On going projects

2004 2003 2002 2001 2000 1999 1997	2005 TTF-1 and RET promoter SNPs: regulation of RET transcription in Hirschsprung's disease. Garcia-Barcelo MM, Ganster RW, Lui VCH, Leon TYY, So MT, Lau AMF, Fu M, Sham MH, Knight J, Zannini MS, Sham PC and Tam PKH. Hum Mol Genet. (2005) Jan;14:191-204 (IF 8.597) The significance of Rac signaling pathway in HCC cell motility: implication for new therapeutic target. Lee TKW, Man K, Ho JWY, Wang XH, Poon RTP, Sun CKW, Ng KTP, Ng IOL, Xu R and Fan ST. Carcinogenesis (2005) Mar; 26 (3): 681-7 (IF 5.375) Novel RET mutation produces a truncated RET receptor lacking the intracellular signaling domain in a three generation family with Hirschsprung's disease. Lui VCH, Leon TYY, Garcia-Barcelo MM, Ganster RW, Chen BLS, Hutson JM and Tam PKH. Clin Chem (2005) Aug;51(8):1552-1554. (I.F.: 6.5) Effects of a Novel Immunomodulating Agent FTY720 on Angiogenesis and Tumor Growth in Hepatocellular Carcinoma Ho JWY, Man K, Sun CKW, Lee TKW, Poon RTP and Fan ST. Molecular Cancer Therapeutics (2005) sep; 4(9): 1430-8 (IF 5.242) 　 FTY720: a promising agent for treatment of metastatic hepatocellular carcinoma. Lee TKW, Man K, Ho JWY, Poon RTP, Xu Y, Sun CKW, Ng KTP, Chu ACH, Ng IO, Sun HC, Tang ZY, Xu R and Fan ST. Clinical Cancer Research (2005) Dec 1;11(23):8458-66 (IF 5.623 　 FTY720 attenuates hepatic ischemia-reperfusion injury in normal and cirrhotic liver. Man K, Ng KTP, Lee TKW, Lo CM, Sun CKW, Li XL, Zhao Y, Ho JWY and Fan ST. American Journal of Transplantation (2005); 5: 40-49 (IF 5.306) The dysregulation of phosphatidylinositol 3-kinase/Akt pathway contributes to ischemic injury during rat liver graft preservation. Li XL, Man K, Ng KT, Sun CK, Lo CM and Fan ST. American Journal of Transplantation (2005); 5 (6): 1264-75 (IF 5.306)

2005 2003 2002 2001 2000 1999 1997	2004 Clinical significance of thrombospondin 1 expression in hepatocellular carcinoma. Poon RT, Chung KK, Cheung ST, Lau CP, Tong SW, Leung KL, Yu WC, Tuszynski GP, Fan ST. Clinical Cancer Research 15; 10 (12 Pt 1): 4150-7 Jun 2004 Dendritic cells: sentinels against pathogens. Chung NPY, Chen Y, Chan VSF, Tam PKH, Lin CLS Histology and Histopathology 19 (1): 317-324 Jan 2004 Different testicular gene expression patterns in the first spermatogenic cycle of postnatal and vitamin A-deficient rat testis Lee KF, Yeung WS, Chow JF, Shum CK, Luk JM Biol Reprod 2004 Apr;70(4):1010-7. Epub 2003 Dec 03 Embryonic development of the ganglion plexuses and the concentric layer structure of human gut: a topographical study. Fu M, Tam PK, Sham MH, Lui VCH. Anat Embryol (Berl). 208(1):33-41 Apr 2004 Expression of hepatocyte-like phenotypes in bone marrow stromal cells after HGF induction. Wang PP, Wang JH, Yan ZP, Hu MY, Lau GK, Fan ST, Luk JM. Biochem Biophys Res Commun. 