and its receptor analogs differentially modulate the immunoreactivity for neuronal or endothelial nitric oxide synthase in the rat brain following focal ischemia with reperfusion, Journal of Biomedical Science. 2005, 12: 267-278.

Researcher : Chen TM

List of Research Outputs

Kong K.P., Prokunina-Olsson L., Wong W.H.S., Lau W.C.S., Chen T.M., Alarcon-Riquelme M. and Lau Y.L., A New Haplotype of PDCD1 is Associated with Rheumatoid Arthritis in Hong Kong Chinese, Arthritis & Rheumatism. 2005, 52(4): 1058-1062.

Researcher : Chen WH

Project Title:	Enoxaparin combined with epitfibatide or abciximab versus unfractionated heparin combined with epitfibatide or abciximab in percutaneous coronary intervention: obersvations on efficacy, safety, anticoagulation profile, and level of platelet inhibition
Investigator(s):	Chen WH, Lau CP
Department:	Medicine
Source(s) of Funding:	Other Funding Scheme
Start Date:	06/2001

Abstract:

To compare the safety, efficacy, anticoagulation profile and level of platelet inhibition in patients undergoing percutaneous coronary intervention using enoxaparin/eptifibatide, unfractionated heparin/epitfibatide, enoxaparin/abciximab, and unfractionated heparin/abciximab.

Project Title:	A prospective study to investigate the determinants of the quantity of embolized debris during native vessel percutaneous coronary intervention
Investigator(s):	Chen WH, Lau CP
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002

Abstract:

To identity the clinical and lesion characteristics that determine the quantity of embolized debris captured by a distal protection device during native vessel PCI.

Project Title:	A prospective study to evaluate the relation between aspirin resistance and the incidence and magnitude of myonecrosis after percutaneous coronary intervention
Investigator(s):	Chen WH, Lau CP
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Abstract:

To compare the incidence and magnitude of myoecrosis between aspirin-sensitive and -resistant patients undergoing PCI.

List of Research Outputs

Chen W.H., Lee P.Y., Ng W., Kwok J.Y.Y., Cheng X., Tse H.F. and Lau C.P., Prevalence profile, and predictors of aspirin resistance measured by the Ultegra Rapid Platelet Function Assay-ASA in patients with coronary artery disease, J Am Coll Cardiol. 2005, 45: 382A.

Quan V.H., Huynh R., Seifert P.A., Kuchela A., Chen W.H., Sutsch G., Eisenhauer A.C. and Rogers C., Morphometric analysis of particulate debris extracted by four different embolic protection devices from coronary arteries, aortocoronary saphenous vein conduits, and carotid arteries., Am J Cardiol. 2005, 95(12): 1415-9.

Researcher : Chen X

List of Research Outputs

Li V.S.W., Wong C.W., Chan T.L., Chan A.S.W., Zhao W., Chu K.M., Chen X., Yuen S.T., Leung S.Y. and So S., Mutations of PIK3CA in gastric adenocarcinoma, BioMed Central Cancer. 2005, 5: 29.

Researcher : Cheng CH

List of Research Outputs

Cheung B.M.Y., Lam T.H., Lam K.S.L., Tam S., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., Follow Up of the Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., High Blood Pressure is Related to Obesity in Hong Kong, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Lipid Profile of the Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Obesity in the Hong Kong Cardiovascular Risk Factor Prevalence Survey-2 (CRISPS2) Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of Diabetes Mellitus (DM) in the Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Wat N.M.S., Lo L.F., Chau F.Y., Lam T.H., Leung G.M., Tam S., Cheng C.H., Kumana C.R., Lau C.P. and Lam K.S.L., Prevalence of Hypertension in Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort, J Hong Kong Coll Cardiol. 2004, 12: 33.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Relationship Between Hypertension and Obesity in Hong Kong, 3rd Asian-Pacific Congress on Hypertension, Singapore 2004.

Cheung B.M.Y., Lam T.H., Lam K.S.L., Tam S., Wat N.M.S., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., The Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort - Results at 7 Years, J Hypertens. 2004, 22 (Suppl 2): S268-269.

Man Y.B., Cheung B.M.Y., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of Hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004.

Researcher : Cheng CK

Project Title:	Epigenetic and genetic regulation of the cell cycle checkpoint protein Rad9 in breast cancer
Investigator(s):	Cheng CK, Chan VNY, Chow LWC
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004
Completion Date:	04/2006

Abstract:

To explore the potential usefulness of Rad9 as a molecular marker for breast cancer.

List of Research Outputs

Researcher : Cheng KY

List of Research Outputs

Lam K.S.L., Dan Q., Xu A., Shen J., Cheng K.Y. and Xu J., Adiponectin stimulates the production o fmaganese superoxide dismutase (SOD2) in human aortic smooth muscle cells, 12th International Congress of Endocrinology, Aug 31 – Sep 4, 2004, Lisbon, Portugal. 2004, A442(1242).

Tso A.W.K., Wat N.M.S., Xu A., Sham P.C., Rong R., Cheng K.Y., Fong H.Y., Janus E.D. and Lam K.S.L., The adiponectin gene G276T polymorphism is a risk factor for the development of the metabolic syndrome over a period of 5 years in southern Chinese, 12th International Congress of Endocrinology, Aug 31 – Sep 4, 2004, Lisbon, Portugal. 2004, 318 P949.

Wat N.M.S., Tso A.W.K., Xu A., Sham P.C., Rong R., Cheng K.Y., Fong H.Y., Janus E.D. and Lam K.S.L., The adiponectin gene T45G polymorphism is associated with central obesity and persistent glucose intolerance in high-risk Chinese subjects over 5 years, 12th International Congress of Endocrinology, Aug 31 – Sep 4, 2004, Lisbon, Portugal. 2004.

Xu J., Wat N.M.S., Xu A., Cheng K.Y., Sham P.C., Janus E.D. and Lam K.S.L., The G/G Genotype of the -420 C→G Polymorphism in the Resistin Gene Promoter Is Associated with Post-Challenge Glycaemia in Southern Chinese, The Endocrine Society’s 87th Annual Meeting, June 4-7, 2005, San Diego, USA. 2005.

Xu J., Wat N.M.S., Xu A., Cheng K.Y., Sham P.C., Janus E.D. and Lam K.S.L., The G/G genotype of the ->G polymorphism in the resistin gene promoter is associated with post-challenge glycaemia in Southern Chinese, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005. Endocrinology 26.

Researcher : Cheng SW

List of Research Outputs

Lui S.L., Cheng S.W., Ng E., Yip P.S., Tse K.C., Lam M.F., Lai K.N. and Lo W.K., A randomized prospective comparison of intraperitoneal cefazolin plus netilimicin versus cefazolin plus ceftazidime in the treatment of CAPD peritonitis, Nephrology Dialysis Transplantation. 2005, 10 (suppl): A68.

Researcher : Cheng X

List of Research Outputs

Chen W.H., Lee P.Y., Ng W., Kwok J.Y.Y., Cheng X., Tse H.F. and Lau C.P., Prevalence profile, and predictors of aspirin resistance measured by the Ultegra Rapid Platelet Function Assay-ASA in patients with coronary artery disease, J Am Coll Cardiol. 2005, 45: 382A.

Researcher : Cheung BMY

Project Title:	Hong Kong cardiovascular risk factor prevalence study-2 (CRISPS-2)
Investigator(s):	Cheung BMY, Lam KSL, Lau CP, Cheng CH, Tam S, Wat NMS, Lam TH
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	10/2001

Abstract:

To determine the cumulative incidence of hypertension and diabetes, which are risk factors for cardiovascular diseases, in the cohort of subjects recruited in the Hong Kong Cardiovascular Risk Factor Prevalence Study in 1995-6; to determine the incidence of cardiovascular and non-cardiovascular diseases since the Hong Kong Cardiovascular Risk Factor Prevalence Study in 1995-6; to analyse the baseline factors to see if they are predictors of hypertension and diabetes, and if so, to quantify the risk and to study their interactions; to measure changes in baseline risk factors, which may have important consequences on public health.

Project Title:	Hypertension genes in Hong Kong Chinese
Investigator(s):	Cheung BMY, Lau CP
Department:	Medicine
Source(s) of Funding:	Low Budget High Impact Programme
Start Date:	11/2001

Abstract:

To study several new candidate genes that have been identified in whole genome search. By targeting specific candidate genes in our large bank of accurately defined hypertensive patients and normal controls, we can achieve high power in either confirming or refuting their association with hypertension in a Chinese population.

Project Title:	Advantages of blood pressure optimisation
Investigator(s):	Cheung BMY, Lau CP, Tse HF
Department:	Medicine
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2003

Abstract:

To compare optimal blood pressure control with conventional blood pressure targets in hypertensive patients in terms of target organ damage and tolerability.

Project Title:	Does urotensin II, the most potent vasoconstrictor known, cause high blood pressure?
Investigator(s):	Cheung BMY
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003
Completion Date:	10/2004

Abstract:

To confirm that plasma urotensin II is raised in hypertension in man and to identify the factors leading to its elevation in vivo; to study the promoter region of the urotensin II gene, identify single nucleotide polymorphisms in Hong Kong Chinese and correlate these with plasma urotensin II level and blood pressure; to study in vitro, in a cell culture model, how the gene expression of urotensin II is altered by factors known to be important in hypetension.

Project Title:	A gene locus for hypertension and obesity on chromosome 17
Investigator(s):	Cheung BMY
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

To identify single nucleotide Polymorphisms in the 17p12 region of chromosome 17 associated with hypertension and obesity; to assess their functional significance in relation to blood pressure, obesity and relevant metabolic and hormonal variables.

List of Research Outputs

Ambekar C.S., Lee J.S.K., Cheung B.M.Y., Chan L.C., Liang R.H.S. and Kumana C.R., Metabolism of Chloramphenicol Succinate, a Competitive Substrate and Inhibitor of Succinate Dehydrogenase: Possible Reason for its Toxicity, Toxicology in Vitro. 2004, 18: 441-7.

Cheung B.M.Y., Wong L.Y.F., Li Y.Y. and Tang F., Adenomedullin expression and cytokine response in experimentally induced endotoxaemia, 4th Symposium of Adrenomedullin and Proadrenomedullin N-20 peptide, Zurich. P16. 2004.

Cheung B.M.Y., Li Y.Y. and Wong L.Y.F., Adrenomedullin: Its Roles in the Cardiovascular System, Seminars Vasc Med. 2004, 4(2): 129-134.

Cheung B.M.Y., Man Y.B., Tse H.F., Kumana C.R. and Lau C.P., Advantages of Blood Pressure Optimisation Study, J Hong Kong Coll Cardiol . 2004, 12: 33.

Cheung B.M.Y., Leung Y.H., Man Y.B., Wong L.Y.F. and Lau C.P., Association of Blood Pressure and Obesity with a Single Nucleotide Polymorphism at 17p12, American Journal of Hypertension. 2005, 18(5) Suppl: A79.

Cheung B.M.Y., Leung Y.H., Man Y.B. and Lau C.P., Association of Essential Hypertension with the WNK4 Gene, the Molecular Switch Controlling Renal Sodium and Potassium Excretion, Cardiovasc Drugs Thera. 2004, 18 (Suppl) 1: 8.

Cheung B.M.Y., Man Y.B., Leung Y.H. and Wong L.Y.F., Association of Single Nucleotide Polymorphisms in the Urotensin II Gene with Plasma Insulin and Hypertension, American Journal of Hypertension. 2005, 18: 79A.

Cheung B.M.Y., Beta-Blockers a Second Rate Treatment for Hypertension?, J HK Coll Cardiol. 2005, 13: 1-3.

Cheung B.M.Y., Leung Y.H., Man Y.B. and Wong L.Y.F., Elevated Plasma Concentration of Urotensin II in Hypertension, 3rd Asian-Pacific Congress on Hypertension, Singapore 2004.

Cheung B.M.Y., Leung Y.H., Man Y.B. and Wong L.Y.F., Elevated Plasma Concentration of Urotensin II in Hypertension, J Hypertens. 2004, 22 (Suppl 2): S188.

Cheung B.M.Y., Lam T.H., Lam K.S.L., Tam S., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., Follow Up of the Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., High Blood Pressure is Related to Obesity in Hong Kong, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Au T.H.Y., Chan S.Y., Lam C.M., Lau S.H., Lee R.P., Lee S.F., Lo W.S., Sin E.H.F., Tang M.Y. and Tsang H.H., Hypertension is Associated with Anxiety But Not Depression in Hong Kong Chinese, 3rd Asian-Pacific Congress on Hypertension, Singapore 2004.

Cheung B.M.Y., Au T.H.Y., Chan S.Y., Lam C.M., Lau S.H., Lee R.P., Lee S.F., Lo W.S., Sin E.H.F., Tang M.Y. and Tsang H.H., Hypertension is associated with increased anxiety but not depression in Hong Kong, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004.

Cheung B.M.Y., Hwang I.S.S., Li C., Tsang K.W.T., Leung Y.H., Kumana C.R. and Tang F., Increased Adrenomedullin Expression in Lungs in Endotoxaemia, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Lipid Profile of the Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Cheung G.T.Y., Lauder I.J., Lau C.P. and Kumana C.R., Meta-analysis of Large Outcome Trials of Angiotensin Receptor Blockers in Hypertension, American Journal of Hypertension. 2005, 18(5) Suppl: A53.

Cheung B.M.Y., Lauder I.J. and Kumana C.R., Meta-analysis of Large Randomised Controlled Trials that Evaluate Cardiovascular Outcomes After Stain Treatment, 8th Scientific Meeting of the Hong Kong Pharmacology Society in Association with the Shanghai Pharmacology Society, Hong Kong 2004.

Cheung B.M.Y., Lauder I.J. and Kumana C.R., Meta-analysis of Large Randomised Controlled Trials to Evaluate the Impact of Statins on Cardiovascular Outcomes, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Obesity in the Hong Kong Cardiovascular Risk Factor Prevalence Survey-2 (CRISPS2) Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Leung Y.H., Man Y.B. and Wong L.Y.F., Plasma Concentration of Urotensin II is Raised in Hypertension, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004.

Cheung B.M.Y., Leung Y.H., Man Y.B. and Wong L.Y.F., Plasma Concentration of Urotensin II is Raised in Hypertension, J Hypertens. 2004, 22: 1341-4.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of Diabetes Mellitus (DM) in the Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Wat N.M.S., Lo L.F., Chau F.Y., Lam T.H., Leung G.M., Tam S., Cheng C.H., Kumana C.R., Lau C.P. and Lam K.S.L., Prevalence of Hypertension in Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort, J Hong Kong Coll Cardiol. 2004, 12: 33.

Cheung B.M.Y., Law C.Y., Ho G.Y.Y., McGhee S.M., Man Y.B., Ng P.P.Y., Kumana C.R. and Lau C.P., Randomised Controlled Trial of Low Salt Diet Versus Drug Treatment in the Management of Mild hypertension, 8th Scientific Meeting of the Hong Kong Pharmacology Socieity in Association with the Shanghai Pharmacology Society, Hong Kong 2004.

Cheung B.M.Y., Lo L.F., Fong D.Y.T., Chan M.Y., Wong W.H.S., Lau C.P., Lam K.S.L., Wong V.C.N. and Karlberg J.P.E., Randomised Controlled Trial of Qigong in Hypertension, Cardiovasc Drugs Thera. 2004, 28 (suppl) 1: 28.

Cheung B.M.Y., Lo L.F., Fong D.Y.T., Chan M.Y., Wong W.H.S., Lau C.P., Lam K.S.L., Wong V.C.W. and Karlberg J.P.E., Randomised controlled trial of qigong in hypertension, J Hong Kong Coll Cardiol. 2004, 12: 34.

Cheung B.M.Y., Lo L.F., Fong D.Y.T., Chan M.Y., Wong S.H.T., Wong V.C.W., Lam K.S.L., Lau C.P. and Karlberg J.P.E., Randomised controlled trial of qigong in the treatment of mild essential hypertension, J Hum Hypertens. 2005, 19(9): 697-704.

Cheung B.M.Y., Law C.Y., Ho G.Y.Y., McGhee S.M., Man Y.B., Ng P.P.Y., Kumana C.R. and Lau C.P., Randomsed Controlled Trial of Low Salt Diet Versus Drug Treatment in Hypertension, Cardiovasc Drugs Thera. 2004, 18 (Suppl) 1: 15.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Relationship Between Hypertension and Obesity in Hong Kong, 3rd Asian-Pacific Congress on Hypertension, Singapore 2004.

