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Surgical oncology - cancer genetics; gene therapy; global gene expression profiling in human diseases by micro-array analysis; liver cancer proteomics; cancer biomarkers.

Development - developmental genetics; molecular mechanism and signaling in neural development; conditional knockout mouse model.

Immunology - transplantation immunology; mechanism of immune tolerance induction; molecular and cellular basis of inflammation; cell adhesion molecules; leukocyte activation and migration; immune response to hepatitis

Contact Persons:

Dr. V. Lui

Tel: 2819 9607

Fax:2819 9623

E-mail: vchlui@hkucc.hku.hk

Dr. J. Luk

Tel: 2819 9628

Fax: 2819 9636

E-mail: jmluk@hkucc.hku.hk

Web: http://web.hku.hk/~jmluk/

Clinical projects: Prognostic significance of micrometastasis in breast cancer; Study of acute phase response after operation; Study of wound healing and relation of healing with matrix metalloproteinases.

Laboratory projects: Histoculture drug response assay; Induction of apoptosis by polysaccharide peptide (PSP) on breast cancers; Molecular mechanism of apoptotic action of PSP; Molecular mechanism of tumor invasion; Detection of micrometastasis in breast cancer by molecular approaches.

Contact Person:

Dr. Ava Kwong

Tel: 2855 4773

Fax: 2817 2291

E-mail: avakwong@hkucc.hku.hk

Clinical projects: Analysis of long term results of CABG in patients with diabetes mellitus; Multivariate analysis of mortality and morbidity in redo vavular replacement, multivalent off-pump coronary bypass surgery, infective endocarditis and aortic aneurysm surgery; Analysis of long term survival in congenital cardiac surgery such as Fontan operation, arterial switch operation and adolescent tetralogy of Fallot; Analysis of relationship between subarterial ventricular septal defect and aortic valve prolapse: determination of timing of surgical correction; Correlation of intraoperative cerebral blood flow doppler assessment and postoperative psychoneurological dysfunction.

Contact Person

Dr. L.C. Cheng

Tel: 2518 2639/2630

Fax: 25533436

E-mail: chenglc@hkucc.hku.hk

Clinical projects: Total mesorectal excision of rectal cancer; Adjuvant radiotherapy and chemotherapy for Dukes’ B2 and C tumor after curative resection (in collaboration with Department of Radiotherapy and Oncology; Queen Mary Hospital); Familial and hereditary colorectal cancer; Laparoscopic procedures for colorectal cancer; Surgery for recurrent cancer, Haemorrhoids; Anal physiology and adhesion.

Contact Person

Dr. Judy Ho

Tel: 2855 4762

Fax: 2872 8425

E-mail: judyho@hkucc.hku.hk

Clinical projects: Parathyroid autotransplantation: clinical and molecular studies; Risk group analysis in thyroid carcinoma.

Laboratory projects: Oncogene expression in thyroid and endocrine tumors; Rapid PTH assay in parathyroid surgery; Ret-protooncogene expression in papillary carcinoma of thyroid; Genetic study of multiple endocrine neoplasia syndromes.

Contact Person

Dr. C.Y. Lo

Tel: 2855 4773

Fax: 2817 2291

E-mail: cylo@hkucc.hku.hk

Clinical projects: Preoperative chemoradiation for treatment of esophageal cancer; Chemoradiation as definitive palliative treatment for esophageal cancer; Intraluminal brachytherapy for treatment of esophageal cancer; Metallic stenting for esophageal cancer; Thoracoscopic esophageal resection for esophageal and hypopharyngeal cancer; Minimal Access surgey for achalasia; Swallowing disorders: manometry; Gastroesophageal reflux disease in Chinese; Quality of life in patients with esophageal cancer; Endoscopic ultrasound in staging of esophageal cancer.

Laboratory projects: Molecular genetics of esophageal cancer

Contact Person

Professor S. Law

Tel: 2855 4774

Fax: 2819 4221

E-mail: slaw@hkucc.hku.hk

Clinical projects: Foreign body ingestion; Ulcer disease and their complications(e.g., laparoscopic surgery, therapeutic endoscopy for bleeding, management of perforated ulcer); Helicobacter pylori infection; Gastrc tumours (adenocarcinoma, gastrointestinal stromal tumour, lymphoma); Upper gastrointestinal endoscopy; Endoscopic ultrasonography. 

Laboratory projects: Ulcer diseases (e.g., growth factors, ulcerogenesis); Gastric adenocarcinoma (e.g., molecular genetics, novel therapeutic approaches); Gastric stromal tumor (e.g., molecular genetics).