30;320(3):712-6 Jul 2004 FK 409 ameliorates small-for-size liver graft injury by attentuation of portal hypertension and down-regulation of Egr-1 pathway. Man K, Lee TK, Liang TB, Lo CM, Fung PC, Tsui SH, Li XL, Ng KT, Fan ST. Ann Surg 240 (1): 159-68 Jul 2004 Heme oxygenase-1 potentiates the survival of small-for-size liver graft. Yang ZF, Tsui TY, Ho DW, Tang TC, Fan ST. Liver Transplantation 10 (6): 784-93 Jun 2004 Linking inflammation to acute rejection in small-for-size liver allografts: The potential role of early macrophage activation. Yang ZF, Ho DWY, Chu ACY, Wang YQ, Fan ST American Journal of Transplantation 4 (2): 196-209 FEB 2004 Overexpression of LI-cadherin in gastric cancer is associated with lymph node metastasis. Ko S, Chu KM, Luk JM, Wong BW, Yuen ST, Leung SY, Wong J. Biochem Biophys Res Commun 25;319(2):562-8 Jun 2004 Smoking and drinking can induce p15 methylation in the upper aerodigestive tract of healthy individuals and patients with head and neck squamous cell carcinoma. Chang HW, Ling GS, Wei Wi, Yuen AP. Cancer. 1; 101(1): 125-32 Jul 2004

2005 2004 2002 2001 2000 1999 1997	2003 A compromise between self-enhancement and honesty: Chinese self-evaluations on social desirability scales Liu CX, Xiao JA, Yang ZF Psychological Reports 92 (1): 291-298 FEB 2003 HOXB5 expression is spatially and temporarily regulated in human embryonic gut during neural crest cell colonization and differentiation of enteric neuroblasts. Fu M, Lui VCH, Sham MH, Cheung ANY, Tam PK. Dev Dyn. 228:1-10. 2003 Identification of liver-intestine cadherin in hepatocellular carcinoma - a potential disease marker Wong BW, Luk JM, Ng IO, Hu MY, Liu KD, Fan ST Biochemical and Biophysical Research Communications 311 (3): 618-624 NOV 21 2003 Identification of novel genes expressed during spermatogenesis in stage-synchronized rat testes by differential display. Luk JM, Mok BW, Shum CK, Yeung WS, Tam PC, Tse JY, Chow JF, Woo J, Kam K, Lee KF Biochemical and Biophysical Research Communications 307 (4): 782-790 AUG 8 2003 Insulin in University of Wisconsin solution exacerbates the ischemic injury and decreases the graft survival rate in rat liver transplantation Li XL, Man K, Liu YF, Lee TKW, Tsui SHT, Lau CK, Lo CM, Fan ST Transplantation 76 (1): 44-49 JUL 15 2003 Intragraft gene expression profiles by cDNA microarray in small-for-size liver grafts Man K, Lo CM, Lee TKW, Li XL, Ng IOL, Fan ST Liver Transplantation 9 (4): 425-432 APR 2003 Li-cadherin (CDH 17), a potential biomarker for hepatocellular carcinoma Wong BW, Fan ST, Luk JM FASEB Journal 17 (4): A255-A256 Part 1 Suppl. S MAR 14 2003 Liver-intestine cadherin: A potential disease marker for hepatocellular carcinoma. Luk JM, Wong BWY, Hu MY, Fan ST Hepatology 38 (4): 515 Suppl. 1 OCT 2003 Long-term liver allograft survival induced by combined treatment with rAAV-hCTLA4Ig gene transfer and low-dose FK506 Yang ZF, Wu XB, Tsui TY, Hou Y, Luk JM, Fan ST Transplantation 75 (3): 303-308 FEB 15 2003 Recombinant adeno-associated virus vector: Is it ideal for gene delivery in liver transplantation? Yang ZF, Wu XB, Tsui TY, Hou YD, Luk JM, Fan ST Liver Transplantation 9 (4): 411-420 APR 2003 Quantitative correlation of serum levels and tumor expression of vascular endothelial growth factor in patients with hepatocellular carcinoma Poon RTP, Lau CPY, Cheung ST, Yu WC, Fan ST Cancer Research 63 (12): 3121-3126 JUN 15 2003 3 ' Splicing variants of ret receptor tyrosine kinase are differentially expressed in mouse embryos and in adult mice Lee KY, Samy ET, Sham MH, Tam PKH, Lui VCH Biochimica ET Biophysica ACTA-Gene Structure and Expression 1627 (1): 26-38 MAY 13 2003 The effect of cyclooxygenase-2 (COX-2) inhibitor, Celecoxib, on xenograft of