Cheung B.M.Y., Sartans for Hypertension - Implications of the Valsartan Antihypertensive Long-Term Use Evaluation, Hong Kong Medical Journal. 2004, 10(5): 359.

Cheung B.M.Y., Lam T.H., Lam K.S.L., Tam S., Wat N.M.S., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., The Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort - Results at 7 Years, J Hypertens. 2004, 22 (Suppl 2): S268-269.

Cheung B.M.Y., Au T.H.Y., Chan S.Y., Lam C.M., Lau S.H., Lee R.P., Lee S.F., Lo W.S., Sin E.H.F., Tang M.Y. and Tsang H.H., The Relationship Between Hypertension, Anxiety and Depression In Hong Kong Chinese, Exp Clin Cardiol. 2005, 10(1): 21-24.

Cheung B.M.Y., Law C.Y., McGhee S.M., Ng P.P.Y., Kumana C.R. and Lau C.P., The Relationship Between Sodium and Blood Pressure in Hong Kong Chinese, Clin Res Regul Aff. 2004, 21(2): 145-154.

Hui C.K., Cheung B.M.Y. and Lau G., Pharmacokinetics of pitavastatin in subjects with Child-Pugh A and B cirrhosis, Br J Clin Pharmacol. 2005, 59: 291-7.

Hung I.F.N. and Cheung B.M.Y., A Review on Lopinavir/Ritonavir, Medical Progress. 2005, 32: 345-8.

Kumana C.R., Cheung G.T.Y., Lauder I.J. and Cheung B.M.Y., Long-term combination therapy with aspirin and clopidogrel, J Cardiovasc Pharmacol Ther. 2004, 9(4): 223-5.

Kumana C.R., Cheung B.M.Y., Cheung G.T.Y., Ovedal T., Pederson B. and Lauder I.J., Rhythm vs.rate control of atrial fibrillation meta-analysed by number needed to treat, Br J Clin Pharmacol. Blackwell Publishing Ltd, 2005, 60(4): 347-54.

Man Y.B., Wong L.Y.F. and Cheung B.M.Y., Association of Urotensin II rs7367534 C>T Polymorphism with Hypertension, J HK Coll Cardiol . 2004, 12: 110.

Man Y.B., Cheung B.M.Y., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of Hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004.

Ong K.L., Wong L.Y.F., Man Y.B., Lam K.S.L. and Cheung B.M.Y., Hypertension is associated with a single nucleotide polymorphism in the uroteinsin II gene, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005.

Ong K.L., Cheung B.M.Y. and Lam K.S.L., Urotensin II and the Circulatory System, Hong Kong J Nephrol . 2005, 7: 9-14.

Ong K.L., Lam K.S.L. and Cheung B.M.Y., Urotensin II: Its Function in Health and Its Role in Disease, Cardiovascular Drugs Therapy. 2005, 19(1): 65-75.

Rong R., Xu A., Cheung B.M.Y., Cheung G. and Lam K.S.L., Identification of Three Novel Missense Mutations of the Human Melanocortin-4 Receptor Gene in a Chinese Obesity Population, Endocrine Society's 86th Annual Meeting, New Orleans 2004.

Wong L.Y.F., Cheung B.M.Y., Li Y.Y. and Tang F., Adrenomedullin expression and its effects on cytokine response of rat macrophages to lipopolysaccharide, 4th Symposium of Adrenomedullin and Proadrenomedullin N-20 peptide, Zurich. S20. 2004.

Wong L.Y.F., Cheung B.M.Y. and Tang F., Adrenomedullin is Both Proinflammatory and Antiinflammatory: Its Effects on Gene Expression and Secretion of Cytokines and Macrophage Migration Inhibitory Factor in NR8383 Macrophage Cell Line, Endocrinology. 2005, 146: 1321-1327.

Wong L.Y.F., Cheung B.M.Y. and Tang F., Expressions of Urotensin II and Urotensin II Receptor are Up-regulated in Cardiovascular Tissues in Experimentally Induced Endotoxaemia, American Journal of hypertension. 2005, 18: 125A.

Wong L.Y.F., Man Y.B., Leung Y.H. and Cheung B.M.Y., Interleukin-6 Gene -573G>C Promoter Polymorphism is Associated with Plasma Fibrinogen Level and Hypertension in Hong Kong Chinese, American Journal of Hypertension. 2005, 18: 186A.

Wong L.Y.F., Cheung B.M.Y., Li C. and Tang F., Temporal Changes in Cytokine Levels in Plasma and Various Peripheral Tissues of Rat After Treatment with Lipopolysaccharide, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004.

Wong Y.L. and Cheung B.M.Y., Utilisation of Antihypertensive Drugs in a Hypertension Outpatient Clinic in 1998 and 2004, Cardiovasc Drugs Thera. 2004, 18 (Suppl) 1: 23.

Yu C.M., Lau C.P., Chau J., McGhee S.M., Kong S.L., Cheung B.M.Y. and Li L.S.W., A short course of cardiac rehabilitation program is highly cost effective in improving long-term quality of life in patients with recent myocardial infarction or percutaneous coronary intervention, Archives of Physical Medicine and Rehabilitation. 2004, 85(12): 1915-22.

Researcher : Cheung GTY

List of Research Outputs

Au W.Y., Cheung G.T.Y., Yuen W.H., Kumana C.R. and Kwong Y.L., Successful treatment of relapsed acute promyelocytic leukemia in a patient receiving continuous ambulatory peritoneal dialysis with oral arsenic trioxide, Archite Internal Medicine. 2005, 165: 1067-1068.

Chan L.S., Cheung G.T.Y., Lauder I.J. and Kumana C.R., Screening For Fever By Remote Sensing Infrared Thermographic Camera, Journal of Travel Medicine. 2004, 11: 273-297.

Cheung B.M.Y., Cheung G.T.Y., Lauder I.J., Lau C.P. and Kumana C.R., Meta-analysis of Large Outcome Trials of Angiotensin Receptor Blockers in Hypertension, American Journal of Hypertension. 2005, 18(5) Suppl: A53.

Kumana C.R., Cheung G.T.Y., Lauder I.J. and Cheung B.M.Y., Long-term combination therapy with aspirin and clopidogrel, J Cardiovasc Pharmacol Ther. 2004, 9(4): 223-5.

Kumana C.R., Cheung B.M.Y., Cheung G.T.Y., Ovedal T., Pederson B. and Lauder I.J., Rhythm vs.rate control of atrial fibrillation meta-analysed by number needed to treat, Br J Clin Pharmacol. Blackwell Publishing Ltd, 2005, 60(4): 347-54.

Kumana C.R., Cheung G.T.Y., Lauder I.J. and Chan L.S., Screening for Fever by Means of Infrared Thermographic Camera, 11th Ineternational Congress of infectious diseases – Mexico 2004 (Published in: International Journal of Infectious Diseases). 2004, 8(Supl 1): S110.

Kumana C.R., Cheung G.T.Y. and Lau W.C.S., Severe digital ischaemia treated with phosphodiesterase inhibitors, Annals of Rheumatic Diseases. 2004, 63: 1522-1524.

Researcher : Cheung KL

List of Research Outputs

Chan O.O., Chu K.M., Sun Y., Cheung K.L., Lam S.K., Yuen R.M.F., Hui W.M. and Wong B.C.Y., The association between Interleukin 1 beta polymorphism and hypermethylation at tumor suppressor genes in gastric cancer. Conference paper at the Annual Meeting of the American Gastroenterology Associatoin, Digestive Diseases Week (DDW) Chicago, Illinois, USA. May 14-19, Gastroenterology. 2005, 128(4 Suppl 2): A399.

Gu Q., Xia H.H.X., Wang W., Wang J., Wong R.W.M., Chan O.O., Yuen M.F., Lam S.K., Cheung K.L., Liu X.G. and Wong B.C.Y., Effect of Cyclo-Oxygenase Inhibitors on Helicobacter pylori Susceptibility to Metronidazole and Clarithromycin, Alimentary Pharmacology and Therapeutics. 2004, 20: 675-681.

Wong R.W.M., Huang J., Xia H.H.X., Fung F.M.Y., Tong S.M., Cheung K.L., Ho Y.K., Lai K.C., Chan C.K., Chan O.O., Hui C.K., Lam S.K. and Wong B.C.Y., Low-dose rabeprazole, amoxicillin and metronidazole triple therapy for the treatment of Helicobacter pylori infection in Chinese patients , Journal of Gastroenterology and Hepatology. 2005, 20(6): 935-940.

Researcher : Cheung RTF

Project Title:	Neuroprotective potential of neuropeptide Y-Y1 receptor inhibition
Investigator(s):	Cheung RTF
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002
Completion Date:	10/2004

Abstract:

To explore the neuroprotective potential of NPY-Y1 receptor inhibition in both in vivo and in vitro stroke models.

Project Title:	Cognitive impairment and dementia among stroke patients in Hong Kong
Investigator(s):	Cheung RTF
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Abstract:

To study: (1) the prevalence and risk factors of vascular cognitive impairment and dementia in Chinese stroke patients and (2) the incidence and risk factors of vascular cognitive impairment and dementia upon follow up of Chinese stroke patients without dementia during initial assessment.

Project Title:	Use of functional magnetic resonance imaging to predict benefits of acupuncture for stroke patients with persistent motor or language deficits
Investigator(s):	Cheung RTF, Li LSW, Yang ES, Leung KP, Li G, Au Yeung K.M.
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	10/2004

Abstract:

To use functional magnetic resonance imaging (MRI) to identify stroke patients with or without activations of brain sites relevant to their persistent arm paralysis or language impairment during stimulation of the deficit-implicated acupoints and then apply randomized, double-blinded, acupoint-controlled clinical trials to confirm the benefits of acupuncture in post-stroke rehabilitation of the deficit. The results will confirm the value of functional MRI in identifying responders to acupuncture in post-stroke motor or language rehabilitation and reveal the benefit of acupuncture treatment over certain disease-implicated acupoints.

Project Title:	Role of ischemia in Alzheimer's disease - an experimental study in transgenic mice
Investigator(s):	Cheung RTF
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

To study (1) the influence of genotype on the cerebral blood flow and infarct volume of transgenic mice overexpressing amyloid precursor protein (APP) alone or with human mutant presenilin-1 (PS-1) gene following photothrombotic stroke, and to study (2) the effects of photothrombotic stroke on the sensorimotor functions and visuospatial memory in the APP transgenic mice and APP/PS-1 double transgenic mice.

Project Title:	Use of functional magnetic resonance imaging to predict benefits of acupuncture for stroke patients with persistent motor or language deficits
Investigator(s):	Cheung RTF
Department:	Medicine
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

Refer to hard copy

List of Research Outputs

Chan K.H., Cheung R.T.F., Au Yeung K.M., Mak W., Cheng T.S. and Ho S.L., A lady with suicidal history presented with speech and walking difficulties, Journal of Clinical Neuroscience. 2005, 12: 303-305.

Chan K.H., Cheung R.T.F., Mak W., Lee R., Fong C.Y., Cheng T.S. and Ho S.L., Cerebral infarction complicating tuberculous meningitis (TBM), 17th Annual Scientific Meeting, The Hong Kong Neurological Society. 2004, 10: 8.

Chan K.H., Cheung R.T.F., Lee R., Mak W., Cheng T.S. and Ho S.L., Cerebral infarcts complicating tuberculous meningitis, Cerebrovascular Diseases. 2005, 19: 391-395.

Chan K.H., Cheung R.T.F., Lui W.M., Mak W. and Ho S.L., Cerebral venous thrombosis in a gentleman with fever, convulsion and frontotemporal haemorrhages, Journal of Clinical Neuroscience. 2005, 12: 186-188.

Chan K.H., Tsang K.L., Fong C.Y., Cheung R.T.F. and Ho S.L., Idiopathic severe recurrent transverse myelitis: a restricted variant of neuromyelitis optica, Clinical Neurology and Neurosurgery. 2005, 107: 132-135.

Chan K.H., Mak W., Cheng T.S., Cheung R.T.F. and Ho S.L., Natural course of patients with acute myelitis, 17th Annual Scientific Meeting, The Hong Kong Neurological Society. 2004, 10: 6.

Chan K.H., Cheung R.T.F., AuYeung K.M., Mak W. and Ho S.L., Wilson's Disease With Depression And Parkinsonism., J Clin Neurosci. 2005, 12(3): 303-5.

Chen S. and Cheung R.T.F., Neuropeptide Y-Y1 receptor agonist worsens while antagonist improves survival of cultured Y1-expressing neuronal cells following oxygen and glucose deprivation, Journal of Biomedical Science. 2004, 11: 781-788.

Cheung R.T.F., Acute Stroke Management, Healthy Aging: Joint Scientific Meeting of the Centre of Endocrinology & Diabetes, Institute of Cardiovascular Basic Physician Training, Hong Kong Region (West). 2004.

Cheung R.T.F., Advances in Stroke Management, Novel Treatment of Neurological Disease, Joint Scientific Meeting, Hong Kong College of Physicians and Hong Kong College of Paediatrcians. 2004.

Cheung R.T.F., Advances in stroke management, Joint Scientific Meeting on “Novel Treatment of Common Medical Disorders”, Hong Kong College of Physicians & Hong Kong College of Paediatricians. 2004, 13.

Cheung R.T.F., Cerebral Disease in Diabetes, Symposium on Neurology & Diabetes, ABC Series of Symposia on Diabetes: “N”, Diabetes Division of the Hong Kong Society of Endocrinology, Metabolism and Reproduction. 2004.

Cheung R.T.F., Cerebral Perfusion Parameters in Acute, Subacute, or Chronic Middle Cerebral Artery Territory Ischemia, Symposium A1 on Stroke Diagnosis, Sino-British Joint Conference on Neurology 2004. 2004.

Cheung R.T.F., Cerebral perfusion parameters in acute, subacute, or chronic middle cerebral artery territory ischemia, Sino-British Joint Conference on Neurology. 2004, 34-35.

Cheung R.T.F., Cerebrovascular Disease, Men’s Health, The Federation’s Annual Scientific Meeting 2004, The Federation of Medical Societies of Hong Kong. 2004.

Cheung R.T.F., Cerebrovascular disease, Men’s Health, The Federation’s Annual Scientific Meeting. 2004, 12.

Cheung R.T.F., Chairman of Organizing Committee, 17th Annual Scientific Meeting, The Hong Kong Neurological Society. 2004.

Cheung R.T.F., Chairman of Organizing Committee, The Hong Kong Stroke Symposium & Workshop 2004. 2004, 5.

Cheung R.T.F., Chairman of Scientific Session, Third Quarterly Scientific Meeting, Hong Kong Stroke Society. 2004.

Cheung R.T.F., Chairman of Session, Frontiers in Biomedical Research. 2004.

Cheung R.T.F., Chairman of Session, New Diagnostic and Therapeutic Techniques for Aging Diseases, Joint Clinical Symposium of Heart, Brain, Hormone and Healthy Aging Center of HKU and Mayo Clinic. 2004.

Cheung R.T.F., Chairman, Neurology Journal Club on The Role of Acetylcholinesterase Inhibitor in the Treatment of Vascular Dementia. 2005.

Cheung R.T.F., Chairman, Round Table Discussion on Impact of Antihypertensive and Lipid Lowering Agents on Carotid Atherosclerosis and Intima Media Thickness. 2005.

Cheung R.T.F., Chairperson of a Session, The Second Asia Pacific Conference Against Stroke. 2005.

Cheung R.T.F., Current CT & MRI Techniques in Stroke, Symposium on Up-to-date Neuroimaging of Cerebrovascular Disease, The Second Asian Pacific Congress Against Stroke, Chiangmai, Thailand. 2005.

Cheung R.T.F., Editor of Program Book, Hong Kong Stroke Symposium & Workshop 2004. 2004, 5.

Cheung R.T.F., Editorial Board, MIMS Neurology & Psychiatry Guide. 2004.

Cheung R.T.F., Editorial Board, Reviews on Recent Clinical Trials. 2005.

Cheung R.T.F., Editorial Board, Stroke. 2005.

Cheung R.T.F., European Stroke Initiative Recommendations for Stroke Management – Update 2003, Official Chinese Translation for European Stroke Initiatives. 2005.

Cheung R.T.F., Faculty Member, Chairman of Session, The First Global Conference on Cardiovascular Clinical Trials and Pharmacotherapy, The Second World Heart Federation Global Conference on Cardiovascular Clinical Trials, and the 13th International Society of Cardiovascular Pharmacotherapy Congress. 2004.

Cheung R.T.F., Functional Imaging in Cerebrovascular Disease, Symposium III on Functional Imaging, Stents and Stroke Center, Hong Kong Stroke Symposium and Workshop 2004. 2004.