Contact Person

Dr. K.M. Chu

Tel: 2855 4637

Fax: 2819 4221

E-mail: chukm@hkucc.hku.hk

Clinical projects: Reconstructive options after major resections in head and neck region; Whole organ histological section to study patterns of tumor extension; Nutritional study for patients undergoing major head and neck surgey; Effects of radiotherapy on free tissue transferred with microvascular technique; Nasopharyngeal cancer, hearing problems.

Contact Person

Professor W. Wei

Tel: 2855 4237

Fax: 2818 4407

E-mail: hrmswwi@hkucc.hku.hk

Clinical projects: Hepatocellular carcinoma: hepatocarcinogenesis and hepatitis B virus, angiogenesis, cryotherapy, randomised controlled trials including non-operative treatment, surgical techniques and adjuvant therapy after hepatic resection; Liver transplantation: animal model for small size liver transplant and artificial liver support, clinical application of living related liver transplant in adults; Biliary pancreatitis, acute cholangitis, intrahepatic stones, malignant biliary obstruction; Endoscopic and laparoscopic ultrasonography.

Laboratory projects: Liver transplantation - animal model for small size liver transplant and artificial liver support; Hepatocellular carcinoma- hepatocarcinogenesis and hepatitis B virus, angiogenesis.

Contact Person

Professor S.T. Fan; E-mail: hrmsfst@hkucc.hku.hk or

Professor Ronnie Poon; E-mail: poontp@hkucc.hku.hk

Tel: 2855 4703

Fax: 2818 4407

Clinical projects: Event related evoked potentials in brain damaged patients; Pituitary tumor; Monitoring in head injury; Cerebral blood flow study; Clinical course and pathophysiology of vasospasm and hyperaemia after traumatic head injury; Measurement of cerebral blood flow velocity to define the physiological relationship between velocity and blood flow; Phase-contrast velocity MRI for flow dynamics of cerebrospinal fluid.

Contact Person

Dr. K.N. Hung

Tel: 2855 3368/3773

Fax: 2818 4350

E-mail: hungkn@hkucc.hku.hk

Clinical projects: Acoustic rhinomanometry in children; Turbinectomy for hypertrophic inferior turbinate; Orbital decompression for thyrotoxicosis; Cochlea implant for children; Otoacoustic emission for screening of high-risk newborn babies; Dizziness and balance problems.

Contact Person

Professor P.W. Yuen

Tel: 2855 4394

Fax: 2819 3790

E-mail: pwyuen@hku.hk

Clinical projects: Metabolic response of neonates to major surgey; Biliary atresia and choledochal cyst; Liver transplantation; Experimental small bowel transplantation; Intestinal ischaemia-reperfusion; Transplantation immunology; Childhood cancers; Dendritic cell biology in transplantation and anti-tumor therapy.

Laboratory projects: Developmental biology; Molecular genetics and pathology of Hirschsprung's disease and related neural crest disorders; Embryonic and fetal development of gut; Cellular mechanisms involved in VACTERL association, including esophageal atresia and duodenal atresia.

Contact Person

Professor P.K.H. Tam

Tel: 2855 4850/3536

Fax: 2817 3155

E-mail: paultam@hkucc.hku.hk

Clinical projects: Effect of growth factors on wound healing after radiotherapy; Keloid and hypertrophic scars.

Contact Person

Professor W. Wei

Tel: 2855 4237

Fax: 2818 4407

E-mail: hrmswwi@hkucc.hku.hk

Clinical projects: Molecular study of bladder cancer; Day surgery for ureteric stone: Surgical treatment of male infertility; Various treatment options for erectile dysfunction; Medical and surgical treatment of begnin prostatic hyperplasia; Evaluation & treatment of prostatitis; Urethral sphincter physiology.

Laboratory projects: Molecular study of bladder cancer.

Contact Person

Dr. PC Tam

Tel: 2855 3023

Fax: 2872 8425

E-mail: tampc@ha.org.hk

Clinical projects: Prospective study correlating demographic and biochemical risk factors and the severity and degree of progression and the long-term natural history of atherosclerosis in patients with peripheral arterial diseases; Study, using ultrasonography, of the prevalence and the risks of deep-vein thrombosis in the Chinese population; Computer-assisted carotid plaque morphology.

Laboratory projects: Study of the molecular basis and cellular signaling involved in the pathogenesis of abdominal aortic aneurysms; Expression of different cellular receptors and the modulators of extracellular matrix protein in human aneurismal aortic wall.

Contact Person

Professor S.W.K. Cheng

Tel: 2855 4962

Fax: 2855 4961

E-mail: wkcheng@hku.hk

Students are required to attend and give presentation at departmental research meetings and research laboratory meetings. There will be an laboratory induction course in September and January each year for new registered research students.