hepatocellular carcinoma (HCC) in nude mice. Tang TC, Poon RT, Guan XY, Fan ST Clinical Cancer Research 9 (16): 6149S-6149S Part 2 Suppl. S DEC 1 2003 The study of p16 and p15 gene methylation in head and neck squamous cell carcinoma and their quantitative evaluation in plasma by real-time PCR Wong TS, Man MWL, Lam AKY, Wei WI, Kwong YL, Yuen APW European Journal of Cancer 39 (13): 1881-1887 SEP 2003 Tissue factor expression correlates with tumor angiogenesis and invasiveness in human hepatocellular carcinoma Poon RTP, Lau CPY, Ho JWY, Yu WC, Fan ST, Wong J Clinical Cancer Research 9 (14): 5339-5345 NOV 1 2003
2005 2004 2003 2001 2000 1999 1997	2002 Clinicopathologic significance of bcl-2 expression in the surgical treatment of oral tongue carcinoma Yuen APW, Lam KY, Choy JTH, Ho WK, Wong LY, Wei WI European Journal of Surgical Oncology 28 (6): 667-672 SEP 2002 High frequency of promoter hypermethylation of the death-associated protein-kinase gene in nasopharyngeal carcinoma and its detection in the peripheral blood of patients Wong TS, Chang HW, Tang KC, Wei WI, Kwong DLW, Sham JST, Yuen APW, Kwong YL Clinical Cancer Research 8 (2): 433-437 FEB 2002 Identify metastasis-associated genes in hepatocellular carcinoma through clonality delineation for multinodular tumor Cheung ST, Chen X, Guan XY, Wong SY, Tai LS, Ng IOL, So S, Fan ST Cancer Research 62 (16): 4711-4721 AUG 15 2002 Liver as an ideal target for gene therapy: Expression of CTLA4Ig by retroviral gene transfer Cheung ST, Tsui TY, Wang WL, Yang ZF, Wong SY, Ip YC, Luk J, Fan ST Journal of Gastroenterology and Hepatology 17 (9): 1008-1014 SEP 2002 Loss of E-cadherin expression resulting from promoter hypermethylation in oral tongue carcinoma and its prognostic significance Chang HW, Chow V, Lam KY, Wei WI, Yuen APW Cancer 94 (2): 386-392 JAN 15 2002 Tumor microvessel density as a predictor of recurrence after resection of hepatocellular carcinoma: A prospective study Poon RTP, Ng IOL, Lau C, Yu WC, Yang ZF, Fan ST, Wong J Journal of Clinical Oncology 20 (7): 1775-1785 APR 1 2002
2005 2004 2003 2002 2000 1999 1997	2001 A comparative study of the clinicopathological significance of E-cadherin and catenins (alpha,beta,gamma) expression in the surgical management of oral tongue carcinoma Chow V, Yuen APW, Lam KY, Tsao GSW, Ho WK, Wei WI Journal of Cancer Research and Clinical Oncology 127 (1): 59-63 JAN 2001 Novel mutations of SOX10 suggest a dominant negative role in Waardenburg-Shah syndrome. Sham MH, Lui VCH, Chen BL, Fu M, Tam PK. J Med Genet. 38(9):E30. Sep 2001 Management of extensive cervical nodal metastasis in nasopharyngeal carcinoma after radiotherapy - A clinicopathological study Wei WI, Ho WK, Cheng ACK, Wu XQ, Li GKH, Nicholls J, Yuen PW, Sham JST Archives of Otolaryngology-Head & Neck Surgery 127 (12): 1457-1462 DEC 2001 Prognostic significance of serum p53 protein and p53 antibody in patients with surgical treatment for head and neck squamous cell carcinoma Chow V, Yuen APW, Lam KY, Ho WK, Wei WI Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 23 (4): 286-291 APR 2001 SOX10 is abnormally expressed in aganglionic bowel of Hirschsprung's disease infants. Sham MH, Lui VCH, Fu M, Chen B, Tam PK. Gut. 49(2):220-6. Aug 2001 Telomerase activity in small cell esophageal carcinoma Chow V, Law S, Lam KY, Luk JM, Wong J Diseases of the Esophagus 14 (2): 139-142 2001 The clinicopathological significance of bcl-2 expression in the surgical treatment of laryngeal carcinoma Yuen APW, Lam KY, Choy JTH, Ho WK, Wei WI Clinical Otolaryngology 26 (2): 129-133 APR 2001