Cheung R.T.F., Functional MRI and acupuncture in recovery after stroke, Frontier in Biomedical Research, HKU 2004. 52.

Cheung R.T.F., Functional MRI and acupuncture in recovery after stroke, Healthy Aging: Joint Scientific Meeting of the Centre of Endocrinology & Diabetes, Institute of Cardiovascular Science & Medicine and Neuroscience Research Centre, Frontiers in Biomedical Research. 2004.

Cheung R.T.F. and Lo G.M.Y.G., Functional imaging in cerebrovascular disease, Hong Kong Stroke Symposium & Workshop 2004. 5: 27-28.

Cheung R.T.F., Local Experience of Thrombolysis for Ischaemic Stroke, Scientific Symposium, Hong Kong Society of Critical Care Medicine. 2004.

Cheung R.T.F., Melatonin Protects Against Focal Ischemic/Reperfusion Injury in the Rat, Symposium on Physiological Basis of Melatonin Function, Shanghai International Conference on Physiological Biophysics. 2004.

Cheung R.T.F., Melatonin protects against focal ischemic/reperfusion injury in the rat, Shanghai International Conference on Physiological Biophysics. 2004, 44.

Cheung R.T.F., Member of Organizing Committee and Publicity Subcommittee, Brain Awareness Week 2005. 2005.

Cheung R.T.F., Mystery of recurrent stroke – a young lady’s case. Part II, Ming Pao Weekly (Chinese Magazine). 2005.

Cheung R.T.F., Mystery of recurrent stroke – a young lady’s case. Part I, Ming Pao Weekly (Chinese Magazine). 2005.

Cheung R.T.F. and Chen S., Neuropeptide Y and its receptor analogs differentially modulate the immunoreactivity for neuronal or endothelial nitric oxide synthase in the rat brain following focal ischemia with reperfusion, Journal of Biomedical Science. 2005, 12: 267-278.

Cheung R.T.F., Organizer and Chairman, Roundtable Meeting on Medical Management of Intracranial Artery Stenosis. 2005.

Cheung R.T.F., Organizer and Chairman, Scientific Meeting on Secondary Risk Prevention in Stroke, The Hong Kong Neurological Society. 2005.

Cheung R.T.F., Perfusion CT in acute or chronic cerebral ischemia and brain activations on functional MRI during acupuncture, Second Asian Pacific Conference Against Stroke. 2005, 83.

Cheung R.T.F., Prophylaxis and Treatment - Information for doctors in hospitals and practice - Update 2003/2004 - PDF Flyer of European Stroke Initiative, Official Chinese Translation for European Stroke Initiatives. 2005.

Cheung R.T.F., Stroke Prevention, University Health Service, University of Hong Kong. 2004.

Cheung R.T.F., Stroke – the third leading cause of death, Metro Daily (Chinese Newspaper) . 2004, 26, 41.

Cheung R.T.F., Thrombolytic Therapy For Acute Ischaemic Stroke – We Are Not Ready!, Controversies in Stroke Management, Second Quarterly Scientific Meeting 2004, Hong Kong Stroke Society. 2004.

Cheung R.T.F. and Cheng P.W., Thrombolytic and interventional therapy for acute ischaemic stroke – are we ready in Hong Kong?, 17th Annual Scientific Meeting, The Hong Kong Neurological Society. 2004, 10: 21.

Cheung R.T.F., Thrombolytic and interventional therapy for acute ischaemic stroke – are we ready in Hong Kong?, Symposium on Stroke, 17th Annual Scientific Meeting, The Hong Kong Neurological Society. 2004.

Cheung R.T.F., Update in Stroke Management, Continuous Medical Education in Internal Medicine 2004/2005, Internal Medicine Service, Centro Hospitalar C.S. Januario, Government of Macau Special Administrative Region. 2004.

Cheung R.T.F., Update on management of dementia, Medical Progress. 2004, 31: 453-460.

Khong P.L., Zhou L.J., Ooi C.G.C., Chung B.H.Y., Cheung R.T.F. and Wong V.C.N., The Evaluation of Wallerian Degeneration in Chronic Paediatric Middle Cerebral Artery Infarction Using Diffusion Tensor MR Imaging, Cerebrovascular Diseases. Karger, 2004, 18: 240-247.

Li G., Cheung R.T.F., Au Yeung K.M. and Yang E.S., An fMRI Study of sensorimotor deficit-related acupoints in stroke patients with persistent motor deficits, Society for Neuroscience 2004. 263.7.

Mak W., Tsang K.L., Tsoi T.H., AuYeung K.M.A., Chan K.H., Cheng T.S., Cheung R.T.F. and Ho S.L., Bath-related Headache, Cephalalgia. 2005, 25(3): 191-8.

Mak W., Chan K.H., Cheung R.T.F. and Ho S.L., Hypertensive encephalopathy: BP lowering complicated by posterior circulation ischemic stroke, Neurology. 2004, 63: 1131-1132.

Mak W., Cheung R.T.F. and Ho S.L., Racial/ethnic differences in cerebrovascular disease – HK perspective, Hong Kong Stroke Symposium & Workshop 2004. 5: 42-46.

Mak W., Cheung R.T.F. and Ho S.L., Riches-Cannieu anastomosis: an electrophysiology study in Hong Kong Chinese and its implications in carpal tunnel syndrome, 17th Annual Scientific Meeting, The Hong Kong Neurological Society. 2004, 10: 11.

Mak W., Cheung R.T.F. and Ho S.L., Why is intracranial large-artery steno-occlusive disease more common in Asians? A human evolutionary hypothesis and its implications, 17th Annual Scientific Meeting, The Hong Kong Neurological Society. 2004, 10: 29.

Mak W., Tsang K.L., Tsoi T.H., Au Yeung K.M., Chan K.H., Cheng T.S., Cheung R.T.F. and Ho S.L., “Thundery Shower”: a novel headache syndrome, 17th Annual Scientific Meeting, The Hong Kong Neurological Society. 2004, 10: 30.

Ng P.W., Huang C.Y., Cheung R.T.F., Wong K.S., Wong C.K. and Lam J.M., Transient ischaemic attack patients are often under-evaluated, Hong Kong Medical Journal. 2004, 10: 293-294.

Pei Z. and Cheung R.T.F., Pretreatment with melatonin exerts anti-inflammatory effects against ischemia/reperfusion injury in a rat middle cerebral artery occlusion stroke model, Journal of Pineal Research. 2004, 37: 85-91.

Tsoi T.H. and Cheung R.T.F., Workshop VI: NIHSS training and certification, Hong Kong Stroke Symposium & Workshop 2004. 5: 64-67.

Zou L., Tang F. and Cheung R.T.F., Cerebral ischemia induces neuronal damage in APP/PS1 double transgenic mice via activation of JNK/P38 pathway, Society for Neuroscience 2004. 443.6.

Researcher : Cheung WC

List of Research Outputs

Au W.Y., Cheung W.C. and Tung H.M., Gilbert's syndrome complicating long term parental nutrition, Journal of hepatology.. 2004, 41(1): 168-169.

Researcher : Cheung WMW

Project Title:	Setting up in vitro model systems for studying the functional roles of nuclear receptor PPARgamma during osteoblastogenesis
Investigator(s):	Cheung WMW, Kung AWC
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	09/2004

Abstract:

To identify the correlation between expression level of PPARγ and the stages of osteoblastogenesis; to set up in vitro cell models for studying the functional role(s) of PPARγ during osteoblastogenesis; to identify the effect of PPARγ blockage on the induction of osteoblastogenesis in mesenchymal stem cells.

List of Research Outputs

Kung A.W.C., Lau H.L., Paterson A.D., Cheung W.M.W., Luk K.D.K. and Chan V.N.Y., Test of linkage and/or association of genes and bone mineral density in Chinese, 26th Annual Meeting of the American Society for Bone & Mineral Research, October 1-5, 2004, Seattle, USA. Journal of Bone and Mineral Research. 2004, 19(Supl 1): SU159.

Researcher : Chik SCC

List of Research Outputs

Huang F., Ma L., Wu A.Y.Y., Tian L., Chan K.W., Trendell-Smith N.J., Lam A.C., Chan A.K.L., Lo C.K., Chik S.C.C., Ko K.H., To K.W., Kam S.K., Fong L.P., Li X.S., Leung S.Y., Ng M.H., Stott D.I., Liew F.Y. and MacPherson G.G., Systemic autoimmune disease induced by dendritic cells that have captured necrotic but not apoptotic dying cells, Proceedings of the 12th International Congress of Immunology and the 4th Annual Conference of FOCIS, Montreal, Canada, July 18-23, 2004. 2004.

Researcher : Chim JCS

List of Research Outputs

Au W.Y., Ma S.Y., Chim J.C.S., Choy C., Loong F., Lie A.K.W., Lam C.C.K., Leung A.Y.H., Tse E.W.C., Yau C.C., Liang R.H.S. and Kwong Y.L., Clinicopathologic features and treatment outcome of mature T-cell and natural killer-cell lymphomas diagnosed according to the World Health Organization classification scheme: a single center experience of 10 years, Annals of Oncology. 2005, 16(2): 206-214.

Au W.Y., Chim J.C.S., Lie A.K.W., Leung A.Y.H., Tse E.W.C., Ma S.Y., Liang R.H.S., Pang A.W.K., Kumana C.R. and Kwong Y.L., Treatment of relapsed acute promyelocytic leukemia by arsenic-based strategies without hematopoietic stem cell transplantation in Hong Kong: a seven-year experience, American Society of Haematology Annual Scientific Meeting. 2004.

Chim J.C.S., Wong K.Y., Loong F. and Srivastava G., Absence of ATM hypermethylation in mantle cell and follicular lymphoma, Leukemia. 2005, 19(5): 880-2.

Chim J.C.S., Wong S.S.Y., Lam C.C.K. and Chan K.W., Concurrent hyperreactive malarial splenomegaly and quartan malarial nephropathy – Plasmodium malariae revisited, Haematologica. 2004, 89(7): ECR21.

Chim J.C.S., Ma E.S.K., Loong F. and Kwong Y.L., Diagnostic cues for natural killer cell lymphoma: primary nodal presentation and the role of in situ hybridisation for Epstein-Barr virus encoded early small RNA in detecting occult bone marrow involvement, Journal of clinical pathology. 2005, 58(4): 443-5.

Chim J.C.S. and Ma E.S.K., Eosinophilic leukemic transformation in polycythemia rubra vera (PRV), Leukaemia & Lymphoma. 2005, 46(3): 447-50.

Chim J.C.S., Loong F., Ma E.S.K., Cheung W.W.W., Chim J.C.S. and Ooi C.G.C., Extramedullary cardiac plasmacytoma presenting with cardiac tamponade, Journal of Clinical Oncology. 2005, 23(13): 3140-3.

Chim J.C.S. and Kwong Y.L., How frequent is SOCS1 methylation in acute myeloid leukaemia?, British Journal of Haematology. 2004, 127(5): 609-11.

Chim J.C.S., Ho J.W.C., Ooi C.G.C., Choy C. and Liang R.H.S., Primary anaplastic large cell lymphoma of the pancreas, Leukaemia & Lymphoma. 2005, 46(3): 457-9.

Chim J.C.S., Loong F., Leung A.Y.H., Tsang J. and Ooi C.G.C., Primary follicular lymphoma of the small intestine, Leukaemia & Lymphoma. 2004, 45(7): 1463-6.

Chim J.C.S., Ooi C.G.C., Loong F., Au W.Y., Au W.Y. and Lie A.K.W., Side effects and good effects from new chemotherapeutic agents. Bortezomib in primary refractory plasmacytoma, Journal of Clinical Oncology. 2005, 23(10): 2426-8.

Hui C.K., Bowden S., Jackson K., Au W.Y., Fong D.Y.T., Lie A.K.W., Chim J.C.S., Liang R.H.S. and Lau G., Clinical significance of intrahepatic hepatitis B virus covalently closed circular DNA in chronic hepatitis B patients who received cytotoxic chemotheraphy, Blood. 2005, 105(6): 2616-2617.

Hui C.K., Lie A.K.W., Au W.Y., Ma S.Y., Leung A.Y.H., Zhang H., Sun J.Z., Cheung W.W.W., Chim J.C.S., Kwong Y.L., Liang R.H.S. and Lau G., Effectiveness of prophylactic Anti-HBV therapy in allogeneic hematopoietic stem cell transplantation with HBsAg positive donors, American Journal of Transplantation. 2005, 5(6): 1437-45.

Wong R.W.S., Loong F., Ooi C.G.C., Tse T.C. and Chim J.C.S., Primary granulocytic sarcoma of the mediastinum, Leukaemia & Lymphoma. 2004, 45(9):1931-3.

Researcher : Ching CK

List of Research Outputs

Wong B.C.Y., Chan O.O., Wong K.W., Ching C.K., Wong R.W.M., Tam S., Lai K.C., Chan C.K., Yuen R.M.F. and Lam S.K., A pilot study of participation in faecal occult blood testing and screening colonoscopy after health education in Hong Kong, European Journal of Cancer Preview. 2005, 14(2): 181-184.

Researcher : Chow KM

List of Research Outputs

Ho S.P., Chan M.M.W., Chow K.M., Ip M.S.M. and Mak J.C.W., Antioxidant enzyme activities in healthy Chinese adults: influence of age, gender, and smoking, Respirology. 2005, 10: 305-309.

Wang J., Law K.W., Ip M.S.M., Wu A.Y.Y., Wong M.K., Lam B., Chow K.M. and Chan M.M.W., Effect of asthma self management programme on asthma morbidity and health care utilization in adult patients admitted to hospital with acute asthma in Hong Kong: A randomized controlled trial, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A91.

Researcher : Chow WS

List of Research Outputs

Tan K.C.B., Chow W.S., Lam J.C.M., Lam B., Wong W.K., Tam S. and Ip M.S.M., HDL dysfunction in obstructive sleep apnea, Atherosclerosis. 2005-02-01, 2005, Epub ahead of print.

Tan K.C.B., Xu A., Chow W.S., Ai W.H.G., Tam S. and Lam K.S.L., Hypoadiponectinemia is associated with impaired endothelium-dependent vasodilatation, Journal of Clinical and Endocrinological Metabolism. 2004, 89(2): 765-9.

Xu A., Chan K.W., Wang Y., Zhang J., Hoo R.L.C., Xu J., Chow W.S. and Lam K.S.L., Angiopoietin-like Protein 4 Decreases Blood Glucose and Improves Glucose Tolerance but Induces Hyperlipidemia and Hepatic Steatosis in Mice, Proceedings of the National Academy of Sciences of the United States of America. 2005, 102: 6086-6091.

Xu A., Lam M.C., Chan K.W., Wang Y., Zhang J.C.L., Xu J., Chen B., Chow W.S., Tso A.W. and Lam K.S.L., Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice, Proc Natl Academic Science USA. 2005, 102(17): 6086-91.

Researcher : Choy CBY

List of Research Outputs

Lo W.K., Lui S.L., Chan D.T.M., Li F.K., Lam M.F., Tse K.C., Tang C.S.O., Choy C.B.Y. and Lai K.N., Minimal and optimal peritoneal Kt/V targets: results of an anuric peritoneal dialysis patient's survival analysis. , Kidney International. 2005, 67(5): 2032-2038.

Lui S.L., Tang S., Li F.K., Choy C.B.Y., Chan D.T.M., Lo W.K. and Lai K.N., Tuberculous infection in southern Chinese renal transplant recipients, Clinical transplantation. 2004, 18(6): 666-671.

Researcher : Chu ACY

List of Research Outputs

Ho W.L., Chan Y.L., Kwok H.H., Mak W., Chu A.C.Y., Kung M.H.W., Ramsden D.B. and Ho S.L., mpp+ Modulates Mitochondrial Uncoupling Protein Ucp2, Ucp4 And Ucp5 Expression In Catecholaminergic (sk-n-sh) Cells , J Neurosci Res. 2005, 81(2): 261-8.

Researcher : Chu CYA

List of Research Outputs

Ho W.L., Kwok H.H., Chu C.Y.A., Ho W.M., Kung M.H.W., Ramdsen D.B. and Ho S.L., Silencing of UCP5 enhances MPP+-induced neurotoxicity in SH-SY5Y cells., 9th International Congress of Parkinson’s disease & Movement Disorders, New Orleans, USA. 2005.

Researcher : Chu LW

Project Title:	A dementia outreach programme in Central, Western and Southern districts of Hong Kong
Investigator(s):	Chu LW, Lam KSL, Lee PWH
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	09/2003

Abstract:

To achieve early detection of dementia, through an outreach dementia-screening programme.

List of Research Outputs

Researcher : Chu MY

List of Research Outputs

Chu M.Y., Wong R.W.S., Ho R., Yeung D., Lau S.K., Kwong E. and Lau W.C.S., Utilisation of the Chinese arthritis impact measurement scales-2 (CAIMS-2): capturing clinical status changes in patients with rheumatoid arthritis (RA), 11th APLAR Bi-annual Congress, Jeju, Korea 11-16 September 2004.

Chu M.Y., Chiu P.K.Y., Cheng I., Tang W.M. and Lau W.C.S., Utilisation of the Chinese arthritis impact measurement scales-2 short form (CAIMS-2 SF) in detecting clinical status changes in osteoarthritis (OA) patients who participated in a clinical trial of green-lipped mussel extracts, 11th APLAR Bi-annual Congres, Jeju, Korea 11-16 September 2004.

Lau W.C.S., Chiu P.K.Y., Chu M.Y., Cheng I.Y.W., Tang W.M., Man R.Y.K. and Halpern G.M., Treatment of knee osteoarthritis with Lyprinol, lipid extract of the green-lipped mussel - a double-blind placebo-controlled study, Progress in Nutrition. 2004, 6(1): 17-31.

Researcher : Chuh AAT

List of Research Outputs

Chuh A.A.T. and Chan H.H.L., Effect On Quality Of Life In Patients With Pityriasis Rosea: Is It Associated With Rash Severity?, International Journal Of Dermatology. 2005, 44(5): 372-7.

Chuh A.A.T., Chan H.H.L. and Zawar V., Is Human Herpesvirus 7 The Causative Agent Of Pityriasis Rosea?--a Critical Review, International Journal Of Dermatology. 2004, 43(12): 870-5.

Researcher : Chung SSM

Project Title:	Osmoregulation in lens
Investigator(s):	Chung SSM
Department:	Institute of Molecular Biology
Source(s) of Funding:	Outstanding RGC Projects
Start Date:	09/1998

Abstract:

It is imperative to have a better understanding of the mechanisms leading to various cataracts such that preventive measures can be developed. Since maintaining the ionic strength and ionic composition in the lens is essential for the transparency of the lens, we plan to study the mechanism of osmoregulation in this organ. Transgenic mice that over-express aldose reductase and sodium dependent myoinositol transporter in their lenses will be used to increase the lens' level of sorbitol and myoinositol, respectively. We will determine if high level of these osmolytes causes cataract development, and see when the level of one osmolyte is high, will the lens compensate by reducing the level of other osmolytes. We will also determine whether high intracellular osmotic pressure affects the regulation of expression of genes that control the level of osmolytes such as aldose reductase, sodium dependent myoinositol transporter, and taurine transporter.

Project Title:	Effects of early postnatal feeding on fatty acid metabolism
Investigator(s):	Chung SSM, Sheng HP
Department:	Institute of Molecular Biology
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	11/2002

Abstract:

Both epidemiological studies and animal studies have shown that prenatal and early postnatal nutrition not only affects infant growth and development, it also predetermines future metabolism, performance adn morbidity. This study addresses the problems of nutritional environment during the sucking period on lipid metabolism and later-life obesity.

Project Title:	Mechanism of Nogo-A inhibition of axonal regeneration
Investigator(s):	Chung SSM, Chung SK, Ju G.
Department:	Institute of Molecular Biology
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2003

Abstract:

To develop Nogo gene knockout mice to determine the role of this gene in the inhibition of axonal regeneration and its physiological functions; to develop transgenic mice that overexpress Nogo-A in their Schwann cells to determine if that would make their PNS non-permissive for axonal regeneraton; to develop transgenic mice that overexpress mutant Nogo-A with the Nogo-66 or aa623-640 region deleted to determine which domain is responsible for the inhibitory effect of Nogo-A.

Project Title:	Polyol pathway in diabetic dyslipidemia
Investigator(s):	Chung SSM
Department:	Institute of Molecular Biology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2003

Abstract:

To determine if AR null mutation reduces plasma TG levels in diabetic mice; to determine if ARI reduces plasma TG in diabetic mice; to determine if AR null mutation or ARI nor ARI normalizes LDL and HDL leviabetic mice.

Project Title:	Aldose reductase in diabetic cataract
Investigator(s):	Chung SSM
Department:	Institute of Molecular Biology
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2003

Abstract:

In the slow-developing diabetic cataract, chronic AR-induced oxidative stress impairs the lens' osmoregulatory machinery such that lens can no longer accommodate modest increase in sorbitol, leading to cataract development; We planned to test this model by determing if AR-induced osmotic stress and oxidative stress are both important for the pathogenesis of the slow developing cataract; to determine if osmotic stress and oxidative stress act synergistically to cause cataract development ; to investigate how the impairment in the epithelial cells affects the protein aggregation in the underlying fiber cells to cause lens opacity; to characterize the changes in the epithelial cells during cataract development.

Project Title:	Aldose reductase in diabetic cataract
Investigator(s):	Chung SSM
Department:	Institute of Molecular Biology
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	10/2004

Abstract:

To determine if the antioxidant can prevent AR-induced slow-developing cataract; to determine the osmolyte content and oxidative status of the slow-developing cataract; to compare the morphological changes in the acute diabetic cataract and the slow developing cataract; to determine if there is apoptosis in the epithelial cells of the precataractous lenses.

Project Title:	Aldose reductase in diabetic cataract
Investigator(s):	Chung SSM
Department:	Institute of Molecular Biology
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

Refer to hard copy

List of Research Outputs

Researcher : Cui J

List of Research Outputs

Jiang X., Tu S., Cui J., Lin M.C., Xia H.H.X., Wong R.W.M., Chan O.O., Yuen M.F., Jiang S.H., Lam S.K., Kung H., Soh J.W., Weinstein I.B. and Wong B.C.Y., Antisense Targeting Protein Kinase C Alpha and Beta1 Inhibits Gastric Carcinogenesis, Cancer Research. 2004, 64: 5787-5794.

Tu S., Cui J., Liston P., Jiang X., Xu R., Lin M.C., Zhu Y.B., Zou B., Ng S.M., Jiang S.H., Xia H.H.X., Wong R.W.M., Chan O.O., Yuen R.M.F., Lam S.K., Kung H. and Wong B.C.Y., Gene Therapy for Colon Cancer by Adeno-Associated Viral Vector-Mediated Transfer of Survivin Cys84Ala Mutant, Gastroenterology. 2005, 128: 361-375.

Researcher : Dan Q

List of Research Outputs

Dan Q., Wong L.C., Chung S.K., Chung S.S.M. and Lam K.S.L., Interaction between the polyol pathway and non-enzymatic glycation on aortic smooth muscle cell migration and monocyte adhesion, Life Science. 2004, 76(4): 445-59.

Lam K.S.L., Dan Q., Xu A., Shen J., Cheng K.Y. and Xu J., Adiponectin stimulates the production o fmaganese superoxide dismutase (SOD2) in human aortic smooth muscle cells, 12th International Congress of Endocrinology, Aug 31 – Sep 4, 2004, Lisbon, Portugal. 2004, A442(1242).

Lam K.S.L., Xu A., Tan K.C.B., Wang Y., Dan Q., Chung S.K. and Chung S.S.M., Inflammation and diabetic atherosclerosis: New players in the field, Int Atherosclerosis Society 2005 Commentaries (Epub). 2005.

Xu J., Dan Q., Chan V.N.Y., Wat N.M.S., Tam S., Tiu S.C., Lee K.F., Siu S.C., Tsang M.W., Fung L.M., Chan K.W. and Lam K.S.L., Genetic and Clinical Characteristics of Maturity-onset Diabetes of the Young in Chinese Patients, European Journal of Human Genetics. 2005, 13: 422-427.

Researcher : Deng X

List of Research Outputs

Deng X., Sun H., Lau C.P. and Li G.R., Protein Tyrosine Kinase Modulates Voltage-gated Delayed Rectifier Potassium Channels In Rat Mesenchymal Stem Cells From Bone Marrow, Journal of Hong Kong College Cardiology. 2004, 12: 101(P12).

Li G.R., Sun H., Deng X. and Lau C.P., Characterization of ionic currents in human mesenchymal stem cells from bone marrow, Stem Cells. 2005, 23: 371-382.

Li G.R., Deng X., Sun H. and Lau C.P., Ion Channels And Cell Proliferation In Mesenchymal Stem Cells From Rat Bone Marrow, Biophysical Journal . 2005, 88(2/2): 547a.

Researcher : Ding H

List of Research Outputs

Ding H., Wand B.E., Jia J.D., Xia H.H.X., Wong B.C.Y., Zhao C.H. and Xu Y.L., Effects of octreotide on expression of L-type voltage-operated calcium channels and on intracellular Ca2+ in activated hepatic stellate cells, Chinese Medical Journal. 2004, 117(6): 913-916.

Researcher : Dong M

List of Research Outputs

Dong M., Lau C.P., Gao Z. and Li G.R., Effects Of Protein Tyrosine Kinase Inhibitors On Cloned Human Cardiac IKs Expressed In Hek 293 Cell Line., Journal of Hong Kong College Cardiology. 2004, 12(3/4): 93.

Tian M., Dong M., Chiu S.W., Lau C.P. and Li G.R., Effects Of Clotrimazole On Human Cardiac Repolarization Potassium Currents, Journal of Hong Kong College Cardiology. 2004, 12(3/4): 101(P11).

Wang Y., Dong M., Lau C.P. and Li G.R., Modulation of human Ehter-a-go-go-related potassium (hERG) channels by protein tyrosine kinases, Journal of Hong Kong College Cardiology. 2004, 12(3/4): 102(P15).

Researcher : Epstein R

Project Title:	Evolutionarily conserved patterns of synonymous codon bias in wild-type orthologous and paralogous gene sequences, and comparison with patterns of bias in human tumour genomes
Investigator(s):	Epstein R
Department:	Medicine
Source(s) of Funding:	Seed Funding for New Staff
Start Date:	09/2003

Abstract:

To clarify whether these evident associations of synonymous codon bias with function and/or with methylation are interdependent or independent.

Project Title:	The contribution of receptor downregulation to the efficacy of anticancer drugs targeting the catalytic activity of ErbB-family oncoproteins
Investigator(s):	Epstein R
Department:	Medicine
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2004

Abstract:

Refer to hard copy

List of Research Outputs

Cheung Y.B., Wong L.C., Tay M.H., Toh C.K., Koo W.H., Epstein R. and Goh C., Order effects in the assessment of quality of life in cancer patients, Quality of Life Research. 2004, 13(7): 1217-23.

Epstein R., Journal impact factors do not equitably reflect academic staff performance in different medical subspecialties, Journal of investigative medicine. 2004, 52(8): 531-6.

Epstein R., The CXCL12-CXCR4 chemotactic pathway as a target of adjuvant breast cancer therapies, Nature Reviews Cancer. 2004, 4 (11): 901-909.

Tsang J.W., Leung A.W., Yau T.C., Liang R.H.S., Yeung D.W., Leung T.W.T., Teo P.M., Cheung P.S. and Epstein R., Multidisciplinary management of early-stage breast cancer in the Asia-Pacific region, Medical Progress. 2004, 31: 485-96.

Researcher : Feng Z

List of Research Outputs

Li G., Xia H.H.X., Chen M.H., Chan O.O., Cho C.H., Lam S.K., Berg D., Feng Z., Langenbach R. and Wong B.C.Y., Effects of Cyclooxygenase-1 and -2 Gene Disruption on Helicobacter pylori-Induced Inflammation, Apoptosis and Proliferation, Journal of Gastroenterology and Hepatology. 2004, 19(Suppl.): A299.

Xia H.H.X., Li G., Chen M.H., Chan O.O., Cho C.H., Lam S.K., Berg D., Feng Z., Langenbach R. and Wong B.C.Y., Cyclooxygenase-1 and -2 Gene Disruption Potentiate TH1 Polarization in Response to Helicobacter pylori, Journal of Gastroenterology and Hepatology. 2004, 19(Suppl.): A366.

Researcher : Fong CY

List of Research Outputs

Chan K.H., Cheung R.T.F., Mak W., Lee R., Fong C.Y., Cheng T.S. and Ho S.L., Cerebral infarction complicating tuberculous meningitis (TBM), 17th Annual Scientific Meeting, The Hong Kong Neurological Society. 2004, 10: 8.

Chan K.H., Tsang K.L., Fong C.Y., Cheung R.T.F. and Ho S.L., Idiopathic severe recurrent transverse myelitis: a restricted variant of neuromyelitis optica, Clinical Neurology and Neurosurgery. 2005, 107: 132-135.

Lui C.H.T., Fong C.Y., Kwan P., Hui A.C.F., Fong K.Y. and Wong V.C.N., A Population-Based Epidemiological Study of Epilepsy in Hong Kong, 5th Asian & Oceanian Epilepsy Congress, Bangkok, Thailand, 28-31 August 2004. 23.

Researcher : Fong HY

List of Research Outputs

Tso A.W.K., Wat N.M.S., Xu A., Sham P.C., Rong R., Cheng K.Y., Fong H.Y., Janus E.D. and Lam K.S.L., The adiponectin gene G276T polymorphism is a risk factor for the development of the metabolic syndrome over a period of 5 years in southern Chinese, 12th International Congress of Endocrinology, Aug 31 – Sep 4, 2004, Lisbon, Portugal. 2004, 318 P949.

Wat N.M.S., Tso A.W.K., Xu A., Sham P.C., Rong R., Cheng K.Y., Fong H.Y., Janus E.D. and Lam K.S.L., The adiponectin gene T45G polymorphism is associated with central obesity and persistent glucose intolerance in high-risk Chinese subjects over 5 years, 12th International Congress of Endocrinology, Aug 31 – Sep 4, 2004, Lisbon, Portugal. 2004.

Researcher : Fong KY

List of Research Outputs

Lui C.H.T., Fong C.Y., Kwan P., Hui A.C.F., Fong K.Y. and Wong V.C.N., A Population-Based Epidemiological Study of Epilepsy in Hong Kong, 5th Asian & Oceanian Epilepsy Congress, Bangkok, Thailand, 28-31 August 2004. 23.

Researcher : Fung FMY

List of Research Outputs

Wong R.W.M., Huang J., Xia H.H.X., Fung F.M.Y., Tong S.M., Cheung K.L., Ho Y.K., Lai K.C., Chan C.K., Chan O.O., Hui C.K., Lam S.K. and Wong B.C.Y., Low-dose rabeprazole, amoxicillin and metronidazole triple therapy for the treatment of Helicobacter pylori infection in Chinese patients , Journal of Gastroenterology and Hepatology. 2005, 20(6): 935-940.

Researcher : Fung PCW

Project Title:	Development of a novel natural antioxidant with strong anti-aging and protective properties for skin
Investigator(s):	Fung PCW, Shen J
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	07/2002

Abstract:

To develop a novel antioxidants from herbal products which can scavenge superoxide, hydroxyl and lipid peroxide free radicals in skin.

Project Title:	Roles of plasma membrane cholesterol homeostasis in regulating neuronal oxidative damage of ischemic stroke
Investigator(s):	Fung PCW, Shen J
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Abstract:

To understand the roles of plasma membrane cholesterol homeostasis in protecting neuronal cells from oxidative damage during ischemic stroke.

List of Research Outputs

Chang C., Ren J., Fung P.C.W., Hung Y.S., Shen J.G. and Chan F.H.Y., Novel sparse component analysis approach to free radical EPR spectra decomposition, Journal of Magnetic Resonance. 2005, 175: 242-255.

Chen J.H., Tipoe G.L., Liong E.C., So H.S.H., Leung K.M., Tom W.M., Fung P.C.W. and Nanji A.A., Green tea polyphenols prevent toxin-induced hepatotoxicity in mice by down-regulating inducible nitric oxide-derived prooxidants, American Journal of Clinical Nutrition. 2004, 80: 742-751.

Ho K.M.T., Li A.Z., Yiu M.K., Lee K.C., Lui V.C.H., Fung P.C.W., Yiu T.F. and Tam P.K.H., Altered expression of aquaporin-2 in human explants with chronic renal allograft dysfunction, BJU International. 2005, 95: 1104-1108.

Man K., Lee K.W., Liang T.B., Lo C.M., Fung P.C.W., Tsui H.T., Li X.L., Ng T.P. and Fan S.T., FK409 ameliorates small-for-size liver graft injury by attenuation of portal hypertension and down-regulation of Egr-1 pathway, Annals of Surgery. 2004, 240(1): 159-168.