2005 2004 2003 2002 2001 1999 1997	2000 Clinicopathological significance of p53 and p21 expression in the surgical treatment of laryngeal carcinoma Yuen PW, Lam KY, Choy JTH, Ho WK, Wei WI Anticancer Research 20 (6C): 4863-4866 NOV-DEC 2000 Comparison of University of Wisconsin and St. Thomas' Hospital solutions on endothelium-derived hyperpolarizing factor-mediated function in coronary micro-arteries Ge ZD, He GW Transplantation 70 (1): 22-31 JUL 15 2000 Difference in endothelium-derived hyperpolarizing factor-mediated hyperpolarization and nitric oxide release between human internal mammary artery and saphenous vein Liu ZG, Ge ZD, He GW Circulation 102 (19): 296-301 Suppl. S NOV 7 2000 Endothelium-dependent hyperpolarization and relaxation resistance to N-G-nitro-L-arginine and indomethacin in coronary circulation Ge ZD, Zhang XH, Fung PCW, He GW Cardiovascular Research 46 (3): 547-556 JUN 2000 Intracerebral hemorrhage after liver transplantation Wang WL, Yang ZF, Lo CM, Liu CL, Fan ST Liver Transplantation 6 (3): 345-348 MAY 2000 Nitric oxide (NO) release and K+ channels involved in bradykinin (BK)-induced hyperpolarization resistant to indomethacin and N-G-nitro-L-arginine (L-NNA) in coronary micro-artery. Ge ZD, He GW FASEB Journal 14 (4): A461-A461 MAR 15 2000 Mapping of LPS-binding site on human leukocyte integrin beta-2 subunit. Mok BW, Luk JM Molecular Biology of the Cell 11: 1367 Suppl. S DEC 2000
2005 2004 2003 2002 2001 2000 1997	1999 Altered endothelium-derived hyperpolarizing factor-mediated endothelial function in coronary microarteries by St Thomas' Hospital solution Ge ZD, He GW Journal of Thoracic and Cardiovascular Surgery 118 (1): 173-180 JUL 1999 Differential expression of gap-junction gene connexin 31 in seminiferous epithelium of rat testes. Mok BW, Yeung WSB, Luk JM FEBS Letters 453 (3): 243-248 JUN 25 1999 Difference in hyperpolarization mediated by endothelium-derived hyperpolarizing factor between human internal thoracic artery and saphenous vein Liu ZG, Ge ZD, He GW Circulation 100 (18): 3158 Suppl. S NOV 2 1999 Effect of University of Wisconsin solution (UWS) on hyperpolarization-mediated relaxation in coronary micro-arteries: Comparison to St. Thomas solution (STS). Ge ZD, He GW FASEB Journal 13 (4): A511-A511 Part 1 Suppl. S MAR 12 1999 Nitric oxide (NO)-independent, hyperpolarization-mediated relaxation involves multiple K+ channels in porcine micro-coronary arteries. He GW, Ge ZD FASEB Journal 13 (4): A511-A511 Part 1 Suppl. S MAR 12 1999 Role of nitric oxide in intestinal ischaemia-reperfusion injury studied using electron paramagnetic resonance Chan KL, Zhang XH, Fung PCW, Guo WH, Tam PKH British Journal of Surgery 86 (11): 1427-1432 NOV 1999
2005 2004 2003 2002 2001 2000 1999	1997 Management of fulminant hepatic failure at Queen Mary Hospital Fan ST, Lo CM, Lo RJW, Fung KY, Wei W, Chen YB, Lai CL, Ng IOL, Yuen KY, Chan J, Wong J Chinese Medical Journal 110 (6): 482-484 JUN 1997

　