Ren J., Shen J., Xhan F. .H., Shen G.G. and Fung P.C.W., Real time detectionn of nitric oxide in the blood of rats following renal ischemia by ESR spectroscopy, 13th Annual Meeting of ISMRM, Miami, Florida. San Francesco, USA, ISMRM, 2005, 1: 2555.

Sun X., Krissansen G.W., Fung P.C.W., Xu S., Shi J., Man K., Fan S.T. and Xu R., Anti-angiogenic therapy subsequent to adeno-associated-virus-mediated immunotherapy eradicates lymphomas that disseminate to the liver, International Journal of Cancer. 2004, 113(4): 670-677.

Tang M., Chang C., Fung P.C.W., Chau K.T. and Chan F.H.Y., An effective way of distinguishing premature ventricular contraction from sinus based on analysis of chaotic feature, IEE Advances in Medical Signal and Information Processing Conference. Malta, 2004, 85-91.

Researcher : Gao Z

List of Research Outputs

Dong M., Lau C.P., Gao Z. and Li G.R., Effects Of Protein Tyrosine Kinase Inhibitors On Cloned Human Cardiac IKs Expressed In Hek 293 Cell Line., Journal of Hong Kong College Cardiology. 2004, 12(3/4): 93.

Gao Z., Sun H., Chiu S.W., Lau C.P. and Li G.R., Effects Of Diltiazem And Nifedipine On Transient Outward And Ultra-rapid Delayed Rectifier Potassium Currents In Human Atrial Myocytes, Br J Pharmacol. 2005, 144: 495-604.

Researcher : Gisselsson DL

List of Research Outputs

Gisselsson D.L., Lu M., Tsao G.S.W., Man C.W.Y., Jin C., Jin C., HOglund M., Kwong Y.L. and Jin Y., Telomere-mediated mitotic disturbances in immortalized ovarian epithelial cells reproduce chromosomal losses and breakpoints from ovarian carcinoma, Genes, Chromosomes and Cancer. 2004, 42(1): 22-23.

Researcher : Gu J

List of Research Outputs

Gu J., Lee K.K., Kwan E.Y.W., Lam K.F., Ho A.Y.Y., Tam S. and Kung A.W.C., Determinants of bone mineral density in Asian men, 26th Annual Meeting of the American Society for Bone & Mineral Research, October 1-5, 2004, Seattle, USA. Journal of Bone and Mineral Research. 2004, 19(Supl 1): SU115.

Gu J., Lee K.K., Cheung E.Y.N., Lam K.F., Ho A.Y.Y., Tam S. and Kung A.W.C., Determinants of bone mineral density in Asian men, HKU 10th Medical Research Conference. 2005.

Gu J., Chan V.N.Y. and Kung A.W.C., Determinants of bone mineral density in early postmenopausal Asian women: The significance of family history of fracture, 6th Regional Osteoporosis Conference, 21-22 May 2005, Hong Kong. 2005.

Researcher : Gu Q

List of Research Outputs

Gu Q., Wang J., Xia H.H.X., Lin M.C., He H., Zou B., Tu S., Yang Y., Liu X.G., Lam S.K., Wong R.W.M., Chan O.O., Yuen R.M.F., Kung H. and Wong B.C.Y., Activation of the Caspase-8/Bid and Bax Pathways in Aspirin-Induced Apoptosis in Gastric Cancer, Carcinogenesis. 2005, 26(3): 541-546.

Gu Q., Xia H.H.X., Wang W., Wang J., Wong R.W.M., Chan O.O., Yuen M.F., Lam S.K., Cheung K.L., Liu X.G. and Wong B.C.Y., Effect of Cyclo-Oxygenase Inhibitors on Helicobacter pylori Susceptibility to Metronidazole and Clarithromycin, Alimentary Pharmacology and Therapeutics. 2004, 20: 675-681.

Wang J., Zou B., Gu Q., Jiang B., Zhuang Z., Xia H.H.X., Lin M.C., Lam S.K., Kung H. and Wong B.C.Y., Down-regulation of XAF1 expression by its interacting protein FHL2 via p53-mediated transcription regulation, Gastroenterology. 2005, 128(4 Suppl 2): A105.

Wang J., Gu Q., He H., Jiang B., Zhuang Z., Xia H.H.X., Lin M.C., Lam S.K., Kung H. and Wong B.C.Y., Down-regulation of XIAP associated factor 1 (XAF1) through Hsf-1 binding in the promoter region, Gastroenterology. 2005, 128(4 Suppl 2): A105.

Wong R.W.M., Xiao S.D., HU P.J., Wang W., Gu Q., Huang J., Xia H.H.X., WU S.M., LI C.J., CHEN M.H., CUI Y., Lai K.C., Hu H.C., Chan C.K., Lam S.K. and Wong B.C.Y., Standard treatment for Helicobacter pylori infection is suboptimal in non-ulcer dyspepsia compared to duodenal ulcer in Chinese, Alimentary Pharmacology and Therapeutics. 2005, 21: 73-81.

Researcher : Gu Q

List of Research Outputs

Researcher : Guo H

List of Research Outputs

Leung J.C.K., Chan L.Y., Tsang W.L., Guo H., Tang S.C.W., Chan D.T.M. and Lai K.N., Differential expression of aquaporins in the kidneys of streptozotocin-induced diabetic mice , Nephrology. 2005, 10: 63-72.

Researcher : He H

List of Research Outputs

Gu Q., Wang J., Xia H.H.X., Lin M.C., He H., Zou B., Tu S., Yang Y., Liu X.G., Lam S.K., Wong R.W.M., Chan O.O., Yuen R.M.F., Kung H. and Wong B.C.Y., Activation of the Caspase-8/Bid and Bax Pathways in Aspirin-Induced Apoptosis in Gastric Cancer, Carcinogenesis. 2005, 26(3): 541-546.

He H., Anti-Tumor Mechanisms of Cyclooxygenase Inhibitors and a c-Jun-N-Terminal Kinase Inhibitor in Gastrointestinal Cancers, 2004.

Wang J., Gu Q., He H., Jiang B., Zhuang Z., Xia H.H.X., Lin M.C., Lam S.K., Kung H. and Wong B.C.Y., Down-regulation of XIAP associated factor 1 (XAF1) through Hsf-1 binding in the promoter region, Gastroenterology. 2005, 128(4 Suppl 2): A105.

Zhuang Z., Tsao G.S.W., Xia H.H.X., He H., Chan O.O., Lam S.K. and Wong B.C.Y., COX-2 inhibition induces apoptosis in human esophageal epithelial cells: implication for chemoprevention, Gastroenterology. 2005, 128(4 Suppl 2): A299.

Researcher : He H

List of Research Outputs

He H., Anti-Tumor Mechanisms of Cyclooxygenase Inhibitors and a c-Jun-N-Terminal Kinase Inhibitor in Gastrointestinal Cancers, 2004.

Researcher : Ho JCM

List of Research Outputs

Chan M.M.W., Tan-Un K.C., Ip M.S.M., Tsang K.W.T., Ho S.P., Ho J.C.M., Chan H. and Lam W.K., Lung Cancer Susceptibility and Polymorphism of Glutathione-S-transferase Genes in Hong Kong, Lung Cancer. 2004, 45(2): 155-160.

Chan M.M.W., Lam W.K., Mak J.C.W., Ho S.P., Chan H.W., Tsang K.W.T., Ip M.S.M., Ho J.C.M., Wong M.P. and Tan-Un K., Polymorphisms of CYP and GST genes, passive smoke and lung cancer risk in Hong Kong Chinese, European Respiratory Journal. 2004, 24: Suppl 48: 457s.

Ho J.C.M., Community Acquired Pneumonia in the Post SARS Era , 9th Hong Kong Medical Forum. 2004.

Ho J.C.M., Lam W.K., Wong M.P., Wong M.K., Ooi C.G.C., Ip M.S.M., Chan M.M.W. and Tsang K.W.T., Lymphoepithelioma-like carcinoma of the lung : experience with ten cases, International Journal of Tuberculosis and Lung Disease. 2004, 8(7): 890-895.

Ho J.C.M., Mak J.C.W., Ho S.P., Ip M.S.M., Tsang K.W.T., Lam W.K. and Chan M.M.W., Manganese superoxide dismutase and catalase genetic polymorphisms activity levels and lung cancer risk in Chinese in Hong Kong, 10th Medical Research Conference, Department of Medicine, The University of Hong Kong, February 2005. Abstract Book: RM 66.

Ho J.C.M., Ho S.P., Chan M.M.W., Mak J.C.W., Ip M.S.M., Ko K.W., Yan C.P.K., Wong M.P., Tsang K.W.T. and Lam W.K., Non-small cell lung cancer in Chinese is associated with disturbance in systemic antioxidant profiles, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December, 2004. Respirology. 2004, 9 (Supp): A114.

Ho J.C.M., Wu A.Y.Y., Lam B., Ooi C.G.C., Khong P.L., Ho P.L., Chan M.M.W., Zhong N.S., Ko K.W., Lam W.K. and Tsang K.W.T., Pentaglobin in steroid-resistant severe acute respiratory syndrome, International Journal of Tuberculosis and Lung Disease. 2004, 8(10): 1173-1179.

Kwok P.W., Leung Y.H., Sun J.Z., Yan C.P.K., Ooi C.G.C., Ho P.L., Ho J.C.M., Tipoe G.L., Lam W.K. and Tsang K.W.T., The Effects of Gelomyrtol Forte on Human Ciliary Beat Frequency in vitro, Abstract Book of the 10th Medical Research Conference, University Department of Medicine, The University of Hong Kong, 19-20 February. 2005, page 65.

Kwok R., Leung Y.H., Sun J.Z., Yan C.P.K., Ooi C.G.C., Ho P.L., Ho J.C.M., Tipoe G.L., Lam W.K. and Tsang K.W.T., The effects of gelomyrtol forte on human ciliary beat frequency in vitro, Respirology. 2004, 9 (Suppl): A162 (290).

Lam W.K., Ho J.C.M., Lam B. and Tsang K.W.T., SARS and impacts on travel, Textbook of Travel Medicine . Bangkok Press, Bangkok, 2004, Chapter 38: 405-414.

Mak J.C.W., Ho J.C.M., Ho S.P., Yu W.C., Yew W.W., Tsang K.W.T., Lam W.K., Ip M.S.M. and Chan M.M.W., Increased oxidative stress and altered antioxidant status in Chinese patients with COPD, European Respiratory Journal. 2004, 24: Suppl 48: 62s.

Mak J.C.W., Ho J.C.M., Ho S.P., Leung C.M., Law K.W., Ip M.S.M. and Chan M.M.W., Polymorphisms of superoxide dismutase and catalase genes and their functional activity levels in Chinese patients with asthma, American Thoracic Society International Conference, San Diego, USA. May 2005. Proceedings of the American Thoracic Society . 2005, p.A78.

Pang C., Fan S., Yiu M.W.C., Tsang K.W.T., Ho J.C.M. and Ooi C.G.C., Clinical utility of multislice CT in the investigation of haemoptysis., 1st World Congress of Thoracic Imaging, Florence, Italy.. 2005.

Tsang K.W.T., Tipoe G.L., Mak J.C.W., Sun J.Z., Wong M.P., Leung R.C.M., Tan K.C.B., MedStat C.K.M., Ho J.C.M., Ho P.L., Rutman A. and Lam W.K., Ciliary central microtubular orientation is of no clinical significance in bronchiectasis, Respiratory Medicine. 2005, 99: 290-297.

Tsang K.W.T., Tipoe G.L., Sun J.Z., Tan K.C.B., Leung Y.H., Yan C.P.K., Ko K.W., Ooi C.G.C., Ho J.C.M. and Lam W.K., Clinical value of ciliary assessment in bronchiectasis, Lung. 2005, 183(2): 73-86.

Researcher : Ho SKN

List of Research Outputs

Chan D.T.M., Tse K.C., Tang C.S.O., Lai K.N. and Ho S.K.N., Prospective study on lamivudine-resistant hepatitis B in renal allograft recipients, American Journal of Transplantation. 2004, 4(7): 1103-1109.

Researcher : Ho SL

Project Title:	Search for a new gene in familial amyotrophic lateral sclerosis
Investigator(s):	Ho SL, Fong CY, Ramsden D.B.
Department:	Medicine
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2003

Abstract:

To carry out more detailed genetic screening of family members and appropriate controls to elucidate whether the theoretical gene and/or any other within this region of the chromosome is associated with the disease; to elucidate expression of this novel protein in healthy human subjects; to investigate whether genetic mutation/s in this gene may be the causal defects in sporadic ALS, which form the large majority of case and for which there is no known cause.

List of Research Outputs

Au W.Y., Mak W., Ho S.L., Leung S.Y. and Kwong Y.L., Reversible paraneoplastic neuropathy associated with T-cell large granular lymphocyte leukemia, Neurology. 2004, 63(3): 588-589.

Cartwright L., Ramsden D.B., Smith S.W., Parsons R.B., Waring R.H., Ho S.L. and Williams A.C., Xenobiotic metabolism and idiopathic Parkinson’s disease. In: Parkinson's Disease (M Ebadi, RF Pfeiffer, Eds), New York, CRC Press Ltd, 2005, 97- 108.

Chan K.H., Cheung R.T.F., Au Yeung K.M., Mak W., Cheng T.S. and Ho S.L., A lady with suicidal history presented with speech and walking difficulties, Journal of Clinical Neuroscience. 2005, 12: 303-305.

Chan K.H., Cheung R.T.F., Mak W., Lee R., Fong C.Y., Cheng T.S. and Ho S.L., Cerebral infarction complicating tuberculous meningitis (TBM), 17th Annual Scientific Meeting, The Hong Kong Neurological Society. 2004, 10: 8.

Chan K.H., Cheung R.T.F., Lee R., Mak W., Cheng T.S. and Ho S.L., Cerebral infarcts complicating tuberculous meningitis, Cerebrovascular Diseases. 2005, 19: 391-395.

Chan K.H., Cheung R.T.F., Lui W.M., Mak W. and Ho S.L., Cerebral venous thrombosis in a gentleman with fever, convulsion and frontotemporal haemorrhages, Journal of Clinical Neuroscience. 2005, 12: 186-188.

Chan K.H., Tsang K.L., Fong C.Y., Cheung R.T.F. and Ho S.L., Idiopathic severe recurrent transverse myelitis: a restricted variant of neuromyelitis optica, Clinical Neurology and Neurosurgery. 2005, 107: 132-135.

Chan K.H., Mak W., Cheng T.S., Cheung R.T.F. and Ho S.L., Natural course of patients with acute myelitis, 17th Annual Scientific Meeting, The Hong Kong Neurological Society. 2004, 10: 6.

Chan K.H., Cheung R.T.F., AuYeung K.M., Mak W. and Ho S.L., Wilson's Disease With Depression And Parkinsonism., J Clin Neurosci. 2005, 12(3): 303-5.

Ho W.L., Chan Y.L., Kwok H.H., Mak W., Chu A.C.Y., Kung M.H.W., Ramsden D.B. and Ho S.L., mpp+ Modulates Mitochondrial Uncoupling Protein Ucp2, Ucp4 And Ucp5 Expression In Catecholaminergic (sk-n-sh) Cells , J Neurosci Res. 2005, 81(2): 261-8.

Ho W.L., Chan Y.L., Leung K.C., Kung M.H.W., Ramsden D.B. and Ho S.L., Potential Role Of Uncoupling Proteins, Ucp2, -4, And -5, In The Neuroprotective Effects Of Estrogen On Mpp+-induced Neurotoxicity. , 8th International Congress of Parkinson's disease & Movement Disorders, Rome, Italy. 2004.

Ho W.L., Kwok H.H., Chu C.Y.A., Ho W.M., Kung M.H.W., Ramdsen D.B. and Ho S.L., Silencing of UCP5 enhances MPP+-induced neurotoxicity in SH-SY5Y cells., 9th International Congress of Parkinson’s disease & Movement Disorders, New Orleans, USA. 2005.

Hon C., Ho S.L., Ma E.S.K., Trendell-Smith N.J. and Au W.Y., High-grade lymphoma after azathioprine treatment for Vogt-Kaganayi-Harada syndrome, Leukemia & Lymphoma . 2005, 46: 289-292.

Lee T.M.C., Chan C.C.H., Ho S.L. and Li L.S.W., Prose memory in patients with idiopathic Parkinson’s disease. , Parkinsonism and Related Disorders . 2005, 11: 453-458.

Mak W., Chan K.H. and Ho S.L., A Case Of Ocular Myasthenia Gravis And Miller Fisher Syndrome, Hospital Medicine. 2005, 66(2): 116-7.

Mak W., Tsang K.L., Tsoi T.H., AuYeung K.M.A., Chan K.H., Cheng T.S., Cheung R.T.F. and Ho S.L., Bath-related Headache, Cephalalgia. 2005, 25(3): 191-8.

Mak W., Chan K.H., Cheung R.T.F. and Ho S.L., Hypertensive encephalopathy: BP lowering complicated by posterior circulation ischemic stroke, Neurology. 2004, 63: 1131-1132.

Mak W., Cheung R.T.F. and Ho S.L., Racial/ethnic differences in cerebrovascular disease – HK perspective, Hong Kong Stroke Symposium & Workshop 2004. 5: 42-46.

Mak W., Cheung R.T.F. and Ho S.L., Riches-Cannieu anastomosis: an electrophysiology study in Hong Kong Chinese and its implications in carpal tunnel syndrome, 17th Annual Scientific Meeting, The Hong Kong Neurological Society. 2004, 10: 11.

Mak W., Cheung R.T.F. and Ho S.L., Why is intracranial large-artery steno-occlusive disease more common in Asians? A human evolutionary hypothesis and its implications, 17th Annual Scientific Meeting, The Hong Kong Neurological Society. 2004, 10: 29.

Mak W., Tsang K.L., Tsoi T.H., Au Yeung K.M., Chan K.H., Cheng T.S., Cheung R.T.F. and Ho S.L., “Thundery Shower”: a novel headache syndrome, 17th Annual Scientific Meeting, The Hong Kong Neurological Society. 2004, 10: 30.

Researcher : Ho SP

List of Research Outputs

Chan M.M.W., Tan-Un K.C., Ip M.S.M., Tsang K.W.T., Ho S.P., Ho J.C.M., Chan H. and Lam W.K., Lung Cancer Susceptibility and Polymorphism of Glutathione-S-transferase Genes in Hong Kong, Lung Cancer. 2004, 45(2): 155-160.

Chan M.M.W., Lam W.K., Mak J.C.W., Ho S.P., Chan H.W., Tsang K.W.T., Ip M.S.M., Ho J.C.M., Wong M.P. and Tan-Un K., Polymorphisms of CYP and GST genes, passive smoke and lung cancer risk in Hong Kong Chinese, European Respiratory Journal. 2004, 24: Suppl 48: 457s.

Ho J.C.M., Mak J.C.W., Ho S.P., Ip M.S.M., Tsang K.W.T., Lam W.K. and Chan M.M.W., Manganese superoxide dismutase and catalase genetic polymorphisms activity levels and lung cancer risk in Chinese in Hong Kong, 10th Medical Research Conference, Department of Medicine, The University of Hong Kong, February 2005. Abstract Book: RM 66.

Ho J.C.M., Ho S.P., Chan M.M.W., Mak J.C.W., Ip M.S.M., Ko K.W., Yan C.P.K., Wong M.P., Tsang K.W.T. and Lam W.K., Non-small cell lung cancer in Chinese is associated with disturbance in systemic antioxidant profiles, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December, 2004. Respirology. 2004, 9 (Supp): A114.

Ho S.P., Chan M.M.W., Chow K.M., Ip M.S.M. and Mak J.C.W., Antioxidant enzyme activities in healthy Chinese adults: influence of age, gender, and smoking, Respirology. 2005, 10: 305-309.

Ho S.P., Chan M.M.W., Wong M.P., Tsang K.W.T., Ip M.S.M., Lam W.K. and Mak J.C.W., Transforming growth factor (TGF)-beta 1 gene common polymorphisms and plasma TGF-beta 1 levels in patients with lung cancer, 10th Medical Research Conference, Department of Medicine, The University of Hong Kong, February 2005. Abstract Book: RM 60.

Ho S.P., Chan M.M.W., Tsang K.W.T., Ip M.S.M., Lam W.K. and Mak J.C.W., Transforming growth factor (TGF)-beta 1 gene common polymorphisms and plasma TGF-beta 1 levels in patients with lung cancer, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A120.

Mak J.C.W., Ho S.P., Leung Y.H., Ho P.L., Ooi C.G.C., Yan C.P.K., Ko K.W., Ip M.S.M., Lam W.K. and Tsang K.W.T., Elevated levels of transforming growth factor- beta 1 in serum of patients with stable bronchiectasis, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A134.

Mak J.C.W., Leung C.M., Ho S.P., Law K.W., Tsang K.W.T., Lam W.K., Ip M.S.M. and Chan M.M.W., Genetic susceptibility of transforming growth factor beta-1 common polymorphisms to Chinese patients with asthma, American Thoracic Society International Conference, San Diego, USA. May 2005. Proceedings of the American Thoracic Society. 2005, p.A78.

Mak J.C.W., Ho J.C.M., Ho S.P., Yu W.C., Yew W.W., Tsang K.W.T., Lam W.K., Ip M.S.M. and Chan M.M.W., Increased oxidative stress and altered antioxidant status in Chinese patients with COPD, European Respiratory Journal. 2004, 24: Suppl 48: 62s.

Mak J.C.W., Ho J.C.M., Ho S.P., Leung C.M., Law K.W., Ip M.S.M. and Chan M.M.W., Polymorphisms of superoxide dismutase and catalase genes and their functional activity levels in Chinese patients with asthma, American Thoracic Society International Conference, San Diego, USA. May 2005. Proceedings of the American Thoracic Society . 2005, p.A78.

Mak J.C.W., Leung H.C., Ho S.P., Lam W.K., Tsang K.W.T., Ip M.S.M. and Chan M.M.W., Systemic antioxidant status in Chinese patients with asthma, European Respiratory Journal. 2004, 24: Suppl 48: 509s.

Mak J.C.W., Leung C.M., Ho S.P., Lam W.K., Tsang K.W.T., Ip M.S.M. and Chan M.M.W., Systemic oxidative and antioxidative status in Chinese patients with asthma, Journal of Allergy and Clinical Immunology. 2004, 114(2): 260-264.

Researcher : Ho WL

List of Research Outputs

Ho W.L., Chan Y.L., Kwok H.H., Mak W., Chu A.C.Y., Kung M.H.W., Ramsden D.B. and Ho S.L., mpp+ Modulates Mitochondrial Uncoupling Protein Ucp2, Ucp4 And Ucp5 Expression In Catecholaminergic (sk-n-sh) Cells , J Neurosci Res. 2005, 81(2): 261-8.

Ho W.L., Chan Y.L., Leung K.C., Kung M.H.W., Ramsden D.B. and Ho S.L., Potential Role Of Uncoupling Proteins, Ucp2, -4, And -5, In The Neuroprotective Effects Of Estrogen On Mpp+-induced Neurotoxicity. , 8th International Congress of Parkinson's disease & Movement Disorders, Rome, Italy. 2004.

Ho W.L., Kwok H.H., Chu C.Y.A., Ho W.M., Kung M.H.W., Ramdsen D.B. and Ho S.L., Silencing of UCP5 enhances MPP+-induced neurotoxicity in SH-SY5Y cells., 9th International Congress of Parkinson’s disease & Movement Disorders, New Orleans, USA. 2005.

Researcher : Ho WL

List of Research Outputs

Researcher : Ho WM

List of Research Outputs

Ho W.L., Kwok H.H., Chu C.Y.A., Ho W.M., Kung M.H.W., Ramdsen D.B. and Ho S.L., Silencing of UCP5 enhances MPP+-induced neurotoxicity in SH-SY5Y cells., 9th International Congress of Parkinson’s disease & Movement Disorders, New Orleans, USA. 2005.

Researcher : Ho YK

List of Research Outputs

Wong R.W.M., Huang J., Xia H.H.X., Fung F.M.Y., Tong S.M., Cheung K.L., Ho Y.K., Lai K.C., Chan C.K., Chan O.O., Hui C.K., Lam S.K. and Wong B.C.Y., Low-dose rabeprazole, amoxicillin and metronidazole triple therapy for the treatment of Helicobacter pylori infection in Chinese patients , Journal of Gastroenterology and Hepatology. 2005, 20(6): 935-940.

Researcher : Hoo RLC

List of Research Outputs

Chan K.W., Xu A., Hoo R.L.C., Tan K.C.B., Zhang J., Lam C.W. and Lam K.S.L., Selective Reduction of the High Molecular Weight Form of Adiponectin by Testosterone: A Potential Mechanism That Underlies the Sexual Dimorphism of Adiponectin Oligomeric Distribution, The Endocrine Society’s 87th Annual Meeting, June 4-7, 2005, San Diego, USA. 2005.

Chan K.W., Xu A., Hoo R.L.C., Lam C.W. and Lam K.S.L., Sexual dimorphism of adiponectin: Why do men have higher risk to diabetes and atherosclerosis than women?, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005. Endocrinology 24.

Chen B., Xu A., Lam C.W., Hoo R.L.C. and Lam K.S.L., Adenovirus-mediated expression of adiponectin alleviates liver fibrosis and induces apoptosis of activated hepatic stellate cells, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005. Endocrinology 23.

Hoo R.L.C., Xu A., Lam C.W., Chen B., Carling D. and Lam K.S.L., Adenovirus-mediated expression of constitutively active AMP-activated protein kinase alleviates diabetes in db/db diabetic mice, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005. Endocrinology 25.

Xu A., Hoo R.L.C., Hoo R.L.C., Lam C.W., Chen B. and Lam K.S.L., Adenovirus-Mediated Expression of Adiponectin Alleviates Endothelial Dysfunction and Oxidative Stress Associated with db/db Diabetic Mice, The Endocrine Society’s 87th Annual Meeting, June 4-7, 2005, San Diego, USA. 2005.

Xu A., Chan K.W., Wang Y., Zhang J., Hoo R.L.C., Xu J., Chow W.S. and Lam K.S.L., Angiopoietin-like Protein 4 Decreases Blood Glucose and Improves Glucose Tolerance but Induces Hyperlipidemia and Hepatic Steatosis in Mice, Proceedings of the National Academy of Sciences of the United States of America. 2005, 102: 6086-6091.

Xu A., Lam C.W., Chan K.W., Zhang J., Hoo R.L.C., Xu J., Chen B. and Lam K.S.L., Angiopoietin-like protein 4 is a novel metabolic hormone with therapeutic potentials for hyperglycemia and insulin resistance, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005. Endocrinology 22.

Xu A., Chan K.W., Hoo R.L.C., Wang Y., Zhang J., Chen B., Cynthia T., Cooper G.J.S. and Lam K.S.L., Testosterone Selectively Reduces the High Molecular Weight Form of Adiponectin by Inhibiting Its Secretion from Adipocytes, The Journal of Biological Chemistry. 2005, 280: 18073-18080.

Xu A., Chan K.W., Hoo R.L.C., Wang Y., Tan K.C.B., Zhang J.C.L., Chen B., Lam M.C., Tse C., Cooper G.J. and Lam K.S.L., Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes, J Biol Chem. 2005, 280(18): 18073-80.

Researcher : Hu HC

Project Title:	A study to validate a symptom severity questionnaire for patents with functional dyspepsia
Investigator(s):	Hu HC, Lam CLK
Department:	Medicine
Source(s) of Funding:	Health Services Research Fund - Full Grants
Start Date:	10/1998

Abstract:

To develop and validate an instrument to measure the severity of symptoms in patients with functional dyspepsia.

List of Research Outputs

Hui C.K., Lai K.C., Wong R.W.M., Yuen R.M.F., Ng M.M.T., Chan C.K., Hu H.C., Cheung W.W., Lai C.L. and Wong B.C.Y., Outpatients Undergoing Therapeutic Endoscopic Retrograde Cholangiopancreatography: Six-hour Versus Overnight Observation , Journal of Gastroenterology and Hepatology. 2004, 19: 1163-1168.

Lai K.C., Hui W.M., Wong B.C.Y., Hu H.C., Chan O.O. and Lam S.K., Lansorprazole but not Rofecoxib reduced dyspeptic symptoms of patients on NSAIDS, Gastroenterology. 2005, 128(4 Suppl 2): A24.

Wong R.W.M., Lai K.C., Hui W.M., Hu H.C., Huang J., Wong Y.H., Xia H.H.X., Chan O.O., Lam S.K. and Wong B.C.Y., Pathophysiology of Gastroesophageal Reflux Diseases in ChineseRole of Transient Lower Esophageal Sphincter Relaxation and Esophageal Motor Dysfunction, American Journal of Gastroenterology. 2004, 99: 2088-2093.

Wong R.W.M., Xiao S.D., HU P.J., Wang W., Gu Q., Huang J., Xia H.H.X., WU S.M., LI C.J., CHEN M.H., CUI Y., Lai K.C., Hu H.C., Chan C.K., Lam S.K. and Wong B.C.Y., Standard treatment for Helicobacter pylori infection is suboptimal in non-ulcer dyspepsia compared to duodenal ulcer in Chinese, Alimentary Pharmacology and Therapeutics. 2005, 21: 73-81.

Wong W.M., Lai K.C., Lam K.F., Hui W.M., Huang J.Q., Xia H.H.X., Hu H.C., Lam C.L.K., Chan C.K., Lam S.K. and Wong B.C.Y., Onset and disappearance of Reflux Symptoms in a Chinese population: a one-year follow-up study, Alimentary Pharmacology and Therapeutics. 2004, 20: 803-812.

Xia B., Xia H.H.X., Lam S.K., Chan O.O., Lai K.C., Hu H.C. and Wong B.C.Y., Trends in prevalence of peptic ulcer disease and Helicobacter pylori infection and frequency of NSAID intake in general practitioner-referred dyspeptic patients over 6 years in Hong Kong, Gastroenterology. 2005, 128(4 Suppl 2): A230.

Researcher : Huang CY

List of Research Outputs

Ng P.W., Huang C.Y., Cheung R.T.F., Wong K.S., Wong C.K. and Lam J.M., Transient ischaemic attack patients are often under-evaluated, Hong Kong Medical Journal. 2004, 10: 293-294.

Researcher : Huang J

List of Research Outputs

Wong R.W.M., Lai K.C., Hui W.M., Hu H.C., Huang J., Wong Y.H., Xia H.H.X., Chan O.O., Lam S.K. and Wong B.C.Y., Pathophysiology of Gastroesophageal Reflux Diseases in ChineseRole of Transient Lower Esophageal Sphincter Relaxation and Esophageal Motor Dysfunction, American Journal of Gastroenterology. 2004, 99: 2088-2093.

Wong R.W.M., Xiao S.D., HU P.J., Wang W., Gu Q., Huang J., Xia H.H.X., WU S.M., LI C.J., CHEN M.H., CUI Y., Lai K.C., Hu H.C., Chan C.K., Lam S.K. and Wong B.C.Y., Standard treatment for Helicobacter pylori infection is suboptimal in non-ulcer dyspepsia compared to duodenal ulcer in Chinese, Alimentary Pharmacology and Therapeutics. 2005, 21: 73-81.

Researcher : Hui CK

List of Research Outputs

Hui C.K., Lie A., Au W.Y., Leung A.Y.H., Ma S.Y., Cheung W.W., Zhang H., Chim C.S., Kwong Y.L., Liang R.H.S. and Lau G., A long-term follow-up study on hepatitis B surface antigen-positive patients undergoing allogeneic hematopoietic stem cell transplantation, Blood. 2005, 106: 464-9.

Hui C.K. and Lau G., Advances in immunomodulating therapy of HBV infection, Int J Med Sci. 2005, 2: 24-29.

Hui C.K., Bowden S., Jackson K., Au W.Y., Fong D.Y.T., Lie A.K.W., Chim J.C.S., Liang R.H.S. and Lau G., Clinical significance of intrahepatic hepatitis B virus covalently closed circular DNA in chronic hepatitis B patients who received cytotoxic chemotheraphy, Blood. 2005, 105(6): 2616-2617.

Hui C.K., Lie A.K.W., Au W.Y., Ma S.Y., Leung A.Y.H., Zhang H., Sun J.Z., Cheung W.W.W., Chim J.C.S., Kwong Y.L., Liang R.H.S. and Lau G., Effectiveness of prophylactic Anti-HBV therapy in allogeneic hematopoietic stem cell transplantation with HBsAg positive donors, American Journal of Transplantation. 2005, 5(6): 1437-45.

Hui C.K., Emerging Leader in Gastroenterology. 2004.

Hui C.K., Zhang H. and Lau G., Management of chronic hepatitis B in treatment-experienced patients, Gastroenterol Clin North Am. 2004, 33: 601-16.

Hui C.K., Sun J., Au W.Y., Lie A.K.W., Yueng Y.H., Zhang H., Lee N.P., Hou J., Liang R.H.S. and Lau G., Occult hepatitis B virus infection in hematopoietic stem cell donors in a hepatitis B virus endemic area, Journal of Hepatology. 2005, 42(6): 813-9.

Hui C.K., Lai K.C., Wong R.W.M., Yuen R.M.F., Ng M.M.T., Chan C.K., Hu H.C., Cheung W.W., Lai C.L. and Wong B.C.Y., Outpatients Undergoing Therapeutic Endoscopic Retrograde Cholangiopancreatography: Six-hour Versus Overnight Observation , Journal of Gastroenterology and Hepatology. 2004, 19: 1163-1168.

Hui C.K., Cheung B.M.Y. and Lau G., Pharmacokinetics of pitavastatin in subjects with Child-Pugh A and B cirrhosis, Br J Clin Pharmacol. 2005, 59: 291-7.

Hui C.K., Yu J., Au W.Y., Zhang H., Bartholomeusz A., Locarnini S., Kwong Y.L., Liang R.H.S. and Lau G., Sexual transmission of hepatitis B infection despite the presence of hepatitis B virus immunity in recipients of allogeneic bone marrow transplantation, J Clin Virol. 2005, 32: 173-8.

Wong D.K.H., Yuen R.M.F., Tse E.W.C., Yuan H., Sum S.M., Hui C.K. and Lai C.L., Detection of Intrahepatic Hepatitis B Virus DNA and Correlation with Hepatic Necroinflammation and Fibrosis, Journal of Clinical Microbiology. 2004, 42: 3920-3924.

Wong D.K.H., Yuen R.M.F., Yuan H., Sum S.M., Hui C.K., Hall J. and Lai C.L., Quantitation of Covalently Closed Circular Hepatitis B Virus DNA in Chronic Hepatitis B Patients, Hepatology. 2004, 40: 727-737.

Wong R.W.M., Huang J., Xia H.H.X., Fung F.M.Y., Tong S.M., Cheung K.L., Ho Y.K., Lai K.C., Chan C.K., Chan O.O., Hui C.K., Lam S.K. and Wong B.C.Y., Low-dose rabeprazole, amoxicillin and metronidazole triple therapy for the treatment of Helicobacter pylori infection in Chinese patients , Journal of Gastroenterology and Hepatology. 2005, 20(6): 935-940.

Yuen R.M.F., Hon C., Hui C.K., Siu C.W. and Lai C.L., Interferon treatment for metastatic hepatocellular carcinoma. Review Series, Hepatitis. 2004, 3: 12-3.

Yuen R.M.F., Tanaka K., Mizokami M., Yuen J.C.H., Hui C.K., Wong D.K.H., Yuan H., Sum S.M., Chan O.O., Wong B.C.Y., Fan S.T. and Lai C.L., Role of hepatitis B virus genotypes Ba and C, core promoter and precore mutations on hepatocellular carcinoma: a case control study, Carcinogenesis. 2004, 25(9): 1593-1598.

Researcher : Hui WM

List of Research Outputs

Chan O.O., Chu K.M., Sun Y., Cheung K.L., Lam S.K., Yuen R.M.F., Hui W.M. and Wong B.C.Y., The association between Interleukin 1 beta polymorphism and hypermethylation at tumor suppressor genes in gastric cancer. Conference paper at the Annual Meeting of the American Gastroenterology Associatoin, Digestive Diseases Week (DDW) Chicago, Illinois, USA. May 14-19, Gastroenterology. 2005, 128(4 Suppl 2): A399.

Lai K.C., Hui W.M., Wong B.C.Y., Hu H.C., Chan O.O. and Lam S.K., Lansorprazole but not Rofecoxib reduced dyspeptic symptoms of patients on NSAIDS, Gastroenterology. 2005, 128(4 Suppl 2): A24.

Wong R.W.M., Hui W.M. and Wong B.C.Y., Diagnosis of Barrett's esophagus in the Asian population, Journal of Gastroenterology and Hepatology. 2005, 20(3): 495.

Wong R.W.M., Lai K.C., Hui W.M., Hu H.C., Huang J., Wong Y.H., Xia H.H.X., Chan O.O., Lam S.K. and Wong B.C.Y., Pathophysiology of Gastroesophageal Reflux Diseases in ChineseRole of Transient Lower Esophageal Sphincter Relaxation and Esophageal Motor Dysfunction, American Journal of Gastroenterology. 2004, 99: 2088-2093.

Wong R.W.M., Hui W.M. and Wong B.C.Y., Reply from authors, Journal of Gastroenterology and Hepatology. 2005, 20(3): 495.

Wong W.M., Lai K.C., Lam K.F., Hui W.M., Huang J.Q., Xia H.H.X., Hu H.C., Lam C.L.K., Chan C.K., Lam S.K. and Wong B.C.Y., Onset and disappearance of Reflux Symptoms in a Chinese population: a one-year follow-up study, Alimentary Pharmacology and Therapeutics. 2004, 20: 803-812.

Researcher : Hui WS

List of Research Outputs

Chan D., Yang L., Hui W.S., Chan W.C.W., Huang J., Shum D.K.Y., Cheung K.M.C., Luo Z.J. and Cheah K.S.E., A splicing mutation in the ext2 gene affects messenger RNA stability in a family with hereditary multiple exostoses, XIXth Meeting of the Federation of the European Connective Tissue Societies, Taormina-Giardini Noxos, Italy. 9-13 July 2004.

Mak J.C.W., Hui W.S., Johnson M.W., Barnes P.J. and Tsang K.W.T., Modulation of Functional Pulmonary β2-Adrenoceptor by Tansforming Growth Factor-β1 in Human Bronchial Epithelial Cells, Abstract Book of the 10th Medical Research Conference, University Department of Medicine, The University of Hong Kong, 19-20 Feb. 2005, page 61.

Pan N.Y., Hui W.S., Tipoe G.L., Tsang K.W.T. and Mak J.C.W., Effects of Glucocorticosteroids and Antimicrobial Drugs on Inhibition of IL-1β- and PDBu-induced IL-8 Release in the Presence of Pyocyanin in Bronchial Epithelial Cell Line, Abstract Book of the 10th Medical Research Conference, University Department of Medicine, The University of Hong Kong, 19-20 February. 2005, page 62.

Researcher : Ip MSM

Project Title:	The efficacy of the modified oral appliance in the treatment of mild and moderate obstructive Sleep Apnoea
Investigator(s):	Ip MSM
Department:	Medicine
Source(s) of Funding:	Other Funding Scheme
Start Date:	02/1997

Abstract:

To assess the efficacy, side effects and patient acceptance of an oral appliance in the treatment of obstructive sleep apnoea; to define the clinical, anthropometric, polysomnographic and cephalometric characteristics that determine treatment response.

Project Title:	The effect of oral appliance (OA) in treatment of obstructive sleep apnoea
Investigator(s):	Ip MSM, Peh WCG, Cooke MS, Kim S.
Department:	Medicine
Source(s) of Funding:	Other Funding Scheme
Start Date:	06/1997

Abstract:

To study the efficacy of OA in teatment of mild/moderate OSA; to study the safety profile of OA.

Project Title:	Role of adiponectin in obstructive sleep apnoea
Investigator(s):	Ip MSM, Lam KSL, Lam J.
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002

Abstract:

To investigate serum adiponectin levels in OSA patients with a spectrum of body mass index (BMI) and sleep disordered breathing (no OSA to severe OSA) and define correlative parameters; to investigate for any difference in adiponectin levels in patients with OSA and BMI-matched subjects with no OSA (3) the impact of nasal Continuous Positive Airway pressure (nCPAP) treatment on adiponectin secretion in subjects with OSA.

Project Title:	Candidate genes of obstructive sleep apnoea syndrome in Hong Kong Chinese
Investigator(s):	Ip MSM, Lam KSL, Song Y, Sham PC, Lam CL
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2005

Abstract:

Refer to hard copy

List of Research Outputs

Chan M.M.W. and Ip M.S.M., Asthma Management, In: Ip SM, Chan MMW, Zhong NS, Lam WK, In: Respiratory Disease- The Asian Perspective. The University Hong Kong Press, 2005, 25-42.

Chan M.M.W. and Ip M.S.M., Asthma management. In: Ed. Ip MSM, Chan MMW, Lam WK, Zhong NS, Respiratory Medicine - An Asian Perspective. Hong Kong University Press, 2005, pp. 25-42.

Chan M.M.W., Tan-Un K.C., Ip M.S.M., Tsang K.W.T., Ho S.P., Ho J.C.M., Chan H. and Lam W.K., Lung Cancer Susceptibility and Polymorphism of Glutathione-S-transferase Genes in Hong Kong, Lung Cancer. 2004, 45(2): 155-160.

Chan M.M.W., Lam W.K., Mak J.C.W., Ho S.P., Chan H.W., Tsang K.W.T., Ip M.S.M., Ho J.C.M., Wong M.P. and Tan-Un K., Polymorphisms of CYP and GST genes, passive smoke and lung cancer risk in Hong Kong Chinese, European Respiratory Journal. 2004, 24: Suppl 48: 457s.

Ho J.C.M., Lam W.K., Wong M.P., Wong M.K., Ooi C.G.C., Ip M.S.M., Chan M.M.W. and Tsang K.W.T., Lymphoepithelioma-like carcinoma of the lung : experience with ten cases, International Journal of Tuberculosis and Lung Disease. 2004, 8(7): 890-895.

Ho J.C.M., Mak J.C.W., Ho S.P., Ip M.S.M., Tsang K.W.T., Lam W.K. and Chan M.M.W., Manganese superoxide dismutase and catalase genetic polymorphisms activity levels and lung cancer risk in Chinese in Hong Kong, 10th Medical Research Conference, Department of Medicine, The University of Hong Kong, February 2005. Abstract Book: RM 66.

Ho J.C.M., Ho S.P., Chan M.M.W., Mak J.C.W., Ip M.S.M., Ko K.W., Yan C.P.K., Wong M.P., Tsang K.W.T. and Lam W.K., Non-small cell lung cancer in Chinese is associated with disturbance in systemic antioxidant profiles, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December, 2004. Respirology. 2004, 9 (Supp): A114.

Ho S.P., Chan M.M.W., Chow K.M., Ip M.S.M. and Mak J.C.W., Antioxidant enzyme activities in healthy Chinese adults: influence of age, gender, and smoking, Respirology. 2005, 10: 305-309.

Ho S.P., Chan M.M.W., Wong M.P., Tsang K.W.T., Ip M.S.M., Lam W.K. and Mak J.C.W., Transforming growth factor (TGF)-beta 1 gene common polymorphisms and plasma TGF-beta 1 levels in patients with lung cancer, 10th Medical Research Conference, Department of Medicine, The University of Hong Kong, February 2005. Abstract Book: RM 60.

Ho S.P., Chan M.M.W., Tsang K.W.T., Ip M.S.M., Lam W.K. and Mak J.C.W., Transforming growth factor (TGF)-beta 1 gene common polymorphisms and plasma TGF-beta 1 levels in patients with lung cancer, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A120.

Ip M.S.M., Co-chairperson in Parallel Session 2B : Chronic obstructive pulmonary disease, 9th Congress of the Asian acific Society of Respirology, December. 2004.

Ip M.S.M., Associate Editor, CHEST. 2005.

Ip M.S.M., Co-chairperson in Paraellel Session 3B : Sleep Disordered Breathing, 9th Congress of the Asian Pacific Society of Respirology, December. 2004.

Ip M.S.M., Co-chairperson in Presidential best papers presentation , 9th Congress of the Asian Pacific Society of Respirology, December. 2004.

Ip M.S.M., Current status and problems of medical treatment of asthma in Asian countries - working toward the decrease of asthma deaths and improvement in patient QOL, 15th Congress of INTERASTHMA Japan/North Asia, Tokyo, Japan, July 2004. 2004.

Ip M.S.M., Member, Programme Committee, Assembly on Respiration, Neurobiology and Sleep, American Thoracic Society Meeting, May. 2005.

Ip M.S.M., Member, The Dental Council of Hong Kong. 2004.

Ip M.S.M., OSA and the metabolic syndrome, 9th Congress of the Asian Pacific Society of Respirology, Hong Kong, December 2004. 2004.

Ip M.S.M. and Guilleminaut C.G., Obstructive sleep apnea. In: Ed. Ip MSM, Chan MMW, Lam WK, Zhong NS, Respiratory Medicine - An Asian Perspective. Hong Kong University Press, 2005, pp. 135-157.

Ip M.S.M., Obstructive sleep apnoea, obesity and metabolic syndrome, American Thoracic Society International Conference, San Diego, USA. May . 2005.

Ip M.S.M., Tse H.F. and Lam B., Rebuttal to "vascular dysfunction may be mediated by other mechanisms", American Journal of Respiratory and Critical Care Medicine. 2004, 170: 197-198.

Ip M.S.M., Ko K.W., Lau A.C.W., Yu W.C., Tang K.S., Choo K., Ling S.O., Chan J.W. and Chan M.M.W., Reference values of spirometry for adult Chinese in Hong Kong, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A162.

Ip M.S.M., Chan M.M.W., Lam W.K. and Zhong N.S., Respiratory Medicine - An Asian Perspective. Hong Kong University Press, 2005.

Lam B., Sam K., Mok W.Y.W., Lam J.C., Yam L.Y.C., Lam W.K. and Ip M.S.M., A randomized study of three non-surgical treatment options in mild to moderate obstructive sleep apnea, American Thoracic Society International Conference, San Diego, USA. May 2005. Proceedings of the American Thoracic Society. 2005, p.A303.

Lam B., Ip M.S.M., Tench E. and Ryan C.F., Cranofacial profile in Asian and while subjects with obstructive sleep apnoea, Thorax. 2005, 60(6): 504-510.

Lam B., Tam C.M., Lam S.Y., Wong M.P., Ooi C.G.C., Fung S.L., Ip M.S.M. and Lam W.K., Detection of early lung cancer in high risk population : a prospective study, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A122.

Lam J.C., Ooi C.G.C., Tam S., Lam K.S.L. and Ip M.S.M., Insulin resistance and other cardiovascular risk factors in obstructive sleep apnea, American Thoracic Society International Conference, San Diego, USA. May 2005. Proceedings of the American Thoracic Society. 2005, p.A232.

Lam J.C., Lam K.S.L., Tam S., Lam C.L. and Ip M.S.M., The determinants of blood pressure in relation to obstructive sleep apnea, American Thoracic Society International Conference, San Diego, USA. May 2005. Proceedings of the American Thoracic Society. 2005, p.A878.

Lam J.C.M., Ooi C.G.C., Tam S., Khong P.L., Lam B. and Ip M.S.M., Obesity and dyslipidemia in Chinese patients with obstructive sleep apnea, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A143.

Lam J.C.M., Lam K.S.L., Tam S., Yan S.W. and Ip M.S.M., The determinants of blood pressure in relatin to obstructive sleep apnea, 10th Medical Research Conference, Department of Medicine, The University of Hong Kong, February 2005. Abstract Book: RM 58.

Lam J.C.M., Ooi C.G.C., Lam K.S.L., Tam S., Lai A.Y.K., Tsang K.W.T., Lam W.K. and Ip M.S.M., The relationship of insulin resistance, obesity and sleep-disordered breathing , 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology . 2004, 9 (Supp): A143.

Lam J.C.M., Ooi C.G.C., Lam K.S.L., Tam S., Lai A.Y.K., Tsang K.W.T., Lam W.K. and Ip M.S.M., The relationship of insulin resistance, obesity and sleep-disordered breathing, 10th Medical Research Conference, Department of Medicine, The University of Hong Kong, February 2005. Abstract Book: RM 59.

Lam W.K., Tsang K.W.T., Ooi C.G.C., Ip M.S.M. and Chan M.M.W., Infections: Severe Acute Respiratory Syndrome., In: Ip M, Chan-Yeung M, Lam WK, Zhong NS, Respiratory Medicine, An Asian Perspective. Hong Kong, Hong Kong University Press, 2004, 307-323.

Lam W.K., Tsang K.W.T., Ooi C.G.C., Ip M.S.M. and Chan M.M.W., Severe Acute Respiratory Syndrome. In: Ed. Ip MSM, Chan MMW, Lam WK, Zhong NS, Respiratory Medicine - An Asian Perspective. Hong Kong University Press, 2005, Chapter 18: pp. 307-323.

Mak J.C.W., Ho S.P., Leung Y.H., Ho P.L., Ooi C.G.C., Yan C.P.K., Ko K.W., Ip M.S.M., Lam W.K. and Tsang K.W.T., Elevated levels of transforming growth factor- beta 1 in serum of patients with stable bronchiectasis, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A134.

Mak J.C.W., Leung C.M., Ho S.P., Law K.W., Tsang K.W.T., Lam W.K., Ip M.S.M. and Chan M.M.W., Genetic susceptibility of transforming growth factor beta-1 common polymorphisms to Chinese patients with asthma, American Thoracic Society International Conference, San Diego, USA. May 2005. Proceedings of the American Thoracic Society. 2005, p.A78.

Mak J.C.W., Ho J.C.M., Ho S.P., Yu W.C., Yew W.W., Tsang K.W.T., Lam W.K., Ip M.S.M. and Chan M.M.W., Increased oxidative stress and altered antioxidant status in Chinese patients with COPD, European Respiratory Journal. 2004, 24: Suppl 48: 62s.

Mak J.C.W., Ho J.C.M., Ho S.P., Leung C.M., Law K.W., Ip M.S.M. and Chan M.M.W., Polymorphisms of superoxide dismutase and catalase genes and their functional activity levels in Chinese patients with asthma, American Thoracic Society International Conference, San Diego, USA. May 2005. Proceedings of the American Thoracic Society . 2005, p.A78.

Mak J.C.W., Leung H.C., Ho S.P., Lam W.K., Tsang K.W.T., Ip M.S.M. and Chan M.M.W., Systemic antioxidant status in Chinese patients with asthma, European Respiratory Journal. 2004, 24: Suppl 48: 509s.

Mak J.C.W., Leung C.M., Ho S.P., Lam W.K., Tsang K.W.T., Ip M.S.M. and Chan M.M.W., Systemic oxidative and antioxidative status in Chinese patients with asthma, Journal of Allergy and Clinical Immunology. 2004, 114(2): 260-264.

Patil N.G. and Ip M.S.M., The curriculum journey - where are we now?, Curriculum Reform: Foundation to Consolidation. The University of Hong Kong, 2004, 25-34.

Tan K.C.B., Chow W.S., Lam J.C.M., Lam B., Wong W.K., Tam S. and Ip M.S.M., HDL dysfunction in obstructive sleep apnea, Atherosclerosis. 2005-02-01, 2005, Epub ahead of print.

Tan W.C., Mahayiddin A.A., Charoenratanakul S., Zhong N.S., Seal P., Ip M.S.M., de Guia T., Shim Y.S., Chiang C.H. and Mangunnegoro H., GOLD strategy for the diagnosis, management, and prevention of COPD: An Asia-Pacific Perspective. The Asia Pacific COPD Roundable Group, Respirology. 2005, 10: 9-17.

Tsang K.W.T., Ooi C.G.C. and Ip M.S.M., Airway Diseases : Bronchiectasis., In: Ip M, Chan-Yeung M, Lam WK, Zhong NS., Respiratory Medicine, An Asian Perspective.. Hong Kong, Hong Kong University Press, 2004, 43-59.

Tsang K.W.T., Ooi C.G.C. and Ip M.S.M., Bronchiectasis. In: Ed. Ip MSM, Chan MMW, Lam WK, Zhong NS , Respiratory Medicine - An Asian Perspective. Hong Kong University Press, 2005, pp. 43-59.

Wang J., Law K.W., Ip M.S.M., Wu A.Y.Y., Wong M.K., Lam B., Chow K.M. and Chan M.M.W., Effect of asthma self management programme on asthma morbidity and health care utilization in adult patients admitted to hospital with acute asthma in Hong Kong: A randomized controlled trial, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A91.

Wong J.G.W.S., Cheung E.P.T., Cheung V., Cheung C., Chan M.T.Y., Chua S.E., McAlonan G.M., Tsang K.W.T. and Ip M.S.M., Psychological responses to the SARS outbreak in healthcare students in Hong Kong, Medical Teacher. Taylor & Francis health sciences, 2005, 26 (7): 657-663.

Wong M.K., Lam J.C., Ip S.K., Ip M.S.M., Lam W.K. and Tsang K.W.T., A comparative study on the efficacy of sequential intravenous and oral levofloxacin versus ceftazidime in treatment of infective exacerbation of bronchiectasis, 10th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2005, Abstract Book: RM 64.

Wong M.K., Lam J., Ip S., Lam C.L., Ip M.S.M., Lam W.K. and Tsang K.W.T., Quality of life effect of levofloxacin compared to ceftazidime treatment in infective exacerbation of bronchiectasis, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A135.

Researcher : Ip TP

List of Research Outputs

Leung J.Y., Ho A.Y.Y., Ip T.P., Lee G. and Kung A.W.C., The efficacy and tolerability of risedronate on bone mineral density and bone turnover markers in osteoporotic Chinese women: a randomized placebo-controlled study, Bone. 2005, 36(2): 358-64.

Researcher : Jiang X

List of Research Outputs

Jiang X., Tu S., Cui J., Lin M.C., Xia H.H.X., Wong R.W.M., Chan O.O., Yuen M.F., Jiang S.H., Lam S.K., Kung H., Soh J.W., Weinstein I.B. and Wong B.C.Y., Antisense Targeting Protein Kinase C Alpha and Beta1 Inhibits Gastric Carcinogenesis, Cancer Research. 2004, 64: 5787-5794.

Tu S., Cui J., Liston P., Jiang X., Xu R., Lin M.C., Zhu Y.B., Zou B., Ng S.M., Jiang S.H., Xia H.H.X., Wong R.W.M., Chan O.O., Yuen R.M.F., Lam S.K., Kung H. and Wong B.C.Y., Gene Therapy for Colon Cancer by Adeno-Associated Viral Vector-Mediated Transfer of Survivin Cys84Ala Mutant, Gastroenterology. 2005, 128: 361-375.

Researcher : Jin L

List of Research Outputs

Jin L., Lau H.L., Smith D.K., Lau K.S., Cheung P.T., Kwan E.Y.W., Low L.C.K. and Kung A.W.C., A family with osteoporosis-pseudoglioma syndrome (OPG) due to compound heterozygous mutation of the LRO5 gene, 26th Annual Meeting of the American Society for Bone & Mineral Research, October 1-5, 2004, Seattle, USA. Journal of Bone and Mineral Research . 2004, 19(Supl 1): SA125.

Jin L., Lau H.L., Smith D.K., Lau K.S., Cheung P.T., Kwan E.Y.W., Low L.C.K., Chan V.N.Y. and Kung A.W.C., A family with osteoporosis-pseudoglioma syndrome (OPG) due to compound heterozygous mutation of the LRP5 gene, HKU 10th Medical Research Conference. 2005.

Jin L., Lau H.L., Smith D.K., Lau K.S., Cheung P.T., Kwan E.Y.W., Low L.C.K., Chan V.N.Y. and Kung A.W.C., Family with osteoporosis Pseudolioma Syndrome due to compound heterozygosity of two novel mutations of the LRP5 gene, 6th Regional Osteoporosis Conference, 21-22 May 2005, Hong Kong. 2005.

Researcher : Jin O

List of Research Outputs

Jin O., Sun L.Y., Zhou K.X., Zhang X.S., Feng X.B., Mok T.M.Y. and Lau W.C.S., Lymphocyte apoptosis and macrophage function: correlation with disease activity in systemic lupus erythematosus, Clinical Rheumatology. 2005, 24: 107-110.

Jin O., Chan W.K., Mok T.M.Y., Sun L.Y. and Lau W.C.S., Osteopontin (OPN), matrix metalloproteinase (MMP)-3 and lupus nephritis (LN), 11th APLAR Bi-annual Congress, Jeju, Korea 11-16 September 2004.

Researcher : Jin Y

Project Title:	Cytogenetic and molecular genetic characterization of esophageal carcinomas
Investigator(s):	Jin Y, Kwong YL, Tsao GSW
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	10/2002

Abstract:

To identify, by cytogenetic, fluorescence in situ hybridization (FISH), and molecular genetic approaches, the genetic changes that are important in the malignant transformation of esophageal epithelium; to investigate genetic differences and similarity between immortalized, preneoplastic esophageal epithelial cells and aquamous cell carcinoma (SCC) of the esophagus.

List of Research Outputs

Chung C.M., Man W.Y.C., Jin Y., Jin C., Guan X.Y., Wang Q., Wan T.S.K., Cheung A. and Tsao G.S.W., Amplification and overexpression of Aurora kinase A (AURKA) in immortalized human ovarian epithelial (HOSE) cells, Molecular Carcinogenesis. 2005, 43(3): 165-174.

Gisselsson D.L., Lu M., Tsao G.S.W., Man C.W.Y., Jin C., Jin C., HOglund M., Kwong Y.L. and Jin Y., Telomere-mediated mitotic disturbances in immortalized ovarian epithelial cells reproduce chromosomal losses and breakpoints from ovarian carcinoma, Genes, Chromosomes and Cancer. 2004, 42(1): 22-23.

Jin Y., Jin C., Lu M., Tsao G.S.W., Zhu J., Wennerberg J., Mertens F. and Kwong Y.L., Karyotypic evolution and tumor progression in head and neck squamous cell carcinomas , Cancer Genetics and Cytogenetics . 2005, 156(1): 1-7.

Researcher : Ko KW

List of Research Outputs

Ho J.C.M., Ho S.P., Chan M.M.W., Mak J.C.W., Ip M.S.M., Ko K.W., Yan C.P.K., Wong M.P., Tsang K.W.T. and Lam W.K., Non-small cell lung cancer in Chinese is associated with disturbance in systemic antioxidant profiles, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December, 2004. Respirology. 2004, 9 (Supp): A114.

Ho J.C.M., Wu A.Y.Y., Lam B., Ooi C.G.C., Khong P.L., Ho P.L., Chan M.M.W., Zhong N.S., Ko K.W., Lam W.K. and Tsang K.W.T., Pentaglobin in steroid-resistant severe acute respiratory syndrome, International Journal of Tuberculosis and Lung Disease. 2004, 8(10): 1173-1179.

Mak J.C.W., Ho S.P., Leung Y.H., Ho P.L., Ooi C.G.C., Yan C.P.K., Ko K.W., Ip M.S.M., Lam W.K. and Tsang K.W.T., Elevated levels of transforming growth factor- beta 1 in serum of patients with stable bronchiectasis, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A134.

Tsang K.W.T., Tipoe G.L., Sun J.Z., Tan K.C.B., Leung Y.H., Yan C.P.K., Ko K.W., Ooi C.G.C., Ho J.C.M. and Lam W.K., Clinical value of ciliary assessment in bronchiectasis, Lung. 2005, 183(2): 73-86.

Tsang K.W.T., Tan K.C.B., Ho P.L., Ooi C.G.C., Khong P.L., Leung Y.H., Mak J.C.W., Tipoe G.L., Ko K.W. and Lam W.K., Exhaled nitric oxide in bronchiectasis: the effects of inhaled corticosteroid therapy, International Journal of Tuberculosis and Lung Disease. 2004, 8(11): 1301-1307.

Researcher : Kumana CR

List of Research Outputs

Ambekar C.S., Lee J.S.K., Cheung B.M.Y., Chan L.C., Liang R.H.S. and Kumana C.R., Metabolism of Chloramphenicol Succinate, a Competitive Substrate and Inhibitor of Succinate Dehydrogenase: Possible Reason for its Toxicity, Toxicology in Vitro. 2004, 18: 441-7.

Au W.Y., Cheung G.T.Y., Yuen W.H., Kumana C.R. and Kwong Y.L., Successful treatment of relapsed acute promyelocytic leukemia in a patient receiving continuous ambulatory peritoneal dialysis with oral arsenic trioxide, Archite Internal Medicine. 2005, 165: 1067-1068.

Au W.Y., Chim J.C.S., Lie A.K.W., Leung A.Y.H., Tse E.W.C., Ma S.Y., Liang R.H.S., Pang A.W.K., Kumana C.R. and Kwong Y.L., Treatment of relapsed acute promyelocytic leukemia by arsenic-based strategies without hematopoietic stem cell transplantation in Hong Kong: a seven-year experience, American Society of Haematology Annual Scientific Meeting. 2004.

Chan L.S., Cheung G.T.Y., Lauder I.J. and Kumana C.R., Screening For Fever By Remote Sensing Infrared Thermographic Camera, Journal of Travel Medicine. 2004, 11: 273-297.

Cheung B.M.Y., Man Y.B., Tse H.F., Kumana C.R. and Lau C.P., Advantages of Blood Pressure Optimisation Study, J Hong Kong Coll Cardiol . 2004, 12: 33.

Cheung B.M.Y., Lam T.H., Lam K.S.L., Tam S., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., Follow Up of the Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., High Blood Pressure is Related to Obesity in Hong Kong, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Hwang I.S.S., Li C., Tsang K.W.T., Leung Y.H., Kumana C.R. and Tang F., Increased Adrenomedullin Expression in Lungs in Endotoxaemia, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Lipid Profile of the Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Cheung G.T.Y., Lauder I.J., Lau C.P. and Kumana C.R., Meta-analysis of Large Outcome Trials of Angiotensin Receptor Blockers in Hypertension, American Journal of Hypertension. 2005, 18(5) Suppl: A53.

Cheung B.M.Y., Lauder I.J. and Kumana C.R., Meta-analysis of Large Randomised Controlled Trials that Evaluate Cardiovascular Outcomes After Stain Treatment, 8th Scientific Meeting of the Hong Kong Pharmacology Society in Association with the Shanghai Pharmacology Society, Hong Kong 2004.

Cheung B.M.Y., Lauder I.J. and Kumana C.R., Meta-analysis of Large Randomised Controlled Trials to Evaluate the Impact of Statins on Cardiovascular Outcomes, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Obesity in the Hong Kong Cardiovascular Risk Factor Prevalence Survey-2 (CRISPS2) Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of Diabetes Mellitus (DM) in the Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Wat N.M.S., Lo L.F., Chau F.Y., Lam T.H., Leung G.M., Tam S., Cheng C.H., Kumana C.R., Lau C.P. and Lam K.S.L., Prevalence of Hypertension in Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort, J Hong Kong Coll Cardiol. 2004, 12: 33.

Cheung B.M.Y., Law C.Y., Ho G.Y.Y., McGhee S.M., Man Y.B., Ng P.P.Y., Kumana C.R. and Lau C.P., Randomised Controlled Trial of Low Salt Diet Versus Drug Treatment in the Management of Mild hypertension, 8th Scientific Meeting of the Hong Kong Pharmacology Socieity in Association with the Shanghai Pharmacology Society, Hong Kong 2004.

Cheung B.M.Y., Law C.Y., Ho G.Y.Y., McGhee S.M., Man Y.B., Ng P.P.Y., Kumana C.R. and Lau C.P., Randomsed Controlled Trial of Low Salt Diet Versus Drug Treatment in Hypertension, Cardiovasc Drugs Thera. 2004, 18 (Suppl) 1: 15.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Relationship Between Hypertension and Obesity in Hong Kong, 3rd Asian-Pacific Congress on Hypertension, Singapore 2004.

Cheung B.M.Y., Lam T.H., Lam K.S.L., Tam S., Wat N.M.S., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., The Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort - Results at 7 Years, J Hypertens. 2004, 22 (Suppl 2): S268-269.

Cheung B.M.Y., Law C.Y., McGhee S.M., Ng P.P.Y., Kumana C.R. and Lau C.P., The Relationship Between Sodium and Blood Pressure in Hong Kong Chinese, Clin Res Regul Aff. 2004, 21(2): 145-154.

Kumana C.R., Cheung G.T.Y., Lauder I.J. and Cheung B.M.Y., Long-term combination therapy with aspirin and clopidogrel, J Cardiovasc Pharmacol Ther. 2004, 9(4): 223-5.

Kumana C.R., Cheung B.M.Y., Cheung G.T.Y., Ovedal T., Pederson B. and Lauder I.J., Rhythm vs.rate control of atrial fibrillation meta-analysed by number needed to treat, Br J Clin Pharmacol. Blackwell Publishing Ltd, 2005, 60(4): 347-54.

Kumana C.R., Cheung G.T.Y., Lauder I.J. and Chan L.S., Screening for Fever by Means of Infrared Thermographic Camera, 11th Ineternational Congress of infectious diseases – Mexico 2004 (Published in: International Journal of Infectious Diseases). 2004, 8(Supl 1): S110.

Kumana C.R., Cheung G.T.Y. and Lau W.C.S., Severe digital ischaemia treated with phosphodiesterase inhibitors, Annals of Rheumatic Diseases. 2004, 63: 1522-1524.

Man Y.B., Cheung B.M.Y., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of Hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004.

Researcher : Kung AWC

Project Title: